Gene Expression Literature Summary

• Symbol: Calr
• Name: calreticulin
• ID: MGI:88252

34 matching records from 34 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E8.5	E9.5	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E	P
Immunohistochemistry (section)		1	1		1				1				3				1		2			5
In situ RNA (section)																					1	1
Immunohistochemistry (whole mount)	1																					1
Northern blot						1	1	1	1	1	1	1	2			1	2
Western blot		1	1	2			1		2	1	2	1	1	1	2	1	1	1	3	1	2	10
RT-PCR				1							1							1
cDNA clones																1						1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Calr  calreticulin   (Synonyms: Calregulin, CRT)
Results	Reference
1*	J:326959 Anunciado-Koza RP, Stohn JP, Hernandez A, Koza RA, Social and maternal behavior in mesoderm specific transcript (Mest)-deficient mice. PLoS One. 2022;17(7):e0271913
1	J:231655 Barber M, Arai Y, Morishita Y, Vigier L, Causeret F, Borello U, Ledonne F, Coppola E, Contremoulins V, Pfrieger FW, Tissir F, Govindan S, Jabaudon D, Proux-Gillardeaux V, Galli T, Pierani A, Migration Speed of Cajal-Retzius Cells Modulated by Vesicular Trafficking Controls the Size of Higher-Order Cortical Areas. Curr Biol. 2015 Oct 5;25(19):2466-78
1	J:228212 Cinque L, Forrester A, Bartolomeo R, Svelto M, Venditti R, Montefusco S, Polishchuk E, Nusco E, Rossi A, Medina DL, Polishchuk R, De Matteis MA, Settembre C, FGF signalling regulates bone growth through autophagy. Nature. 2015 Dec 10;528(7581):272-5
1	J:176023 del Barco Barrantes I, Coya JM, Maina F, Arthur JS, Nebreda AR, Genetic analysis of specific and redundant roles for p38alpha and p38beta MAPKs during mouse development. Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12764-9
1*	J:250104 Flodby P, Li C, Liu Y, Wang H, Marconett CN, Laird-Offringa IA, Minoo P, Lee AS, Zhou B, The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development. Am J Respir Cell Mol Biol. 2016 Jul;55(1):135-49
1*	J:323825 Giffen KP, Li Y, Liu H, Zhao XC, Zhang CJ, Shen RJ, Wang T, Janesick A, Chen BB, Gong SS, Kachar B, Jin ZB, He DZ, Mutation of SLC7A14 causes auditory neuropathy and retinitis pigmentosa mediated by lysosomal dysfunction. Sci Adv. 2022 Apr 8;8(14):eabk0942
3*	J:79924 Greene ND, Leung KY, Wait R, Begum S, Dunn MJ, Copp AJ, Differential protein expression at the stage of neural tube closure in the mouse embryo. J Biol Chem. 2002 Nov 1;277(44):41645-51
3	J:122471 Hattori K, Nakamura K, Hisatomi Y, Matsumoto S, Suzuki M, Harvey RP, Kurihara H, Hattori S, Yamamoto T, Michalak M, Endo F, Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart. Mol Genet Metab. 2007 Jul;91(3):285-93
5*	J:48588 Hershberger ME, Tuan RS, Placental 57-kDa Ca(2+)-binding protein: regulation of expression and function in trophoblast calcium transport. Dev Biol. 1998 Jul 1;199(1):80-92
1	J:157011 Hryciw T, MacDonald JI, Phillips R, Seah C, Pasternak S, Meakin SO, The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule-associated protein expressed in migrating and differentiated neurons. J Neurochem. 2010 Feb;112(4):924-39
5*	J:157110 Jungwirth M, Dear ML, Brown P, Holbrook K, Goodchild R, Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinA. Hum Mol Genet. 2010 Mar 1;19(5):888-900
1	J:336227 Karatsai O, Lehka L, Wojton D, Grabowska AI, Duda MK, Lenartowski R, Redowicz MJ, Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166748
1	J:75520 Kovacs CS, Chafe LL, Woodland ML, McDonald KR, Fudge NJ, Wookey PJ, Calcitropic gene expression suggests a role for the intraplacental yolk sac in maternal-fetal calcium exchange. Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E721-32
5	J:95310 Lepourcelet M, Tou L, Cai L, Sawada J, Lazar AJ, Glickman JN, Williamson JA, Everett AD, Redston M, Fox EA, Nakatani Y, Shivdasani RA, Insights into developmental mechanisms and cancers in the mammalian intestine derived from serial analysis of gene expression and study of the hepatoma-derived growth factor (HDGF). Development. 2005 Jan;132(2):415-27
1	J:205743 Liu H, Kim SY, Fu Y, Wu X, Ng L, Swaroop A, Forrest D, An isoform of retinoid-related orphan receptor beta directs differentiation of retinal amacrine and horizontal interneurons. Nat Commun. 2013;4:1813
4	J:119647 Lozyk MD, Papp S, Zhang X, Nakamura K, Michalak M, Opas M, Ultrastructural analysis of development of myocardium in calreticulin-deficient mice. BMC Dev Biol. 2006;6:54
1*	J:111416 Luo S, Mao C, Lee B, Lee AS, GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol Cell Biol. 2006 Aug;26(15):5688-97
1*	J:103128 Machka C, Kersten M, Zobawa M, Harder A, Horsch M, Halder T, Lottspeich F, Hrabe de Angelis M, Beckers J, Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling. Gene Expr Patterns. 2005 Dec;6(1):94-101
1*	J:160900 Mao C, Wang M, Luo B, Wey S, Dong D, Wesselschmidt R, Rawlings S, Lee AS, Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling. PLoS One. 2010;5(5):e10852
1	J:53466 Mesaeli N, Nakamura K, Zvaritch E, Dickie P, Dziak E, Krause KH, Opas M, MacLennan DH, Michalak M, Calreticulin is essential for cardiac development. J Cell Biol. 1999 Mar 8;144(5):857-68
1	J:90021 Mesaeli N, Phillipson C, Impaired p53 expression, function, and nuclear localization in calreticulin-deficient cells. Mol Biol Cell. 2004 Apr;15(4):1862-70
1*	J:198561 Mikedis MM, Downs KM, Widespread but tissue-specific patterns of interferon-induced transmembrane protein 3 (IFITM3, FRAGILIS, MIL-1) in the mouse gastrula. Gene Expr Patterns. 2013 Oct;13(7):225-39
1*	J:136836 Noordermeer D, Branco MR, Splinter E, Klous P, van Ijcken W, Swagemakers S, Koutsourakis M, van der Spek P, Pombo A, de Laat W, Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region. PLoS Genet. 2008 Mar;4(3):e1000016
1	J:61550 Rauch F, Prud'homme J, Arabian A, Dedhar S, St-Arnaud R, Heart, brain, and body wall defects in mice lacking calreticulin. Exp Cell Res. 2000 Apr 10;256(1):105-11
1	J:332399 Sato K, Suzuki-Utsunomiya K, Mitsui S, Ono S, Shimakura K, Otomo A, Hadano S, Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes. Biochem Biophys Res Commun. 2023 Jan 1;638:168-175
2	J:308971 Serin N, Dihazi GH, Tayyeb A, Lenz C, Muller GA, Zeisberg M, Dihazi H, Calreticulin Deficiency Disturbs Ribosome Biogenesis and Results in Retardation in Embryonic Kidney Development. Int J Mol Sci. 2021 May 30;22(11)
1	J:227218 Sharma P, Abbasi C, Lazic S, Teng AC, Wang D, Dubois N, Ignatchenko V, Wong V, Liu J, Araki T, Tiburcy M, Ackerley C, Zimmermann WH, Hamilton R, Sun Y, Liu PP, Keller G, Stagljar I, Scott IC, Kislinger T, Gramolini AO, Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun. 2015;6:8391
1	J:163656 Smits P, Bolton AD, Funari V, Hong M, Boyden ED, Lu L, Manning DK, Dwyer ND, Moran JL, Prysak M, Merriman B, Nelson SF, Bonafe L, Superti-Furga A, Ikegawa S, Krakow D, Cohn DH, Kirchhausen T, Warman ML, Beier DR, Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. N Engl J Med. 2010 Jan 21;362(3):206-16
3*	J:49094 Tuan RS, Cavanaugh ST, Identification and characterization of a calcium-binding protein in the mouse chorioallantoic placenta. Biochem J. 1986 Jan 1;233(1):41-9
5*	J:49045 Tuan RS, Kirwin JJ, Mouse placental 57-kDa calcium-binding protein: I. Cloning of cDNA and characterization of developmental expression. Differentiation. 1988;37(2):98-103
3	J:92195 Tutuncu L, Stein P, Ord TS, Jorgez CJ, Williams CJ, Calreticulin on the mouse egg surface mediates transmembrane signaling linked to cell cycle resumption. Dev Biol. 2004 Jun 1;270(1):246-60
2*	J:302618 Wang B, Iyengar R, Li-Harms X, Joo JH, Wright C, Lavado A, Horner L, Yang M, Guan JL, Frase S, Green DR, Cao X, Kundu M, The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway. Autophagy. 2018;14(5):796-811
1*	J:215393 Yamamoto S, Yamazaki T, Komazaki S, Yamashita T, Osaki M, Matsubayashi M, Kidoya H, Takakura N, Yamazaki D, Kakizawa S, Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity. Dev Biol. 2014 Sep 1;393(1):33-43
8	J:128422 Zhang X, Szabo E, Michalak M, Opas M, Endoplasmic reticulum stress during the embryonic development of the central nervous system in the mouse. Int J Dev Neurosci. 2007 Nov;25(7):455-63