Gene Expression Literature Summary

• Symbol: Cyp26c1
• Name: cytochrome P450, family 26, subfamily c, polypeptide 1
• ID: MGI:2679699

26 matching records from 26 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7.5	E8	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E14	E14.5	E16.5	E18.5	E	P
In situ RNA (section)	1		1	2	2		2		2		4		1	3	2	1		2
In situ RNA (whole mount)	1	2	4	3	5		5		2		1	1				1	1	1
RT-PCR				1	5	1		1		1		1		1		1		1
cDNA clones							1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cyp26c1  cytochrome P450, family 26, subfamily c, polypeptide 1   (Synonyms: EG546726)
Results	Reference
1*	J:167740 Alfano G, Conte I, Caramico T, Avellino R, Arno B, Pizzo MT, Tanimoto N, Beck SC, Huber G, Dolle P, Seeliger MW, Banfi S, Vax2 regulates retinoic acid distribution and cone opsin expression in the vertebrate eye. Development. 2011 Jan;138(2):261-71
1	J:203823 Billings SE, Pierzchalski K, Butler Tjaden NE, Pang XY, Trainor PA, Kane MA, Moise AR, The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB J. 2013 Dec;27(12):4877-89
4	J:150080 Braunstein EM, Monks DC, Aggarwal VS, Arnold JS, Morrow BE, Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis. BMC Dev Biol. 2009;9:31
1*	J:291486 Daniel E, Barlow HR, Sutton GI, Gu X, Htike Y, Cowdin MA, Cleaver O, Cyp26b1 is an essential regulator of distal airway epithelial differentiation during lung development. Development. 2020 Feb 20;147(4):dev181560
1	J:294331 El Shahawy M, Reibring CG, Hallberg K, Neben CL, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A, Sonic Hedgehog Signaling Is Required for Cyp26 Expression during Embryonic Development. Int J Mol Sci. 2019 May 8;20(9):2275
5	J:244957 El Shahawy M, Reibring CG, Neben CL, Hallberg K, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A, Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017 Jul;13(7):e1006914
1	J:261899 Hasten E, McDonald-McGinn DM, Crowley TB, Zackai E, Emanuel BS, Morrow BE, Racedo SE, Dysregulation of TBX1 dosage in the anterior heart field results in congenital heart disease resembling the 22q11.2 duplication syndrome. Hum Mol Genet. 2018 Jun 1;27(11):1847-1857
1	J:266434 Hong SH, Fang S, Lu BC, Nofsinger R, Kawakami Y, Castro GL, Yin Y, Lin C, Yu RT, Downes M, Izpisua Belmonte JC, Shilatifard A, Evans RM, Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10381-10386
1	J:213451 Karpinski BA, Maynard TM, Fralish MS, Nuwayhid S, Zohn IE, Moody SA, LaMantia AS, Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome. Dis Model Mech. 2014 Feb;7(2):245-57
2	J:246472 Lee LM, Leung MB, Kwok RC, Leung YC, Wang CC, McCaffery PJ, Copp AJ, Shum AS, Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes. Diabetes. 2017 Apr;66(4):1041-1051
1	J:222442 Li BI, Matteson PG, Ababon MF, Nato AQ Jr, Lin Y, Nanda V, Matise TC, Millonig JH, The orphan GPCR, Gpr161, regulates the retinoic acid and canonical Wnt pathways during neurulation. Dev Biol. 2015 Jun 1;402(1):17-31
4*	J:146220 Maclean G, Dolle P, Petkovich M, Genetic disruption of CYP26B1 severely affects development of neural crest derived head structures, but does not compromise hindbrain patterning. Dev Dyn. 2009 Mar;238(3):732-45
4	J:98265 Makita T, Duncan SA, Sucov HM, Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol. 2005 Apr 1;280(1):59-72
1*	J:97458 Matt N, Schmidt CK, Dupe V, Dennefeld C, Nau H, Chambon P, Mark M, Ghyselinck NB, Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development. Dev Dyn. 2005 May;233(1):167-76
1	J:266575 Metzler MA, Raja S, Elliott KH, Friedl RM, Tran NQH, Brugmann SA, Larsen M, Sandell LL, RDH10-mediated retinol metabolism and RARalpha-mediated retinoic acid signaling are required for submandibular salivary gland initiation. Development. 2018 Aug 2;145(15):dev164822
1*	J:129602 O'Shaughnessy PJ, Abel M, Charlton HM, Hu B, Johnston H, Baker PJ, Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. Endocrinology. 2007 Jun;148(6):2914-24
3	J:316584 Outhwaite JE, Natale BV, Natale DR, Simmons DG, Expression of aldehyde dehydrogenase family 1, member A3 in glycogen trophoblast cells of the murine placenta. Placenta. 2015 Mar;36(3):304-11
1	J:242314 Racedo SE, Hasten E, Lin M, Devakanmalai GS, Guo T, Ozbudak EM, Cai CL, Zheng D, Morrow BE, Reduced dosage of beta-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome. PLoS Genet. 2017 Mar;13(3):e1006687
3*	J:117754 Roberts C, Ivins S, Cook AC, Baldini A, Scambler PJ, Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick. Hum Mol Genet. 2006 Dec 1;15(23):3394-410
2	J:95023 Sakai Y, Luo T, McCaffery P, Hamada H, Drager UC, CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development. Dev Biol. 2004 Dec 1;276(1):143-57
2*	J:139174 Sato Y, Heuckeroth RO, Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro. Dev Biol. 2008 Aug 1;320(1):185-98
2	J:98515 Sirbu IO, Gresh L, Barra J, Duester G, Shifting boundaries of retinoic acid activity control hindbrain segmental gene expression. Development. 2005 Jun;132(11):2611-22
14*	J:85714 Tahayato A, Dolle P, Petkovich M, Cyp26C1 encodes a novel retinoic acid-metabolizing enzyme expressed in the hindbrain, inner ear, first branchial arch and tooth buds during murine development. Gene Expr Patterns. 2003 Aug;3(4):449-54
4	J:119939 Uehara M, Yashiro K, Mamiya S, Nishino J, Chambon P, Dolle P, Sakai Y, CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse. Dev Biol. 2007 Feb 15;302(2):399-411
2	J:150707 Uehara M, Yashiro K, Takaoka K, Yamamoto M, Hamada H, Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning. Genes Dev. 2009 Jul 15;23(14):1689-98
1*	J:108519 Waters ST, Lewandoski M, A threshold requirement for Gbx2 levels in hindbrain development. Development. 2006 May;133(10):1991-2000