Gene Expression Literature Summary

• Symbol: Mirlet7c-2
• Name: microRNA let7c-2
• ID: MGI:3619050

17 matching records from 17 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E8	E8.5	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
In situ RNA (section)													1				1						2
In situ RNA (whole mount)							1	1
Northern blot					1	1	1	1		1	1			1	1			1			1		2
Western blot													1
RT-PCR	1	1	1	1		1	1	2	2	2	2	2	2	2	1	2	1	2	3	1	2	1	7

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Mirlet7c-2  microRNA let7c-2   (Synonyms: let 7c-2, Mirnlet7c-2, mmu-let-7c-2)
Results	Reference
1	J:190567 Cao L, Kong LP, Yu ZB, Han SP, Bai YF, Zhu J, Hu X, Zhu C, Zhu S, Guo XR, microRNA expression profiling of the developing mouse heart. Int J Mol Med. 2012 Nov;30(5):1095-104
1	J:161968 Cheloufi S, Dos Santos CO, Chong MM, Hannon GJ, A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature. 2010 Jun 3;465(7298):584-9
1	J:273987 Chen PY, Qin L, Barnes C, Charisse K, Yi T, Zhang X, Ali R, Medina PP, Yu J, Slack FJ, Anderson DG, Kotelianski V, Wang F, Tellides G, Simons M, FGF regulates TGF-beta signaling and endothelial-to-mesenchymal transition via control of let-7 miRNA expression. Cell Rep. 2012 Dec 27;2(6):1684-96
5*	J:297771 Fairchild CLA, Cheema SK, Wong J, Hino K, Simo S, La Torre A, Let-7 regulates cell cycle dynamics in the developing cerebral cortex and retina. Sci Rep. 2019 Oct 25;9(1):15336
5	J:223798 Golden EJ, Benito-Gonzalez A, Doetzlhofer A, The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):E3864-73
2*	J:112756 Kloosterman WP, Wienholds E, de Bruijn E, Kauppinen S, Plasterk RH, In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes. Nat Methods. 2006 Jan;3(1):27-9
3	J:238411 Miyazawa H, Yamaguchi Y, Sugiura Y, Honda K, Kondo K, Matsuda F, Yamamoto T, Suematsu M, Miura M, Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching. Development. 2017 Jan 01;144(1):63-73
9	J:321070 Osborne JK, Kinney MA, Han A, Akinnola KE, Yermalovich AV, Vo LT, Pearson DS, Sousa PM, Ratanasirintrawoot S, Tsanov KM, Barragan J, North TE, Metzger RJ, Daley GQ, Lin28 paralogs regulate lung branching morphogenesis. Cell Rep. 2021 Jul 20;36(3):109408
2	J:197985 Ota H, Sakurai M, Gupta R, Valente L, Wulff BE, Ariyoshi K, Iizasa H, Davuluri RV, Nishikura K, ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell. 2013 Apr 25;153(3):575-89
1	J:158290 Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn EA, Michel G, Nitsch R, Krappmann D, Wulczyn FG, The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol. 2009 Dec;11(12):1411-20
1	J:199787 Saurat N, Andersson T, Vasistha NA, Molnar Z, Livesey FJ, Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development. Neural Dev. 2013;8:14
10*	J:102849 Schulman BR, Esquela-Kerscher A, Slack FJ, Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis. Dev Dyn. 2005 Dec;234(4):1046-54
2*	J:165465 Sehic A, Risnes S, Khan QE, Khuu C, Osmundsen H, Gene expression and dental enamel structure in developing mouse incisor. Eur J Oral Sci. 2010 Apr;118(2):118-30
1*	J:101078 Smirnova L, Grafe A, Seiler A, Schumacher S, Nitsch R, Wulczyn FG, Regulation of miRNA expression during neural cell specification. Eur J Neurosci. 2005 Mar;21(6):1469-77
5	J:119483 Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA, Maternal microRNAs are essential for mouse zygotic development. Genes Dev. 2007 Mar 15;21(6):644-8
2	J:316662 Wei J, Li H, Wang S, Li T, Fan J, Liang X, Li J, Han Q, Zhu L, Fan L, Zhao RC, let-7 enhances osteogenesis and bone formation while repressing adipogenesis of human stromal/mesenchymal stem cells by regulating HMGA2. Stem Cells Dev. 2014 Jul 1;23(13):1452-63
8	J:270550 Yermalovich AV, Osborne JK, Sousa P, Han A, Kinney MA, Chen MJ, Robinton DA, Montie H, Pearson DS, Wilson SB, Combes AN, Little MH, Daley GQ, Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis. Nat Commun. 2019 Jan 11;10(1):168