Gene Expression Literature Summary

• Symbol: Prdm6
• Name: PR domain containing 6
• ID: MGI:2684938

8 matching records from 8 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E5.5	E6.5	E7.5	E8.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14	E14.5	E15.5	E16.5	E17.5	E18.5	E	P
Immunohistochemistry (section)											1			1			1
In situ RNA (section)							2		2			2		1	2
In situ RNA (whole mount)			1	1	1			1
Northern blot	1	1	2	2	2	1	1	1	2	1	1	1	1	1	1		2
RT-PCR							1		1					1		1	2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Prdm6  PR domain containing 6   (Synonyms: LOC225518, PRISM)
Results	Reference
7*	J:106935 Davis CA, Haberland M, Arnold MA, Sutherland LB, McDonald OG, Richardson JA, Childs G, Harris S, Owens GK, Olson EN, PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells. Mol Cell Biol. 2006 Apr;26(7):2626-36
15	J:209773 Gewies A, Castineiras-Vilarino M, Ferch U, Jahrling N, Heinrich K, Hoeckendorf U, Przemeck GK, Munding M, Gross O, Schroeder T, Horsch M, Karran EL, Majid A, Antonowicz S, Beckers J, Hrabe de Angelis M, Dodt HU, Peschel C, Forster I, Dyer MJ, Ruland J, Prdm6 is essential for cardiovascular development in vivo. PLoS One. 2013;8(11):e81833
2	J:321521 Hong L, Li N, Gasque V, Mehta S, Ye L, Wu Y, Li J, Gewies A, Ruland J, Hirschi KK, Eichmann A, Hendry C, van Dijk D, Mani A, Prdm6 controls heart development by regulating neural crest cell differentiation and migration. JCI Insight. 2022 Feb 2;7(4):e156046
3*	J:144373 Kinameri E, Inoue T, Aruga J, Imayoshi I, Kageyama R, Shimogori T, Moore AW, Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. PLoS One. 2008;3(12):e3859
3*	J:252161 Li N, Subrahmanyan L, Smith E, Yu X, Zaidi S, Choi M, Mane S, Nelson-Williams C, Behjati M, Kazemi M, Hashemi M, Fathzadeh M, Narayanan A, Tian L, Montazeri F, Mani M, Begleiter ML, Coon BG, Lynch HT, Olson EN, Zhao H, Ruland J, Lifton RP, Mani A, Mutations in the Histone Modifier PRDM6 Are Associated with Isolated Nonsyndromic Patent Ductus Arteriosus. Am J Hum Genet. 2016 Jun 2;98(6):1082-1091
8*	J:130641 Wu Y, Ferguson JE 3rd, Wang H, Kelley R, Ren R, McDonough H, Meeker J, Charles PC, Wang H, Patterson C, PRDM6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiation. J Mol Cell Cardiol. 2008 Jan;44(1):47-58
1	J:142646 Yi L, Domyan ET, Lewandoski M, Sun X, Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung. Dev Dyn. 2008 Dec 18;238(1):123-137
4	J:334529 Zou M, Mangum KD, Magin JC, Cao HH, Yarboro MT, Shelton EL, Taylor JM, Reese J, Furey TS, Mack CP, Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility. JCI Insight. 2023 Mar 8;8(5)