Gene Expression Literature Summary

• Symbol: Kiss1
• Name: KiSS-1 metastasis-suppressor
• ID: MGI:2663985

27 matching records from 27 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17	E17.5	E18.5	E19	E	P
Immunohistochemistry (section)			3	2	2	3	1	1	3	1		9
In situ RNA (section)		1	1	2	4			2	2		1	6
In situ reporter (knock in)												1
RT-PCR	1	1			2			2	1			11
cDNA clones												1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Kiss1  KiSS-1 metastasis-suppressor   (Synonyms: kisspeptin, metastin)
Results	Reference
2	J:265821 Biehl MJ, Kaylan KB, Thompson RJ, Gonzalez RV, Weis KE, Underhill GH, Raetzman LT, Cellular fate decisions in the developing female anteroventral periventricular nucleus are regulated by canonical Notch signaling. Dev Biol. 2018 Oct 1;442(1):87-100
1	J:321502 Camera M, Russo I, Zamboni V, Ammoni A, Rando S, Morellato A, Cimino I, Angelini C, Giacobini P, Oleari R, Amoruso F, Cariboni A, Franceschini I, Turco E, Defilippi P, Merlo GR, p140Cap Controls Female Fertility in Mice Acting via Glutamatergic Afference on Hypothalamic Gonadotropin-Releasing Hormone Neurons. Front Neurosci. 2022;16:744693
1	J:335424 Cara AL, Burger LL, Beekly BG, Allen SJ, Henson EL, Auchus RJ, Myers MG, Moenter SM, Elias CF, Deletion of Androgen Receptor in LepRb Cells Improves Estrous Cycles in Prenatally Androgenized Mice. Endocrinology. 2023 Jan 9;164(3)
1	J:286983 Chen X, Wyler SC, Li L, Arnold AG, Wan R, Jia L, Landy MA, Lai HC, Xu P, Liu C, Comparative Transcriptomic Analyses of Developing Melanocortin Neurons Reveal New Regulators for the Anorexigenic Neuron Identity. J Neurosci. 2020 Apr 15;40(16):3165-3177
3	J:217401 Clarkson J, Busby ER, Kirilov M, Schutz G, Sherwood NM, Herbison AE, Sexual differentiation of the brain requires perinatal kisspeptin-GnRH neuron signaling. J Neurosci. 2014 Nov 12;34(46):15297-305
1	J:342617 Dali O, D'Cruz S, Legoff L, Diba Lahmidi M, Heitz C, Merret PE, Kernanec PY, Pakdel F, Smagulova F, Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Life Sci Alliance. 2024 Feb;7(2)
5	J:268511 Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa T, Nagaoka M, Kawaguchi Y, Yanagawa Y, Magnuson MA, Muratani M, Shibuya A, Nabeshima YI, Yanagisawa M, Funato H, Hoshino M, Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain. Cell Rep. 2018 Jul 3;24(1):79-94
3	J:218751 Herreboudt AM, Kyle VR, Lawrence J, Doran J, Colledge WH, Kiss1 mutant placentas show normal structure and function in the mouse. Placenta. 2015 Jan;36(1):52-8
3	J:279329 Huisman C, Cho H, Brock O, Lim SJ, Youn SM, Park Y, Kim S, Lee SK, Delogu A, Lee JW, Single cell transcriptome analysis of developing arcuate nucleus neurons uncovers their key developmental regulators. Nat Commun. 2019 Aug 16;10(1):3696
2	J:276275 Ikeda Y, Kato-Inui T, Tagami A, Maekawa M, Expression of progesterone receptor, estrogen receptors alpha and beta, and kisspeptin in the hypothalamus during perinatal development of gonad-lacking steroidogenic factor-1 knockout mice. Brain Res. 2019 Jun 1;1712:167-179
8	J:310001 Ikeda Y, Tagami A, Komada M, Takahashi M, Expression of Kisspeptin in Gonadotrope Precursors in the Mouse Pituitary during Embryonic and Postnatal Development and in Adulthood. Neuroendocrinology. 2017;105(4):357-371
1	J:226893 Iwakura T, Sakoh M, Tsutiya A, Yamashita N, Ohtani A, Tsuda MC, Ogawa S, Tsukahara S, Nishihara M, Shiga T, Goshima Y, Kato T, Ohtani-Kaneko R, Collapsin response mediator protein 4 affects the number of tyrosine hydroxylase-immunoreactive neurons in the sexually dimorphic nucleus in female mice. Dev Neurobiol. 2013 Jul;73(7):502-17
1	J:257035 Kim YJ, Osborn DP, Lee JY, Araki M, Araki K, Mohun T, Kansakoski J, Brandstack N, Kim HT, Miralles F, Kim CH, Brown NA, Kim HG, Martinez-Barbera JP, Ataliotis P, Raivio T, Layman LC, Kim SH, WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. EMBO Rep. 2018 Feb;19(2):269-289
6*	J:261765 Knoll JG, Clay CM, Bouma GJ, Henion TR, Schwarting GA, Millar RP, Tobet SA, Developmental profile and sexually dimorphic expression of kiss1 and kiss1r in the fetal mouse brain. Front Endocrinol (Lausanne). 2013;4:140
2	J:207602 Kumar D, Freese M, Drexler D, Hermans-Borgmeyer I, Marquardt A, Boehm U, Murine arcuate nucleus kisspeptin neurons communicate with GnRH neurons in utero. J Neurosci. 2014 Mar 5;34(10):3756-66
1	J:226927 Kumar D, Periasamy V, Freese M, Voigt A, Boehm U, In Utero Development of Kisspeptin/GnRH Neural Circuitry in Male Mice. Endocrinology. 2015 Sep;156(9):3084-90
1	J:174086 Layman WS, Hurd EA, Martin DM, Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome. Hum Mol Genet. 2011 Aug 15;20(16):3138-50
4	J:263715 Lee B, Kim J, An T, Kim S, Patel EM, Raber J, Lee SK, Lee S, Lee JW, Dlx1/2 and Otp coordinate the production of hypothalamic GHRH- and AgRP-neurons. Nat Commun. 2018 May 23;9(1):2026
1*	J:178520 Navarro VM, Gottsch ML, Wu M, Garcia-Galiano D, Hobbs SJ, Bosch MA, Pinilla L, Clifton DK, Dearth A, Ronnekleiv OK, Braun RE, Palmiter RD, Tena-Sempere M, Alreja M, Steiner RA, Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse. Endocrinology. 2011 Nov;152(11):4265-75
1	J:181711 Poling MC, Kauffman AS, Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling. Endocrinology. 2012 Feb;153(2):782-93
1*	J:310126 Quarta C, Fisette A, Xu Y, Collden G, Legutko B, Tseng YT, Reim A, Wierer M, De Rosa MC, Klaus V, Rausch R, Thaker VV, Graf E, Strom TM, Poher AL, Gruber T, Le Thuc O, Cebrian-Serrano A, Kabra D, Bellocchio L, Woods SC, Pflugfelder GO, Nogueiras R, Zeltser L, Grunwald Kadow IC, Moon A, Garcia-Caceres C, Mann M, Treier M, Doege CA, Tschop MH, Functional identity of hypothalamic melanocortin neurons depends on Tbx3. Nat Metab. 2019 Feb;1(2):222-235
1	J:308864 Rotgers E, Nicol B, Rodriguez K, Rattan S, Flaws JA, Yao HH, Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts ovarian functions, fertility, and metabolic homeostasis in female mice. FASEB J. 2021 Aug;35(8):e21770
2*	J:221577 Sanz E, Quintana A, Deem JD, Steiner RA, Palmiter RD, McKnight GS, Fertility-regulating Kiss1 neurons arise from hypothalamic POMC-expressing progenitors. J Neurosci. 2015 Apr 8;35(14):5549-56
4*	J:333014 Wartenberg P, Farkas I, Csillag V, Colledge WH, Hrabovszky E, Boehm U, Sexually Dimorphic Neurosteroid Synthesis Regulates Neuronal Activity in the Murine Brain. J Neurosci. 2021 Nov 3;41(44):9177-9191
3	J:316423 Whittaker DE, Oleari R, Gregory LC, Le Quesne-Stabej P, Williams HJ, Torpiano JG, Formosa N, Cachia MJ, Field D, Lettieri A, Ocaka LA, Paganoni AJ, Rajabali SH, Riegman KL, De Martini LB, Chaya T, Robinson IC, Furukawa T, Cariboni A, Basson MA, Dattani MT, A recessive PRDM13 mutation results in congenital hypogonadotropic hypogonadism and cerebellar hypoplasia. J Clin Invest. 2021 Dec 15;131(24):e141587
3*	J:164472 Yi T, Tan K, Cho SG, Wang Y, Luo J, Zhang W, Li D, Liu M, Regulation of embryonic kidney branching morphogenesis and glomerular development by KISS1 receptor (Gpr54) through NFAT2- and Sp1-mediated Bmp7 expression. J Biol Chem. 2010 Jun 4;285(23):17811-20
2*	J:334528 Zheng G, Su Y, Wei L, Yao Y, Wang Y, Luo X, Wang X, Ruan XZ, Li D, Chen Y, SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice. Cell Death Dis. 2023 Apr 6;14(4):249