Symbol Name ID |
Sp7
Sp7 transcription factor 7 MGI:2153568 |
Age | E9.5 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E | P |
Immunohistochemistry (section) | 1 | 5 | 28 | 1 | 25 | 29 | 32 | 13 | 1 | 20 | 33 | |||||||||
In situ RNA (section) | 1 | 1 | 1 | 2 | 6 | 1 | 18 | 2 | 24 | 3 | 21 | 2 | 12 | 1 | 3 | 1 | 12 | 1 | 8 | |
In situ RNA (whole mount) | 2 | 1 | 1 | 1 | 1 | 2 | 2 | 1 | 1 | 1 | ||||||||||
In situ reporter (knock in) | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 1 | ||||||||||||
Northern blot | 1 | 1 | ||||||||||||||||||
Western blot | 2 | 3 | 4 | |||||||||||||||||
RT-PCR | 1 | 2 | 3 | 2 | 9 | 1 | 7 | 1 | 14 | 1 | 9 | 5 | 2 | 12 | 2 | 27 |
Sp7 Sp7 transcription factor 7 (Synonyms: 6430578P22Rik, osterix, Osx) | |
Results | Reference |
2 | J:124269 Abzhanov A, Rodda SJ, McMahon AP, Tabin CJ, Regulation of skeletogenic differentiation in cranial dermal bone. Development. 2007 Sep;134(17):3133-44 |
2 | J:310856 Almubarak A, Lavy R, Srnic N, Hu Y, Maripuri DP, Kume T, Berry FB, Loss of Foxc1 and Foxc2 function in chondroprogenitor cells disrupts endochondral ossification. J Biol Chem. 2021 Jul 29;297(3):101020 |
1 | J:309392 Amano K, Densmore MJ, Lanske B, Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation. J Bone Miner Res. 2015 Dec;30(12):2262-72 |
1 | J:346119 Amano K, Okuzaki D, Kitaoka Y, Kato S, Fujiwara M, Tanaka S, Iida S, Pth1r in Neural Crest Cells Regulates Nasal Cartilage Differentiation. J Dent Res. 2024 Mar;103(3):308-317 |
1 | J:326693 Angelozzi M, Pellegrino da Silva R, Gonzalez MV, Lefebvre V, Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors. Cell Rep. 2022 Jul 12;40(2):111045 |
2 | J:337598 Au TYK, Yip RKH, Wynn SL, Tan TY, Fu A, Geng YH, Szeto IYY, Niu B, Yip KY, Cheung MCH, Lovell-Badge R, Cheah KSE, Hypomorphic and dominant-negative impact of truncated SOX9 dysregulates Hedgehog-Wnt signaling, causing campomelia. Proc Natl Acad Sci U S A. 2023 Jan 3;120(1):e2208623119 |
1 | J:170583 Baek JA, Lan Y, Liu H, Maltby KM, Mishina Y, Jiang R, Bmpr1a signaling plays critical roles in palatal shelf growth and palatal bone formation. Dev Biol. 2011 Feb 15;350(2):520-31 |
1 | J:118257 Bandyopadhyay A, Tsuji K, Cox K, Harfe BD, Rosen V, Tabin CJ, Genetic Analysis of the Roles of BMP2, BMP4, and BMP7 in Limb Patterning and Skeletogenesis. PLoS Genet. 2006 Dec 22;2(12):e216 |
2 | J:237340 Ben Shoham A, Rot C, Stern T, Krief S, Akiva A, Dadosh T, Sabany H, Lu Y, Kadler KE, Zelzer E, Deposition of collagen type I onto skeletal endothelium reveals a new role for blood vessels in regulating bone morphology. Development. 2016 Nov 01;143(21):3933-3943 |
4 | J:339397 Cabrera Pereira A, Dasgupta K, Ho TV, Pacheco-Vergara M, Kim J, Kataria N, Liang Y, Mei J, Yu J, Witek L, Chai Y, Jeong J, Lineage-specific mutation of Lmx1b provides new insights into distinct regulation of suture development in different areas of the calvaria. Front Physiol. 2023;14:1225118 |
2 | J:239074 Cai H, Liu A, Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14751-14756 |
3* | J:231581 Cesario JM, Almaidhan AA, Jeong J, Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development. Gene Expr Patterns. 2016 Mar;20(2):111-9 |
3* | J:267540 Cesario JM, Landin Malt A, Chung JU, Khairallah MP, Dasgupta K, Asam K, Deacon LJ, Choi V, Almaidhan AA, Darwiche NA, Kim J, Johnson RL, Jeong J, Anti-osteogenic function of a LIM-homeodomain transcription factor LMX1B is essential to early patterning of the calvaria. Dev Biol. 2018 Nov 15;443(2):103-116 |
2 | J:261043 Chan WL, Steiner M, Witkos T, Egerer J, Busse B, Mizumoto S, Pestka JM, Zhang H, Hausser I, Khayal LA, Ott CE, Kolanczyk M, Willie B, Schinke T, Paganini C, Rossi A, Sugahara K, Amling M, Knaus P, Chan D, Lowe M, Mundlos S, Kornak U, Impaired proteoglycan glycosylation, elevated TGF-beta signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. PLoS Genet. 2018 Mar;14(3):e1007242 |
1* | J:185962 Chen D, Tian W, Li Y, Tang W, Zhang C, Osteoblast-specific transcription factor Osterix (Osx) and HIF-1alpha cooperatively regulate gene expression of vascular endothelial growth factor (VEGF). Biochem Biophys Res Commun. 2012 Jul 20;424(1):176-81 |
1 | J:269614 Chen H, Guo S, Xia Y, Yuan L, Lu M, Zhou M, Fang M, Meng L, Xiao Z, Ma J, The role of Rho-GEF Trio in regulating tooth root development through the p38 MAPK pathway. Exp Cell Res. 2018 Nov 15;372(2):158-167 |
3 | J:208766 Chen J, Tu X, Esen E, Joeng KS, Lin C, Arbeit JM, Ruegg MA, Hall MN, Ma L, Long F, WNT7B promotes bone formation in part through mTORC1. PLoS Genet. 2014 Jan;10(1):e1004145 |
6 | J:224562 Chen Q, Sinha K, Deng JM, Yasuda H, Krahe R, Behringer RR, de Crombrugghe B, Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation. J Bone Miner Res. 2015 Sep;30(9):1608-17 |
4 | J:223357 Chen Q, Zhang L, de Crombrugghe B, Krahe R, Mesenchyme-specific overexpression of nucleolar protein 66 in mice inhibits skeletal growth and bone formation. FASEB J. 2015 Jun;29(6):2555-65 |
5* | J:296805 Chen S, Gluhak-Heinrich J, Wang YH, Wu YM, Chuang HH, Chen L, Yuan GH, Dong J, Gay I, MacDougall M, Runx2, osx, and dspp in tooth development. J Dent Res. 2009 Oct;88(10):904-9 |
1 | J:336856 Chen X, Li N, Hu P, Li L, Li D, Liu H, Zhu L, Xiao J, Liu C, Deficiency of Fam20b-Catalyzed Glycosaminoglycan Chain Synthesis in Neural Crest Leads to Cleft Palate. Int J Mol Sci. 2023 Jun 1;24(11) |
4 | J:274818 Chen Y, Wang Z, Chen Y, Zhang Y, Conditional deletion of Bmp2 in cranial neural crest cells recapitulates Pierre Robin sequence in mice. Cell Tissue Res. 2019 May;376(2):199-210 |
4* | J:329220 Chen Y, Wu J, Zhang S, Gao W, Liao Z, Zhou T, Li Y, Su D, Liu H, Yang X, Su P, Xu C, Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1alpha-glycolysis axis. Cell Death Dis. 2022 Sep 20;13(9):803 |
1 | J:232617 Chen Z, Yue SX, Zhou G, Greenfield EM, Murakami S, ERK1 and ERK2 regulate chondrocyte terminal differentiation during endochondral bone formation. J Bone Miner Res. 2015 May;30(5):765-74 |
2* | J:201600 Cheng S, Xing W, Zhou X, Mohan S, Haploinsufficiency of osterix in chondrocytes impairs skeletal growth in mice. Physiol Genomics. 2013 Oct 1;45(19):917-23 |
1* | J:166611 Chung IH, Han J, Iwata J, Chai Y, Msx1 and Dlx5 function synergistically to regulate frontal bone development. Genesis. 2010 Nov;48(11):645-55 |
2 | J:217906 Cooley MA, Harikrishnan K, Oppel JA, Miler SF, Barth JL, Haycraft CJ, Reddy SV, Scott Argraves W, Fibulin-1 is required for bone formation and Bmp-2-mediated induction of Osterix. Bone. 2014 Dec;69:30-8 |
2 | J:293199 Crespo-Enriquez I, Hodgson T, Zakaria S, Cadoni E, Shah M, Allen S, Al-Khishali A, Mao Y, Yiu A, Petzold J, Villagomez-Olea G, Pitsillides AA, Irvine KD, Francis-West P, Dchs1-Fat4 regulation of osteogenic differentiation in mouse. Development. 2019 Jul 29;146(14):dev176776 |
1* | J:89221 Dacquin R, Mee PJ, Kawaguchi J, Olmsted-Davis EA, Gallagher JA, Nichols J, Lee K, Karsenty G, Smith A, Knock-in of nuclear localised beta-galactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar. Dev Dyn. 2004 Apr;229(4):826-34 |
2 | J:282348 Dasgupta K, Chung JU, Asam K, Jeong J, Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling. Dev Biol. 2019 Nov 15;455(2):434-448 |
2 | J:98427 Day TF, Guo X, Garrett-Beal L, Yang Y, Wnt/beta-Catenin Signaling in Mesenchymal Progenitors Controls Osteoblast and Chondrocyte Differentiation during Vertebrate Skeletogenesis. Dev Cell. 2005 May;8(5):739-50 |
3 | J:184618 Deckelbaum RA, Holmes G, Zhao Z, Tong C, Basilico C, Loomis CA, Regulation of cranial morphogenesis and cell fate at the neural crest-mesoderm boundary by engrailed 1. Development. 2012 Apr;139(7):1346-58 |
2 | J:104802 Deckelbaum RA, Majithia A, Booker T, Henderson JE, Loomis CA, The homeoprotein engrailed 1 has pleiotropic functions in calvarial intramembranous bone formation and remodeling. Development. 2006 Jan;133(1):63-74 |
1 | J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41 |
2 | J:115876 Dobreva G, Chahrour M, Dautzenberg M, Chirivella L, Kanzler B, Farinas I, Karsenty G, Grosschedl R, SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell. 2006 Jun 2;125(5):971-86 |
2 | J:237001 Duan X, Bradbury SR, Olsen BR, Berendsen AD, VEGF stimulates intramembranous bone formation during craniofacial skeletal development. Matrix Biol. 2016 May-Jul;52-54:127-40 |
2 | J:222247 Duan X, Murata Y, Liu Y, Nicolae C, Olsen BR, Berendsen AD, Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development. Development. 2015 Jun 1;142(11):1984-91 |
2* | J:195901 Ehlen H, Inactivation of anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues. J Bone Miner Res. 2013;28(2):246-59 |
1 | J:127545 Engleka KA, Wu M, Zhang M, Antonucci NB, Epstein JA, Menin is required in cranial neural crest for palatogenesis and perinatal viability. Dev Biol. 2007 Nov 15;311(2):524-37 |
3 | J:294823 Fabik J, Kovacova K, Kozmik Z, Machon O, Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway. Biol Open. 2020 Jul 2;9(6):bio052043 |
2 | J:330128 Fabik J, Psutkova V, Machon O, Meis2 controls skeletal formation in the hyoid region. Front Cell Dev Biol. 2022;10:951063 |
3 | J:308983 Farmer DT, Mlcochova H, Zhou Y, Koelling N, Wang G, Ashley N, Bugacov H, Chen HJ, Parvez R, Tseng KC, Merrill AE, Maxson RE Jr, Wilkie AOM, Crump JG, Twigg SRF, The developing mouse coronal suture at single-cell resolution. Nat Commun. 2021 Aug 10;12(1):4797 |
2 | J:347134 Feng X, Molteni H, Gregory M, Lanza J, Polsani N, Gupta I, Wyetzner R, Hawkins MB, Holmes G, Hopyan S, Harris MP, Atit RP, Apical expansion of calvarial osteoblasts and suture patency is dependent on fibronectin cues. Development. 2024 Apr 1;151(7):dev202371 |
1 | J:317071 Ferguson J, Devarajan M, DiNuoscio G, Saiakhova A, Liu CF, Lefebvre V, Scacheri PC, Atit RP, PRC2 Is Dispensable in Vivo for beta-Catenin-Mediated Repression of Chondrogenesis in the Mouse Embryonic Cranial Mesenchyme. G3 (Bethesda). 2018 Feb 2;8(2):491-503 |
2* | J:255607 Fu X, Xu J, Chaturvedi P, Liu H, Jiang R, Lan Y, Identification of Osr2 Transcriptional Target Genes in Palate Development. J Dent Res. 2017 Nov;96(12):1451-1458 |
1 | J:288683 Gacem N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J, Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N, ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. Nat Commun. 2020 Jan 10;11(1):198 |
2* | J:203540 Gadi J, Jung SH, Lee MJ, Jami A, Ruthala K, Kim KM, Cho NH, Jung HS, Kim CH, Lim SK, The transcription factor protein Sox11 enhances early osteoblast differentiation by facilitating proliferation and the survival of mesenchymal and osteoblast progenitors. J Biol Chem. 2013 Aug 30;288(35):25400-13 |
1 | J:185118 Galli GG, Honnens de Lichtenberg K, Carrara M, Hans W, Wuelling M, Mentz B, Multhaupt HA, Fog CK, Jensen KT, Rappsilber J, Vortkamp A, Coulton L, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Calogero RA, Couchman JR, Lund AH, Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone. PLoS Genet. 2012 May;8(5):e1002711 |
1* | J:338182 Gehlen-Breitbach S, Schmid T, Frob F, Rodrian G, Weider M, Wegner M, Golz L, The Tip60/Ep400 chromatin remodeling complex impacts basic cellular functions in cranial neural crest-derived tissue during early orofacial development. Int J Oral Sci. 2023 Apr 6;15(1):16 |
1 | J:98430 Glass DA 2nd, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G, Canonical wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. 2005 May;8(5):751-64 |
2 | J:199943 Golovchenko S, Hattori T, Hartmann C, Gebhardt M, Gebhard S, Hess A, Pausch F, Schlund B, von der Mark K, Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation. Bone. 2013 Jul;55(1):102-12 |
1 | J:214984 Gonzalez-Martin MC, Mallo M, Ros MA, Long bone development requires a threshold of Hox function. Dev Biol. 2014 Aug 15;392(2):454-65 |
2 | J:189063 Goodnough LH, Chang AT, Treloar C, Yang J, Scacheri PC, Atit RP, Twist1 mediates repression of chondrogenesis by beta-catenin to promote cranial bone progenitor specification. Development. 2012 Dec;139(23):4428-38 |
1 | J:229313 Goodnough LH, Dinuoscio GJ, Atit RP, Twist1 contributes to cranial bone initiation and dermal condensation by maintaining wnt signaling responsiveness. Dev Dyn. 2016 Feb;245(2):144-56 |
3 | J:226667 Goodnough LH, Dinuoscio GJ, Ferguson JW, Williams T, Lang RA, Atit RP, Distinct requirements for cranial ectoderm and mesenchyme-derived wnts in specification and differentiation of osteoblast and dermal progenitors. PLoS Genet. 2014 Feb;10(2):e1004152 |
1 | J:336727 Gorrell L, Makareeva E, Omari S, Otsuru S, Leikin S, ER, Mitochondria, and ISR Regulation by mt-HSP70 and ATF5 upon Procollagen Misfolding in Osteoblasts. Adv Sci (Weinh). 2022 Oct;9(29):e2201273 |
1 | J:295485 Goss M, Socorro M, Monier D, Verdelis K, Napierala D, Trps1 transcription factor regulates mineralization of dental tissues and proliferation of tooth organ cells. Mol Genet Metab. 2019 Apr;126(4):504-512 |
3* | J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257 |
1* | J:138379 Gu S, Wei N, Yu L, Fei J, Chen Y, Shox2-deficiency leads to dysplasia and ankylosis of the temporomandibular joint in mice. Mech Dev. 2008 Aug;125(8):729-42 |
1* | J:134348 Gu S, Wei N, Yu X, Jiang Y, Fei J, Chen Y, Mice with an anterior cleft of the palate survive neonatal lethality. Dev Dyn. 2008 May;237(5):1509-16 |
1* | J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004; |
1* | J:306057 Guo L, Iida A, Bhavani GS, Gowrishankar K, Wang Z, Xue JY, Wang J, Miyake N, Matsumoto N, Hasegawa T, Iizuka Y, Matsuda M, Nakashima T, Takechi M, Iseki S, Yambe S, Nishimura G, Koseki H, Shukunami C, Girisha KM, Ikegawa S, Deficiency of TMEM53 causes a previously unknown sclerosing bone disorder by dysregulation of BMP-SMAD signaling. Nat Commun. 2021 Apr 6;12(1):2046 |
1 | J:275314 Guo S, Zhang Y, Zhou T, Wang D, Weng Y, Wang L, Ma J, Role of GATA binding protein 4 (GATA4) in the regulation of tooth development via GNAI3. Sci Rep. 2017 May 8;7(1):1534 |
2* | J:323190 Guo T, Han X, He J, Feng J, Jing J, Janeckova E, Lei J, Ho TV, Xu J, Chai Y, KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis. Elife. 2022 Feb 25;11:e74595 |
2 | J:150187 Guo X, Mak KK, Taketo MM, Yang Y, The Wnt/beta-catenin pathway interacts differentially with PTHrP signaling to control chondrocyte hypertrophy and final maturation. PLoS One. 2009;4(6):e6067 |
3* | J:125119 Han J, Ishii M, Bringas P Jr, Maas RL, Maxson RE Jr, Chai Y, Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development. Mech Dev. 2007 Sep-Oct;124(9-10):729-45 |
1 | J:256184 Haraguchi R, Kitazawa R, Mori K, Tachibana R, Kiyonari H, Imai Y, Abe T, Kitazawa S, sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss. Sci Rep. 2016 Apr 27;6:25198 |
1 | J:167738 Hardouin SN, Guo R, Romeo PH, Nagy A, Aubin JE, Impaired mesenchymal stem cell differentiation and osteoclastogenesis in mice deficient for Igf2-P2 transcripts. Development. 2011 Jan;138(2):203-13 |
1 | J:338183 Hariri H, Kose O, Bezdjian A, Daniel SJ, St-Arnaud R, USP53 Regulates Bone Homeostasis by Controlling Rankl Expression in Osteoblasts and Bone Marrow Adipocytes. J Bone Miner Res. 2023 Apr;38(4):578-596 |
1 | J:234565 He D, Marie C, Zhao C, Kim B, Wang J, Deng Y, Clavairoly A, Frah M, Wang H, He X, Hmidan H, Jones BV, Witte D, Zalc B, Zhou X, Choo DI, Martin DM, Parras C, Lu QR, Chd7 cooperates with Sox10 and regulates the onset of CNS myelination and remyelination. Nat Neurosci. 2016 May;19(5):678-89 |
1 | J:245766 He F, Soriano P, Dysregulated PDGFRalpha signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification. Development. 2017 Nov 01;144(21):4026-4036 |
2 | J:236411 He X, Ohba S, Hojo H, McMahon AP, AP-1 family members act with Sox9 to promote chondrocyte hypertrophy. Development. 2016 Aug 15;143(16):3012-23 |
1 | J:309228 Hill C, Jacobs B, Kennedy L, Rohde S, Zhou B, Baldwin S, Goudy S, Cranial neural crest deletion of VEGFa causes cleft palate with aberrant vascular and bone development. Cell Tissue Res. 2015 Sep;361(3):711-22 |
2 | J:207974 Hill CR, Yuasa M, Schoenecker J, Goudy SL, Jagged1 is essential for osteoblast development during maxillary ossification. Bone. 2014 May;62:10-21 |
2 | J:98426 Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C, Canonical Wnt/beta-Catenin Signaling Prevents Osteoblasts from Differentiating into Chondrocytes. Dev Cell. 2005 May;8(5):727-38 |
1* | J:233142 Hilton MJ, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, Kronenberg HM, Teitelbaum SL, Ross FP, Kopan R, Long F, Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008 Mar;14(3):306-14 |
2 | J:185618 Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI, Gli1 protein participates in Hedgehog-mediated specification of osteoblast lineage during endochondral ossification. J Biol Chem. 2012 May 18;287(21):17860-9 |
1 | J:217455 Holm E, Aubin JE, Hunter GK, Beier F, Goldberg HA, Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization. Bone. 2015 Feb;71:145-54 |
2 | J:316922 Holmes G, Gonzalez-Reiche AS, Saturne M, Motch Perrine SM, Zhou X, Borges AC, Shewale B, Richtsmeier JT, Zhang B, van Bakel H, Jabs EW, Single-cell analysis identifies a key role for Hhip in murine coronal suture development. Nat Commun. 2021 Dec 8;12(1):7132 |
1 | J:286051 Holmes G, O'Rourke C, Motch Perrine SM, Lu N, van Bakel H, Richtsmeier JT, Jabs EW, Midface and upper airway dysgenesis in FGFR2-related craniosynostosis involves multiple tissue-specific and cell cycle effects. Development. 2018 Oct 5;145(19):dev166488 |
1 | J:237341 Houben A, Kostanova-Poliakova D, Weissenbock M, Graf J, Teufel S, von der Mark K, Hartmann C, beta-catenin activity in late hypertrophic chondrocytes locally orchestrates osteoblastogenesis and osteoclastogenesis. Development. 2016 Oct 15;143(20):3826-3838 |
1 | J:255577 Hsu WH, Chen CM, You LR, COUP-TFII is required for morphogenesis of the neural crest-derived tympanic ring. Sci Rep. 2017 Sep 28;7(1):12386 |
3 | J:94274 Hu H, Hilton MJ, Tu X, Yu K, Ornitz DM, Long F, Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development. 2005 Jan;132(1):49-60 |
1 | J:253972 Hwang SH, White KA, Somatilaka BN, Shelton JM, Richardson JA, Mukhopadhyay S, The G protein-coupled receptor Gpr161 regulates forelimb formation, limb patterning and skeletal morphogenesis in a primary cilium-dependent manner. Development. 2018 Jan 8;145(1):dev154054 |
1 | J:339059 Ihn HJ, Kim JA, Lim J, Nam SH, Hwang SH, Kim YK, Kim JY, Kim JE, Cho ES, Jiang R, Park EK, Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein. J Cell Physiol. 2021 Jan;236(1):480-488 |
5 | J:256071 Iyyanar PPR, Nazarali AJ, Hoxa2 Inhibits Bone Morphogenetic Protein Signaling during Osteogenic Differentiation of the Palatal Mesenchyme. Front Physiol. 2017;8:929 |
2 | J:292597 Jarvis SE, Lee JE, Jewlal E, Barr K, Kelly GM, Laird DW, Willmore KE, Effects of reduced connexin43 function on skull development in the Cx43(I130T/+) mutant mouse that models oculodentodigital dysplasia. Bone. 2020 Jul;136:115365 |
2 | J:233766 Jiang Q, Qin X, Kawane T, Komori H, Matsuo Y, Taniuchi I, Ito K, Izumi S, Komori T, Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development. J Bone Miner Res. 2016 Jul;31(7):1391-404 |
1 | J:339746 Jin R, Zhang H, Lin C, Guo J, Zou W, Chen Z, Liu H, Inhibition of miR338 rescues cleidocranial dysplasia in Runx2 mutant mice partially via the Hif1a-Vegfa axis. Exp Mol Med. 2023 Jan;55(1):69-80 |
2 | J:266558 Jin Y, Cong Q, Gvozdenovic-Jeremic J, Hu J, Zhang Y, Terkeltaub R, Yang Y, Enpp1 inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling. Development. 2018 Sep 20;145(18):dev164830 |
3 | J:154905 Joeng KS, Long F, The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization. Development. 2009 Dec;136(24):4177-85 |
3 | J:178499 Joeng KS, Schumacher CA, Zylstra-Diegel CR, Long F, Williams BO, Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo. Dev Biol. 2011 Nov 15;359(2):222-9 |
14 | J:129783 Kaback LA, Soung do Y, Naik A, Smith N, Schwarz EM, O'Keefe RJ, Drissi H, Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification. J Cell Physiol. 2008 Jan;214(1):173-82 |
2 | J:143588 Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y, BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 2008 Nov;135(22):3801-11 |
1 | J:149607 Kansara M, Tsang M, Kodjabachian L, Sims NA, Trivett MK, Ehrich M, Dobrovic A, Slavin J, Choong PF, Simmons PJ, Dawid IB, Thomas DM, Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice. J Clin Invest. 2009 Apr;119(4):837-51 |
1 | J:226965 Kato K, Bhattaram P, Penzo-Mendez A, Gadi A, Lefebvre V, SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling. J Bone Miner Res. 2015 Sep;30(9):1560-71 |
1 | J:176975 Khavandgar Z, Poirier C, Clarke CJ, Li J, Wang N, McKee MD, Hannun YA, Murshed M, A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization. J Cell Biol. 2011 Jul 25;194(2):277-89 |
3 | J:279226 Kim TH, Bae CH, Lee JC, Kim JE, Yang X, de Crombrugghe B, Cho ES, Osterix regulates tooth root formation in a site-specific manner. J Dent Res. 2015 Mar;94(3):430-8 |
1 | J:263685 Kitami K, Kitami M, Kaku M, Wang B, Komatsu Y, BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development. PLoS Genet. 2018 May;14(5):e1007340 |
1 | J:288306 Kuriki M, Sato F, Arai HN, Sogabe M, Kaneko M, Kiyonari H, Kawakami K, Yoshimoto Y, Shukunami C, Sehara-Fujisawa A, Transient and lineage-restricted requirement of Ebf3 for sternum ossification. Development. 2020 May 12;147(9):dev186239 |
2 | J:202964 Lai LP, Lilley BN, Sanes JR, McMahon AP, Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19450-5 |
1 | J:127543 Lana-Elola E, Rice R, Grigoriadis AE, Rice DP, Cell fate specification during calvarial bone and suture development. Dev Biol. 2007 Nov 15;311(2):335-46 |
2 | J:250555 Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH, Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol. 2017 Mar;19(3):189-201 |
1* | J:308017 Langhans MT, Gao J, Tang Y, Wang B, Alexander P, Tuan RS, Wdpcp regulates cellular proliferation and differentiation in the developing limb via hedgehog signaling. BMC Dev Biol. 2021 Jul 5;21(1):10 |
1 | J:268341 Lee SY, Abel ED, Long F, Glucose metabolism induced by Bmp signaling is essential for murine skeletal development. Nat Commun. 2018 Nov 16;9(1):4831 |
1 | J:243780 Li F, Fu G, Liu Y, Miao X, Li Y, Yang X, Zhang X, Yu D, Gan L, Qiu M, Chen Y, Zhang Z, Zhang Z, ISLET1-Dependent beta-Catenin/Hedgehog Signaling Is Required for Outgrowth of the Lower Jaw. Mol Cell Biol. 2017 Apr 15;37(8) |
4 | J:245974 Li J, Cui Y, Xu J, Wang Q, Yang X, Li Y, Zhang X, Qiu M, Zhang Z, Zhang Z, Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development. J Biol Chem. 2017 Sep 22;292(38):15814-15825 |
4 | J:319475 Liao C, Lu M, Hong Y, Mao C, Chen J, Ren C, Lin M, Chen W, Osteogenic and angiogenic profiles of the palatal process of the maxilla and the palatal process of the palatine bone. J Anat. 2022 Feb;240(2):385-397 |
1 | J:314657 Lin S, Zhang Q, Cao Z, Lu Y, Zhang H, Yan K, Liu Y, McKee MD, Qin C, Chen Z, Feng JQ, Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype. J Biol Chem. 2014 Aug 1;289(31):21533-43 |
1 | J:306541 Lin YC, Niceta M, Muto V, Vona B, Pagnamenta AT, Maroofian R, Beetz C, van Duyvenvoorde H, Dentici ML, Lauffer P, Vallian S, Ciolfi A, Pizzi S, Bauer P, Gruning NM, Bellacchio E, Del Fattore A, Petrini S, Shaheen R, Tiosano D, Halloun R, Pode-Shakked B, Albayrak HM, Isik E, Wit JM, Dittrich M, Freire BL, Bertola DR, Jorge AAL, Barel O, Sabir AH, Al Tenaiji AMJ, Taji SM, Al-Sannaa N, Al-Abdulwahed H, Digilio MC, Irving M, Anikster Y, Bhavani GSL, Girisha KM, Haaf T, Taylor JC, Dallapiccola B, Alkuraya FS, Yang RB, Tartaglia M, SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling. Am J Hum Genet. 2021 Jan 7;108(1):115-133 |
1 | J:352094 Liu C, Zhou N, Li N, Xu T, Chen X, Zhou H, Xie A, Liu H, Zhu L, Wang S, Xiao J, Disrupted tenogenesis in masseter as a potential cause of micrognathia. Int J Oral Sci. 2022 Oct 18;14(1):50 |
1 | J:322701 Liu Y, Chen Q, Jeong HW, Koh BI, Watson EC, Xu C, Stehling M, Zhou B, Adams RH, A specialized bone marrow microenvironment for fetal haematopoiesis. Nat Commun. 2022 Mar 14;13(1):1327 |
1 | J:193842 Lu C, Wan Y, Cao J, Zhu X, Yu J, Zhou R, Yao Y, Zhang L, Zhao H, Li H, Zhao J, He L, Ma G, Yang X, Yao Z, Guo X, Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification. Bone. 2013 Apr;53(2):566-74 |
3 | J:333798 Luo S, Liu Z, Bian Q, Wang X, Ectomesenchymal Six1 controls mandibular skeleton formation. Front Genet. 2023;14:1082911 |
2 | J:347800 Lv Y, Wang Q, Lin C, Zheng X, Zhang Y, Hu X, Overexpression of Fgf18 in cranial neural crest cells recapitulates Pierre Robin sequence in mice. Front Cell Dev Biol. 2024;12:1376814 |
1 | J:176467 Maeno T, Moriishi T, Yoshida CA, Komori H, Kanatani N, Izumi S, Takaoka K, Komori T, Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects. Bone. 2011 Oct;49(4):673-82 |
1* | J:291303 Manickam G, Moffatt P, Murshed M, Role of SMPD3 during Bone Fracture Healing and Regulation of Its Expression. Mol Cell Biol. 2019 Feb 15;39(4) |
1 | J:332099 Maruyama T, Hasegawa D, Valenta T, Haigh J, Bouchard M, Basler K, Hsu W, GATA3 mediates nonclassical beta-catenin signaling in skeletal cell fate determination and ectopic chondrogenesis. Sci Adv. 2022 Dec 2;8(48):eadd6172 |
1 | J:316180 Maruyama T, Jiang M, Abbott A, Yu HI, Huang Q, Chrzanowska-Wodnicka M, Chen EI, Hsu W, Rap1b Is an Effector of Axin2 Regulating Crosstalk of Signaling Pathways During Skeletal Development. J Bone Miner Res. 2017 Sep;32(9):1816-1828 |
2 | J:339245 Maruyama T, Jiang M, Hsu W, Gpr177, a novel locus for bone mineral density and osteoporosis, regulates osteogenesis and chondrogenesis in skeletal development. J Bone Miner Res. 2013 May;28(5):1150-9 |
1 | J:152864 Matsunobu T, Torigoe K, Ishikawa M, de Vega S, Kulkarni AB, Iwamoto Y, Yamada Y, Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev Biol. 2009 Aug 15;332(2):325-38 |
2 | J:153980 Matsushita T, Chan YY, Kawanami A, Balmes G, Landreth GE, Murakami S, Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis. Mol Cell Biol. 2009 Nov;29(21):5843-57 |
1 | J:296737 Matsuura VKSK, Yoshida CA, Komori H, Sakane C, Yamana K, Jiang Q, Komori T, Expression of a Constitutively Active Form of Hck in Chondrocytes Activates Wnt and Hedgehog Signaling Pathways, and Induces Chondrocyte Proliferation in Mice. Int J Mol Sci. 2020 Apr 12;21(8):2682 |
1 | J:264139 Mead TJ, McCulloch DR, Ho JC, Du Y, Adams SM, Birk DE, Apte SS, The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification. JCI Insight. 2018 Apr 5;3(7) |
2 | J:166753 Mirando AJ, Maruyama T, Fu J, Yu HM, Hsu W, beta-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis. BMC Dev Biol. 2010;10:116 |
4* | J:270314 Mitomo K, Matsunaga S, Kitamura K, Nakamura T, Saito A, Komori T, Muramatsu T, Yamaguchi A, Sphenoid bone hypoplasia is a skeletal phenotype of cleidocranial dysplasia in a mouse model and patients. Bone. 2019 Mar;120:176-186 |
3 | J:213581 Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A, Ono N, Kronenberg HM, Frenette PS, Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development. Dev Cell. 2014 May 12;29(3):340-9 |
5 | J:173242 Moisan A, Rivera MN, Lotinun S, Akhavanfard S, Coffman EJ, Cook EB, Stoykova S, Mukherjee S, Schoonmaker JA, Burger A, Kim WJ, Kronenberg HM, Baron R, Haber DA, Bardeesy N, The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification. Dev Cell. 2011 May 17;20(5):583-96 |
1 | J:84790 Mori-Akiyama Y, Akiyama H, Rowitch DH, de Crombrugghe B, Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9360-5 |
9* | J:265083 Mullen RD, Wang Y, Liu B, Moore EL, Behringer RR, Osterix functions downstream of anti-Mullerian hormone signaling to regulate Mullerian duct regression. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8382-8387 |
1 | J:344936 Musa RE, Lester KL, Quickstad G, Vardabasso S, Shumate TV, Salcido RT, Ge K, Shpargel KB, BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation. Development. 2024 Jan 15;151(2):dev202110 |
3 | J:316165 Nakamura E, Hata K, Takahata Y, Kurosaka H, Abe M, Abe T, Kihara M, Komori T, Kobayashi S, Murakami T, Inubushi T, Yamashiro T, Yamamoto S, Akiyama H, Kawaguchi M, Sakata N, Nishimura R, Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice. Commun Biol. 2021 Nov 3;4(1):1258 |
5 | J:74344 Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B, The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002 Jan 11;108(1):17-29 |
1* | J:321553 Neupane S, Berardinelli SJ, Cameron DC, Grady RC, Komatsu DE, Percival CJ, Takeuchi M, Ito A, Liu TW, Nairn AV, Moremen KW, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development. Matrix Biol. 2022 Feb 12; |
1 | J:191589 Nishimura R, Wakabayashi M, Hata K, Matsubara T, Honma S, Wakisaka S, Kiyonari H, Shioi G, Yamaguchi A, Tsumaki N, Akiyama H, Yoneda T, Osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (MMP13) expression in association with transcription factor Runx2 during endochondral ossification. J Biol Chem. 2012 Sep 28;287(40):33179-90 |
3 | J:232190 Noda K, Kitami M, Kitami K, Kaku M, Komatsu Y, Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development. Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2589-97 |
4 | J:181485 Oh JH, Park SY, de Crombrugghe B, Kim JE, Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification. Biochem Biophys Res Commun. 2012 Feb 24;418(4):634-40 |
4 | J:92630 Ohyama Y, Nifuji A, Maeda Y, Amagasa T, Noda M, Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis. Endocrinology. 2004 Oct;145(10):4685-92 |
1 | J:118794 Oka K, Oka S, Sasaki T, Ito Y, Bringas P Jr, Nonaka K, Chai Y, The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev Biol. 2007 Mar 1;303(1):391-404 |
3 | J:179841 Pacheco M, Valencia M, Caparros-Martin JA, Mulero F, Goodship JA, Ruiz-Perez VL, Evc works in chondrocytes and osteoblasts to regulate multiple aspects of growth plate development in the appendicular skeleton and cranial base. Bone. 2012 Jan;50(1):28-41 |
5 | J:239772 Parada C, Han D, Grimaldi A, Sarrion P, Park SS, Pelikan R, Sanchez-Lara PA, Chai Y, Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015 Nov 01;142(21):3734-45 |
2 | J:238876 Park JS, Park GI, Kim JE, Osterix is dispensable for the development of the mouse olfactory bulb. Biochem Biophys Res Commun. 2016 Sep 09;478(1):110-5 |
1 | J:309481 Park NR, Lim KE, Han MS, Che X, Park CY, Kim JE, Taniuchi I, Bae SC, Choi JY, Core Binding Factor beta Plays a Critical Role During Chondrocyte Differentiation. J Cell Physiol. 2016 Jan;231(1):162-71 |
1 | J:264160 Patoine A, Husseini A, Kasaai B, Gaumond MH, Moffatt P, The osteogenic cell surface marker BRIL/IFITM5 is dispensable for bone development and homeostasis in mice. PLoS One. 2017;12(9):e0184568 |
1 | J:258274 Patra D, DeLassus E, Mueller J, Abou-Ezzi G, Sandell LJ, Site-1 protease regulates skeletal stem cell population and osteogenic differentiation in mice. Biol Open. 2018 Feb 22;7(2):bio032094 |
2* | J:287761 Pineault KM, Song JY, Kozloff KM, Lucas D, Wellik DM, Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life. Nat Commun. 2019 Jul 18;10(1):3168 |
1 | J:350324 Polsani N, Yung T, Thomas E, Phung-Rojas M, Gupta I, Denker J, Lau K, Feng X, Ibarra B, Hopyan S, Atit RP, Mesenchymal Wnts are required for morphogenetic movements of calvarial osteoblasts during apical expansion. Development. 2024 Jun 15;151(12):dev202596 |
1 | J:219841 Qin X, Jiang Q, Matsuo Y, Kawane T, Komori H, Moriishi T, Taniuchi I, Ito K, Kawai Y, Rokutanda S, Izumi S, Komori T, Cbfb regulates bone development by stabilizing runx family proteins. J Bone Miner Res. 2015 Apr;30(4):706-14 |
2 | J:299239 Qin X, Jiang Q, Nagano K, Moriishi T, Miyazaki T, Komori H, Ito K, Mark KV, Sakane C, Kaneko H, Komori T, Runx2 is essential for the transdifferentiation of chondrocytes into osteoblasts. PLoS Genet. 2020 Nov;16(11):e1009169 |
2* | J:255349 Rauch F, Geng Y, Lamplugh L, Hekmatnejad B, Gaumond MH, Penney J, Yamanaka Y, Moffatt P, Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice. Bone. 2018 Feb;107:131-142 |
1 | J:335294 Redhead Y, Gibbins D, Lana-Elola E, Watson-Scales S, Dobson L, Krause M, Liu KJ, Fisher EMC, Green JBA, Tybulewicz VLJ, Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077 |
1 | J:202828 Regard JB, Malhotra D, Gvozdenovic-Jeremic J, Josey M, Chen M, Weinstein LS, Lu J, Shore EM, Kaplan FS, Yang Y, Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med. 2013 Nov;19(11):1505-12 |
2* | J:306391 Roth DM, Baddam P, Lin H, Vidal-Garcia M, Aponte JD, De Souza ST, Godziuk D, Watson AES, Footz T, Schachter NF, Egan SE, Hallgrimsson B, Graf D, Voronova A, The Chromatin Regulator Ankrd11 Controls Palate and Cranial Bone Development. Front Cell Dev Biol. 2021;9:645386 |
2 | J:306205 Ruengsinpinya L, Murakami T, Nakamura E, Takahata Y, Hata K, Nakaminami Y, Okae H, Nishimura R, G protein subunit beta1 is an important mediator of the late stage of endochondral ossification. Biochem Biophys Res Commun. 2020 Nov 26;533(1):90-96 |
3* | J:160652 Sahara S, Kawakami Y, Izpisua Belmonte JC, O'Leary DD, Sp8 exhibits reciprocal induction with Fgf8 but has an opposing effect on anterior-posterior cortical area patterning. Neural Dev. 2007;2:10 |
1 | J:182752 Sasagawa S, Takemori H, Uebi T, Ikegami D, Hiramatsu K, Ikegawa S, Yoshikawa H, Tsumaki N, SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice. Development. 2012 Mar;139(6):1153-63 |
2 | J:105169 Sasaki T, Ito Y, Bringas P Jr, Chou S, Urata MM, Slavkin H, Chai Y, TGF{beta}-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development. Development. 2006 Jan;133(2):371-81 |
1 | J:208432 Schwarz D, Varum S, Zemke M, Scholer A, Baggiolini A, Draganova K, Koseki H, Schubeler D, Sommer L, Ezh2 is required for neural crest-derived cartilage and bone formation. Development. 2014 Feb;141(4):867-77 |
3 | J:153638 Seo HS, Serra R, Tgfbr2 is required for development of the skull vault. Dev Biol. 2009 Oct 15;334(2):481-90 |
7 | J:140421 Shibata S, Yokohama-Tamaki T, An in situ hybridization study of Runx2, Osterix, and Sox9 in the anlagen of mouse mandibular condylar cartilage in the early stages of embryogenesis. J Anat. 2008 Sep;213(3):274-83 |
1 | J:294895 Shpargel KB, Mangini CL, Xie G, Ge K, Magnuson T, The KMT2D Kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology. Development. 2020 Jul 17;147(21):dev187997 |
1 | J:194442 Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, Hilton MJ, Wang Y, Chen D, BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci. 2011 Oct 15;124(Pt 20):3428-40 |
1* | J:156025 Sinha KM, Yasuda H, Coombes MM, Dent SY, de Crombrugghe B, Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J. 2010 Jan 6;29(1):68-79 |
1 | J:159823 Sohaskey ML, Jiang Y, Zhao JJ, Mohr A, Roemer F, Harland RM, Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. J Cell Biol. 2010 May 3;189(3):511-25 |
3 | J:295946 Sohn WJ, Gwon GJ, Kim HS, Neupane S, Cho SJ, Lee JH, Yamamoto H, Choi JY, An CH, Lee Y, Shin HI, Lee S, Kim JY, Mesenchymal signaling in dorsoventral differentiation of palatal epithelium. Cell Tissue Res. 2015 Dec;362(3):541-56 |
2 | J:119030 Spater D, Hill TP, O'sullivan RJ, Gruber M, Conner DA, Hartmann C, Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Development. 2006 Aug;133(15):3039-49 |
1* | J:147246 Spoorendonk KM, Peterson-Maduro J, Renn J, Trowe T, Kranenbarg S, Winkler C, Schulte-Merker S, Retinoic acid and Cyp26b1 are critical regulators of osteogenesis in the axial skeleton. Development. 2008 Nov;135(22):3765-74 |
3 | J:333326 Suh J, Kim NK, Shim W, Lee SH, Kim HJ, Moon E, Sesaki H, Jang JH, Kim JE, Lee YS, Mitochondrial fragmentation and donut formation enhance mitochondrial secretion to promote osteogenesis. Cell Metab. 2023 Feb 7;35(2):345-360.e7 |
2* | J:285711 Sweat YY, Sweat M, Mansaray M, Cao H, Eliason S, Adeyemo WL, Gowans LJJ, Eshete MA, Anand D, Chalkley C, Saadi I, Lachke SA, Butali A, Amendt BA, Six2 regulates Pax9 expression, palatogenesis and craniofacial bone formation. Dev Biol. 2020 Feb 15;458(2):246-256 |
2 | J:205050 Swinehart IT, Schlientz AJ, Quintanilla CA, Mortlock DP, Wellik DM, Hox11 genes are required for regional patterning and integration of muscle, tendon and bone. Development. 2013 Nov;140(22):4574-82 |
2 | J:314589 Takahata Y, Hagino H, Kimura A, Urushizaki M, Kobayashi S, Wakamori K, Fujiwara C, Nakamura E, Yu K, Kiyonari H, Bando K, Murakami T, Komori T, Hata K, Nishimura R, Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2. Commun Biol. 2021 Oct 19;4(1):1199 |
1* | J:180593 Tang W, Yang F, Li Y, de Crombrugghe B, Jiao H, Xiao G, Zhang C, Transcriptional regulation of Vascular Endothelial Growth Factor (VEGF) by osteoblast-specific transcription factor Osterix (Osx) in osteoblasts. J Biol Chem. 2012 Jan 13;287(3):1671-8 |
1 | J:125052 Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara K, Komiya S, Maruyama I, Lotz M, Bianchi ME, Asahara H, Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification. Mol Cell Biol. 2007 Aug;27(16):5650-63 |
2* | J:269344 Teng CS, Ting MC, Farmer DT, Brockop M, Maxson RE, Crump JG, Altered bone growth dynamics prefigure craniosynostosis in a zebrafish model of Saethre-Chotzen syndrome. Elife. 2018 Oct 25;7:e37024 |
4* | J:321550 Ting MC, Farmer DT, Teng CS, He J, Chai Y, Crump JG, Maxson RE, Embryonic requirements for Tcf12 in the development of the mouse coronal suture. Development. 2022 Jan 1;149(1):dev199575 |
2* | J:344830 Tsutsumi-Arai C, Arai Y, Tran A, Salinas M, Nakai Y, Orikasa S, Ono W, Ono N, A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2. J Dent Res. 2024 Jan;103(1):91-100 |
1 | J:183534 Tu X, Chen J, Lim J, Karner CM, Lee SY, Heisig J, Wiese C, Surendran K, Kopan R, Gessler M, Long F, Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1. PLoS Genet. 2012 Mar;8(3):e1002577 |
1* | J:180304 Tu X, Joeng KS, Long F, Indian hedgehog requires additional effectors besides Runx2 to induce osteoblast differentiation. Dev Biol. 2012 Feb 1;362(1):76-82 |
1 | J:117333 Tu X, Joeng KS, Nakayama KI, Nakayama K, Rajagopal J, Carroll TJ, McMahon AP, Long F, Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell. 2007 Jan;12(1):113-27 |
1 | J:335804 Umar M, Bartoletti G, Dong C, Gahankari A, Browne D, Deng A, Jaramillo J, Sammarco M, Simkin J, He F, Characterizing the role of Pdgfra in calvarial development. Dev Dyn. 2023 May;252(5):589-604 |
5 | J:340401 Varadinkova S, Oralova V, Clarke M, Frampton J, Knopfova L, Lesot H, Bartos P, Matalova E, Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor. Front Cell Dev Biol. 2023;11:1168866 |
1 | J:309718 Veistinen LK, Mustonen T, Hasan MR, Takatalo M, Kobayashi Y, Kesper DA, Vortkamp A, Rice DP, Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets. Front Physiol. 2017;8:1036 |
1 | J:300455 Vu TH, Takechi M, Shimizu M, Kitazawa T, Higashiyama H, Iwase A, Kurihara H, Iseki S, Dlx5-augmentation in neural crest cells reveals early development and differentiation potential of mouse apical head mesenchyme. Sci Rep. 2021 Jan 22;11(1):2092 |
2 | J:311534 Wan Y, Lantz B, Cusack BJ, Szabo-Rogers HL, Prickle1 regulates differentiation of frontal bone osteoblasts. Sci Rep. 2018 Dec 21;8(1):18021 |
1 | J:316121 Wang JR, Wang CJ, Xu CY, Wu XK, Hong D, Shi W, Gong Y, Chen HX, Long F, Wu XM, Signaling Cascades Governing Cdc42-Mediated Chondrogenic Differentiation and Mensenchymal Condensation. Genetics. 2016 Mar;202(3):1055-69 |
4 | J:286823 Wang L, Tang Q, Xu J, Li H, Yang T, Li L, Machon O, Hu T, Chen Y, The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice. J Biol Chem. 2020 Apr 17;295(16):5449-5460 |
4 | J:321350 Warner DR, Wells JP, Greene RM, Pisano MM, Gene expression changes in the secondary palate and mandible of Prdm16(-/-) mice. Cell Tissue Res. 2013 Mar;351(3):445-52 |
2 | J:320628 Watanabe-Takano H, Ochi H, Chiba A, Matsuo A, Kanai Y, Fukuhara S, Ito N, Sako K, Miyazaki T, Tainaka K, Harada I, Sato S, Sawada Y, Minamino N, Takeda S, Ueda HR, Yasoda A, Mochizuki N, Mechanical load regulates bone growth via periosteal Osteocrin. Cell Rep. 2021 Jul 13;36(2):109380 |
1 | J:156633 Watanabe-Takano H, Takano K, Keduka E, Endo T, M-Ras is activated by bone morphogenetic protein-2 and participates in osteoblastic determination, differentiation, and transdifferentiation. Exp Cell Res. 2010 Feb 1;316(3):477-90 |
1 | J:236410 Watson EC, Koenig MN, Grant ZL, Whitehead L, Trounson E, Dewson G, Coultas L, Apoptosis regulates endothelial cell number and capillary vessel diameter but not vessel regression during retinal angiogenesis. Development. 2016 Aug 15;143(16):2973-82 |
3 | J:185130 Wei J, Shi Y, Zheng L, Zhou B, Inose H, Wang J, Guo XE, Grosschedl R, Karsenty G, miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J Cell Biol. 2012 May 14;197(4):509-21 |
1* | J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130 |
1 | J:229488 Wiszniak S, Harvey N, Schwarz Q, Cell autonomous roles of Nedd4 in craniofacial bone formation. Dev Biol. 2016 Feb 1;410(1):98-107 |
2 | J:214660 Wu M, Li C, Zhu G, Wang Y, Jules J, Lu Y, McConnell M, Wang YJ, Shao JZ, Li YP, Chen W, Deletion of core-binding factor beta (Cbfbeta) in mesenchymal progenitor cells provides new insights into Cbfbeta/Runxs complex function in cartilage and bone development. Bone. 2014 Aug;65:49-59 |
2 | J:281388 Xu J, Huang Z, Wang W, Tan X, Li H, Zhang Y, Tian W, Hu T, Chen YP, FGF8 Signaling Alters the Osteogenic Cell Fate in the Hard Palate. J Dent Res. 2018 May;97(5):589-596 |
4 | J:283053 Xu J, Wang L, Li H, Yang T, Zhang Y, Hu T, Huang Z, Chen Y, Shox2 regulates osteogenic differentiation and pattern formation during hard palate development in mice. J Biol Chem. 2019 Nov 29;294(48):18294-18305 |
3* | J:307192 Yadav PS, Feng S, Cong Q, Kim H, Liu Y, Yang Y, Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2020100118 |
1* | J:308829 Yamaguchi H, Meyer MD, He L, Senavirathna L, Pan S, Komatsu Y, The molecular complex of ciliary and golgin protein is crucial for skull development. Development. 2021 Jul 1;148(13):dev199559 |
4 | J:263887 Yan J, Li J, Hu J, Zhang L, Wei C, Sultana N, Cai X, Zhang W, Cai CL, Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development. J Biol Chem. 2018 Jun 15;293(24):9162-9175 |
1* | J:165583 Yang F, Tang W, So S, de Crombrugghe B, Zhang C, Sclerostin is a direct target of osteoblast-specific transcription factor osterix. Biochem Biophys Res Commun. 2010 Oct 1;400(4):684-8 |
1 | J:347414 Yang J, Zhu L, Pan H, Ueharu H, Toda M, Yang Q, Hallett SA, Olson LE, Mishina Y, A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis. J Clin Invest. 2024 Mar 11;134(8) |
1* | J:213921 Yang L, Tsang KY, Tang HC, Chan D, Cheah KS, Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12097-102 |
4 | J:326460 Yang R, Li R, Huang Z, Zuo Y, Yue H, Wu H, Gu F, Wang F, He M, Bian Z, Mycn deficiency underlies the development of orofacial clefts in mice and humans. Hum Mol Genet. 2022 Mar 3;31(5):803-815 |
2* | J:256083 Yang T, Moore M, He F, Pten regulates neural crest proliferation and differentiation during mouse craniofacial development. Dev Dyn. 2018 Feb;247(2):304-314 |
2 | J:235737 Ye W, Song Y, Huang Z, Osterwalder M, Ljubojevic A, Xu J, Bobick B, Abassah-Oppong S, Ruan N, Shamby R, Yu D, Zhang L, Cai CL, Visel A, Zhang Y, Cobb J, Chen Y, A unique stylopod patterning mechanism by Shox2-controlled osteogenesis. Development. 2016 Jul 15;143(14):2548-60 |
2 | J:306388 Yen YT, Chien M, Wu PY, Hung SC, PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation. Commun Biol. 2021 Jun 2;4(1):658 |
2* | J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48 |
1* | J:171806 Young B, Minugh-Purvis N, Shimo T, St-Jacques B, Iwamoto M, Enomoto-Iwamoto M, Koyama E, Pacifici M, Indian and sonic hedgehogs regulate synchondrosis growth plate and cranial base development and function. Dev Biol. 2006 Nov 1;299(1):272-82 |
1* | J:316481 Yu D, Hu J, Sheng Z, Fu G, Wang Y, Chen Y, Pan Z, Zhang X, Wu Y, Sun H, Dai J, Lu L, Ouyang H, Dual roles of misshapen/NIK-related kinase (MINK1) in osteoarthritis subtypes through the activation of TGFbeta signaling. Osteoarthritis Cartilage. 2020 Jan;28(1):112-121 |
1 | J:97498 Yunker LA, Undersander A, Lian JB, Stein GS, Carlson CS, Mauro LJ, The tyrosine phosphatase, OST-PTP, is expressed in mesenchymal progenitor cells early during skeletogenesis in the mouse. J Cell Biochem. 2004 Nov 1;93(4):761-73 |
1 | J:134882 Zhang C, Cho K, Huang Y, Lyons JP, Zhou X, Sinha K, McCrea PD, de Crombrugghe B, Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6936-41 |
2* | J:183533 Zhang C, Dai H, de Crombrugghe B, Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx. Biochem Biophys Res Commun. 2012 Apr 20;420(4):782-6 |
1 | J:195577 Zhang C, Tang W, Li Y, Matrix metalloproteinase 13 (MMP13) is a direct target of osteoblast-specific transcription factor osterix (Osx) in osteoblasts. PLoS One. 2012;7(11):e50525 |
1 | J:178091 Zhang C, Tang W, Li Y, Yang F, Dowd DR, MacDonald PN, Osteoblast-specific transcription factor Osterix increases vitamin D receptor gene expression in osteoblasts. PLoS One. 2011;6(10):e26504 |
1 | J:274043 Zhang H, Takeda H, Tsuji T, Kamiya N, Kunieda T, Mochida Y, Mishina Y, Loss of Function of Evc2 in Dental Mesenchyme Leads to Hypomorphic Enamel. J Dent Res. 2017 Apr;96(4):421-429 |
1 | J:168525 Zhang S, Xiao Z, Luo J, He N, Mahlios J, Quarles LD, Dose-dependent effects of Runx2 on bone development. J Bone Miner Res. 2009 Nov;24(11):1889-904 |
1 | J:202215 Zhang X, Ting K, Bessette CM, Culiat CT, Sung SJ, Lee H, Chen F, Shen J, Wang JJ, Kuroda S, Soo C, Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in Runx2(+/-) mice. J Bone Miner Res. 2011 Apr;26(4):777-91 |
3 | J:218833 Zhao H, Zhou W, Yao Z, Wan Y, Cao J, Zhang L, Zhao J, Li H, Zhou R, Li B, Wei G, Zhang Z, French CA, Dekker JD, Yang Y, Fisher SE, Tucker HO, Guo X, Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Dev Biol. 2015 Feb 15;398(2):242-54 |
3* | J:125598 Zheng L, Iohara K, Ishikawa M, Into T, Takano-Yamamoto T, Matsushita K, Nakashima M, Runx3 negatively regulates Osterix expression in dental pulp cells. Biochem J. 2007 Jul 1;405(1):69-75 |
7 | J:292430 Zhou T, Gao B, Fan Y, Liu Y, Feng S, Cong Q, Zhang X, Zhou Y, Yadav PS, Lin J, Wu N, Zhao L, Huang D, Zhou S, Su P, Yang Y, Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ss-catenin. Elife. 2020 Mar 18;9:e52779 |
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