Gene Expression Literature Summary

• Symbol: Tet3
• Name: tet methylcytosine dioxygenase 3
• ID: MGI:2446229

33 matching records from 33 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E6	E6.5	E7	E7.5	E8.5	E9	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)	1																	1					1			1		3
In situ RNA (section)										1	1			1				1	1			2		1	1	1		3
Immunohistochemistry (whole mount)	5	2		1
In situ RNA (whole mount)								2		2	1		3	1		1						1
In situ reporter (knock in)													1															1
Western blot	1																											1
RT-PCR	2	3	2	1	1	1	1	2	1	1	2	1	4	4	1	2	1	2		3		2	2	2	2	2	1	11
cDNA clones																1	1				1							1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Tet3  tet methylcytosine dioxygenase 3   (Synonyms: B430006D22Rik, D230004J03Rik)
Results	Reference
2	J:236575 Amouroux R, Nashun B, Shirane K, Nakagawa S, Hill PW, D'Souza Z, Nakayama M, Matsuda M, Turp A, Ndjetehe E, Encheva V, Kudo NR, Koseki H, Sasaki H, Hajkova P, De novo DNA methylation drives 5hmC accumulation in mouse zygotes. Nat Cell Biol. 2016 Feb;18(2):225-33
1*	J:271018 Auclair G, Borgel J, Sanz LA, Vallet J, Guibert S, Dumas M, Cavelier P, Girardot M, Forne T, Feil R, Weber M, EHMT2 directs DNA methylation for efficient gene silencing in mouse embryos. Genome Res. 2016 Feb;26(2):192-202
2	J:332685 Chen GD, Fatima I, Xu Q, Rozhkova E, Fessing MY, Mardaryev AN, Sharov AA, Xu GL, Botchkarev VA, DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation. Sci Adv. 2023 Jan 13;9(2):eabo7605
3	J:239417 Dai HQ, Wang BA, Yang L, Chen JJ, Zhu GC, Sun ML, Ge H, Wang R, Chapman DL, Tang F, Sun X, Xu GL, TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature. 2016 Oct 27;538(7626):528-532
1	J:242825 Fong KS, Hufnagel RB, Khadka VS, Corley MJ, Maunakea AK, Fogelgren B, Ahmed ZM, Lozanoff S, A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure. Dis Model Mech. 2016 May 01;9(5):585-96
2	J:254851 Hatanaka Y, Tsusaka T, Shimizu N, Morita K, Suzuki T, Machida S, Satoh M, Honda A, Hirose M, Kamimura S, Ogonuki N, Nakamura T, Inoue K, Hosoi Y, Dohmae N, Nakano T, Kurumizaka H, Matsumoto K, Shinkai Y, Ogura A, Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes. Cell Rep. 2017 Sep 19;20(12):2756-2765
7	J:326201 Hayashi T, Eto K, Kadoya Y, Downregulation of ten-eleven translocation-2 triggers epithelial differentiation during organogenesis. Differentiation. 2022 May-Jun;125:45-53
5*	J:169869 Iqbal K, Jin SG, Pfeifer GP, Szabo PE, Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3642-7
1*	J:163464 Ito S, D'Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y, Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature. 2010 Jul 18;466(7310):1129-1133
2	J:226048 Kang J, Lienhard M, Pastor WA, Chawla A, Novotny M, Tsagaratou A, Lasken RS, Thompson EC, Surani MA, Koralov SB, Kalantry S, Chavez L, Rao A, Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):E4236-45
3*	J:202864 Keil KP, Altmann HM, Mehta V, Abler LL, Elton EA, Vezina CM, Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract. Gene Expr Patterns. 2013 Dec;13(8):413-24
11*	J:243754 Khoueiry R, Sohni A, Thienpont B, Luo X, Velde JV, Bartoccetti M, Boeckx B, Zwijsen A, Rao A, Lambrechts D, Koh KP, Lineage-specific functions of TET1 in the postimplantation mouse embryo. Nat Genet. 2017 Jul;49(7):1061-1072
1	J:234375 Kim H, Jang WY, Kang MC, Jeong J, Choi M, Sung Y, Park S, Kwon W, Jang S, Kim MO, Kim SH, Ryoo ZY, TET1 contributes to neurogenesis onset time during fetal brain development in mice. Biochem Biophys Res Commun. 2016 Mar 18;471(4):437-43
5	J:239071 Li X, Yue X, Pastor WA, Lin L, Georges R, Chavez L, Evans SM, Rao A, Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling. Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):E8267-E8276
3	J:337772 Liang X, Aranyi T, Zhou J, Guan Y, Hu H, Liu H, Susztak K, Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment. J Am Soc Nephrol. 2023 Apr 1;34(4):572-589
2	J:279721 Linscott ML, Chung WCJ, TET1 regulates fibroblast growth factor 8 transcription in gonadotropin releasing hormone neurons. PLoS One. 2019;14(7):e0220530
2	J:306136 Manti M, Pui HP, Edstrom S, Risal S, Lu H, Lindgren E, Ohlsson C, Jerlhag E, Benrick A, Deng Q, Stener-Victorin E, Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice. FASEB J. 2020 Nov;34(11):14440-14457
3*	J:284860 Okashita N, Kuroki S, Maeda R, Tachibana M, TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression. Sci Rep. 2019 Sep 17;9(1):13462
11*	J:258221 Rakoczy J, Padmanabhan N, Krzak AM, Kieckbusch J, Cindrova-Davies T, Watson ED, Dynamic expression of TET1, TET2, and TET3 dioxygenases in mouse and human placentas throughout gestation. Placenta. 2017 Nov;59:46-56
1	J:312335 Reyes-Aguirre LI, Lamas M, Oct4 Methylation-Mediated Silencing As an Epigenetic Barrier Preventing Muller Glia Dedifferentiation in a Murine Model of Retinal Injury. Front Neurosci. 2016;10:523
1	J:279154 Shen J, Wang C, Li D, Xu T, Myers J, Ashton JM, Wang T, Zuscik MJ, McAlinden A, O'Keefe RJ, DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism. JCI Insight. 2017 Jun 15;2(12)
1*	J:256230 Shin SW, John Vogt E, Jimenez-Movilla M, Baibakov B, Dean J, Cytoplasmic cleavage of DPPA3 is required for intracellular trafficking and cleavage-stage development in mice. Nat Commun. 2017 Nov 21;8(1):1643
1	J:330735 Smeriglio P, Grandi FC, Taylor SEB, Zalc A, Bhutani N, TET1 Directs Chondrogenic Differentiation by Regulating SOX9 Dependent Activation of Col2a1 and Acan In Vitro. JBMR Plus. 2020 Aug;4(8):e10383
5	J:107647 Thuret S, Bhatt L, O'Leary DD, Simon HH, Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Mol Cell Neurosci. 2004 Mar;25(3):394-405
4*	J:65653 Wertz K, Herrmann BG, Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
2	J:333558 Wu F, Li X, Looso M, Liu H, Ding D, Gunther S, Kuenne C, Liu S, Weissmann N, Boettger T, Atzberger A, Kolahian S, Renz H, Offermanns S, Gartner U, Potente M, Zhou Y, Yuan X, Braun T, Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine. Nat Genet. 2023 Jan;55(1):100-111
2	J:305400 Wu Y, Dong J, Feng S, Zhao Q, Duan P, Xiong M, Wen Y, Lv C, Wang X, Yuan S, Maternal UHRF1 Is Essential for Transcription Landscapes and Repression of Repetitive Elements During the Maternal-to-Zygotic Transition. Front Cell Dev Biol. 2020;8:610773
6	J:194101 Yamaguchi S, Hong K, Liu R, Shen L, Inoue A, Diep D, Zhang K, Zhang Y, Tet1 controls meiosis by regulating meiotic gene expression. Nature. 2012 Dec 20;492(7429):443-7
1	J:333868 Yan R, Cheng X, Gu C, Xu Y, Long X, Zhai J, Sun F, Qian J, Du Y, Wang H, Guo F, Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development. Nat Genet. 2023 Jan;55(1):130-143
1	J:337681 Yang G, Xin Q, Feng I, Wu D, Dean J, Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation. Genes Dev. 2023 May 1;37(9-10):418-431
4	J:354195 Yang Y, Rivera L, Fang S, Cavalier M, Suris A, Zhou Y, Huang Y, Maternal high-fat diet alters Tet-mediated epigenetic regulation during heart development. iScience. 2024 Sep 20;27(9):110631
7	J:205485 Yu C, Zhang YL, Pan WW, Li XM, Wang ZW, Ge ZJ, Zhou JJ, Cang Y, Tong C, Sun QY, Fan HY, CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
1	J:276738 Zeng TB, Han L, Pierce N, Pfeifer GP, Szabo PE, EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidation. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10834-10841