Gene Expression Literature Summary

• Symbol: Cdx4
• Name: caudal type homeobox 4
• ID: MGI:88362

38 matching records from 38 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E1.5	E2	E2.5	E3	E3.5	E4.5	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12.5	E13.5	E14.5	E15	E15.5	E17	E18.5	E	P
Immunohistochemistry (section)											2		1	1
In situ RNA (section)							1		2		1	2	3				1		2	1		2		1	1	4
Immunohistochemistry (whole mount)								2	2	2	5	1	2
In situ RNA (whole mount)										4	7	1	9		4		1	1				2			3
In situ reporter (knock in)								1	1		1	1		1
Northern blot									1		1		1		1			1
Western blot										1	3		1												1
RT-PCR	1	1	1	1	1	1	2	1	1	1	3					1					1		1			2
cDNA clones											3		1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cdx4  caudal type homeobox 4   (Synonyms: Cdx-3, Cdx3, Cdx-4)
Results	Reference
1*	J:81583 Abu-Abed S, Dolle P, Metzger D, Wood C, MacLean G, Chambon P, Petkovich M, Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1. Development. 2003 Apr;130(7):1449-59
1	J:165819 Bialecka M, Wilson V, Deschamps J, Cdx mutant axial progenitor cells are rescued by grafting to a wild type environment. Dev Biol. 2010 Nov 1;347(1):228-34
2	J:239299 Brooke-Bisschop T, Savory JG, Foley T, Ringuette R, Lohnes D, Essential roles for Cdx in murine primitive hematopoiesis. Dev Biol. 2017 Feb 15;422(2):115-124
1	J:3682 Candia AF, Hu J, Crosby J, Lalley PA, Noden D, Nadeau JH, Wright CV, Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development. 1992 Dec;116(4):1123-36
3	J:139339 Chawengsaksophak K, de Graaff W, Rossant J, Deschamps J, Beck F, Cdx2 is essential for axial elongation in mouse development. Proc Natl Acad Sci U S A. 2004 May 18;101(20):7641-5
2*	J:168654 Chung YC, Tsai YJ, Shiu TY, Sun YY, Wang PF, Chen CL, Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus. Gene Expr Patterns. 2011 Jan-Feb;11(1-2):84-92
2	J:79367 Collins EC, Appert A, Ariza-McNaughton L, Pannell R, Yamada Y, Rabbitts TH, Mouse Af9 Is a Controller of Embryo Patterning, Like Mll, Whose Human Homologue Fuses with AF9 after Chromosomal Translocation in Leukemia. Mol Cell Biol. 2002 Oct;22(20):7313-24
1*	J:19211 Conlon FL, Lyons KM, Takaesu N, Barth KS, Kispert A, Herrmann B, Robertson EJ, A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development. 1994 Jul;120(7):1919-28
5*	J:23131 Conlon FL, Wright CV, Robertson EJ, Effects of the TWis mutation on notochord formation and mesodermal patterning. Mech Dev. 1995 Feb;49(3):201-9
2	J:98805 Deschamps J, van Nes J, Developmental regulation of the Hox genes during axial morphogenesis in the mouse. Development. 2005 Jul;132(13):2931-42
1	J:275052 Foley TE, Hess B, Savory JGA, Ringuette R, Lohnes D, Role of Cdx factors in early mesodermal fate decisions. Development. 2019 Apr 1;146(7):dev170498
20*	J:14823 Gamer LW, Wright CV, Murine Cdx-4 bears striking similarities to the Drosophila caudal gene in its homeodomain sequence and early expression pattern. Mech Dev. 1993 Sep;43(1):71-81
1	J:291490 Garriock RJ, Chalamalasetty RB, Zhu J, Kennedy MW, Kumar A, Mackem S, Yamaguchi TP, A dorsal-ventral gradient of Wnt3a/beta-catenin signals controls mouse hindgut extension and colon formation. Development. 2020 Apr 12;147(8):dev185108
5	J:103327 Gaunt SJ, Drage D, Trubshaw RC, cdx4/lacZ and cdx2/lacZ protein gradients formed by decay during gastrulation in the mouse. Int J Dev Biol. 2005;49(8):901-8
4	J:139149 Gaunt SJ, Drage D, Trubshaw RC, Increased Cdx protein dose effects upon axial patterning in transgenic lines of mice. Development. 2008 Aug;135(15):2511-20
2*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
7*	J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
2*	J:69781 Ikeya M, Takada S, Wnt-3a is required for somite specification along the anteroposterior axis of the mouse embryo and for regulation of cdx-1 expression. Mech Dev. 2001 May;103(1-2):27-33
1	J:343326 Kim SE, Chothani PJ, Shaik R, Pollard W, Finnell RH, Pax3 lineage-specific deletion of Gpr161 is associated with spinal neural tube and craniofacial malformations during embryonic development. Dis Model Mech. 2023 Nov 1;16(11)
3	J:247259 Naruse C, Shibata S, Tamura M, Kawaguchi T, Abe K, Sugihara K, Kato T, Nishiuchi T, Wakana S, Ikawa M, Asano M, New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice. FASEB J. 2017 Jun;31(6):2252-2266
6	J:99302 Rosanas-Urgell A, Marfany G, Garcia-Fernandez J, Pdx1-related homeodomain transcription factors are distinctly expressed in mouse adult pancreatic islets. Mol Cell Endocrinol. 2005 Jun 15;237(1-2):59-66
2	J:154904 Savory JG, Bouchard N, Pierre V, Rijli FM, De Repentigny Y, Kothary R, Lohnes D, Cdx2 regulation of posterior development through non-Hox targets. Development. 2009 Dec;136(24):4099-110
2	J:170172 Savory JG, Mansfield M, St Louis C, Lohnes D, Cdx4 is a Cdx2 target gene. Mech Dev. 2011 Jan-Feb;128(1-2):41-8
3*	J:149234 Savory JG, Pilon N, Grainger S, Sylvestre JR, Beland M, Houle M, Oh K, Lohnes D, Cdx1 and Cdx2 are functionally equivalent in vertebral patterning. Dev Biol. 2009 Jun 1;330(1):114-22
3*	J:148363 Sewell W, Sparrow DB, Smith AJ, Gonzalez DM, Rappaport EF, Dunwoodie SL, Kusumi K, Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Dev Biol. 2009 May 15;329(2):400-9
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
2	J:180902 van de Ven C, Bialecka M, Neijts R, Young T, Rowland JE, Stringer EJ, Van Rooijen C, Meijlink F, Novoa A, Freund JN, Mallo M, Beck F, Deschamps J, Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone. Development. 2011 Aug;138(16):3451-62
3	J:104372 van Nes J, de Graaff W, Lebrin F, Gerhard M, Beck F, Deschamps J, The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice. Development. 2006 Feb;133(3):419-28
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
5	J:136405 Wang Y, Yabuuchi A, McKinney-Freeman S, Ducharme DM, Ray MK, Chawengsaksophak K, Archer TK, Daley GQ, Cdx gene deficiency compromises embryonic hematopoiesis in the mouse. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7756-61
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
1*	J:28717 Winnier G, Blessing M, Labosky PA, Hogan BL, Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 1995 Sep 1;9(17):2105-16
1*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
4	J:154781 Young T, Rowland JE, van de Ven C, Bialecka M, Novoa A, Carapuco M, van Nes J, de Graaff W, Duluc I, Freund JN, Beck F, Mallo M, Deschamps J, Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. Dev Cell. 2009 Oct;17(4):516-26
1	J:206311 Zhao T, Gan Q, Stokes A, Lassiter RN, Wang Y, Chan J, Han JX, Pleasure DE, Epstein JA, Zhou CJ, beta-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development. 2014 Jan;141(1):148-57
2	J:325944 Zhao T, McMahon M, Reynolds K, Saha SK, Stokes A, Zhou CJ, The role of Lrp6-mediated Wnt/beta-catenin signaling in the development and intervention of spinal neural tube defects in mice. Dis Model Mech. 2022 Jun 1;15(6):dmm049517
1*	J:150714 Zhao X, Duester G, Effect of retinoic acid signaling on Wnt/beta-catenin and FGF signaling during body axis extension. Gene Expr Patterns. 2009 Sept;9(6):430-5