Gene Expression Literature Summary

• Symbol: Noto
• Name: notochord homeobox
• ID: MGI:3053002

21 matching records from 21 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12.5	E13.5	E15	E15.5	E
In situ RNA (section)			1	2	2	1		2	1
In situ RNA (whole mount)	1	2	4	7	4	5	1	8		3	1	2	1	1	1	1	1
In situ reporter (knock in)			1	1	2	1		2		1		2	1				1
cDNA clones								2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Noto  notochord homeobox   (Synonyms: Flh, MmNot, Not, tc)
Results	Reference
17*	J:91405 Abdelkhalek HB, Beckers A, Schuster-Gossler K, Pavlova MN, Burkhardt H, Lickert H, Rossant J, Reinhardt R, Schalkwyk LC, Muller I, Herrmann BG, Ceolin M, Rivera-Pomar R, Gossler A, The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev. 2004 Jul 15;18(14):1725-36
1	J:182741 Alten L, Schuster-Gossler K, Beckers A, Groos S, Ulmer B, Hegermann J, Ochs M, Gossler A, Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1. Development. 2012 Apr;139(7):1276-84
2	J:220460 Andre P, Song H, Kim W, Kispert A, Yang Y, Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27
1	J:213344 Barratt KS, Glanville-Jones HC, Arkell RM, The Zic2 gene directs the formation and function of node cilia to control cardiac situs. Genesis. 2014 Jun;52(6):626-35
2	J:222988 Beckers A, Alten L, Viebahn C, Andre P, Gossler A, The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15765-70
3	J:254597 Bhargava S, Cox B, Polydorou C, Gresakova V, Korinek V, Strnad H, Sedlacek R, Epp TA, Chawengsaksophak K, The epigenetic modifier Fam208a is required to maintain epiblast cell fitness. Sci Rep. 2017 Aug 24;7(1):9322
2	J:261380 Concepcion D, Hamada H, Papaioannou VE, Tbx6 controls left-right asymmetry through regulation of Gdf1. Biol Open. 2018 May 4;7(5):bio032565
2	J:294824 Dias A, Lozovska A, Wymeersch FJ, Novoa A, Binagui-Casas A, Sobral D, Martins GG, Wilson V, Mallo M, A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation. Elife. 2020 Jun 29;9:e56615
1	J:301045 Guo SS, Au TYK, Wynn S, Aszodi A, Chan D, Fassler R, Cheah KSE, beta1 Integrin regulates convergent extension in mouse notogenesis, ensures notochord integrity and the morphogenesis of vertebrae and intervertebral discs. Development. 2020 Nov 18;147(22):dev192724
2	J:195910 Maier JA, Lo Y, Harfe BD, Foxa1 and Foxa2 are required for formation of the intervertebral discs. PLoS One. 2013;8(1):e55528
2	J:177256 McCann MR, Tamplin OJ, Rossant J, Seguin CA, Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development. Dis Model Mech. 2011 Jan;5(1):73-82
1*	J:330741 Orchard P, White JS, Thomas PE, Mychalowych A, Kiseleva A, Hensley J, Allen B, Parker SCJ, Keegan CE, Genome-wide chromatin accessibility and transcriptome profiling show minimal epigenome changes and coordinated transcriptional dysregulation of hedgehog signaling in Danforth's short tail mice. Hum Mol Genet. 2019 Mar 1;28(5):736-750
1	J:356781 Peng G, Suo S, Chen J, Chen W, Liu C, Yu F, Wang R, Chen S, Sun N, Cui G, Song L, Tam PP, Han JD, Jing N, Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo. Dev Cell. 2016 Mar 21;36(6):681-97
1	J:283645 Peng G, Suo S, Cui G, Yu F, Wang R, Chen J, Chen S, Liu Z, Chen G, Qian Y, Tam PPL, Han JJ, Jing N, Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature. 2019 Aug;572(7770):528-532
16*	J:93513 Plouhinec JL, Granier C, Le Mentec C, Lawson KA, Saberan-Djoneidi D, Aghion J, Shi DL, Collignon J, Mazan S, Identification of the mammalian Not gene via a phylogenomic approach. Gene Expr Patterns. 2004 Nov;5(1):11-22
2	J:205747 Polydorou C, Georgiades P, Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation. Nat Commun. 2013;4:1658
1*	J:252050 Sung YH, Baek IJ, Kim YH, Gho YS, Oh SP, Lee YJ, Lee HW, PIERCE1 is critical for specification of left-right asymmetry in mice. Sci Rep. 2016 Jun 16;6:27932
1*	J:143778 Tamplin OJ, Cox BJ, Rossant J, Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Dev Biol. 2011 Dec 15;360(2):415-25
2*	J:153634 Ukita K, Hirahara S, Oshima N, Imuta Y, Yoshimoto A, Jang CW, Oginuma M, Saga Y, Behringer RR, Kondoh H, Sasaki H, Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord. Mech Dev. 2009 Oct;126(10):791-803
5	J:130469 Yamanaka Y, Tamplin OJ, Beckers A, Gossler A, Rossant J, Live imaging and genetic analysis of mouse notochord formation reveals regional morphogenetic mechanisms. Dev Cell. 2007 Dec;13(6):884-96
1*	J:162174 Zizic Mitrecic M, Mitrecic D, Pochet R, Kostovic-Knezevic L, Gajovic S, The mouse gene Noto is expressed in the tail bud and essential for its morphogenesis. Cells Tissues Organs. 2010 Jul;192(2):85-92