Gene Expression Literature Summary

• Symbol: Egfl7
• Name: EGF-like domain 7
• ID: MGI:2449923

22 matching records from 22 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2.5	E3.5	E4	E4.5	E7.5	E8	E8.5	E9	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E18	E18.5	E	P
Immunohistochemistry (section)												2			3		1			1			1		6
In situ RNA (section)							2		2	2	1	3	1		1	1	2	7	2		1	2	1		8
Immunohistochemistry (whole mount)				1	1
In situ RNA (whole mount)										1
In situ reporter (knock in)							1	1	1		1	2		1											1
Northern blot							1		1		1	1		1	1					1					2
Western blot												1			1								1		2
RT-PCR	1	1	1	1		1				1	1	2	1	1	2	1			1			1		1	10
cDNA clones							1				1	1	1	1
RNase protection												1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Egfl7  EGF-like domain 7   (Synonyms: vascular endothelial-statin, VE-statin, Zneu1)
Results	Reference
1*	J:325730 Ahuja N, Hiltabidle MS, Rajasekhar H, Voss S, Lu SZ, Barlow HR, Cowdin MA, Daniel E, Vaddaraju V, Anandakumar T, Black E, Cleaver O, Maynard C, Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
12	J:249355 Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, Bauerle T, Hartwig J, Baumgart J, Kruger M, Radyushkin K, Alberi L, Berninger B, Schmidt MHH, Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat Commun. 2017 Jun 28;8:15922
3*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
10*	J:137617 Campagnolo L, Moscatelli I, Pellegrini M, Siracusa G, Stuhlmann H, Expression of EGFL7 in primordial germ cells and in adult ovaries and testes. Gene Expr Patterns. 2008 Jul;8(6):389-96
3	J:310307 Chim SM, Kuek V, Chow ST, Lim BS, Tickner J, Zhao J, Chung R, Su YW, Zhang G, Erber W, Xian CJ, Rosen V, Xu J, EGFL7 is expressed in bone microenvironment and promotes angiogenesis via ERK, STAT3, and integrin signaling cascades. J Cell Physiol. 2015 Jan;230(1):82-94
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
18*	J:90268 Fitch MJ, Campagnolo L, Kuhnert F, Stuhlmann H, Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells. Dev Dyn. 2004 Jun;230(2):316-24
1*	J:304253 Jones MR, Dilai S, Lingampally A, Chao CM, Danopoulos S, Carraro G, Mukhametshina R, Wilhelm J, Baumgart-Vogt E, Al Alam D, Chen C, Minoo P, Zhang JS, Bellusci S, A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Front Genet. 2018;9:746
2	J:143206 Kuhnert F, Mancuso MR, Hampton J, Stankunas K, Asano T, Chen CZ, Kuo CJ, Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development. 2008 Dec;135(24):3989-93
2	J:242904 Lacko LA, Hurtado R, Hinds S, Poulos MG, Butler JM, Stuhlmann H, Altered feto-placental vascularization, feto-placental malperfusion and fetal growth restriction in mice with Egfl7 loss of function. Development. 2017 Jul 01;144(13):2469-2479
12*	J:316190 Lacko LA, Massimiani M, Sones JL, Hurtado R, Salvi S, Ferrazzani S, Davisson RL, Campagnolo L, Stuhlmann H, Novel expression of EGFL7 in placental trophoblast and endothelial cells and its implication in preeclampsia. Mech Dev. 2014 Aug;133:163-76
6	J:167379 Nichol D, Shawber C, Fitch MJ, Bambino K, Sharma A, Kitajewski J, Stuhlmann H, Impaired angiogenesis and altered Notch signaling in mice overexpressing endothelial Egfl7. Blood. 2010 Dec 23;116(26):6133-43
1*	J:198109 Oeschger FM, Wang WZ, Lee S, Garcia-Moreno F, Goffinet AM, Arbones ML, Rakic S, Molnar Z, Gene expression analysis of the embryonic subplate. Cereb Cortex. 2012 Jun;22(6):1343-59
1	J:286013 Outhwaite JE, Patel J, Simmons DG, Secondary Placental Defects in Cxadr Mutant Mice. Front Physiol. 2019;10:622
5	J:90570 Parker LH, Schmidt M, Jin SW, Gray AM, Beis D, Pham T, Frantz G, Palmieri S, Hillan K, Stainier DY, De Sauvage FJ, Ye W, The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature. 2004 Apr 15;428(6984):754-8
2	J:330449 Rusidze M, Faure MC, Sicard P, Raymond-Letron I, Giton F, Vessieres E, Prevot V, Henrion D, Arnal JF, Cornil CA, Lenfant F, Loss of function of the maternal membrane oestrogen receptor ERalpha alters expansion of trophoblast cells and impacts mouse fertility. Development. 2022 Oct 1;149(19):dev200683
4	J:124110 Schmidt M, Paes K, De Maziere A, Smyczek T, Yang S, Gray A, French D, Kasman I, Klumperman J, Rice DS, Ye W, EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution. Development. 2007 Aug;134(16):2913-23
11*	J:86366 Soncin F, Mattot V, Lionneton F, Spruyt N, Lepretre F, Begue A, Stehelin D, VE-statin, an endothelial repressor of smooth muscle cell migration. EMBO J. 2003 Nov 3;22(21):5700-11
5	J:139708 Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R, Olson EN, The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell. 2008 Aug;15(2):261-71
6*	J:53033 Xiong JW, Leahy A, Lee HH, Stuhlmann H, Vezf1: A Zn finger transcription factor restricted to endothelial cells and their precursors. Dev Biol. 1999 Feb 15;206(2):123-41
1	J:201159 Zhou P, Zhang Y, Ma Q, Gu F, Day DS, He A, Zhou B, Li J, Stevens SM, Romo D, Pu WT, Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15395-400