Gene Expression Literature Summary

• Symbol: Fev
• Name: FEV transcription factor, ETS family member
• ID: MGI:2449712

46 matching records from 46 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)		1	1	2	4		3			1
In situ RNA (section)			2	2	8	2	10	4	1	12		2	5	2	1	1	2	12
In situ RNA (whole mount)			1		3	1	1
Western blot																		1
RT-PCR	1		1		1		3	1		3		3	1	1		3		4
cDNA clones											1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fev  FEV transcription factor, ETS family member   (Synonyms: mPet-1, Pet1, Pex1)
Results	Reference
2	J:333987 Bohuslavova R, Fabriciova V, Lebron-Mora L, Malfatti J, Smolik O, Valihrach L, Benesova S, Zucha D, Berkova Z, Saudek F, Evans SM, Pavlinkova G, ISL1 controls pancreatic alpha cell fate and beta cell maturation. Cell Biosci. 2023 Mar 10;13(1):53
3	J:171595 Bonnin A, Goeden N, Chen K, Wilson ML, King J, Shih JC, Blakely RD, Deneris ES, Levitt P, A transient placental source of serotonin for the fetal forebrain. Nature. 2011 Apr 21;472(7343):347-50
1	J:88192 Brodski C, Weisenhorn DM, Signore M, Sillaber I, Oesterheld M, Broccoli V, Acampora D, Simeone A, Wurst W, Location and size of dopaminergic and serotonergic cell populations are controlled by the position of the midbrain-hindbrain organizer. J Neurosci. 2003 May 15;23(10):4199-207
1	J:268361 Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB, Lineage dynamics of murine pancreatic development at single-cell resolution. Nat Commun. 2018 Sep 25;9(1):3922
4	J:217405 Carcagno AL, Di Bella DJ, Goulding M, Guillemot F, Lanuza GM, Neurogenin3 restricts serotonergic neuron differentiation to the hindbrain. J Neurosci. 2014 Nov 12;34(46):15223-33
3	J:86557 Cheng L, Chen CL, Luo P, Tan M, Qiu M, Johnson R, Ma Q, Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype. J Neurosci. 2003 Nov 5;23(31):9961-7
3	J:282280 Chleilat E, Mallmann R, Spanagel R, Klugbauer N, Krieglstein K, Roussa E, Spatiotemporal Role of Transforming Growth Factor Beta 2 in Developing and Mature Mouse Hindbrain Serotonergic Neurons. Front Cell Neurosci. 2019;13:427
2	J:265050 Chleilat E, Skatulla L, Rahhal B, Hussein MT, Feuerstein M, Krieglstein K, Roussa E, TGF-beta Signaling Regulates Development of Midbrain Dopaminergic and Hindbrain Serotonergic Neuron Subgroups. Neuroscience. 2018 Jun 15;381:124-137
1	J:166770 Coppola E, d'Autreaux F, Rijli FM, Brunet JF, Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation. Development. 2010 Dec;137(24):4211-20
1*	J:88591 Craven SE, Lim KC, Ye W, Engel JD, de Sauvage F, Rosenthal A, Gata2 specifies serotonergic neurons downstream of sonic hedgehog. Development. 2004 Mar;131(5):1165-73
1	J:217450 Dias JM, Alekseenko Z, Applequist JM, Ericson J, Tgfbeta signaling regulates temporal neurogenesis and potency of neural stem cells in the CNS. Neuron. 2014 Dec 3;84(5):927-39
2	J:313289 Dias JM, Alekseenko Z, Jeggari A, Boareto M, Vollmer J, Kozhevnikova M, Wang H, Matise MP, Alexeyenko A, Iber D, Ericson J, A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells. Sci Adv. 2020 Sep;6(38)
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2	J:85552 Ding YQ, Marklund U, Yuan W, Yin J, Wegman L, Ericson J, Deneris E, Johnson RL, Chen ZF, Lmx1b is essential for the development of serotonergic neurons. Nat Neurosci. 2003 Sep;6(9):933-8
1*	J:279056 Donovan LJ, Spencer WC, Kitt MM, Eastman BA, Lobur KJ, Jiao K, Silver J, Deneris ES, Lmx1b is required at multiple stages to build expansive serotonergic axon architectures. Elife. 2019 Jul 29;8:e48788
2*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
6	J:237535 Haugas M, Tikker L, Achim K, Salminen M, Partanen J, Gata2 and Gata3 regulate the differentiation of serotonergic and glutamatergic neuron subtypes of the dorsal raphe. Development. 2016 Dec 01;143(23):4495-4508
2	J:81450 Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, Yamamoto B, Silver J, Weeber EJ, Sweatt JD, Deneris ES, Pet-1 ETS Gene Plays a Critical Role in 5-HT Neuron Development and Is Required for Normal Anxiety-like and Aggressive Behavior. Neuron. 2003 Jan 23;37(2):233-47
4	J:128441 Jacob J, Ferri AL, Milton C, Prin F, Pla P, Lin W, Gavalas A, Ang SL, Briscoe J, Transcriptional repression coordinates the temporal switch from motor to serotonergic neurogenesis. Nat Neurosci. 2007 Nov;10(11):1433-9
2	J:152424 Jacob J, Storm R, Castro DS, Milton C, Pla P, Guillemot F, Birchmeier C, Briscoe J, Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development. 2009 Jul;136(14):2477-85
1	J:112633 Jukkola T, Lahti L, Naserke T, Wurst W, Partanen J, FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region. Dev Biol. 2006 Sep 1;297(1):141-57
1	J:143527 Kala K, Haugas M, Lillevali K, Guimera J, Wurst W, Salminen M, Partanen J, Gata2 is a tissue-specific post-mitotic selector gene for midbrain GABAergic neurons. Development. 2009 Jan;136(2):253-62
2	J:220591 Kim JY, Kim A, Zhao ZQ, Liu XY, Chen ZF, Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem. Mol Brain. 2014;7:48
3	J:125767 Kobberup S, Nyeng P, Juhl K, Hutton J, Jensen J, ETS-family genes in pancreatic development. Dev Dyn. 2007 Nov;236(11):3100-10
1	J:229533 Kouwenhoven WM, Veenvliet JV, van Hooft JA, van der Heide LP, Smidt MP, Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function. Biol Open. 2016;5(3):279-88
4	J:165266 Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S, Deneris ES, Pet-1 is required across different stages of life to regulate serotonergic function. Nat Neurosci. 2010 Oct;13(10):1190-8
5*	J:240101 Lv J, Wang L, Gao Y, Ding YQ, Liu F, 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017 Feb;214(2):529-545
10	J:191410 Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS, Convergence of the insulin and serotonin programs in the pancreatic beta-cell. Diabetes. 2011 Dec;60(12):3208-16
1	J:243715 Ohta Y, Okabe T, Larmour C, Di Rocco A, Maijenburg MW, Phillips A, Speck NA, Wakitani S, Nakamura T, Yamada Y, Enomoto-Iwamoto M, Pacifici M, Iwamoto M, Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg. Arthritis Rheumatol. 2015 Oct;67(10):2679-90
3	J:214095 Osipovich AB, Long Q, Manduchi E, Gangula R, Hipkens SB, Schneider J, Okubo T, Stoeckert CJ Jr, Takada S, Magnuson MA, Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Development. 2014 Aug;141(15):2939-49
2*	J:172381 Osterberg N, Wiehle M, Oehlke O, Heidrich S, Xu C, Fan CM, Krieglstein K, Roussa E, Sim1 is a novel regulator in the differentiation of mouse dorsal raphe serotonergic neurons. PLoS One. 2011;6(4):e19239
2	J:91076 Pattyn A, Simplicio N, van Doorninck JH, Goridis C, Guillemot F, Brunet JF, Ascl1/Mash1 is required for the development of central serotonergic neurons. Nat Neurosci. 2004 Jun;7(6):589-95
4	J:82563 Pattyn A, Vallstedt A, Dias JM, Samad OA, Krumlauf R, Rijli FM, Brunet JF, Ericson J, Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors. Genes Dev. 2003 Mar 15;17(6):729-37
1	J:336513 Patzek S, Liu Z, de la O S, Chang S, Byrnes LE, Zhang X, Ornitz DM, Sneddon JB, Loss of Fgf9 in mice leads to pancreatic hypoplasia and asplenia. iScience. 2023 Apr 21;26(4):106500
5	J:218991 Pelosi B, Migliarini S, Pacini G, Pratelli M, Pasqualetti M, Generation of Pet1210-Cre transgenic mouse line reveals non-serotonergic expression domains of Pet1 both in CNS and periphery. PLoS One. 2014;9(8):e104318
5	J:75806 Pfaar H, von Holst A, Vogt Weisenhorn DM, Brodski C, Guimera J, Wurst W, mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons. Dev Genes Evol. 2002 Feb;212(1):43-6
1	J:89367 Puelles E, Annino A, Tuorto F, Usiello A, Acampora D, Czerny T, Brodski C, Ang SL, Wurst W, Simeone A, Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain. Development. 2004 May;131(9):2037-48
1	J:123685 Saarimaki-Vire J, Peltopuro P, Lahti L, Naserke T, Blak AA, Vogt Weisenhorn DM, Yu K, Ornitz DM, Wurst W, Partanen J, Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain. J Neurosci. 2007 Aug 8;27(32):8581-92
1	J:179397 Schachterle W, Rojas A, Xu SM, Black BL, ETS-dependent regulation of a distal Gata4 cardiac enhancer. Dev Biol. 2012 Jan 15;361(2):439-49
1	J:95392 Simon HH, Scholz C, O'Leary DD, Engrailed genes control developmental fate of serotonergic and noradrenergic neurons in mid- and hindbrain in a gene dose-dependent manner. Mol Cell Neurosci. 2005 Jan;28(1):96-105
1	J:86868 Simon R, Lufkin T, Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation. Mol Cell Biol. 2003 Dec;23(24):9046-60
1	J:316104 Song L, Liu Y, Yu Y, Duan X, Qi S, Liu Y, Shh signaling guides spatial pathfinding of raphespinal tract axons by multidirectional repulsion. Cell Res. 2012 Apr;22(4):697-716
1	J:297100 Tikker L, Casarotto P, Singh P, Biojone C, Piepponen TP, Estartus N, Seelbach A, Sridharan R, Laukkanen L, Castren E, Partanen J, Inactivation of the GATA Cofactor ZFPM1 Results in Abnormal Development of Dorsal Raphe Serotonergic Neuron Subtypes and Increased Anxiety-Like Behavior. J Neurosci. 2020 Nov 4;40(45):8669-8682
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2	J:161774 Wang S, Turner EE, Expression of dopamine pathway genes in the midbrain is independent of known ETS transcription factor activity. J Neurosci. 2010 Jul 7;30(27):9224-7
4*	J:116706 Zhao ZQ, Scott M, Chiechio S, Wang JS, Renner KJ, Gereau RW 4th, Johnson RL, Deneris ES, Chen ZF, Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci. 2006 Dec 6;26(49):12781-8