Gene Expression Literature Summary

• Symbol: Acvr1
• Name: activin A receptor, type 1
• ID: MGI:87911

56 matching records from 56 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2	E2.5	E3	E3.5	E4	E4.5	E5.5	E6	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)												1	1	2	1	2		1		1		2		2			1	1		2		1				3	1
In situ RNA (section)														1		3	1		2			7		3		3		8		3		3		2		2		1	5
Immunohistochemistry (whole mount)														1	2	2	1	1		1		1								1
In situ RNA (whole mount)														1		2	2		2	1	2			1		1		1		1
In situ reporter (knock in)																																							1
Northern blot													2								2				1				2				1						1
RT-PCR	1	1	1	1	2	1	1	2	1	2	1	1				1		2	2			2	1	2	2	4	2	5	1	1	2	2	1	4	1	3			6
cDNA clones											1	1		1								1								1
RNase protection																										1		1		1						1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Acvr1  activin A receptor, type 1   (Synonyms: ActR-I, ActRIA, Acvr, Acvr1a, Acvrlk2, Alk-2, ALK2, Alk8, D330013D15Rik, SKR1, Tsk7L)
Results	Reference
1	J:284333 Arai HN, Sato F, Yamamoto T, Woltjen K, Kiyonari H, Yoshimoto Y, Shukunami C, Akiyama H, Kist R, Sehara-Fujisawa A, Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate. Cell Rep. 2019 Oct 15;29(3):603-616.e5
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
6	J:219394 Boroviak T, Loos R, Bertone P, Smith A, Nichols J, The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
2	J:160559 Caronia G, Wilcoxon J, Feldman P, Grove EA, Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior. J Neurosci. 2010 May 5;30(18):6291-301
1	J:286635 Chen SY, Lu KM, Ko HA, Huang TH, Hao JH, Yan YT, Chang SL, Evans SM, Liu FC, Parcellation of the striatal complex into dorsal and ventral districts. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7418-7429
3	J:196652 Choe Y, Kozlova A, Graf D, Pleasure SJ, Bone morphogenic protein signaling is a major determinant of dentate development. J Neurosci. 2013 Apr 17;33(16):6766-75
4*	J:77383 de Caestecker MP, Bottomley M, Bhattacharyya S, Payne TL, Roberts AB, Yelick PC, The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII. Biochem Biophys Res Commun. 2002 May 24;293(5):1556-65
3	J:91660 de Sousa Lopes SM, Roelen BA, Monteiro RM, Emmens R, Lin HY, Li E, Lawson KA, Mummery CL, BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev. 2004 Aug 1;18(15):1838-49
7*	J:82773 Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P, Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev Dyn. 2003 Apr;226(4):663-74
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:164103 Du Y, Xiao Q, Yip HK, Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade. Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3764-73
3*	J:87407 Dudas M, Nagy A, Laping NJ, Moustakas A, Kaartinen V, Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev Biol. 2004 Feb 1;266(1):96-108
10*	J:90453 Dudas M, Sridurongrit S, Nagy A, Okazaki K, Kaartinen V, Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells. Mech Dev. 2004 Feb;121(2):173-82
7	J:54394 Gu Z, Reynolds EM, Song J, Lei H, Feijen A, Yu L, He W, MacLaughlin DT , van den Eijnden-van Raaij J , Donahoe PK , Li E, The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development. 1999 Jun;126(11):2551-61
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:309228 Hill C, Jacobs B, Kennedy L, Rohde S, Zhou B, Baldwin S, Goudy S, Cranial neural crest deletion of VEGFa causes cleft palate with aberrant vascular and bone development. Cell Tissue Res. 2015 Sep;361(3):711-22
2*	J:218259 Hill CR, Jacobs BH, Brown CB, Barnett JV, Goudy SL, Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis. Dev Dyn. 2015 Feb;244(2):122-33
3	J:207974 Hill CR, Yuasa M, Schoenecker J, Goudy SL, Jagged1 is essential for osteoblast development during maxillary ossification. Bone. 2014 May;62:10-21
1	J:341277 Ishan M, Wang Z, Zhao P, Yao Y, Stice SL, Wells L, Mishina Y, Liu HX, Taste papilla cell differentiation requires the regulation of secretory protein production by ALK3-BMP signaling in the tongue mesenchyme. Development. 2023 Sep 15;150(18):dev201838
3	J:99699 Jiang FX, Harrison LC, Convergence of bone morphogenetic protein and laminin-1 signaling pathways promotes proliferation and colony formation by fetal mouse pancreatic cells. Exp Cell Res. 2005 Aug 1;308(1):114-22
1	J:90988 Kaartinen V, Dudas M, Nagy A, Sridurongrit S, Lu MM, Epstein JA, Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development. 2004 Jul;131(14):3481-90
1	J:143588 Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y, BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 2008 Nov;135(22):3801-11
4*	J:95020 Kishigami S, Yoshikawa S, Castranio T, Okazaki K, Furuta Y, Mishina Y, BMP signaling through ACVRI is required for left-right patterning in the early mouse embryo. Dev Biol. 2004 Dec 1;276(1):185-93
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1	J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
1	J:193698 Li W, Xiong Y, Shang C, Twu KY, Hang CT, Yang J, Han P, Lin CY, Lin CJ, Tsai FC, Stankunas K, Meyer T, Bernstein D, Pan M, Chang CP, Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1738-43
2	J:356545 Li X, Madison BB, Zacharias W, Kolterud A, States D, Gumucio DL, Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk. Physiol Genomics. 2007 May 11;29(3):290-301
2	J:225912 Liang GJ, Zhang XF, Wang JJ, Sun YC, Sun XF, Cheng SF, Li L, De Felici M, Shen W, Activin A Accelerates the Progression of Fetal Oocytes Throughout Meiosis and Early Oogenesis in the Mouse. Stem Cells Dev. 2015 Oct 15;24(20):2455-65
2	J:346631 Liu L, Zhang X, Geng HR, Qiao YN, Gui YH, Zhao JY, High paternal homocysteine causes ventricular septal defects in mouse offspring. iScience. 2024 Apr 19;27(4):109447
1	J:238888 Luo W, Zhao X, Jin H, Tao L, Zhu J, Wang H, Hemmings BA, Yang Z, Akt1 signaling coordinates BMP signaling and beta-catenin activity to regulate second heart field progenitor development. Development. 2015 Feb 15;142(4):732-42
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
7*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
2*	J:103164 Minina E, Schneider S, Rosowski M, Lauster R, Vortkamp A, Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Gene Expr Patterns. 2005 Dec;6(1):102-109
1*	J:57670 Mishina Y, Crombie R, Bradley A, Behringer RR, Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. Dev Biol. 1999 Sep 15;213(2):314-26
1	J:118511 Nakamura M, Matzuk MM, Gerstmayer B, Bosio A, Lauster R, Miyachi Y, Werner S, Paus R, Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin. FASEB J. 2003 Mar;17(3):497-9
2	J:233662 Noda K, Mishina Y, Komatsu Y, Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice. Dev Biol. 2016 Jul 15;415(2):306-13
2*	J:108109 Oxburgh L, Chu GC, Michael SK, Robertson EJ, TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development. 2004 Sep;131(18):4593-605
1	J:248982 Pan H, Zhang H, Abraham P, Komatsu Y, Lyons K, Kaartinen V, Mishina Y, BmpR1A is a major type 1 BMP receptor for BMP-Smad signaling during skull development. Dev Biol. 2017 Sep 1;429(1):260-270
1	J:147287 Retting KN, Song B, Yoon BS, Lyons KM, BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development. 2009 Apr;136(7):1093-104
7*	J:42540 Roelen BA, Goumans MJ, van Rooijen MA, Mummery CL, Differential expression of BMP receptors in early mouse development. Int J Dev Biol. 1997 Aug;41(4):541-9
4	J:22323 Roelen BA, Lin HY, Knezevic V, Freund E, Mummery CL, Expression of TGF-beta s and their receptors during implantation and organogenesis of the mouse embryo. Dev Biol. 1994 Dec;166(2):716-28
4*	J:157819 Shimogori T, Lee DA, Miranda-Angulo A, Yang Y, Wang H, Jiang L, Yoshida AC, Kataoka A, Mashiko H, Avetisyan M, Qi L, Qian J, Blackshaw S, A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
1	J:164086 Suzuki Y, Ohga N, Morishita Y, Hida K, Miyazono K, Watabe T, BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J Cell Sci. 2010 May 15;123(Pt 10):1684-92
2*	J:130714 Tachikawa K, Sasaki S, Maeda T, Nakajima K, Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex. Neurosci Res. 2008 Feb;60(2):135-46
7	J:212416 Thomas PS, Rajderkar S, Lane J, Mishina Y, Kaartinen V, AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity. Dev Biol. 2014 Jun 15;390(2):191-207
2	J:187204 Thomas PS, Sridurongrit S, Ruiz-Lozano P, Kaartinen V, Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development. PLoS One. 2012;7(4):e35539
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
3*	J:302550 Towler OW, Peck SH, Kaplan FS, Shore EM, Dysregulated BMP signaling through ACVR1 impairs digit joint development in fibrodysplasia ossificans progressiva (FOP). Dev Biol. 2021 Feb;470:136-146
8*	J:27756 Verschueren K, Dewulf N, Goumans MJ, Lonnoy O, Feijen A, Grimsby S, Vandi Spiegle K, ten Dijke P, Moren A, Vanscheeuwijck P, Heldin CH, Miyazono K, Mummery C, Van Den Eijnden-Van Raaij J, Huylebroeck D, Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogenesis. Mech Dev. 1995 Jul;52(1):109-23
2	J:108374 Vesper AH, Raetzman LT, Camper SA, Role of prophet of Pit1 (PROP1) in gonadotrope differentiation and puberty. Endocrinology. 2006 Apr;147(4):1654-63
3	J:235682 Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsee J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE, Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly. Development. 2016 Jun 1;143(11):1958-70
6	J:69633 Visser JA, Olaso R, Verhoef-Post M, Kramer P, Themmen AP, Ingraham HA, The serine/threonine transmembrane receptor ALK2 mediates Mullerian inhibiting substance signaling. Mol Endocrinol. 2001 Jun;15(6):936-45
1	J:278336 Wang W, Chun H, Baek J, Sadik JE, Shirazyan A, Razavi P, Lopez N, Lyons KM, The TGFbeta type I receptor TGFbetaRI functions as an inhibitor of BMP signaling in cartilage. Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15570-15579
1	J:347414 Yang J, Zhu L, Pan H, Ueharu H, Toda M, Yang Q, Hallett SA, Olson LE, Mishina Y, A BMP-controlled metabolic/epigenetic signaling cascade directs midfacial morphogenesis. J Clin Invest. 2024 Mar 11;134(8)
14*	J:61348 Yoshikawa SI, Aota S, Shirayoshi Y, Okazaki K, The ActR-I activin receptor protein is expressed in notochord, lens placode and pituitary primordium cells in the mouse embryo. Mech Dev. 2000 Mar 1;91(1-2):439-44
1	J:262085 Yu Z, Tang PL, Wang J, Bao S, Shieh JT, Leung AW, Zhang Z, Gao F, Wong SY, Hui AL, Gao Y, Dung N, Zhang ZG, Fan Y, Zhou X, Zhang Y, Wong DS, Sham PC, Azhar A, Kwok PY, Tam PP, Lian Q, Cheah KS, Wang B, Song YQ, Mutations in Hnrnpa1 cause congenital heart defects. JCI Insight. 2018 Jan 25;3(2)