Gene Expression Literature Summary

• Symbol: Cd68
• Name: CD68 antigen
• ID: MGI:88342

67 matching records from 67 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10	E10.5	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)	1	1	4	2	5	2	6	2	3	4	3	6	1	3	5	2	1	36
In situ RNA (section)								2				1
Immunohistochemistry (whole mount)					1	1		1										1
Western blot											1
RT-PCR							1											7
cDNA clones												1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cd68  CD68 antigen   (Synonyms: gp110, Lamp4, macrosialin, Scard1)
Results	Reference
1*	J:192255 Ahn J, Gutman D, Saijo S, Barber GN, STING manifests self DNA-dependent inflammatory disease. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19386-91
1	J:339612 Altounian M, Bellon A, Mann F, Neuronal miR-17-5p contributes to interhemispheric cortical connectivity defects induced by prenatal alcohol exposure. Cell Rep. 2023 Aug 22;42(9):113020
1	J:273194 Anderson SR, Zhang J, Steele MR, Romero CO, Kautzman AG, Schafer DP, Vetter ML, Complement Targets Newborn Retinal Ganglion Cells for Phagocytic Elimination by Microglia. J Neurosci. 2019 Mar 13;39(11):2025-2040
1	J:267338 Angelim MKSC, Maia LMSS, Mouffle C, Ginhoux F, Low D, Amancio-Dos-Santos A, Makhoul J, Le Corronc H, Mangin JM, Legendre P, Embryonic macrophages and microglia ablation alter the development of dorsal root ganglion sensory neurons in mouse embryos. Glia. 2018 Nov;66(11):2470-2486
6	J:179150 Blackwell TS, Hipps AN, Yamamoto Y, Han W, Barham WJ, Ostrowski MC, Yull FE, Prince LS, NF-kappaB signaling in fetal lung macrophages disrupts airway morphogenesis. J Immunol. 2011 Sep 1;187(5):2740-7
1	J:164021 Bremer J, O'Connor T, Tiberi C, Rehrauer H, Weis J, Aguzzi A, Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination. PLoS One. 2010;5(8):e12450
1	J:332098 Chen X, Tang AT, Tober J, Yang J, Leu NA, Sterling S, Chen M, Yang Y, Mericko-Ishizuka P, Speck NA, Kahn ML, Mouse placenta fetal macrophages arise from endothelial cells outside the placenta. Dev Cell. 2022 Dec 5;57(23):2652-2660.e3
1	J:303595 Colijn S, Gao S, Ingram KG, Menendez M, Muthukumar V, Silasi-Mansat R, Chmielewska JJ, Hinsdale M, Lupu F, Griffin CT, The NuRD chromatin-remodeling complex enzyme CHD4 prevents hypoxia-induced endothelial Ripk3 transcription and murine embryonic vascular rupture. Cell Death Differ. 2020 Feb;27(2):618-631
3	J:211622 DeFalco T, Bhattacharya I, Williams AV, Sams DM, Capel B, Yolk-sac-derived macrophages regulate fetal testis vascularization and morphogenesis. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2384-93
1	J:228958 Dieterich LC, Klein S, Mathelier A, Sliwa-Primorac A, Ma Q, Hong YK, Shin JW, Hamada M, Lizio M, Itoh M, Kawaji H, Lassmann T, Daub CO, Arner E, Carninci P, Hayashizaki Y, Forrest AR, Wasserman WW, Detmar M, DeepCAGE Transcriptomics Reveal an Important Role of the Transcription Factor MAFB in the Lymphatic Endothelium. Cell Rep. 2015 Nov 17;13(7):1493-504
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:178079 Erblich B, Zhu L, Etgen AM, Dobrenis K, Pollard JW, Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits. PLoS One. 2011;6(10):e26317
1	J:333262 Feng S, Wen H, Liu K, Xiong M, Li J, Gui Y, Lv C, Zhang J, Ma X, Wang X, Yuan S, hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation with PTBP1 and AR, and is essential for male fertility in mice. Development. 2023 Feb 15;150(3):dev201040
2*	J:186497 Flaht A, Jankowska-Steifer E, Radomska DM, Madej M, Gula G, Kujawa M, Ratajska A, Cellular phenotypes and spatio-temporal patterns of lymphatic vessel development in embryonic mouse hearts. Dev Dyn. 2012 Sep;241(9):1473-86
1	J:288683 Gacem N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J, Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N, ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development. Nat Commun. 2020 Jan 10;11(1):198
2	J:243226 Geraud C, Koch PS, Zierow J, Klapproth K, Busch K, Olsavszky V, Leibing T, Demory A, Ulbrich F, Diett M, Singh S, Sticht C, Breitkopf-Heinlein K, Richter K, Karppinen SM, Pihlajaniemi T, Arnold B, Rodewald HR, Augustin HG, Schledzewski K, Goerdt S, GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis. J Clin Invest. 2017 Mar 01;127(3):1099-1114
3	J:302563 Gula G, Ruminski S, Niderla-Bielinska J, Jasinska A, Kiernozek E, Jankowska-Steifer E, Flaht-Zabost A, Ratajska A, Potential functions of embryonic cardiac macrophages in angiogenesis, lymphangiogenesis and extracellular matrix remodeling. Histochem Cell Biol. 2021 Jan;155(1):117-132
2	J:326548 Ikeda S, Sugioka S, Kimura T, Ashida N, Smooth muscle protein 22alpha-Cre recombination in resting cardiac fibroblasts and hematopoietic precursors. Sci Rep. 2022 Jul 7;12(1):11564
2	J:178369 Iwasaki Y, Otsuka H, Yanagisawa N, Hisamitsu H, Manabe A, Nonaka N, Nakamura M, In situ proliferation and differentiation of macrophages in dental pulp. Cell Tissue Res. 2011 Oct;346(1):99-109
1	J:314108 Jecrois ES, Zheng W, Bornhorst M, Li Y, Treisman DM, Muguyo D, Huynh S, Andrew SF, Wang Y, Jiang J, Pierce BR, Mao H, Krause MK, Friend A, Nadal-Nicolas F, Stasheff SF, Li W, Zong H, Packer RJ, Zhu Y, Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors. Dev Cell. 2021 Oct 25;56(20):2871-2885.e6
3*	J:102103 Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T, A neurogenomics approach to gene expression analysis in the developing brain. Brain Res Mol Brain Res. 2004 Dec 20;132(2):116-27
1*	J:322730 Kieu TQ, Tazawa K, Kawashima N, Noda S, Fujii M, Nara K, Hashimoto K, Han P, Okiji T, Kinetics of LYVE-1-positive M2-like macrophages in developing and repairing dental pulp in vivo and their pro-angiogenic activity in vitro. Sci Rep. 2022 Mar 25;12(1):5176
1	J:342326 Kim KH, Oprescu SN, Snyder MM, Kim A, Jia Z, Yue F, Kuang S, PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors. Cell Rep. 2023 Oct 24;42(11):113329
4	J:309657 Kishimoto I, Okano T, Nishimura K, Motohashi T, Omori K, Early Development of Resident Macrophages in the Mouse Cochlea Depends on Yolk Sac Hematopoiesis. Front Neurol. 2019;10:1115
1*	J:95137 Komohara Y, Terasaki Y, Kaikita K, Suzuki H, Kodama T, Takeya M, Clearance of apoptotic cells is not impaired in mouse embryos deficient in class A scavenger receptor types I and II (CD204). Dev Dyn. 2005 Jan;232(1):67-74
1*	J:231259 Krill KT, Gurdziel K, Heaton JH, Simon DP, Hammer GD, Dicer deficiency reveals microRNAs predicted to control gene expression in the developing adrenal cortex. Mol Endocrinol. 2013 May;27(5):754-68
1	J:237822 Lee J, Harris AN, Holley CL, Mahadevan J, Pyles KD, Lavagnino Z, Scherrer DE, Fujiwara H, Sidhu R, Zhang J, Huang SC, Piston DW, Remedi MS, Urano F, Ory DS, Schaffer JE, Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. J Clin Invest. 2016 Dec 01;126(12):4616-4625
1	J:258230 Leferink PS, Breeuwsma N, Bugiani M, van der Knaap MS, Heine VM, Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter. Glia. 2018 Apr;66(4):862-873
2	J:257184 Leid J, Carrelha J, Boukarabila H, Epelman S, Jacobsen SE, Lavine KJ, Primitive Embryonic Macrophages are Required for Coronary Development and Maturation. Circ Res. 2016 May 13;118(10):1498-511
1*	J:293091 Li Z, Li Y, Jiao J, Neural progenitor cells mediated by H2A.Z.2 regulate microglial development via Cxcl14 in the embryonic brain. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24122-24132
2	J:317555 Liu KX, Edwards B, Lee S, Finelli MJ, Davies B, Davies KE, Oliver PL, Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis. Brain. 2015 May;138(Pt 5):1167-81
1	J:340420 Liu N, Kawahira N, Nakashima Y, Nakano H, Iwase A, Uchijima Y, Wang M, Wu SM, Minamisawa S, Kurihara H, Nakano A, Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5. Nat Commun. 2023 Sep 5;14(1):5398
1*	J:99055 Liu Y, Endo Y, Homma S, Kanno K, Yaginuma H, Fujita T, Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse. Mol Immunol. 2005 Jul;42(11):1265-73
3	J:339241 Liu, K., Intercellular genetic tracing of cardiac endothelium in the developing heart. Dev Cell. 2023 Aug 21;58(16):1502-1512
2	J:257373 Logan CM, Bowen CJ, Menko AS, Induction of Immune Surveillance of the Dysmorphogenic Lens. Sci Rep. 2017 Nov 24;7(1):16235
1	J:326298 Lyras EM, Zimmermann K, Wagner LK, Dorr D, Klose CSN, Fischer C, Jung S, Yona S, Hovav AH, Stenzel W, Dommerich S, Conrad T, Leutz A, Mildner A, Tongue immune compartment analysis reveals spatial macrophage heterogeneity. Elife. 2022 Jun 24;11:e77490
1	J:355331 Mao Y, Meng Y, Zou K, Qin N, Wang Y, Yan J, Chen P, Cheng Y, Shi W, Zhou C, Chen H, Sheng J, Liu X, Pan J, Huang H, Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance. J Neuroinflammation. 2024 Oct 4;21(1):249
1	J:322988 Markert F, Storch A, Hyperoxygenation During Mid-Neurogenesis Accelerates Cortical Development in the Fetal Mouse Brain. Front Cell Dev Biol. 2022;10:732682
1	J:356223 Martinez-Ramirez AS, Borders TL, Paul L, Schipma M, Wang X, Korobova F, Wright CV, Sosa-Pineda B, Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development. Gastro Hep Adv. 2022;1(5):807-823
1	J:354440 McClure JJ, McIlroy GD, Symons RA, Clark SM, Cunningham I, Han W, Kania K, Colella F, Rochford JJ, De Bari C, Roelofs AJ, Disentangling the detrimental effects of local from systemic adipose tissue dysfunction on articular cartilage in the knee. Osteoarthritis Cartilage. 2024 Aug 3;
2*	J:252121 McCoy AM, Herington JL, Stouch AN, Mukherjee AB, Lakhdari O, Blackwell TS, Prince LS, IKKbeta Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis. Am J Pathol. 2017 Dec;187(12):2635-2644
1	J:329931 Molla MR, Shimizu A, Komeno M, Rahman NIA, Soh JEC, Nguyen LKC, Khan MR, Tesega WW, Chen S, Pang X, Tanaka-Okamoto M, Takashima N, Sato A, Suzuki T, Ogita H, Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity. Commun Biol. 2022 Oct 7;5(1):1071
1	J:229930 Nechiporuk T, McGann J, Mullendorff K, Hsieh J, Wurst W, Floss T, Mandel G, The REST remodeling complex protects genomic integrity during embryonic neurogenesis. Elife. 2016;5:e09584
2	J:317760 Ochsenbein AM, Karaman S, Proulx ST, Goldmann R, Chittazhathu J, Dasargyri A, Chong C, Leroux JC, Stanley ER, Detmar M, Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling. Angiogenesis. 2016 Oct;19(4):513-24
1	J:296045 Patmore DM, Jassim A, Nathan E, Gilbertson RJ, Tahan D, Hoffmann N, Tong Y, Smith KS, Kanneganti TD, Suzuki H, Taylor MD, Northcott P, Gilbertson RJ, DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma. Dev Cell. 2020 Aug 24;54(4):455-470.e5
2	J:310306 Pimentel-Coelho PM, Michaud JP, Rivest S, Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury. J Neurosci. 2013 Jul 10;33(28):11556-72
3	J:217594 Plosa EJ, Young LR, Gulleman PM, Polosukhin VV, Zaynagetdinov R, Benjamin JT, Im AM, van der Meer R, Gleaves LA, Bulus N, Han W, Prince LS, Blackwell TS, Zent R, Epithelial beta1 integrin is required for lung branching morphogenesis and alveolarization. Development. 2014 Dec;141(24):4751-62
2	J:97958 Rezaie P, Corbisiero V, Male D, Transient expression of MIDC-8 in the normal mouse brain. Neurosci Lett. 2005 Apr 4;377(3):189-94
1	J:187706 Rigato C, Swinnen N, Buckinx R, Couillin I, Mangin JM, Rigo JM, Legendre P, Le Corronc H, Microglia Proliferation Is Controlled by P2X7 Receptors in a Pannexin-1-Independent Manner during Early Embryonic Spinal Cord Invasion. J Neurosci. 2012 Aug 22;32(34):11559-11573
1	J:306249 Rosin JM, Marsters CM, Malik F, Far R, Adnani L, Schuurmans C, Pittman QJ, Kurrasch DM, Embryonic Microglia Interact with Hypothalamic Radial Glia during Development and Upregulate the TAM Receptors MERTK and AXL following an Insult. Cell Rep. 2021 Jan 5;34(1):108587
1	J:305421 Rosin JM, Sinha S, Biernaskie J, Kurrasch DM, A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors. Dev Cell. 2021 May 3;56(9):1326-1345.e6
1	J:321802 Rosin JM, Tretiakov N, Hanniman E, Hampton K, Kurrasch DM, Gestational Bisphenol A Exposure Impacts Embryonic Hypothalamic Microglia Numbers, Ramification, and Phagocytic Cups. Front Neurosci. 2022;16:830399
1	J:104918 Seki T, Hong KH, Oh SP, Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development. Lab Invest. 2006 Feb;86(2):116-29
4	J:272602 Shigeta A, Huang V, Zuo J, Besada R, Nakashima Y, Lu Y, Ding Y, Pellegrini M, Kulkarni RP, Hsiai T, Deb A, Zhou B, Nakano H, Nakano A, Endocardially Derived Macrophages Are Essential for Valvular Remodeling. Dev Cell. 2019 Mar 11;48(5):617-630.e3
1	J:348283 Solon M, Ge N, Hambro S, Haller S, Jiang J, Baca M, Preston J, Maltzman A, Wickliffe KE, Liang Y, Reja R, Nickles D, Newton K, Webster JD, ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1. Cell Death Differ. 2024 May;31(5):672-682
4	J:231970 Stevens SM, Gise Av, VanDusen N, Zhou B, Pu WT, Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart. Dev Biol. 2016 May 15;413(2):153-9
1*	J:329327 Swierczek-Lasek B, Tolak L, Bijoch L, Stefaniuk M, Szpak P, Kalaszczynska I, Streminska W, Ciemerych MA, Archacka K, Comparison of Muscle Regeneration after BMSC-Conditioned Medium, Syngeneic, or Allogeneic BMSC Injection. Cells. 2022 Sep 12;11(18)
1	J:187204 Thomas PS, Sridurongrit S, Ruiz-Lozano P, Kaartinen V, Deficient signaling via Alk2 (Acvr1) leads to bicuspid aortic valve development. PLoS One. 2012;7(4):e35539
1	J:297631 Villalobos E, Criollo A, Schiattarella GG, Altamirano F, French KM, May HI, Jiang N, Nguyen NUN, Romero D, Roa JC, Garcia L, Diaz-Araya G, Morselli E, Ferdous A, Conway SJ, Sadek HA, Gillette TG, Lavandero S, Hill JA, Fibroblast Primary Cilia Are Required for Cardiac Fibrosis. Circulation. 2019 May 14;139(20):2342-2357
1*	J:64739 Wada R, Tifft CJ, Proia RL, Microglial activation precedes acute neurodegeneration in sandhoff disease and is suppressed by bone marrow transplantation. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10954-9
1*	J:181634 Wallgard E, Nitzsche A, Larsson J, Guo X, Dieterich LC, Dimberg A, Olofsson T, Ponten FC, Makinen T, Kalen M, Hellstrom M, Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development. Dev Dyn. 2012 Apr;241(4):770-86
2	J:344239 Wang Y, Wang W, Su L, Ji F, Zhang M, Xie Y, Zhang T, Jiao J, BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development. Dev Cell. 2024 Jan 8;59(1):108-124.e7
1	J:353434 Williamson AE, Liyanage S, Hassanshahi M, Dona MSI, Toledo-Flores D, Tran DXA, Dimasi C, Schwarz N, Fernando S, Salagaras T, Long A, Kazenwadel J, Harvey NL, Drummond GR, Vinh A, Chandrakanthan V, Misra A, Neufeld Z, Tan JTM, Martelotto L, Polo JM, Bonder CS, Pinto AR, Sharma S, Nicholls SJ, Bursill CA, Psaltis PJ, Discovery of an embryonically derived bipotent population of endothelial-macrophage progenitor cells in postnatal aorta. Nat Commun. 2024 Aug 17;15(1):7097
1	J:229029 Yamamoto K, Miki Y, Sato M, Taketomi Y, Nishito Y, Taya C, Muramatsu K, Ikeda K, Nakanishi H, Taguchi R, Kambe N, Kabashima K, Lambeau G, Gelb MH, Murakami M, The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia. J Exp Med. 2015 Oct 19;212(11):1901-19
1	J:329439 Zhang M, Su L, Wang W, Li C, Liang Q, Ji F, Jiao J, Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development. Cell Rep. 2022 Sep 13;40(11):111350
2*	J:282278 Zhou Y, Bennett TM, Shiels A, A charged multivesicular body protein (CHMP4B) is required for lens growth and differentiation. Differentiation. 2019 Sep - Oct;109:16-27
1	J:277057 Zhu X, Xie S, Xu T, Wu X, Han M, Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders. Mol Metab. 2017 Jun;6(6):494-502