Gene Expression Literature Summary

• Symbol: Rtl1
• Name: retrotransposon Gaglike 1
• ID: MGI:2656842

29 matching records from 29 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E8.5	E9.5	E10.5	E11	E11.5	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E19	E	P
Immunohistochemistry (section)							1		2							1			3
In situ RNA (section)							3		1										2
Northern blot	1				1					1		1	1	1		2		2	3
Western blot									1		1		2						3
RT-PCR		2	4	2		1	5	2	8		3		3		1	2		2	13
cDNA clones																	1		1
RNase protection											1								1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Rtl1  retrotransposon Gaglike 1   (Synonyms: Mar, Mart1, Mor1)
Results	Reference
4*	J:96508 Brandt J, Schrauth S, Veith AM, Froschauer A, Haneke T, Schultheis C, Gessler M, Leimeister C, Volff JN, Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals. Gene. 2005 Jan 17;345(1):101-11
2	J:182286 Charalambous M, Ferron SR, da Rocha ST, Murray AJ, Rowland T, Ito M, Schuster-Gossler K, Hernandez A, Ferguson-Smith AC, Imprinted gene dosage is critical for the transition to independent life. Cell Metab. 2012 Feb 8;15(2):209-21
6	J:334072 Chou MY, Hu MC, Chen PY, Hsu CL, Lin TY, Tan MJ, Lee CY, Kuo MF, Huang PH, Wu VC, Yang SH, Fan PC, Huang HY, Akbarian S, Loo TH, Stewart CL, Huang HP, Gau SS, Huang HS, RTL1/PEG11 imprinted in human and mouse brain mediates anxiety-like and social behaviors and regulates neuronal excitability in the locus coeruleus. Hum Mol Genet. 2022 Sep 10;31(18):3161-3180
1	J:108137 Fukasawa M, Morita S, Kimura M, Horii T, Ochiya T, Hatada I, Genomic imprinting in Dicer1-hypomorphic mice. Cytogenet Genome Res. 2006;113(1-4):138-43
2	J:153616 Gabory A, Ripoche MA, Le Digarcher A, Watrin F, Ziyyat A, Forne T, Jammes H, Ainscough JF, Surani MA, Journot L, Dandolo L, H19 acts as a trans regulator of the imprinted gene network controlling growth in mice. Development. 2009 Oct;136(20):3413-21
2	J:227271 Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du J, Li CJ, Gan ZJ, Gao X, Chen HQ, Zhu MS, Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13627-32
7*	J:146496 Hagan JP, O'Neill BL, Stewart CL, Kozlov SV, Croce CM, At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1. PLoS One. 2009;4(2):e4352
1	J:287095 Hara S, Terao M, Muramatsu A, Takada S, Efficient production and transmission of CRISPR/Cas9-mediated mutant alleles at the IG-DMR via generation of mosaic mice using a modified 2CC method. Sci Rep. 2019 Dec 27;9(1):20202
5*	J:192195 Himes KP, Koppes E, Chaillet JR, Generalized disruption of inherited genomic imprints leads to wide-ranging placental defects and dysregulated fetal growth. Dev Biol. 2013 Jan 1;373(1):72-82
4*	J:224145 Ito M, Sferruzzi-Perri AN, Edwards CA, Adalsteinsson BT, Allen SE, Loo TH, Kitazawa M, Kaneko-Ishino T, Ishino F, Stewart CL, Ferguson-Smith AC, A trans-homologue interaction between reciprocally imprinted miR-127 and Rtl1 regulates placenta development. Development. 2015 Jul 15;142(14):2425-30
10*	J:299191 Kitazawa M, Hayashi S, Imamura M, Takeda S, Oishi Y, Kaneko-Ishino T, Ishino F, Deficiency and overexpression of Rtl1 in the mouse cause distinct muscle abnormalities related to Temple and Kagami-Ogata syndromes. Development. 2020 Sep 2;147(21):dev185918
9	J:309146 Kitazawa M, Sutani A, Kaneko-Ishino T, Ishino F, The role of eutherian-specific RTL1 in the nervous system and its implications for the Kagami-Ogata and Temple syndromes. Genes Cells. 2021 Mar;26(3):165-179
2*	J:251670 Kumamoto S, Takahashi N, Nomura K, Fujiwara M, Kijioka M, Uno Y, Matsuda Y, Sotomaru Y, Kono T, Overexpression of microRNAs from the Gtl2-Rian locus contributes to postnatal death in mice. Hum Mol Genet. 2017 Oct 01;26(19):3653-3662
3	J:132025 Labialle S, Yang L, Ruan X, Villemain A, Schmidt JV, Hernandez A, Wiltshire T, Cermakian N, Naumova AK, Coordinated diurnal regulation of genes from the Dlk1-Dio3 imprinted domain: implications for regulation of clusters of non-paralogous genes. Hum Mol Genet. 2008 Jan 1;17(1):15-26
1	J:143283 Li X, Ito M, Zhou F, Youngson N, Zuo X, Leder P, Ferguson-Smith AC, A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cell. 2008 Oct;15(4):547-57
2*	J:91849 Lin SP, Youngson N, Takada S, Seitz H, Reik W, Paulsen M, Cavaille J, Ferguson-Smith AC, Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Nat Genet. 2003 Sep;35(1):97-102
2*	J:192572 Qu C, Jiang T, Li Y, Wang X, Cao H, Xu H, Qu J, Chen JG, Gene expression and IG-DMR hypomethylation of maternally expressed gene 3 in developing corticospinal neurons. Gene Expr Patterns. 2013 Jan;13(1-2):51-6
1*	J:266963 Saito T, Hara S, Kato T, Tamano M, Muramatsu A, Asahara H, Takada S, A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1-Dio3 domain during embryonic development. Hum Mol Genet. 2018 Sep 15;27(18):3283-3292
1	J:241393 Saito T, Hara S, Tamano M, Asahara H, Takada S, Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice. J Reprod Dev. 2017 Feb 16;63(1):101-109
2	J:195360 Seibt J, Armant O, Le Digarcher A, Castro D, Ramesh V, Journot L, Guillemot F, Vanderhaeghen P, Bouschet T, Expression at the imprinted dlk1-gtl2 locus is regulated by proneural genes in the developing telencephalon. PLoS One. 2012;7(11):e48675
2	J:84074 Seitz H, Youngson N, Lin SP, Dalbert S, Paulsen M, Bachellerie JP, Ferguson-Smith AC, Cavaille J, Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene. Nat Genet. 2003 Jul;34(3):261-2
1	J:108133 Sekita Y, Wagatsuma H, Irie M, Kobayashi S, Kohda T, Matsuda J, Yokoyama M, Ogura A, Schuster-Gossler K, Gossler A, Ishino F, Kaneko-Ishino T, Aberrant regulation of imprinted gene expression in Gtl2lacZ mice. Cytogenet Genome Res. 2006;113(1-4):223-9
2	J:132647 Sekita Y, Wagatsuma H, Nakamura K, Ono R, Kagami M, Wakisaka N, Hino T, Suzuki-Migishima R, Kohda T, Ogura A, Ogata T, Yokoyama M, Kaneko-Ishino T, Ishino F, Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta. Nat Genet. 2008 Feb;40(2):243-8
2*	J:147577 Takahashi N, Okamoto A, Kobayashi R, Shirai M, Obata Y, Ogawa H, Sotomaru Y, Kono T, Deletion of Gtl2, imprinted non-coding RNA, with its differentially methylated region induces lethal parent-origin-dependent defects in mice. Hum Mol Genet. 2009 May 15;18(10):1879-88
1	J:324246 Van de Pette M, Dimond A, Galvao AM, Millership SJ, To W, Prodani C, McNamara G, Bruno L, Sardini A, Webster Z, McGinty J, French PMW, Uren AG, Castillo-Fernandez J, Watkinson W, Ferguson-Smith AC, Merkenschlager M, John RM, Kelsey G, Fisher AG, Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice. Nat Commun. 2022 May 5;13(1):2464
1*	J:344890 Zhang L, Han Z, He H, Zhang X, Zhang M, Li B, Wu Q, Meg8-DMR as the Secondary Regulatory Region Regulates the Expression of MicroRNAs While It Does Not Affect Embryonic Development in Mice. Genes (Basel). 2023 Jun 14;14(6)
4	J:346630 Zhang X, He H, Yu H, Teng X, Wang Z, Li C, Li J, Yang H, Shen J, Wu T, Zhang F, Zhang Y, Wu Q, Maternal RNA transcription in Dlk1-Dio3 domain is critical for proper development of the mouse placental vasculature. Commun Biol. 2024 Mar 23;7(1):363
3*	J:166176 Zhou Y, Cheunsuchon P, Nakayama Y, Lawlor MW, Zhong Y, Rice KA, Zhang L, Zhang X, Gordon FE, Lidov HG, Bronson RT, Klibanski A, Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene. Development. 2010 Aug;137(16):2643-52
2	J:281273 Zhu W, Botticelli EM, Kery RE, Mao Y, Wang X, Yang A, Wang X, Zhou J, Zhang X, Soberman RJ, Klibanski A, Zhou Y, Meg3-DMR, not the Meg3 gene, regulates imprinting of the Dlk1-Dio3 locus. Dev Biol. 2019 Nov 1;455(1):10-18