Gene Expression Literature Summary

• Symbol: Lin28b
• Name: lin-28 homolog B
• ID: MGI:3584032

22 matching records from 22 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E6.5	E7.5	E9.5	E10.5	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	P
Immunohistochemistry (section)					1	1			2		2				1			2	3
In situ RNA (section)					2	1	1	1	2		1		1
In situ RNA (whole mount)				1	2	2
In situ reporter (knock in)							1												1
Western blot				2	1		4	1	4	1	5	1	2	1	5	2		4	5
RT-PCR	1	1	1		2	4	3		4		4	2	4		3	2	1	3	8

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Lin28b  lin-28 homolog B   (Synonyms: 2810403D23Rik, D030047M17Rik)
Results	Reference
2*	J:272567 Aires R, de Lemos L, Novoa A, Jurberg AD, Mascrez B, Duboule D, Mallo M, Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes. Dev Cell. 2019 Feb 11;48(3):383-395.e8
3*	J:264256 Bernardo AS, Jouneau A, Marks H, Kensche P, Kobolak J, Freude K, Hall V, Feher A, Polgar Z, Sartori C, Bock I, Louet C, Faial T, Kerstens HHD, Bouissou C, Parsonage G, Mashayekhi K, Smith JC, Lazzari G, Hyttel P, Stunnenberg HG, Huynen M, Pedersen RA, Dinnyes A, Mammalian embryo comparison identifies novel pluripotency genes associated with the naive or primed state. Biol Open. 2018 Aug 17;7(8):bio033282
1	J:283931 Chang MY, Oh B, Choi JE, Sulistio YA, Woo HJ, Jo A, Kim J, Kim EH, Kim SW, Hwang J, Park J, Song JJ, Kwon OC, Henry Kim H, Kim YH, Ko JY, Heo JY, Lee MJ, Lee M, Choi M, Chung SJ, Lee HS, Lee SH, LIN28A loss of function is associated with Parkinson's disease pathogenesis. EMBO J. 2019 Dec 16;38(24):e101196
11*	J:252127 Dong N, Liu Y, Zhang T, Zhao L, Tian J, Ruan J, Different expression patterns of Lin28 and Lin28b in mouse molar development. Arch Oral Biol. 2017 Oct;82:280-285
2*	J:328711 Fernandez-Guerrero M, Zdral S, Castilla-Ibeas A, Lopez-Delisle L, Duboule D, Ros MA, Time-sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis. Dev Dyn. 2022 Sep;251(9):1550-1575
8	J:223798 Golden EJ, Benito-Gonzalez A, Doetzlhofer A, The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3864-73
1	J:278246 Herrlinger S, Shao Q, Yang M, Chang Q, Liu Y, Pan X, Yin H, Xie LW, Chen JF, Lin28-mediated temporal promotion of protein synthesis is crucial for neural progenitor cell maintenance and brain development in mice. Development. 2019 May 28;146(10):dev173765
2*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
2	J:162687 Matsubara S, Takahashi T, Kimura AP, Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression. Gene. 2010 Oct 1;465(1-2):17-29
2*	J:258725 Meares GP, Rajbhandari R, Gerigk M, Tien CL, Chang C, Fehling SC, Rowse A, Mulhern KC, Nair S, Gray GK, Berbari NF, Bredel M, Benveniste EN, Nozell SE, MicroRNA-31 is required for astrocyte specification. Glia. 2018 May;66(5):987-998
2	J:331901 Muthu V, Rohacek AM, Yao Y, Rakowiecki SM, Brown AS, Zhao YT, Meyers J, Won KJ, Ramdas S, Brown CD, Peterson KA, Epstein DJ, Genomic architecture of Shh-dependent cochlear morphogenesis. Development. 2019 Sep 19;146(18)
5*	J:219223 Nagalakshmi VK, Lindner V, Wessels A, Yu J, microRNA-dependent temporal gene expression in the ureteric bud epithelium during mammalian kidney development. Dev Dyn. 2015 Mar;244(3):444-56
7*	J:214596 Nguyen LH, Robinton DA, Seligson MT, Wu L, Li L, Rakheja D, Comerford SA, Ramezani S, Sun X, Parikh MS, Yang EH, Powers JT, Shinoda G, Shah SP, Hammer RE, Daley GQ, Zhu H, Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. Cancer Cell. 2014 Aug 11;26(2):248-61
15	J:321070 Osborne JK, Kinney MA, Han A, Akinnola KE, Yermalovich AV, Vo LT, Pearson DS, Sousa PM, Ratanasirintrawoot S, Tsanov KM, Barragan J, North TE, Metzger RJ, Daley GQ, Lin28 paralogs regulate lung branching morphogenesis. Cell Rep. 2021 Jul 20;36(3):109408
7	J:272391 Robinton DA, Chal J, Lummertz da Rocha E, Han A, Yermalovich AV, Oginuma M, Schlaeger TM, Sousa P, Rodriguez A, Urbach A, Pourquie O, Daley GQ, The Lin28/let-7 Pathway Regulates the Mammalian Caudal Body Axis Elongation Program. Dev Cell. 2019 Feb 11;48(3):396-405.e3
6	J:222249 Tu HC, Schwitalla S, Qian Z, LaPier GS, Yermalovich A, Ku YC, Chen SC, Viswanathan SR, Zhu H, Nishihara R, Inamura K, Kim SA, Morikawa T, Mima K, Sukawa Y, Yang J, Meredith G, Fuchs CS, Ogino S, Daley GQ, LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans. Genes Dev. 2015 May 15;29(10):1074-86
2	J:211179 Urbach A, Yermalovich A, Zhang J, Spina CS, Zhu H, Perez-Atayde AR, Shukrun R, Charlton J, Sebire N, Mifsud W, Dekel B, Pritchard-Jones K, Daley GQ, Lin28 sustains early renal progenitors and induces Wilms tumor. Genes Dev. 2014 May 1;28(9):971-82
3*	J:270658 Wang XW, Li Q, Liu CM, Hall PA, Jiang JJ, Katchis CD, Kang S, Dong BC, Li S, Zhou FQ, Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration. Cell Rep. 2018 Sep 4;24(10):2540-2552.e6
4	J:342003 Xiao S, Zhang W, Li J, Manley NR, Lin28 regulates thymic growth and involution and correlates with MHCII expression in thymic epithelial cells. Front Immunol. 2023;14:1261081
7	J:221409 Yang M, Yang SL, Herrlinger S, Liang C, Dzieciatkowska M, Hansen KC, Desai R, Nagy A, Niswander L, Moss EG, Chen JF, Lin28 promotes the proliferative capacity of neural progenitor cells in brain development. Development. 2015 May 1;142(9):1616-27
16	J:270550 Yermalovich AV, Osborne JK, Sousa P, Han A, Kinney MA, Chen MJ, Robinton DA, Montie H, Pearson DS, Wilson SB, Combes AN, Little MH, Daley GQ, Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis. Nat Commun. 2019 Jan 11;10(1):168
1	J:314661 Zhang Q, Huang R, Ye Y, Guo X, Lu J, Zhu F, Gong X, Zhang Q, Yan J, Luo L, Zhuang S, Chen Y, Zhao X, Evans SM, Jiang C, Liang X, Sun Y, Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. Cell Death Dis. 2018 Feb 14;9(2):247