Gene Expression Literature Summary

• Symbol: Spred2
• Name: sprouty-related EVH1 domain containing 2
• ID: MGI:2150019

12 matching records from 12 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8	E8.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16	E16.5	E	P
Immunohistochemistry (section)								1	1					1
In situ RNA (section)		1	1		1		1		1	1
Immunohistochemistry (whole mount)														1
In situ RNA (whole mount)		1	1				1			2
In situ reporter (knock in)	1	1	1	1	1	1	1	1
Western blot							1		1		1	1		1
RT-PCR						1	1	1	1	1			2	1
cDNA clones			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Spred2  sprouty-related EVH1 domain containing 2   (Synonyms: Spred-2)
Results	Reference
1	J:226487 Bagheri-Fam S, Ono M, Li L, Zhao L, Ryan J, Lai R, Katsura Y, Rossello FJ, Koopman P, Scherer G, Bartsch O, Eswarakumar JV, Harley VR, FGFR2 mutation in 46,XY sex reversal with craniosynostosis. Hum Mol Genet. 2015 Dec 1;24(23):6699-710
2	J:112701 Bailey PJ, Klos JM, Andersson E, Karlen M, Kallstrom M, Ponjavic J, Muhr J, Lenhard B, Sandelin A, Ericson J, A global genomic transcriptional code associated with CNS-expressed genes. Exp Cell Res. 2006 Oct 1;312(16):3108-19
1	J:293772 Bird AD, Croft BM, Harada M, Tang L, Zhao L, Ming Z, Bagheri-Fam S, Koopman P, Wang Z, Akita K, Harley VR, Ovotesticular disorders of sex development in FGF9 mouse models of human synostosis syndromes. Hum Mol Genet. 2020 Aug 3;29(13):2148-2161
6	J:108170 Engelhardt CM, Bundschu K, Messerschmitt M, Renne T, Walter U, Reinhard M, Schuh K, Expression and subcellular localization of Spred proteins in mouse and human tissues. Histochem Cell Biol. 2004 Dec;122(6):527-38
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:259186 Heng X, Guo Q, Leung AW, Li JY, Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Elife. 2017 May 10;6:e23253
3*	J:243411 Rutledge EA, Benazet JD, McMahon AP, Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Development. 2017 Sep 01;144(17):3177-3188
1*	J:149737 Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van Heyningen V, Rubenstein JL, Livesey FJ, The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. PLoS Genet. 2009 Jun;5(6):e1000511
5*	J:168653 Sylvestersen KB, Herrera PL, Serup P, Rescan C, Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):105-11
13*	J:165397 Tuduce IL, Schuh K, Bundschu K, Spred2 expression during mouse development. Dev Dyn. 2010 Nov;239(11):3072-85
2*	J:286739 Wazin F, Lovicu FJ, The negative regulatory Spred1 and Spred2 proteins are required for lens and eye morphogenesis. Exp Eye Res. 2020 Feb;191:107917
1	J:345586 Wazin F, Lovicu FJ, Conditional Ablation of Spred1 and Spred2 in the Eye Lens Negatively Impacts Its Development and Growth. Cells. 2024 Feb 6;13(4)