Gene Expression Literature Summary

• Symbol: Spred1
• Name: sprouty protein with EVH-1 domain 1, related sequence
• ID: MGI:2150016

11 matching records from 11 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E11.5	E12.5	E13.5	E14	E14.5	E15.5	E16	E16.5	E17	E	P
Immunohistochemistry (section)			1		1
In situ RNA (section)	1	1		1		1		1	1		1
Immunohistochemistry (whole mount)											1
In situ RNA (whole mount)		1				2
Western blot	1	1		1	1		1	1	1		1
RT-PCR	1	1	1		1	1				2	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Spred1  sprouty protein with EVH-1 domain 1, related sequence   (Synonyms: 5730461F13Rik, Spred-1)
Results	Reference
1	J:226487 Bagheri-Fam S, Ono M, Li L, Zhao L, Ryan J, Lai R, Katsura Y, Rossello FJ, Koopman P, Scherer G, Bartsch O, Eswarakumar JV, Harley VR, FGFR2 mutation in 46,XY sex reversal with craniosynostosis. Hum Mol Genet. 2015 Dec 1;24(23):6699-710
1	J:293772 Bird AD, Croft BM, Harada M, Tang L, Zhao L, Ming Z, Bagheri-Fam S, Koopman P, Wang Z, Akita K, Harley VR, Ovotesticular disorders of sex development in FGF9 mouse models of human synostosis syndromes. Hum Mol Genet. 2020 Aug 3;29(13):2148-2161
5	J:108170 Engelhardt CM, Bundschu K, Messerschmitt M, Renne T, Walter U, Reinhard M, Schuh K, Expression and subcellular localization of Spred proteins in mouse and human tissues. Histochem Cell Biol. 2004 Dec;122(6):527-38
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:259186 Heng X, Guo Q, Leung AW, Li JY, Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Elife. 2017 May 10;6:e23253
6*	J:155794 Phoenix TN, Temple S, Spred1, a negative regulator of Ras-MAPK-ERK, is enriched in CNS germinal zones, dampens NSC proliferation, and maintains ventricular zone structure. Genes Dev. 2010 Jan 1;24(1):45-56
3*	J:243411 Rutledge EA, Benazet JD, McMahon AP, Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Development. 2017 Sep 01;144(17):3177-3188
5*	J:168653 Sylvestersen KB, Herrera PL, Serup P, Rescan C, Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):105-11
3	J:154087 Trimarchi JM, Stadler MB, Cepko CL, Individual retinal progenitor cells display extensive heterogeneity of gene expression. PLoS One. 2008;3(2):e1588
2*	J:286739 Wazin F, Lovicu FJ, The negative regulatory Spred1 and Spred2 proteins are required for lens and eye morphogenesis. Exp Eye Res. 2020 Feb;191:107917
1	J:345586 Wazin F, Lovicu FJ, Conditional Ablation of Spred1 and Spred2 in the Eye Lens Negatively Impacts Its Development and Growth. Cells. 2024 Feb 6;13(4)