Gene Expression Literature Summary

• Symbol: Scube3
• Name: signal peptide, CUB domain, EGF-like 3
• ID: MGI:3045253

6 matching records from 6 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E	P
Immunohistochemistry (section)												1
In situ RNA (section)		1	2	2	1	2	2	2	2	1		1
Immunohistochemistry (whole mount)			1
In situ RNA (whole mount)	1	1	1
In situ reporter (knock in)		1	2	1	1	1	1		1
Western blot											2
RT-PCR												2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Scube3  signal peptide, CUB domain, EGF-like 3   (Synonyms: D030038I21Rik)
Results	Reference
1	J:246645 Adikusuma F, Pederick D, McAninch D, Hughes J, Thomas P, Functional Equivalence of the SOX2 and SOX3 Transcription Factors in the Developing Mouse Brain and Testes. Genetics. 2017 Jul;206(3):1495-1503
12*	J:119915 Haworth K, Smith F, Zoupa M, Seppala M, Sharpe PT, Cobourne MT, Expression of the Scube3 epidermal growth factor-related gene during early embryonic development in the mouse. Gene Expr Patterns. 2007 Apr;7(5):630-634
2	J:306541 Lin YC, Niceta M, Muto V, Vona B, Pagnamenta AT, Maroofian R, Beetz C, van Duyvenvoorde H, Dentici ML, Lauffer P, Vallian S, Ciolfi A, Pizzi S, Bauer P, Gruning NM, Bellacchio E, Del Fattore A, Petrini S, Shaheen R, Tiosano D, Halloun R, Pode-Shakked B, Albayrak HM, Isik E, Wit JM, Dittrich M, Freire BL, Bertola DR, Jorge AAL, Barel O, Sabir AH, Al Tenaiji AMJ, Taji SM, Al-Sannaa N, Al-Abdulwahed H, Digilio MC, Irving M, Anikster Y, Bhavani GSL, Girisha KM, Haaf T, Taylor JC, Dallapiccola B, Alkuraya FS, Yang RB, Tartaglia M, SCUBE3 loss-of-function causes a recognizable recessive developmental disorder due to defective bone morphogenetic protein signaling. Am J Hum Genet. 2021 Jan 7;108(1):115-133
1	J:154739 Quina LA, Wang S, Ng L, Turner EE, Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. J Neurosci. 2009 Nov 11;29(45):14309-22
9*	J:168645 Xavier GM, Economou A, Senna Guimaraes AL, Sharpe PT, Cobourne MT, Characterization of a mouse Scube3 reporter line. Genesis. 2010 Dec;48(12):684-92
8	J:195784 Xavier GM, Panousopoulos L, Cobourne MT, Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse. PLoS One. 2013;8(1):e55274