Gene Expression Literature Summary

• Symbol: Adamts16
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 16
• ID: MGI:2429637

14 matching records from 14 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E10.5	E11.5	E12.5	E13	E13.5	E14	E14.5	E15.5	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)				1	1	1	1	1	1		1		1	1
In situ RNA (section)		1	2	1		2		5	3	1	1	1		2
In situ RNA (whole mount)			1	3		1		1	2
RT-PCR	1			2	1			2	1			1	1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Adamts16  ADAM metallopeptidase with thrombospondin type 1 motif 16   (Synonyms: MGC:37086)
Results	Reference
3*	J:261618 Cao M, Ouyang J, Guo J, Lin S, Chen S, Metalloproteinase Adamts16 Is Required for Proper Closure of the Optic Fissure. Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1167-1177
1	J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1*	J:165751 Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
4	J:28082 Holmberg M, Leonardsson G, Ny T, The species-specific differences in the cAMP regulation of the tissue-type plasminogen activator gene between rat, mouse and human is caused by a one-nucleotide substitution in the cAMP-responsive element of the promoters. Eur J Biochem. 1995 Jul 15;231(2):466-74
5	J:199656 Jacobi CL, Rudigier LJ, Scholz H, Kirschner KM, Transcriptional regulation by the Wilms tumor protein, Wt1, suggests a role of the metalloproteinase Adamts16 in murine genitourinary development. J Biol Chem. 2013 Jun 28;288(26):18811-24
15	J:353576 Lin Y, Yang Q, Lin X, Liu X, Qian Y, Xu D, Cao N, Han X, Zhu Y, Hu W, He X, Yu Z, Kong X, Zhu L, Zhong Z, Liu K, Zhou B, Wang Y, Peng J, Zhu W, Wang J, Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation. Circulation. 2024 Feb 20;149(8):605-626
6*	J:283272 Livermore C, Warr N, Chalon N, Siggers P, Mianne J, Codner G, Teboul L, Wells S, Greenfield A, Male mice lacking ADAMTS-16 are fertile but exhibit testes of reduced weight. Sci Rep. 2019 Nov 20;9(1):17195
1	J:222626 McClelland KS, Bell K, Larney C, Harley VR, Sinclair AH, Oshlack A, Koopman P, Bowles J, Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells. Biol Reprod. 2015 Jun;92(6):145
4*	J:280280 Rutledge EA, Parvez RK, Short KM, Smyth IM, McMahon AP, Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease. Dev Biol. 2019 Oct 15;454(2):156-169
1	J:321251 Yang N, Zhang Q, Ye S, Lu T, Sun M, Wang L, Wang M, Pan YH, Dang S, Zhang W, Adamts18 Deficiency Causes Spontaneous SMG Fibrogenesis in Adult Mice. J Dent Res. 2022 Feb;101(2):226-234
1	J:276149 Zhu R, Pan YH, Sun L, Zhang T, Wang C, Ye S, Yang N, Lu T, Wisniewski T, Dang S, Zhang W, ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice. Neuroscience. 2019 Feb 10;399:53-64