Gene Expression Literature Summary

• Symbol: Cers3
• Name: ceramide synthase 3
• ID: MGI:2681008

9 matching records from 9 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E15.5	E16.5	E17.5	E18	E18.5	P
Immunohistochemistry (section)							1
In situ RNA (section)	1					1
Western blot							1
RT-PCR		1	1	1	1	3	2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cers3  ceramide synthase 3   (Synonyms: 4930550L11Rik, CerS3, Lass3, LOC233330, related to TRH3, T3L)
Results	Reference
1*	J:243218 Hooper JE, Feng W, Li H, Leach SM, Phang T, Siska C, Jones KL, Spritz RA, Hunter LE, Williams T, Systems biology of facial development: contributions of ectoderm and mesenchyme. Dev Biol. 2017 Jun 01;426(1):97-114
1	J:317805 Kato A, Ito M, Sanaki T, Okuda T, Tsuchiya N, Yoshimoto R, Yukioka H, Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of omega-O-acylceramide in mice. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Feb;1867(2):159085
1	J:216600 Lau CG, Marikawa Y, Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Mol Reprod Dev. 2014 Nov;81(11):994-1008
1*	J:286705 Miyamoto M, Itoh N, Sawai M, Sassa T, Kihara A, Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid omega-Hydroxylase Crucial to Acylceramide Production. J Invest Dermatol. 2020 Feb;140(2):319-326.e4
1	J:283325 Oberbeck N, Pham VC, Webster JD, Reja R, Huang CS, Zhang Y, Roose-Girma M, Warming S, Li Q, Birnberg A, Wong W, Sandoval W, Komuves LG, Yu K, Dugger DL, Maltzman A, Newton K, Dixit VM, The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function. Nature. 2019 Oct;574(7777):249-253
1*	J:242353 Pichery M, Huchenq A, Sandhoff R, Severino-Freire M, Zaafouri S, Opalka L, Levade T, Soldan V, Bertrand-Michel J, Lhuillier E, Serre G, Maruani A, Mazereeuw-Hautier J, Jonca N, PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier. Hum Mol Genet. 2017 May 15;26(10):1787-1800
1*	J:204477 Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A, Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production. Mol Cell Biol. 2013 Jul;33(14):2787-96
3*	J:196477 Wang Z, Kirkwood JS, Taylor AW, Stevens JF, Leid M, Ganguli-Indra G, Indra AK, Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development. J Invest Dermatol. 2013 Mar;133(3):668-76
3	J:346053 Zhang J, Ruiz M, Bergh PO, Henricsson M, Stojanovic N, Devkota R, Henn M, Bohlooly-Y M, Hernandez-Hernandez A, Alsheimer M, Boren J, Pilon M, Shibuya H, Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. Nat Commun. 2024 Mar 14;15(1):2315