Gene Expression Literature Summary

• Symbol: Frem2
• Name: Fras1 related extracellular matrix protein 2
• ID: MGI:2444465

23 matching records from 23 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)			1	1			2		2		5		3		1		2		1	1	5
In situ RNA (section)			1		3		2		2	1	5		2						1		1
Immunohistochemistry (whole mount)											1								1		1
In situ RNA (whole mount)	1		2	1	1		2		1		1		1							1
In situ reporter (knock in)										1										1	1
Northern blot																					1
Western blot													1
RT-PCR		1		1	1	1		1	1	1		1	1	1		1		1	1		1
cDNA clones																					1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Frem2  Fras1 related extracellular matrix protein 2   (Synonyms: 6030440P17Rik, 8430406N05Rik, b2b1562Clo, my, ne)
Results	Reference
1	J:200175 Beck TF, Shchelochkov OA, Yu Z, Kim BJ, Hernandez-Garcia A, Zaveri HP, Bishop C, Overbeek PA, Stockton DW, Justice MJ, Scott DA, Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3. PLoS One. 2013;8(3):e58830
2*	J:192553 Beck TF, Veenma D, Shchelochkov OA, Yu Z, Kim BJ, Zaveri HP, van Bever Y, Choi S, Douben H, Bertin TK, Patel PI, Lee B, Tibboel D, de Klein A, Stockton DW, Justice MJ, Scott DA, Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice. Hum Mol Genet. 2013 Mar 1;22(5):1026-38
6*	J:117883 Chiotaki R, Petrou P, Giakoumaki E, Pavlakis E, Sitaru C, Chalepakis G, Spatiotemporal distribution of Fras1/Frem proteins during mouse embryonic development. Gene Expr Patterns. 2007 Feb;7(4):381-8
1	J:272608 Cohen I, Zhao D, Menon G, Nakayama M, Koseki H, Zheng D, Ezhkova E, PRC1 preserves epidermal tissue integrity independently of PRC2. Genes Dev. 2019 Jan 1;33(1-2):55-60
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:237202 Fantauzzo KA, Soriano P, PDGFRbeta regulates craniofacial development through homodimers and functional heterodimers with PDGFRalpha. Genes Dev. 2016 Nov 01;30(21):2443-2458
1*	J:231595 Gurdziel K, Vogt KR, Walton KD, Schneider GK, Gumucio DL, Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26
11	J:98344 Jadeja S, Smyth I, Pitera JE, Taylor MS, van Haelst M, Bentley E, McGregor L, Hopkins J, Chalepakis G, Philip N, Perez Aytes A, Watt FM, Darling SM, Jackson I, Woolf AS, Scambler PJ, Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs. Nat Genet. 2005 May;37(5):520-5
13*	J:124197 Kiyozumi D, Sugimoto N, Nakano I, Sekiguchi K, Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1. Matrix Biol. 2007 Jul;26(6):456-462
7*	J:111788 Kiyozumi D, Sugimoto N, Sekiguchi K, Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):11981-6
2	J:185210 Kiyozumi D, Takeichi M, Nakano I, Sato Y, Fukuda T, Sekiguchi K, Basement membrane assembly of the integrin alpha8beta1 ligand nephronectin requires Fraser syndrome-associated proteins. J Cell Biol. 2012 May 28;197(5):677-89
3	J:313559 Lipp SN, Jacobson KR, Hains DS, Schwarderer AL, Calve S, 3D Mapping Reveals a Complex and Transient Interstitial Matrix During Murine Kidney Development. J Am Soc Nephrol. 2021 Apr 19;
4	J:335095 Lipp SN, Jacobson KR, Schwaderer AL, Hains DS, Calve S, FOXD1 is required for 3D patterning of the kidney interstitial matrix. Dev Dyn. 2023 Apr;252(4):463-482
1	J:206208 Makrygiannis AK, Pavlakis E, Petrou P, Kalogeraki E, Chalepakis G, Segmental and restricted localization pattern of Fras1 in the developing meningeal basement membrane in mouse. Histochem Cell Biol. 2013 Nov;140(5):595-601
2*	J:335090 McLaughlin MT, Sun MR, Beames TG, Steward AC, Theisen JWM, Chung HM, Everson JL, Moskowitz IP, Sheets MD, Lipinski RJ, Frem1 activity is regulated by Sonic hedgehog signaling in the cranial neural crest mesenchyme during midfacial morphogenesis. Dev Dyn. 2023 Apr;252(4):483-494
1	J:191040 Ola R, Jakobson M, Kvist J, Perala N, Kuure S, Braunewell KH, Bridgewater D, Rosenblum ND, Chilov D, Immonen T, Sainio K, Sariola H, The GDNF target Vsnl1 marks the ureteric tip. J Am Soc Nephrol. 2011 Feb;22(2):274-84
2*	J:128304 Petrou P, Pavlakis E, Dalezios Y, Chalepakis G, Basement membrane localization of Frem3 is independent of the Fras1/Frem1/Frem2 protein complex within the sublamina densa. Matrix Biol. 2007 Oct;26(8):652-8
1	J:317601 Pitera JE, Woolf AS, Basson MA, Scambler PJ, Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome. J Am Soc Nephrol. 2012 Nov;23(11):1790-6
3*	J:243411 Rutledge EA, Benazet JD, McMahon AP, Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Development. 2017 Sep 01;144(17):3177-3188
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
6	J:101189 Timmer JR, Mak TW, Manova K, Anderson KV, Niswander L, Tissue morphogenesis and vascular stability require the Frem2 protein, product of the mouse myelencephalic blebs gene. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11746-50
1*	J:166958 Yates LL, Papakrivopoulou J, Long DA, Goggolidou P, Connolly JO, Woolf AS, Dean CH, The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. Hum Mol Genet. 2010 Dec 1;19(23):4663-76
1*	J:279933 Zhang X, Wang D, Dongye M, Zhu Y, Chen C, Wang R, Long E, Liu Z, Wu X, Lin D, Chen J, Lin Z, Wang J, Li W, Li Y, Li D, Lin H, Loss-of-function mutations in FREM2 disrupt eye morphogenesis. Exp Eye Res. 2019 Apr;181:302-312