Symbol Name ID |
Fat4
FAT atypical cadherin 4 MGI:3045256 |
Age | E9.5 | E10.5 | E11.5 | E12.5 | E13.5 | E14.5 | E15.5 | E16.5 | E18.5 | P |
Immunohistochemistry (section) | 2 | 2 | ||||||||
In situ RNA (section) | 2 | 2 | 4 | 5 | 1 | 7 | 1 | 1 | 3 | 1 |
Immunohistochemistry (whole mount) | 1 | 1 | 1 | |||||||
In situ reporter (knock in) | 1 | 1 | ||||||||
Western blot | 1 | |||||||||
RT-PCR | 1 | 1 | 1 | 1 | 3 | |||||
cDNA clones | 1 |
Fat4 FAT atypical cadherin 4 (Synonyms: 6030410K14Rik) | |
Results | Reference |
2 | J:226938 Bagherie-Lachidan M, Reginensi A, Pan Q, Zaveri HP, Scott DA, Blencowe BJ, Helmbacher F, McNeill H, Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool. Development. 2015 Aug 1;142(15):2564-73 |
1* | J:309377 Betterman KL, Sutton DL, Secker GA, Kazenwadel J, Oszmiana A, Lim L, Miura N, Sorokin L, Hogan BM, Kahn ML, McNeill H, Harvey NL, Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. J Clin Invest. 2020 Jun 1;130(6):3315-3328 |
1 | J:293199 Crespo-Enriquez I, Hodgson T, Zakaria S, Cadoni E, Shah M, Allen S, Al-Khishali A, Mao Y, Yiu A, Petzold J, Villagomez-Olea G, Pitsillides AA, Irvine KD, Francis-West P, Dchs1-Fat4 regulation of osteogenic differentiation in mouse. Development. 2019 Jul 29;146(14):dev176776 |
1 | J:295217 Drake KA, Chaney CP, Das A, Roy P, Kwartler CS, Rakheja D, Carroll TJ, Stromal beta-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor. Development. 2020 Jul 31;147(21):dev189597 |
3* | J:163217 Ishiuchi T, Misaki K, Yonemura S, Takeichi M, Tanoue T, Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex. J Cell Biol. 2009 Jun 15;185(6):959-67 |
2 | J:235727 Kuta A, Mao Y, Martin T, Ferreira de Sousa C, Whiting D, Zakaria S, Crespo-Enriquez I, Evans P, Balczerski B, Mankoo B, Irvine KD, Francis-West PH, Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae. Development. 2016 Jul 1;143(13):2367-75 |
1 | J:309338 Lodge EJ, Xekouki P, Silva TS, Kochi C, Longui CA, Faucz FR, Santambrogio A, Mills JL, Pankratz N, Lane J, Sosnowska D, Hodgson T, Patist AL, Francis-West P, Helmbacher F, Stratakis C, Andoniadou CL, Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development. JCI Insight. 2020 Oct 27;5(23) |
1 | J:239657 Mao Y, Francis-West P, Irvine KD, Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching. Development. 2015 Aug 01;142(15):2574-85 |
2 | J:239940 Mao Y, Kuta A, Crespo-Enriquez I, Whiting D, Martin T, Mulvaney J, Irvine KD, Francis-West P, Dchs1-Fat4 regulation of polarized cell behaviours during skeletal morphogenesis. Nat Commun. 2016 May 05;7:11469 |
4 | J:169135 Mao Y, Mulvaney J, Zakaria S, Yu T, Morgan KM, Allen S, Basson MA, Francis-West P, Irvine KD, Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development. Development. 2011 Mar;138(5):947-57 |
1 | J:251466 Ohmori T, Tanigawa S, Kaku Y, Fujimura S, Nishinakamura R, Sall1 in renal stromal progenitors non-cell autonomously restricts the excessive expansion of nephron progenitors. Sci Rep. 2015 Oct 29;5:15676 |
3 | J:243807 Ragni CV, Diguet N, Le Garrec JF, Novotova M, Resende TP, Pop S, Charon N, Guillemot L, Kitasato L, Badouel C, Dufour A, Olivo-Marin JC, Trouve A, McNeill H, Meilhac SM, Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun. 2017 Feb 27;8:14582 |
2 | J:286590 Rao-Bhatia A, Zhu M, Yin WC, Coquenlorge S, Zhang X, Woo J, Sun Y, Dean CH, Liu A, Hui CC, Shivdasani RA, McNeill H, Hopyan S, Kim TH, Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development. Dev Cell. 2020 Mar 9;52(5):647-658.e6 |
5* | J:102257 Rock R, Schrauth S, Gessler M, Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila. Dev Dyn. 2005 Nov;234(3):747-55 |
3 | J:286313 Shea CA, Rolfe RA, McNeill H, Murphy P, Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation. Dev Dyn. 2020 Apr;249(4):523-542 |
6 | J:230957 Sugiyama Y, Shelley EJ, Badouel C, McNeill H, McAvoy JW, Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation. Invest Ophthalmol Vis Sci. 2015 Jun;56(6):4099-107 |
1 | J:300975 Weiss AC, Rivera-Reyes R, Englert C, Kispert A, Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney. J Pathol. 2020 Nov;252(3):290-303 |
1 | J:195852 Xie Q, Yang Y, Huang J, Ninkovic J, Walcher T, Wolf L, Vitenzon A, Zheng D, Gotz M, Beebe DC, Zavadil J, Cvekl A, Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain. PLoS One. 2013;8(1):e54507 |
2 | J:252306 Zakaria S, Mao Y, Kuta A, de Sousa CF, Gaufo GO, McNeill H, Hindges R, Guthrie S, Irvine KD, Francis-West PH, Regulation of neuronal migration by Dchs1-Fat4 planar cell polarity. Curr Biol. 2014 Jul 21;24(14):1620-1627 |
1 | J:331689 Zhang CH, Gao Y, Hung HH, Zhuo Z, Grodzinsky AJ, Lassar AB, Creb5 coordinates synovial joint formation with the genesis of articular cartilage. Nat Commun. 2022 Nov 26;13(1):7295 |
2 | J:274885 Zhang H, Bagherie-Lachidan M, Badouel C, Enderle L, Peidis P, Bremner R, Kuure S, Jain S, McNeill H, FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling. Dev Cell. 2019 Mar 25;48(6):780-792.e4 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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