Gene Expression Literature Summary

• Symbol: Mirlet7b
• Name: microRNA let7b
• ID: MGI:2676794

26 matching records from 26 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E8.5	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	P
In situ RNA (section)											1	1		1	2		1		2				1	1
In situ RNA (whole mount)								1	1
Northern blot																								1
Western blot														1
RT-PCR	2	2	2	2	1	1	1	1	3	1	2	6	3	6	7	1	4	2	3	1	3	1	2	14

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mirlet7b  microRNA let7b   (Synonyms: Mirnlet7b, mmu-let-7b)
Results	Reference
1	J:356372 Agrawal R, Tran U, Wessely O, The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/Lhx1. Development. 2009 Dec;136(23):3927-36
2*	J:165521 Aguilar AL, Piskol R, Beitzinger M, Zhu JY, Kruspe D, Aszodi A, Moser M, Englert C, Meister G, The small RNA expression profile of the developing murine urinary and reproductive systems. FEBS Lett. 2010 Nov 5;584(21):4426-34
1	J:356413 Amanai M, Brahmajosyula M, Perry AC, A restricted role for sperm-borne microRNAs in mammalian fertilization. Biol Reprod. 2006 Dec;75(6):877-84
1	J:273987 Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M, FGF regulates TGF-beta signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2012 Dec 27;2(6):1684-96
3	J:138346 Dogini DB, Ribeiro PA, Rocha C, Pereira TC, Lopes-Cendes I, MicroRNA expression profile in murine central nervous system development. J Mol Neurosci. 2008 Jul;35(3):331-7
1	J:291476 Dori M, Cavalli D, Lesche M, Massalini S, Alieh LHA, de Toledo BC, Khudayberdiev S, Schratt G, Dahl A, Calegari F, MicroRNA profiling of mouse cortical progenitors and neurons reveals miR-486-5p as a regulator of neurogenesis. Development. 2020 May 11;147(9):dev190520
4*	J:297771 Fairchild CLA, Cheema SK, Wong J, Hino K, Simo S, La Torre A, Let-7 regulates cell cycle dynamics in the developing cerebral cortex and retina. Sci Rep. 2019 Oct 25;9(1):15336
2	J:211776 Ghosh T, Aprea J, Nardelli J, Engel H, Selinger C, Mombereau C, Lemonnier T, Moutkine I, Schwendimann L, Dori M, Irinopoulou T, Henrion-Caude A, Benecke AG, Arnold SJ, Gressens P, Calegari F, Groszer M, MicroRNAs Establish Robustness and Adaptability of a Critical Gene Network to Regulate Progenitor Fate Decisions during Cortical Neurogenesis. Cell Rep. 2014 Jun 26;7(6):1779-88
3	J:223798 Golden EJ, Benito-Gonzalez A, Doetzlhofer A, The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3864-73
2*	J:112756 Kloosterman WP, Wienholds E, de Bruijn E, Kauppinen S, Plasterk RH, In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes. Nat Methods. 2006 Jan;3(1):27-9
1	J:131828 Kobayashi T, Lu J, Cobb BS, Rodda SJ, McMahon AP, Schipani E, Merkenschlager M, Kronenberg HM, Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):1949-54
1*	J:187631 Kredo-Russo S, Mandelbaum AD, Ness A, Alon I, Lennox KA, Behlke MA, Hornstein E, Pancreas-enriched miRNA refines endocrine cell differentiation. Development. 2012 Aug;139(16):3021-31
7	J:335513 Liu W, Chen J, Yang C, Lee KF, Lee YL, Chiu PC, Zhang Y, Duan YG, Liu K, Yeung WS, Expression of microRNA let-7 in cleavage embryos modulates cell fate determination and formation of mouse blastocysts. Biol Reprod. 2022 Dec 10;107(6):1452-1463
3	J:238411 Miyazawa H, Yamaguchi Y, Sugiura Y, Honda K, Kondo K, Matsuda F, Yamamoto T, Suematsu M, Miura M, Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching. Development. 2017 Jan 01;144(1):63-73
3	J:165457 Mukhopadhyay P, Brock G, Pihur V, Webb C, Pisano MM, Greene RM, Developmental microRNA expression profiling of murine embryonic orofacial tissue. Birth Defects Res A Clin Mol Teratol. 2010 Jul;88(7):511-34
3	J:207231 Nishino J, Kim S, Zhu Y, Zhu H, Morrison SJ, A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife. 2013;2:e00924
9	J:321070 Osborne JK, Kinney MA, Han A, Akinnola KE, Yermalovich AV, Vo LT, Pearson DS, Sousa PM, Ratanasirintrawoot S, Tsanov KM, Barragan J, North TE, Metzger RJ, Daley GQ, Lin28 paralogs regulate lung branching morphogenesis. Cell Rep. 2021 Jul 20;36(3):109408
1	J:315740 Prevot PP, Augereau C, Simion A, Van den Steen G, Dauguet N, Lemaigre FP, Jacquemin P, Let-7b and miR-495 stimulate differentiation and prevent metaplasia of pancreatic acinar cells by repressing HNF6. Gastroenterology. 2013 Sep;145(3):668-78.e3
6	J:188151 Repetto E, Briata P, Kuziner N, Harfe BD, McManus MT, Gherzi R, Rosenfeld MG, Trabucchi M, Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet. 2012 Jul;8(7):e1002823
7	J:272391 Robinton DA, Chal J, Lummertz da Rocha E, Han A, Yermalovich AV, Oginuma M, Schlaeger TM, Sousa P, Rodriguez A, Urbach A, Pourquie O, Daley GQ, The Lin28/let-7 Pathway Regulates the Mammalian Caudal Body Axis Elongation Program. Dev Cell. 2019 Feb 11;48(3):396-405.e3
1	J:199787 Saurat N, Andersson T, Vasistha NA, Molnar Z, Livesey FJ, Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development. Neural Dev. 2013;8:14
1*	J:275368 Shu P, Wu C, Liu W, Ruan X, Liu C, Hou L, Zeng Y, Fu H, Wang M, Chen P, Zhang X, Yin B, Yuan J, Qiang B, Peng X, The spatiotemporal expression pattern of microRNAs in the developing mouse nervous system. J Biol Chem. 2019 Mar 8;294(10):3444-3453
8	J:283783 Shu P, Wu C, Ruan X, Liu W, Hou L, Fu H, Wang M, Liu C, Zeng Y, Chen P, Yin B, Yuan J, Qiang B, Peng X, Zhong W, Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Neocortex. Dev Cell. 2019 Jun 3;49(5):764-785.e4
1	J:344338 Subramanian M, Mills WT 4th, Paranjpe MD, Onuchukwu US, Inamdar M, Maytin AR, Li X, Pomerantz JL, Meffert MK, Growth-suppressor microRNAs mediate synaptic overgrowth and behavioral deficits in Fragile X mental retardation protein deficiency. iScience. 2024 Jan 19;27(1):108676
5	J:119483 Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA, Maternal microRNAs are essential for mouse zygotic development. Genes Dev. 2007 Mar 15;21(6):644-8
8	J:270550 Yermalovich AV, Osborne JK, Sousa P, Han A, Kinney MA, Chen MJ, Robinton DA, Montie H, Pearson DS, Wilson SB, Combes AN, Little MH, Daley GQ, Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis. Nat Commun. 2019 Jan 11;10(1):168