Gene Expression Literature Summary

• Symbol: Adamts3
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 3
• ID: MGI:3045353

14 matching records from 14 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E10.5	E11.5	E12.5	E13.5	E14	E14.5	E15.5	E16	E16.5	E17	E17.5	E18.5	E	P
In situ RNA (section)	1			2	2			2	1	1		1	1	1	4
In situ RNA (whole mount)			1
RT-PCR	1	2			1	1	2			1	1				3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Adamts3  ADAM metallopeptidase with thrombospondin type 1 motif 3   (Synonyms: 1100001H14Rik, 6330442E02Rik)
Results	Reference
1*	J:274320 Cao J, Spielmann M, Qiu X, Huang X, Ibrahim DM, Hill AJ, Zhang F, Mundlos S, Christiansen L, Steemers FJ, Trapnell C, Shendure J, The single-cell transcriptional landscape of mammalian organogenesis. Nature. 2019 Feb;566(7745):496-502
1*	J:165751 Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
6	J:245044 Janssen L, Dupont L, Bekhouche M, Noel A, Leduc C, Voz M, Peers B, Cataldo D, Apte SS, Dubail J, Colige A, ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis. Angiogenesis. 2016 Jan;19(1):53-65
1	J:351385 Kaneko N, Hirai K, Oshima M, Yura K, Hattori M, Maeda N, Ohtaka-Maruyama C, ADAMTS2 promotes radial migration by activating TGF-beta signaling in the developing neocortex. EMBO Rep. 2024 Jul;25(7):3090-3115
1	J:271625 Kim KH, Nakaoka Y, Augustin HG, Koh GY, Myocardial Angiopoietin-1 Controls Atrial Chamber Morphogenesis by Spatiotemporal Degradation of Cardiac Jelly. Cell Rep. 2018 May 22;23(8):2455-2466
6	J:107394 Le Goff C, Somerville RP, Kesteloot F, Powell K, Birk DE, Colige AC, Apte SS, Regulation of procollagen amino-propeptide processing during mouse embryogenesis by specialization of homologous ADAMTS proteases: insights on collagen biosynthesis and dermatosparaxis. Development. 2006 Apr;133(8):1587-96
1	J:345473 Lee JG, Yon JM, Kim G, Lee SG, Kim CY, Cheong SA, Kim HY, Yu J, Kim K, Sung YH, Yoo HJ, Woo DC, Rho JK, Ha CH, Pack CG, Oh SH, Lim JS, Han YM, Hong EJ, Seong JK, Lee HW, Lee SW, Lee KU, Kim CJ, Nam SY, Cho YS, Baek IJ, PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487
2	J:333263 Neupane S, Goto J, Berardinelli SJ, Ito A, Haltiwanger RS, Holdener BC, Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ. Glycobiology. 2021 Sep 9;31(8):988-1004
5	J:240398 Ogino H, Hisanaga A, Kohno T, Kondo Y, Okumura K, Kamei T, Sato T, Asahara H, Tsuiji H, Fukata M, Hattori M, Secreted Metalloproteinase ADAMTS-3 Inactivates Reelin. J Neurosci. 2017 Mar 22;37(12):3181-3191
1	J:171966 van Berlo JH, Elrod JW, van den Hoogenhof MM, York AJ, Aronow BJ, Duncan SA, Molkentin JD, The transcription factor GATA-6 regulates pathological cardiac hypertrophy. Circ Res. 2010 Oct 15;107(8):1032-40
1	J:361964 Wang M, Liu H, Zhang M, Niu X, Sun M, Wang F, Ni Y, Hong T, Zhang W, Dang S, The secreted protease ADAMTS18 links early isoform transformation and maturation of glomerular basement membrane macromolecules to the integrity of the glomerular filtration barrier. Biochem Biophys Res Commun. 2025 Mar 1;750:151386
1	J:291718 Yamakage Y, Kato M, Hongo A, Ogino H, Ishii K, Ishizuka T, Kamei T, Tsuiji H, Miyamoto T, Oishi H, Kohno T, Hattori M, A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum. Mol Cell Neurosci. 2019 Oct;100:103401
1	J:281878 Yook C, Kim K, Kim D, Kang H, Kim SG, Kim E, Kim SY, A TBR1-K228E Mutation Induces Tbr1 Upregulation, Altered Cortical Distribution of Interneurons, Increased Inhibitory Synaptic Transmission, and Autistic-Like Behavioral Deficits in Mice. Front Mol Neurosci. 2019;12:241
1	J:276149 Zhu R, Pan YH, Sun L, Zhang T, Wang C, Ye S, Yang N, Lu T, Wisniewski T, Dang S, Zhang W, ADAMTS18 Deficiency Affects Neuronal Morphogenesis and Reduces the Levels of Depression-like Behaviors in Mice. Neuroscience. 2019 Feb 10;399:53-64