Gene Expression Literature Summary

• Symbol: Bdnf
• Name: brain derived neurotrophic factor
• ID: MGI:88145

115 matching records from 115 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)					1				3		3		1		3	1	2	1	3		6		2	11
In situ RNA (section)				1	4	1	5	2	5		4	1	8		5		2			1	3			16
Immunohistochemistry (whole mount)																					1
In situ RNA (whole mount)											2				1						1			1
In situ reporter (knock in)			1		1		2		4		3	1	2	1			2		1	1	2			3
Northern blot		1	1	2													1			1				3
Western blot							1	1	2		4		1		3				1		2			10
RT-PCR	1				1	2	1	3	3	1	5	1	9		4	2	7	2	4		8	1	2	25

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Bdnf  brain derived neurotrophic factor
Results	Reference
1	J:82462 Agerman K, Hjerling-Leffler J, Blanchard MP, Scarfone E, Canlon B, Nosrat C, Ernfors P, BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development. Development. 2003 Apr;130(8):1479-91
1*	J:81579 Aguado F, Carmona MA, Pozas E, Aguilo A, Martinez-Guijarro FJ, Alcantara S, Borrell V, Yuste R, Ibanez CF, Soriano E, BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2. Development. 2003 Apr;130(7):1267-80
3	J:160730 Alavian KN, Sgado P, Alberi L, Subramaniam S, Simon HH, Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev. 2009;4:11
3	J:181188 Aoki H, Hara A, Era T, Kunisada T, Yamada Y, Genetic ablation of Rest leads to in vitro-specific derepression of neuronal genes during neurogenesis. Development. 2012 Feb;139(4):667-77
4	J:251150 Aoki H, Ogino H, Tomita H, Hara A, Kunisada T, Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells. PLoS One. 2016;11(9):e0163042
2	J:344220 Bai X, Wang B, Cui Y, Tian S, Zhang Y, You L, Chang YZ, Gao G, Hepcidin deficiency impairs hippocampal neurogenesis and mediates brain atrophy and memory decline in mice. J Neuroinflammation. 2024 Jan 9;21(1):15
2	J:98945 Ballas N, Grunseich C, Lu DD, Speh JC, Mandel G, REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell. 2005 May 20;121(4):645-57
4	J:194255 Baydyuk M, Xie Y, Tessarollo L, Xu B, Midbrain-derived neurotrophins support survival of immature striatal projection neurons. J Neurosci. 2013 Feb 20;33(8):3363-9
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
3	J:65040 Botchkareva NV, Botchkarev VA, Albers KM, Metz M, Paus R, Distinct roles for nerve growth factor and brain-derived neurotrophic factor in controlling the rate of hair follicle morphogenesis. J Invest Dermatol. 2000 Feb;114(2):314-20
1	J:119559 Bouwman J, Spijker S, Schut D, Wachtler B, Ylstra B, Smit AB, Verhage M, Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse. J Neurochem. 2006 Oct;99(1):84-96
2	J:164699 Breuskin I, Bodson M, Thelen N, Thiry M, Borgs L, Nguyen L, Stolt C, Wegner M, Lefebvre PP, Malgrange B, Glial but not neuronal development in the cochleo-vestibular ganglion requires Sox10. J Neurochem. 2010 Sep;114(6):1827-39
1	J:338914 Cao B, Xia Y, Cai Z, Wang Z, Tang C, Song Y, Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model. Neuroscience. 2023 Aug 1;524:137-148
1*	J:83933 Cheng A, Wang S, Cai J, Rao MS, Mattson MP, Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain. Dev Biol. 2003 Jun 15;258(2):319-33
5*	J:157986 Childs AJ, Bayne RA, Murray AA, Martins Da Silva SJ, Collins CS, Spears N, Anderson RA, Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development. Dev Dyn. 2010 Feb 19;239(4):1211-1219
4	J:74172 Chou HC, Chien CL, Lu KS, The distribution of PGP9. 5, BDNF and NGF in the vallate papilla of adult and developing mice. Anat Embryol (Berl). 2001 Aug;204(2):161-9
2*	J:93143 Clough RL, Sud R, Davis-Silberman N, Hertzano R, Avraham KB, Holley M, Dawson SJ, Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity. Biochem Biophys Res Commun. 2004 Nov 5;324(1):372-81
3	J:72304 Coppola V, Kucera J, Palko ME, Martinez-De Velasco J, Lyons WE, Fritzsch B, Tessarollo L, Dissection of NT3 functions in vivo by gene replacement strategy. Development. 2001 Nov;128(21):4315-27
1	J:40384 Craig JC, Eberwine JH, Calvin JA, Wlodarczyk B, Bennett GD, Finnell RH, Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology. Biochem Mol Med. 1997 Apr;60(2):81-91
2	J:102722 Dennis KE, Levitt P, Regional expression of brain derived neurotrophic factor (BDNF) is correlated with dynamic patterns of promoter methylation in the developing mouse forebrain. Brain Res Mol Brain Res. 2005 Oct 31;140(1-2):1-9
1	J:133953 Deppmann CD, Mihalas S, Sharma N, Lonze BE, Niebur E, Ginty DD, A model for neuronal competition during development. Science. 2008 Apr 18;320(5874):369-73
1	J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
1*	J:250135 Ding M, Weng C, Fan S, Cao Q, Lu Z, Purkinje Cell Degeneration and Motor Coordination Deficits in a New Mouse Model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay. Front Mol Neurosci. 2017;10:121
4	J:64681 Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kraemer R, Hahn R, Wang S, Ibanez CF, Rafii S, Hempstead BL, Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development. 2000 Nov;127(21):4531-40
1	J:200106 Duncan JS, Fritzsch B, Continued expression of GATA3 is necessary for cochlear neurosensory development. PLoS One. 2013;8(4):e62046
1*	J:17123 Ernfors P, Lee KF, Jaenisch R, Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature. 1994 Mar 10;368(6467):147-50
4	J:337923 Esvald EE, Tuvikene J, Kiir CS, Avarlaid A, Tamberg L, Sirp A, Shubina A, Cabrera-Cabrera F, Pihlak A, Koppel I, Palm K, Timmusk T, Revisiting the expression of BDNF and its receptors in mammalian development. Front Mol Neurosci. 2023;16:1182499
2	J:253696 Feng S, Xing C, Shen T, Qiao Y, Wang R, Chen J, Liao J, Lu Z, Yang X, Abd-Allah SM, Li J, Jing N, Tang K, Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII. Sci Rep. 2017 Jul 13;7(1):5282
1	J:139608 Fox EA, Murphy MC, Factors regulating vagal sensory development: potential role in obesities of developmental origin. Physiol Behav. 2008 Apr 22;94(1):90-104
3*	J:98114 Friedman RA, Makmura L, Biesiada E, Wang X, Keithley EM, Eya1 acts upstream of Tbx1, Neurogenin 1, NeuroD and the neurotrophins BDNF and NT-3 during inner ear development. Mech Dev. 2005 May;122(5):625-34
1	J:157908 Fritzsch B, Dillard M, Lavado A, Harvey NL, Jahan I, Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity. PLoS One. 2010;5(2):e9377
2	J:98393 Fritzsch B, Matei VA, Nichols DH, Bermingham N, Jones K, Beisel KW, Wang VY, Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber retention. Dev Dyn. 2005 Jun;233(2):570-83
2	J:323615 Fu Y, Zhou Y, Zhang YL, Zhao B, Zhang XL, Zhang WT, Lu YJ, Lu A, Zhang J, Zhang J, Loss of neurodevelopmental-associated miR-592 impairs neurogenesis and causes social interaction deficits. Cell Death Dis. 2022 Apr 1;13(4):292
1	J:214739 Glerup S, Olsen D, Vaegter CB, Gustafsen C, Sjoegaard SS, Hermey G, Kjolby M, Molgaard S, Ulrichsen M, Boggild S, Skeldal S, Fjorback AN, Nyengaard JR, Jacobsen J, Bender D, Bjarkam CR, Sorensen ES, Fuchtbauer EM, Eichele G, Madsen P, Willnow TE, Petersen CM, Nykjaer A, SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 2014 Jun 4;82(5):1074-87
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
2	J:88594 Guha U, Gomes WA, Samanta J, Gupta M, Rice FL, Kessler JA, Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo. Development. 2004 Mar;131(5):1175-86
5	J:167838 Harlow DE, Yang H, Williams T, Barlow LA, Epibranchial placode-derived neurons produce BDNF required for early sensory neuron development. Dev Dyn. 2011 Feb;240(2):309-23
6	J:119779 Hertzano R, Dror AA, Montcouquiol M, Ahmed ZM, Ellsworth B, Camper S, Friedman TB, Kelley MW, Avraham KB, Lhx3, a LIM domain transcription factor, is regulated by Pou4f3 in the auditory but not in the vestibular system. Eur J Neurosci. 2007 Feb;25(4):999-1005
1*	J:177585 Hesse K, Vaupel K, Kurt S, Buettner R, Kirfel J, Moser M, AP-2delta is a crucial transcriptional regulator of the posterior midbrain. PLoS One. 2011;6(8):e23483
1	J:83661 Holm PC, Rodriguez FJ, Kresse A, Canals JM, Silos-Santiago I, Arenas E, Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons. Development. 2003 Aug;130(15):3535-45
3	J:276557 Hong GS, Lee SH, Lee B, Choi JH, Oh SJ, Jang Y, Hwang EM, Kim H, Jung J, Kim IB, Oh U, ANO1/TMEM16A regulates process maturation in radial glial cells in the developing brain. Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12494-12499
2	J:187349 Hu XL, Cheng X, Cai L, Tan GH, Xu L, Feng XY, Lu TJ, Xiong H, Fei J, Xiong ZQ, Conditional deletion of NRSF in forebrain neurons accelerates epileptogenesis in the kindling model. Cereb Cortex. 2011 Sep;21(9):2158-65
7	J:165547 Huang T, Krimm RF, Developmental expression of Bdnf, Ntf4/5, and TrkB in the mouse peripheral taste system. Dev Dyn. 2010 Oct;239(10):2637-46
2*	J:74160 Ivanova T, Beyer C, Pre- and postnatal expression of brain-derived neurotrophic factor mRNA/protein and tyrosine protein kinase receptor B mRNA in the mouse hippocampus. Neurosci Lett. 2001 Jul 6;307(1):21-4
2	J:242970 Jahan I, Pan N, Kersigo J, Calisto LE, Morris KA, Kopecky B, Duncan JS, Beisel KW, Fritzsch B, Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival. PLoS One. 2012;7(1):e30853
1	J:178512 Jiang Y, Matevossian A, Guo Y, Akbarian S, Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice. Neuropharmacology. 2011 Jun;60(7-8):1088-97
1	J:102289 Kablar B, Belliveau AC, Presence of neurotrophic factors in skeletal muscle correlates with survival of spinal cord motor neurons. Dev Dyn. 2005 Nov;234(3):659-69
2	J:155405 Katayama K, Zine A, Ota M, Matsumoto Y, Inoue T, Fritzsch B, Aruga J, Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice. PLoS One. 2009;4(11):e7786
1	J:126357 Kawamura K, Kawamura N, Fukuda J, Kumagai J, Hsueh AJ, Tanaka T, Regulation of preimplantation embryo development by brain-derived neurotrophic factor. Dev Biol. 2007 Nov 1;311(1):147-58
1*	J:246056 Khrimian L, Obri A, Ramos-Brossier M, Rousseaud A, Moriceau S, Nicot AS, Mera P, Kosmidis S, Karnavas T, Saudou F, Gao XB, Oury F, Kandel E, Karsenty G, Gpr158 mediates osteocalcin's regulation of cognition. J Exp Med. 2017 Oct 02;214(10):2859-2873
4	J:115894 Kim EY, Hong YB, Go SH, Lee B, Jung SC, Downregulation of neurotrophic factors in the brain of a mouse model of Gaucher disease; implications for neuronal loss in Gaucher disease. Exp Mol Med. 2006 Aug 31;38(4):348-56
1	J:66787 Kim WY, Fritzsch B, Serls A, Bakel LA, Huang EJ, Reichardt LF, Barth DS, Lee JE, NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development. 2001 Feb;128(3):417-26
1	J:91006 Koponen E, Voikar V, Riekki R, Saarelainen T, Rauramaa T, Rauvala H, Taira T, Castren E, Transgenic mice overexpressing the full-length neurotrophin receptor trkB exhibit increased activation of the trkB-PLCgamma pathway, reduced anxiety, and facilitated learning. Mol Cell Neurosci. 2004 May;26(1):166-81
1	J:342051 Koutsioumpa C, Santiago C, Jacobs K, Lehnert BP, Barrera V, Hutchinson JN, Schmelyun D, Lehoczky JA, Paul DL, Ginty DD, Skin-type-dependent development of murine mechanosensory neurons. Dev Cell. 2023 Oct 23;58(20):2032-2047.e6
2	J:142444 Kumanogoh H, Asami J, Nakamura S, Inoue T, Balanced expression of various TrkB receptor isoforms from the Ntrk2 gene locus in the mouse nervous system. Mol Cell Neurosci. 2008 Nov;39(3):465-77
1	J:285409 Li Y, Jiao J, Deficiency of TRPM2 leads to embryonic neurogenesis defects in hyperthermia. Sci Adv. 2020 Jan;6(1):eaay6350
1	J:285865 Liu C, Zhang L, Wu J, Sui X, Xu Y, Huang L, Han Y, Zhu H, Li Y, Sun X, Qin C, AnkG hemizygous mice present cognitive impairment and elevated anxiety/depressive-like traits associated with decreased expression of GABA receptors and postsynaptic density protein. Exp Brain Res. 2017 Nov;235(11):3375-3390
4	J:192549 Liu Y, Rutlin M, Huang S, Barrick CA, Wang F, Jones KR, Tessarollo L, Ginty DD, Sexually dimorphic BDNF signaling directs sensory innervation of the mammary gland. Science. 2012 Dec 7;338(6112):1357-60
1	J:168630 Louhivuori V, Vicario A, Uutela M, Rantamaki T, Louhivuori LM, Castren E, Tongiorgi E, Akerman KE, Castren ML, BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse. Neurobiol Dis. 2011 Feb;41(2):469-80
1*	J:310166 Lu WC, Zhou YX, Qiao P, Zheng J, Wu Q, Shen Q, The protocadherin alpha cluster is required for axon extension and myelination in the developing central nervous system. Neural Regen Res. 2018 Mar;13(3):427-433
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1	J:98518 Mantela J, Jiang Z, Ylikoski J, Fritzsch B, Zacksenhaus E, Pirvola U, The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear. Development. 2005 May;132(10):2377-88
3	J:49747 Martinez A, Alcantara S, Borrell V, Del Rio JA, Blasi J, Otal R, Campos N, Boronat A, Barbacid M, Silos-Santiago I, Soriano E, TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections. J Neurosci. 1998 Sep 15;18(18):7336-50
2	J:102293 Matei V, Pauley S, Kaing S, Rowitch D, Beisel KW, Morris K, Feng F, Jones K, Lee J, Fritzsch B, Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit. Dev Dyn. 2005 Nov;234(3):633-50
3	J:177127 McCarthy DM, Zhang X, Darnell SB, Sangrey GR, Yanagawa Y, Sadri-Vakili G, Bhide PG, Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain. J Neurosci. 2011 Sep 21;31(38):13400-11
1	J:335232 McCoy ME, Kamitakahara AK, Ontogeny and Trophic Factor Sensitivity of Gastrointestinal Projecting Vagal Sensory Cell Types. eNeuro. 2023 Apr;10(4):ENEURO.0511-22.2023
1*	J:160811 McDowell KA, Hutchinson AN, Wong-Goodrich SJ, Presby MM, Su D, Rodriguiz RM, Law KC, Williams CL, Wetsel WC, West AE, Reduced cortical BDNF expression and aberrant memory in Carf knock-out mice. J Neurosci. 2010 Jun 2;30(22):7453-65
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1	J:169044 Pan N, Jahan I, Kersigo J, Kopecky B, Santi P, Johnson S, Schmitz H, Fritzsch B, Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti. Hear Res. 2011 May;275(1-2):66-80
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1	J:218988 Smith KM, Maragnoli ME, Phull PM, Tran KM, Choubey L, Vaccarino FM, Fgfr1 inactivation in the mouse telencephalon results in impaired maturation of interneurons expressing parvalbumin. PLoS One. 2014;9(8):e103696
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