Gene Expression Literature Summary

• Symbol: Mcph1
• Name: microcephaly, primary autosomal recessive 1
• ID: MGI:2443308

11 matching records from 11 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E12	E12.5	E13.5	E14	E14.5	E15.5	E16	E16.5	E	P
Immunohistochemistry (section)	1		1			1			1
In situ RNA (section)	1	1	1	1		2	1		1		1
Immunohistochemistry (whole mount)			1
Western blot			2			2					1
RT-PCR		1			1			1		1	5
cDNA clones										1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mcph1  microcephaly, primary autosomal recessive 1   (Synonyms: 5430437K10Rik, BRIT1, D030046N04Rik)
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
5*	J:180706 Gruber R, Zhou Z, Sukchev M, Joerss T, Frappart PO, Wang ZQ, MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. Nat Cell Biol. 2011 Nov;13(11):1325-34
1	J:306320 Ho UY, Feng CA, Yeap YY, Bain AL, Wei Z, Shohayeb B, Reichelt ME, Homer H, Khanna KK, Bowles J, Ng DCH, WDR62 is required for centriole duplication in spermatogenesis and manchette removal in spermiogenesis. Commun Biol. 2021 May 31;4(1):645
9	J:304136 Journiac N, Gilabert-Juan J, Cipriani S, Benit P, Liu X, Jacquier S, Faivre V, Delahaye-Duriez A, Csaba Z, Hourcade T, Melinte E, Lebon S, Violle-Poirsier C, Oury JF, Adle-Biassette H, Wang ZQ, Mani S, Rustin P, Gressens P, Nardelli J, Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly. Cell Rep. 2020 Apr 14;31(2):107506
1	J:262823 Kasowitz SD, Ma J, Anderson SJ, Leu NA, Xu Y, Gregory BD, Schultz RM, Wang PJ, Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 2018 May;14(5):e1007412
1	J:307535 Liu X, Schneble-Lohnert N, Kristofova M, Qing X, Labisch J, Hofmann S, Ehrenberg S, Sannai M, Jorss T, Ori A, Godmann M, Wang ZQ, The N-terminal BRCT domain determines MCPH1 function in brain development and fertility. Cell Death Dis. 2021 Feb 1;12(2):143
1	J:301847 Ni L, Xie H, Tan L, Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models. Mol Reprod Dev. 2016 Dec;83(12):1060-1069
6	J:176173 Passemard S, El Ghouzzi V, Nasser H, Verney C, Vodjdani G, Lacaud A, Lebon S, Laburthe M, Robberecht P, Nardelli J, Mani S, Verloes A, Gressens P, Lelievre V, VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling. J Clin Invest. 2011 Aug 1;121(8):3071-87
1	J:354248 Vial Y, Nardelli J, Bonnard AA, Rousselot J, Souyri M, Gressens P, Cave H, Drunat S, Mcph1, mutated in primary microcephaly, is also crucial for erythropoiesis. EMBO Rep. 2024 May;25(5):2418-2440
2	J:328987 Wang Y, Zong W, Sun W, Chen C, Wang ZQ, Li T, The Central Domain of MCPH1 Controls Development of the Cerebral Cortex and Gonads in Mice. Cells. 2022 Aug 31;11(17)
1	J:261356 Zhou ZW, Tapias A, Bruhn C, Gruber R, Sukchev M, Wang ZQ, DNA damage response in microcephaly development of MCPH1 mouse model. DNA Repair (Amst). 2013 Aug;12(8):645-55