Gene Expression Literature Summary

• Symbol: App
• Name: amyloid beta precursor protein
• ID: MGI:88059

58 matching records from 58 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8	E8.5	E9.5	E10	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E	P
Immunohistochemistry (section)		1	1		1		3	3		2		2		1	1	4			1	2		1	10
In situ RNA (section)					2		2		1	3		4	1	2		1	1	1		1		3	6
Immunohistochemistry (whole mount)																				1
In situ RNA (whole mount)	1	1	1		1
Northern blot				1					1				1	1			1	1		1	1	1	2
Western blot						1	1			3	2	3	1		1	1	4	2	1			1	20
RT-PCR		1	1					1		1				1		1	1	1			1		8

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

App  amyloid beta precursor protein   (Synonyms: Abeta, Adap, appican, betaAPP, Cvap, E030013M08Rik, protease nexin II)
Results	Reference
7	J:63791 Akaaboune M, Allinquant B, Farza H, Roy K, Magoul R, Fiszman M, Festoff BW, Hantai D, Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle. Mol Cell Neurosci. 2000 Apr;15(4):355-67
2	J:209333 Almenar-Queralt A, Kim SN, Benner C, Herrera CM, Kang DE, Garcia-Bassets I, Goldstein LS, Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem. 2013 Dec 6;288(49):35222-36
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
2	J:30461 Bendotti C, Forloni GL, Morgan RA, O'Hara BF, Oster-Granite ML, Reeves RH, Gearhart JD, Coyle JT, Neuroanatomical localization and quantification of amyloid precursor protein mRNA by in situ hybridization in the brains of normal, aneuploid, and lesioned mice. Proc Natl Acad Sci U S A. 1988 May;85(10):3628-32
1	J:228732 Berg JM, Lee C, Chen L, Galvan L, Cepeda C, Chen JY, Penagarikano O, Stein JL, Li A, Oguro-Ando A, Miller JA, Vashisht AA, Starks ME, Kite EP, Tam E, Gdalyahu A, Al-Sharif NB, Burkett ZD, White SA, Fears SC, Levine MS, Wohlschlegel JA, Geschwind DH, JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron. 2015 Dec 16;88(6):1173-91
1	J:294517 Billingsley CN, Allen JR, Baumann DD, Deitz SL, Blazek JD, Newbauer A, Darrah A, Long BC, Young B, Clement M, Doerge RW, Roper RJ, Non-trisomic homeobox gene expression during craniofacial development in the Ts65Dn mouse model of Down syndrome. Am J Med Genet A. 2013 Aug;161A(8):1866-74
1	J:273599 Cheng S, Liu T, Hu Y, Xia Y, Hou J, Huang C, Zou X, Liang J, Stone Shi Y, Zheng Y, Lu J, Chen G, Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors. J Neurosci. 2019 Mar 20;39(12):2195-2207
2	J:207796 Choi HY, Liu Y, Tennert C, Sugiura Y, Karakatsani A, Kroger S, Johnson EB, Hammer RE, Lin W, Herz J, APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice. Elife. 2013;2:e00220
1	J:172287 Esteve P, Sandonis A, Cardozo M, Malapeira J, Ibanez C, Crespo I, Marcos S, Gonzalez-Garcia S, Toribio ML, Arribas J, Shimono A, Guerrero I, Bovolenta P, SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis. Nat Neurosci. 2011 May;14(5):562-9
1	J:104122 Ferrer I, Kapfhammer JP, Hindelang C, Kemp S, Troffer-Charlier N, Broccoli V, Callyzot N, Mooyer P, Selhorst J, Vreken P, Wanders RJ, Mandel JL, Pujol A, Inactivation of the peroxisomal ABCD2 transporter in the mouse leads to late-onset ataxia involving mitochondria, Golgi and endoplasmic reticulum damage. Hum Mol Genet. 2005 Dec 1;14(23):3565-77
1	J:168231 Forni PE, Fornaro M, Guenette S, Wray S, A role for FE65 in controlling GnRH-1 neurogenesis. J Neurosci. 2011 Jan 12;31(2):480-91
1	J:94148 Frederikse PH, Yun E, Kao HT, Zigler JS Jr, Sun Q, Qazi AS, Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation. Mol Vis. 2004 Oct 25;10:794-804
2	J:333985 Gao Y, Sun Y, Islam S, Nakamura T, Tomita T, Zou K, Michikawa M, Presenilin 1 deficiency impairs Abeta42-to-Abeta40- and angiotensin-converting activities of ACE. Front Aging Neurosci. 2023;15:1098034
1*	J:80501 Gitton Y, Dahmane N, Baik S, Ruiz I Altaba A, Neidhardt L, Scholze M, Herrmann BG, Kahlem P, Benkahla A, Schrinner S, Yildirimman R, Herwig R, Lehrach H, Yaspo ML, A gene expression map of human chromosome 21 orthologues in the mouse. Nature. 2002 Dec 5;420(6915):586-90
1	J:87048 Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA, Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development. 2004 Jan;131(1):165-79
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:105160 Guenette S, Chang Y, Hiesberger T, Richardson JA, Eckman CB, Eckman EA, Hammer RE, Herz J, Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. EMBO J. 2006 Jan 25;25(2):420-31
1*	J:308689 Gyllborg D, Ahmed M, Toledo EM, Theofilopoulos S, Yang S, Ffrench-Constant C, Arenas E, The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation. Stem Cell Reports. 2018 Sep 11;11(3):651-664
2	J:310131 Haytural H, Lundgren JL, Kose TB, Jorda-Siquier T, Kalcheva M, Seed Ahmed M, Winblad B, Sundstrom E, Barthet G, Tjernberg LO, Frykman S, Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies. Front Aging Neurosci. 2019;11:273
5	J:146364 Hebert SS, Horre K, Nicolai L, Bergmans B, Papadopoulou AS, Delacourte A, De Strooper B, MicroRNA regulation of Alzheimer's Amyloid precursor protein expression. Neurobiol Dis. 2009 Mar;33(3):422-8
1	J:83512 Hikake T, Mori T, Iseki K, Hagino S, Zhang Y, Takagi H, Yokoya S, Wanaka A, Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development. Anat Embryol (Berl). 2003 Apr;206(5):373-80
3	J:149815 Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW, Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci. 2009 Jun 10;29(23):7459-73
1	J:184686 Koch P, Tamboli IY, Mertens J, Wunderlich P, Ladewig J, Stuber K, Esselmann H, Wiltfang J, Brustle O, Walter J, Presenilin-1 L166P Mutant Human Pluripotent Stem Cell-Derived Neurons Exhibit Partial Loss of gamma-Secretase Activity in Endogenous Amyloid-beta Generation. Am J Pathol. 2012 Jun;180(6):2404-16
1	J:100024 Kuwako K, Hosokawa A, Nishimura I, Uetsuki T, Yamada M, Nada S, Okada M, Yoshikawa K, Disruption of the paternal necdin gene diminishes TrkA signaling for sensory neuron survival. J Neurosci. 2005 Jul 27;25(30):7090-9
1	J:36884 Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS, Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. J Neurosci. 1996 Dec 1;16(23):7513-25
3	J:157314 Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS, Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biol. 2009;10(10):R104
2	J:221387 Liu L, Fujino K, Nishimura M, Pre-synaptic localization of the gamma-secretase-inhibiting protein p24alpha2 in the mammalian brain. J Neurochem. 2015 May;133(3):422-31
1	J:236499 Liu L, Watanabe N, Akatsu H, Nishimura M, Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease. Neuroscience. 2016 Aug 25;330:236-46
6	J:188237 Liu W, Liu C, Zhu J, Shu P, Yin B, Gong Y, Qiang B, Yuan J, Peng X, MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice. Neurobiol Aging. 2012 Mar;33(3):522-34
8	J:95286 Lopez-Sanchez N, Muller U, Frade JM, Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein. Neuroscience. 2005;130(1):51-60
8	J:25487 Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van den Berghe H, Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase,alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein. Neuroscience. 1995 Apr;65(4):1009-25
3*	J:65205 Marcinkiewicz M, Seidah NG, Coordinated expression of beta-amyloid precursor protein and the putative beta-secretase BACE and alpha-secretase ADAM10 in mouse and human brain. J Neurochem. 2000 Nov;75(5):2133-43
1	J:160742 Pla P, Hirsch MR, Le Crom S, Reiprich S, Harley VR, Goridis C, Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors. Neural Dev. 2008;3:14
1	J:312384 Pohlkamp T, Xian X, Wong CH, Durakoglugil MS, Werthmann GC, Saido TC, Evers BM, White CL 3rd, Connor J, Hammer RE, Herz J, NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load. Elife. 2021 Oct 7;10:e72034
1*	J:238377 Potter AS, Potter SS, Molecular Anatomy of Palate Development. PLoS One. 2015;10(7):e0132662
4*	J:190417 Rama N, Goldschneider D, Corset V, Lambert J, Pays L, Mehlen P, Amyloid precursor protein regulates netrin-1-mediated commissural axon outgrowth. J Biol Chem. 2012 Aug 24;287(35):30014-23
7*	J:80502 Reymond A, Marigo V, Yaylaoglu MB, Leoni A, Ucla C, Scamuffa N, Caccioppoli C, Dermitzakis ET, Lyle R, Banfi S, Eichele G, Antonarakis SE, Ballabio A, Human chromosome 21 gene expression atlas in the mouse. Nature. 2002 Dec 5;420(6915):582-6
7*	J:18694 Salbaum JM, Ruddle FH, Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons. J Exp Zool. 1994 Jun 1;269(2):116-27
3	J:242215 Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Muller UC, Kins S, Eggert S, APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. J Neurosci. 2017 May 24;37(21):5345-5365
2	J:309447 Sharaf A, Rahhal B, Spittau B, Roussa E, Localization of reelin signaling pathway components in murine midbrain and striatum. Cell Tissue Res. 2015 Feb;359(2):393-407
1	J:71535 Simpson MT, MacLaurin JG, Xu D, Ferguson KL, Vanderluit JL, Davoli MA, Roy S, Nicholson DW, Robertson GS, Park DS, Slack RS, Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice. J Neurosci. 2001 Sep 15;21(18):7089-98
2*	J:167625 Smith P, Al Hashimi A, Girard J, Delay C, Hebert SS, In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs. J Neurochem. 2011 Jan;116(2):240-7
2	J:290398 Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, Gennarino VA, Wasco W, Schmahmann JD, Albers MW, Zoghbi HY, Tanzi RE, Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription. Cell. 2019 Aug 22;178(5):1159-1175.e17
1*	J:142399 Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Muller U, van Leuven F, Lutjohann D, Walter J, Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. J Neurosci. 2008 Nov 12;28(46):12097-106
2*	J:141291 Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J, Lickert H, Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. BMC Genomics. 2008;9(1):511
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
4	J:319557 Vella LJ, Cappai R, Identification of a novel amyloid precursor protein processing pathway that generates secreted N-terminal fragments. FASEB J. 2012 Jul;26(7):2930-40
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2	J:255943 Wang B, Li H, Mutlu SA, Bowser DA, Moore MJ, Wang MC, Zheng H, The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance. eNeuro. 2017 May-Jun;4(3):ENEURO.0185-17.2017
4	J:152457 Wang Z, Wang B, Yang L, Guo Q, Aithmitti N, Songyang Z, Zheng H, Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci. 2009 Sep 2;29(35):10788-801
3	J:219929 Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ 3rd, Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer's Disease. Neuron. 2015 Mar 4;85(5):967-81
1	J:325764 Xia Y, Zhang Y, Xu M, Zou X, Gao J, Ji MH, Chen G, Presenilin enhancer 2 is crucial for the transition of apical progenitors into neurons but into not basal progenitors in the developing hippocampus. Development. 2022 May 15;149(10):dev200272
2	J:234942 Xu W, Weissmiller AM, White JA 2nd, Fang F, Wang X, Wu Y, Pearn ML, Zhao X, Sawa M, Chen S, Gunawardena S, Ding J, Mobley WC, Wu C, Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest. 2016 May 2;126(5):1815-33
1	J:255722 Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, Nishina H, Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Sci Rep. 2017 Aug 4;7(1):7348
1	J:344837 Yang S, Niou ZX, Enriquez A, LaMar J, Huang JY, Ling K, Jafar-Nejad P, Gilley J, Coleman MP, Tennessen JM, Rangaraju V, Lu HC, NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport. Mol Neurodegener. 2024 Jan 29;19(1):13
1	J:71606 Yu H, Saura CA, Choi S, Sun LD, Yang X, Handler M, Kawarabayashi T, Younkin L, Fedeles B, Wilson MA, Younkin S, Kandel ER, Kirkwood A, Shen J, App processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron. 2001 Sep 13;31(5):713-26
1	J:287863 Zeng F, Ma X, Zhu L, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, Wang X, The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability. PLoS Biol. 2019 Dec;17(12):e3000525
1	J:210257 Zhang W, Thevapriya S, Kim PJ, Yu WP, Shawn Je H, King Tan E, Zeng L, Amyloid precursor protein regulates neurogenesis by antagonizing miR-574-5p in the developing cerebral cortex. Nat Commun. 2014;5:3330