Symbol Name ID |
Ank3
ankyrin 3, epithelial MGI:88026 |
Age | E7.5 | E8.5 | E9 | E9.5 | E10.5 | E11.5 | E12.5 | E13.5 | E14.5 | E15.5 | E16 | E16.5 | E17.5 | E18.5 | E19 | E20 | E | P |
Immunohistochemistry (section) | 1 | 2 | 1 | 2 | 2 | 3 | 1 | 1 | 2 | 2 | 1 | 1 | 2 | 11 | ||||
In situ RNA (section) | 1 | 1 | 2 | 2 | 2 | 2 | ||||||||||||
Immunohistochemistry (whole mount) | 1 | 1 | ||||||||||||||||
In situ RNA (whole mount) | 1 | 1 | ||||||||||||||||
In situ reporter (knock in) | 1 | |||||||||||||||||
Western blot | 1 | 1 | 2 | 1 | 8 | |||||||||||||
RT-PCR | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 5 |
Ank3 ankyrin 3, epithelial (Synonyms: 2900054D09Rik, Ank-3, AnkG, Ankyrin-3, Ankyrin-G) | |
Results | Reference |
1 | J:281255 Ackermann MA, King B, Lieberman NAP, Bobbili PJ, Rudloff M, Berndsen CE, Wright NT, Hecker PA, Kontrogianni-Konstantopoulos A, Novel obscurins mediate cardiomyocyte adhesion and size via the PI3K/AKT/mTOR signaling pathway. J Mol Cell Cardiol. 2017 Oct;111:27-39 |
4 | J:30147 Barisoni L, Trudel M, Chretien N, Ward L, van Adelsberg J, D'Agati V, Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. Am J Pathol. 1995 Dec;147(6):1728-35 |
1* | J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034 |
1* | J:302571 Casingal CR, Kikkawa T, Inada H, Sasaki Y, Osumi N, Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/beta-catenin, and mTOR signaling during corticogenesis. Mol Brain. 2020 Dec 16;13(1):167 |
1 | J:300948 Chen X, Liu Y, Xu C, Ba L, Liu Z, Li X, Huang J, Simpson E, Gao H, Cao D, Sheng W, Qi H, Ji H, Sanderson M, Cai CL, Li X, Yang L, Na J, Yamamura K, Liu Y, Huang G, Shou W, Sun N, QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function. Nat Commun. 2021 Jan 4;12(1):89 |
2 | J:106392 Eblaghie MC, Reedy M, Oliver T, Mishina Y, Hogan BL, Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. Dev Biol. 2006 Mar 1;291(1):67-82 |
6 | J:231960 Freal A, Fassier C, Le Bras B, Bullier E, De Gois S, Hazan J, Hoogenraad CC, Couraud F, Cooperative Interactions between 480 kDa Ankyrin-G and EB Proteins Assemble the Axon Initial Segment. J Neurosci. 2016 Apr 20;36(16):4421-33 |
1 | J:232973 Hirst CS, Foong JP, Stamp LA, Fegan E, Dent S, Cooper EC, Lomax AE, Anderson CR, Bornstein JC, Young HM, McKeown SJ, Ion channel expression in the developing enteric nervous system. PLoS One. 2015;10(3):e0123436 |
1 | J:300939 Jamann N, Dannehl D, Lehmann N, Wagener R, Thielemann C, Schultz C, Staiger J, Kole MHP, Engelhardt M, Sensory input drives rapid homeostatic scaling of the axon initial segment in mouse barrel cortex. Nat Commun. 2021 Jan 4;12(1):23 |
1* | J:283037 Khalaf B, Roncador A, Pischedda F, Casini A, Thomas S, Piccoli G, Kiebler M, Macchi P, Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons. J Cell Sci. 2019 Sep 26;132(18):jcs222802 |
1 | J:93411 Lacas-Gervais S, Guo J, Strenzke N, Scarfone E, Kolpe M, Jahkel M, De Camilli P, Moser T, Rasband MN, Solimena M, BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial segments. J Cell Biol. 2004 Oct 27;166(7):983-90 |
9* | J:214712 Le Bras B, Freal A, Czarnecki A, Legendre P, Bullier E, Komada M, Brophy PJ, Davenne M, Couraud F, In vivo assembly of the axon initial segment in motor neurons. Brain Struct Funct. 2014 Jul;219(4):1433-50 |
2* | J:282974 Lee M, Liu YC, Chen C, Lu CH, Lu ST, Huang TN, Hsu MT, Hsueh YP, Cheng PL, Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. J Cell Biol. 2020 Feb 3;219(2) |
1 | J:185949 Licatalosi DD, Yano M, Fak JJ, Mele A, Grabinski SE, Zhang C, Darnell RB, Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev. 2012 Jul 15;26(14):1626-42 |
5 | J:285865 Liu C, Zhang L, Wu J, Sui X, Xu Y, Huang L, Han Y, Zhu H, Li Y, Sun X, Qin C, AnkG hemizygous mice present cognitive impairment and elevated anxiety/depressive-like traits associated with decreased expression of GABA receptors and postsynaptic density protein. Exp Brain Res. 2017 Nov;235(11):3375-3390 |
2 | J:210605 Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH, Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 8;509(7499):189-94 |
1* | J:335878 Montanes-Agudo P, Aufiero S, Schepers EN, van der Made I, Cocera-Ortega L, Ernault AC, Richard S, Kuster DWD, Christoffels VM, Pinto YM, Creemers EE, The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes. Cardiovasc Res. 2023 May 22;119(5):1161-1174 |
2* | J:281311 Nakano Y, Wiechert S, Banfi B, Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Cell Rep. 2019 Apr 16;27(3):860-871.e8 |
4* | J:266347 Ogawa Y, Yamaguchi J, Yano M, Uchiyama Y, Okano HJ, Elavl3 regulates neuronal polarity through the alternative splicing of an embryo-specific exon in AnkyrinG. Neurosci Res. 2018 Oct;135:13-20 |
1 | J:268565 Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, Miura E, Mazaki E, Ernst SJ, Cao D, Ohtani H, Itohara S, Yanagawa Y, Montal M, Yuzaki M, Inoue Y, Hensch TK, Noebels JL, Yamakawa K, Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice. Commun Biol. 2018;1 |
2 | J:340358 Oh H, Lee S, Oh Y, Kim S, Kim YS, Yang Y, Choi W, Yoo YE, Cho H, Lee S, Yang E, Koh W, Won W, Kim R, Lee CJ, Kim H, Kang H, Kim JY, Ku T, Paik SB, Kim E, Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice. Nat Commun. 2023 Jun 15;14(1):3547 |
8 | J:270142 Rasiah PK, Maddala R, Bennett V, Rao PV, Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth. Dev Biol. 2019 Feb 1;446(1):119-131 |
1 | J:261596 Schilders K, Eenjes E, Edel G, de Munck AB, van Kempen MB, Demmers J, Wijnen R, Tibboel D, Rottier RJ, Generation of a biotinylatable Sox2 mouse model to identify Sox2 complexes in vivo. Transgenic Res. 2018 Feb;27(1):75-85 |
4 | J:186305 Stankewich MC, Cianci CD, Stabach PR, Ji L, Nath A, Morrow JS, Cell organization, growth, and neural and cardiac development require alphaII-spectrin. J Cell Sci. 2011 Dec 1;124(Pt 23):3956-66 |
2* | J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511 |
1 | J:315116 Tapia M, Del Puerto A, Puime A, Sanchez-Ponce D, Fronzaroli-Molinieres L, Pallas-Bazarra N, Carlier E, Giraud P, Debanne D, Wandosell F, Garrido JJ, GSK3 and beta-catenin determines functional expression of sodium channels at the axon initial segment. Cell Mol Life Sci. 2013 Jan;70(1):105-20 |
3 | J:277380 Telley L, Agirman G, Prados J, Amberg N, Fievre S, Oberst P, Bartolini G, Vitali I, Cadilhac C, Hippenmeyer S, Nguyen L, Dayer A, Jabaudon D, Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. Science. 2019 May 10;364(6440) |
5* | J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23 |
1 | J:219896 Zhang A, Desmazieres A, Zonta B, Melrose S, Campbell G, Mahad D, Li Q, Sherman DL, Reynolds R, Brophy PJ, Neurofascin 140 is an embryonic neuronal neurofascin isoform that promotes the assembly of the node of Ranvier. J Neurosci. 2015 Feb 4;35(5):2246-54 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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