Gene Expression Literature Summary

• Symbol: Chrna1
• Name: cholinergic receptor nicotinic alpha 1 subunit
• ID: MGI:87885

43 matching records from 43 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)																	3		1
In situ RNA (section)					1		1		5	1	2				2	1	5	1	2
In situ RNA (whole mount)	1		1		1	1		1	3	1			1		1		9		3
In situ reporter (knock in)														1					1
Northern blot														1	1	1			2
Western blot														1			1		1
RT-PCR		1		1	1	1	3	1	2	1	2	1	1	1		1	4		9
cDNA clones									1
RNase protection																1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Chrna1  cholinergic receptor nicotinic alpha 1 subunit   (Synonyms: Achr-1, Acra)
Results	Reference
1	J:161300 An MC, Lin W, Yang J, Dominguez B, Padgett D, Sugiura Y, Aryal P, Gould TW, Oppenheim RW, Hester ME, Kaspar BK, Ko CP, Lee KF, Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10702-7
5*	J:36534 Anzai K, Kobayashi S, Kotake H, Murakami H, Korematsu K, Nonaka I, Neural BC1 RNA in mouse skeletal muscle is a denervation-induced RNA whose expression is developmentally regulated. Neurosci Lett. 1996 Sep 27;216(2):81-4
3	J:139507 Berghella L, De Angelis L, De Buysscher T, Mortazavi A, Biressi S, Forcales SV, Sirabella D, Cossu G, Wold BJ, A highly conserved molecular switch binds MSY-3 to regulate myogenin repression in postnatal muscle. Genes Dev. 2008 Aug 1;22(15):2125-38
1*	J:82463 Cachaco AS, Chuva de Sousa Lopes SM, Kuikman I, Bajanca F, Abe K, Baudoin C, Sonnenberg A, Mummery CL, Thorsteinsdottir S, Knock-in of integrin beta 1D affects primary but not secondary myogenesis in mice. Development. 2003 Apr;130(8):1659-71
3	J:172291 Chen F, Liu Y, Sugiura Y, Allen PD, Gregg RG, Lin W, Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors. Nat Neurosci. 2011 May;14(5):570-7
1	J:126558 Chen F, Qian L, Yang ZH, Huang Y, Ngo ST, Ruan NJ, Wang J, Schneider C, Noakes PG, Ding YQ, Mei L, Luo ZG, Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction. Neuron. 2007 Jul 19;55(2):247-60
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:345130 Eguchi T, Tezuka T, Watanabe Y, Inoue-Yamauchi A, Sagara H, Ozawa M, Yamanashi Y, Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice. iScience. 2024 Feb 16;27(2):108997
2	J:102479 Fu AK, Ip FC, Fu WY, Cheung J, Wang JH, Yung WH, Ip NY, Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15224-9
1	J:33098 Gautam M, Noakes PG, Moscoso L, Rupp F, Scheller RH, Merlie JP, Sanes JR, Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996 May 17;85(4):525-35
1*	J:14208 Hasty P, Bradley A, Morris JH, Edmondson DG, Venuti JM, Olson EN, Klein WH, Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene [see comments]. Nature. 1993 Aug 5;364(6437):501-6
1	J:80082 Herbst R, Avetisova E, Burden SJ, Restoration of synapse formation in Musk mutant mice expressing a Musk/Trk chimeric receptor. Development. 2002 Dec;129(23):5449-60
3	J:126807 Hippenmeyer S, Huber RM, Ladle DR, Murphy K, Arber S, ETS transcription factor Erm controls subsynaptic gene expression in skeletal muscles. Neuron. 2007 Sep 6;55(5):726-40
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
2	J:260261 Inoue A, Setoguchi K, Matsubara Y, Okada K, Sato N, Iwakura Y, Higuchi O, Yamanashi Y, Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation. Sci Signal. 2009 Feb 24;2(59):ra7
1	J:104252 Jaworski A, Burden SJ, Neuromuscular synapse formation in mice lacking motor neuron- and skeletal muscle-derived Neuregulin-1. J Neurosci. 2006 Jan 11;26(2):655-61
2	J:271303 Kaplan MM, Sultana N, Benedetti A, Obermair GJ, Linde NF, Papadopoulos S, Dayal A, Grabner M, Flucher BE, Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation. Cell Rep. 2018 Jun 26;23(13):3891-3904
1	J:135587 Li XM, Dong XP, Luo SW, Zhang B, Lee DH, Ting AK, Neiswender H, Kim CH, Carpenter-Hyland E, Gao TM, Xiong WC, Mei L, Retrograde regulation of motoneuron differentiation by muscle beta-catenin. Nat Neurosci. 2008 Mar;11(3):262-8
1	J:99854 Lin W, Dominguez B, Yang J, Aryal P, Brandon EP, Gage FH, Lee KF, Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism. Neuron. 2005 May 19;46(4):569-79
1	J:60191 Lin W, Sanchez HB, Deerinck T, Morris JK, Ellisman M, Lee KF, Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice. Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1299-304
5	J:134988 Liu Y, Padgett D, Takahashi M, Li H, Sayeed A, Teichert RW, Olivera BM, McArdle JJ, Green WN, Lin W, Essential roles of the acetylcholine receptor {gamma}-subunit in neuromuscular synaptic patterning. Development. 2008 Jun;135(11):1957-67
2*	J:34235 Luo ZD, Pincon-Raymond M, Taylor P, Acetylcholinesterase and nicotinic acetylcholine receptor expression diverge in muscular dysgenic mice lacking the L-type calcium channel. J Neurochem. 1996 Jul;67(1):111-8
2*	J:3158 Lyons GE, Moore R, Yahara O, Buckingham ME, Walsh FS, Expression of NCAM isoforms during skeletal myogenesis in the mouse embryo. Dev Dyn. 1992 Jun;194(2):94-104
6*	J:139286 Michalk A, Stricker S, Becker J, Rupps R, Pantzar T, Miertus J, Botta G, Naretto VG, Janetzki C, Yaqoob N, Ott CE, Seelow D, Wieczorek D, Fiebig B, Wirth B, Hoopmann M, Walther M, Korber F, Blankenburg M, Mundlos S, Heller R, Hoffmann K, Acetylcholine receptor pathway mutations explain various fetal akinesia deformation sequence disorders. Am J Hum Genet. 2008 Feb;82(2):464-76
1	J:91066 Misgeld T, Burgess RW, Lewis RM, Cunningham JM, Lichtman JW, Sanes JR, Roles of neurotransmitter in synapse formation: development of neuromuscular junctions lacking choline acetyltransferase. Neuron. 2002 Nov 14;36(4):635-48
2	J:296800 Munezane H, Oizumi H, Wakabayashi T, Nishio S, Hirasawa T, Sato T, Harada A, Yoshida T, Eguchi T, Yamanashi Y, Hashimoto T, Iwatsubo T, Roles of Collagen XXV and Its Putative Receptors PTPsigma/delta in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder. Cell Rep. 2019 Dec 24;29(13):4362-4376.e6
1	J:160510 Nagata K, Kiryu-Seo S, Maeda M, Yoshida K, Morita T, Kiyama H, Damage-induced neuronal endopeptidase is critical for presynaptic formation of neuromuscular junctions. J Neurosci. 2010 May 19;30(20):6954-62
3	J:37005 Noakes PG, Phillips WD, Hanley TA, Sanes JR, Merlie JP, 43K protein and acetylcholine receptors colocalize during the initial stages of neuromuscular synapse formation in vivo. Dev Biol. 1991;155(1):275-80
2	J:353626 Ohkawara B, Kurokawa M, Kanai A, Imamura K, Chen G, Zhang R, Masuda A, Higashi K, Mori H, Suzuki Y, Kurokawa K, Ohno K, Transcriptome profile of subsynaptic myonuclei at the neuromuscular junction in embryogenesis. J Neurochem. 2024 Apr;168(4):342-354
6	J:31818 Piette J, Huchet M, Houzelstein D, Changeux JP, Compartmentalized expression of the alpha- and gamma-subunits of the acetylcholine receptor in recently fused myofibers. Dev Biol. 1993 May;157(1):205-13
2	J:232554 Remedio L, Gribble KD, Lee JK, Kim N, Hallock PT, Delestree N, Mentis GZ, Froemke RC, Granato M, Burden SJ, Diverging roles for Lrp4 and Wnt signaling in neuromuscular synapse development during evolution. Genes Dev. 2016 May 1;30(9):1058-69
1	J:43515 Riethmacher D, Sonnenberg-Riethmacher E, Brinkmann V, Yamaai T , Lewin GR , Birchmeier C, Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature. 1997 Oct 16;389(6652):725-30
4*	J:244196 Roux I, Wu JS, McIntosh JM, Glowatzki E, Assessment of the expression and role of the alpha1-nAChR subunit in efferent cholinergic function during the development of the mammalian cochlea. J Neurophysiol. 2016 Aug 01;116(2):479-92
2	J:216752 Tezuka T, Inoue A, Hoshi T, Weatherbee SD, Burgess RW, Ueta R, Yamanashi Y, The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16556-61
1	J:44406 van der Flier A, Gaspar AC, Thorsteinsdottir S, Baudoin C, Groeneveld E, Mummery CL, Sonnenberg A, Spatial and temporal expression of the beta1D integrin during mouse development. Dev Dyn. 1997 Dec;210(4):472-86
1*	J:221937 Watson JA, Bhattacharyya BJ, Vaden JH, Wilson JA, Icyuz M, Howard AD, Phillips E, DeSilva TM, Siegal GP, Bean AJ, King GD, Phillips SE, Miller RJ, Wilson SM, Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS. PLoS Genet. 2015 Jun;11(6):e1005290
2	J:119654 Weatherbee SD, Anderson KV, Niswander LA, LDL-receptor-related protein 4 is crucial for formation of the neuromuscular junction. Development. 2006 Dec;133(24):4993-5000
1	J:58105 Woldeyesus MT, Britsch S, Riethmacher D, Xu L, Sonnenberg-Riethmacher E, Abou-Rebyeh F, Harvey R, Caroni P, Birchmeier C, Peripheral nervous system defects in erbB2 mutants following genetic rescue of heart development. Genes Dev. 1999 Oct 1;13(19):2538-48
5*	J:74921 Yamane A, Ohnuki Y, Saeki Y, Developmental changes in the nicotinic acetylcholine receptor in mouse tongue striated muscle. J Dent Res. 2001 Sep;80(9):1840-4
1	J:69623 Yang X, Arber S, William C, Li L, Tanabe Y, Jessell TM, Birchmeier C, Burden SJ, Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. Neuron. 2001 May;30(2):399-410
2	J:144429 Yumoto N, Wakatsuki S, Kurisaki T, Hara Y, Osumi N, Frisen J, Sehara-Fujisawa A, Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction. PLoS One. 2008;3(10):e3322
5	J:98291 Yumoto N, Wakatsuki S, Sehara-Fujisawa A, The acetylcholine receptor gamma-to-epsilon switch occurs in individual endplates. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1522-7
1	J:263025 Zoupa M, Xavier GM, Bryan S, Theologidis I, Arno M, Cobourne MT, Gene expression profiling in the developing secondary palate in the absence of Tbx1 function. BMC Genomics. 2018 Jun 4;19(1):429