Gene Expression Literature Summary

• Symbol: Col12a1
• Name: collagen, type XII, alpha 1
• ID: MGI:88448

25 matching records from 25 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E8.5	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)		1	1	1		1	1	1		2	1	1	1		1		2	1		1	3
In situ RNA (section)					1	1	2	1		1		2	1	1				1	3		3
Immunohistochemistry (whole mount)												1
In situ RNA (whole mount)							1			1
Northern blot	2				2								2			2
Western blot																					1
RT-PCR				1	1		1	1	1	4	1	2					1		3		3
cDNA clones										1			1								2
RNase protection																					1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Col12a1  collagen, type XII, alpha 1
Results	Reference
15	J:29946 Bohme K, Li Y, Oh PS, Olsen BR, Primary structure of the long and short splice variants of mouse collagen XII and their tissue-specific expression during embryonic development. Dev Dyn. 1995 Dec;204(4):432-45
2*	J:156788 Bouma GJ, Hudson QJ, Washburn LL, Eicher EM, New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Biol Reprod. 2010 Feb;82(2):380-9
1	J:95359 Brent AE, Braun T, Tabin CJ, Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Development. 2005 Feb;132(3):515-28
1	J:298619 Comai GE, Tesarova M, Dupe V, Rhinn M, Vallecillo-Garcia P, da Silva F, Feret B, Exelby K, Dolle P, Carlsson L, Pryce B, Spitz F, Stricker S, Zikmund T, Kaiser J, Briscoe J, Schedl A, Ghyselinck NB, Schweitzer R, Tajbakhsh S, Local retinoic acid signaling directs emergence of the extraocular muscle functional unit. PLoS Biol. 2020 Nov;18(11):e3000902
1	J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
3	J:295760 Felsenthal N, Rubin S, Stern T, Krief S, Pal D, Pryce BA, Schweitzer R, Zelzer E, Development of migrating tendon-bone attachments involves replacement of progenitor populations. Development. 2018 Dec 18;145(24):dev165381
4*	J:92176 Ficker M, Powles N, Warr N, Pirvola U, Maconochie M, Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule. Dev Biol. 2004 Apr 1;268(1):7-23
1	J:144140 Hill TP, Taketo MM, Birchmeier W, Hartmann C, Multiple roles of mesenchymal beta-catenin during murine limb patterning. Development. 2006 Apr;133(7):1219-29
6*	J:56517 Kania AM, Reichenberger E, Baur ST, Karimbux NY, Taylor RW, Olsen BR, Nishimura I, Structural variation of type XII collagen at its carboxyl-terminal NC1 domain generated by tissue-specific alternative splicing. J Biol Chem. 1999 Jul 30;274(31):22053-9
1	J:100263 Kim IM, Ramakrishna S, Gusarova GA, Yoder HM, Costa RH, Kalinichenko VV, The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature. J Biol Chem. 2005 Jun 10;280(23):22278-86
2	J:308781 Lejard V, Blais F, Guerquin MJ, Bonnet A, Bonnin MA, Havis E, Malbouyres M, Bidaud CB, Maro G, Gilardi-Hebenstreit P, Rossert J, Ruggiero F, Duprez D, EGR1 and EGR2 involvement in vertebrate tendon differentiation. J Biol Chem. 2011 Feb 18;286(7):5855-67
1*	J:308708 Martinez ME, Hernandez A, The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone Sensitivity in the Fetal Brain. Front Neurosci. 2021;15:703730
1	J:241460 Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, Suzuki H, Mori M, Inagawa M, Ichinose S, Lotz MK, Sakai D, Masuda K, Ozaki T, Asahara H, Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. Nat Commun. 2016 Aug 16;7:12503
3	J:230306 Odelin G, Faure E, Kober F, Maurel-Zaffran C, Theron A, Coulpier F, Guillet B, Bernard M, Avierinos JF, Charnay P, Topilko P, Zaffran S, Loss of Krox20 results in aortic valve regurgitation and impaired transcriptional activation of fibrillar collagen genes. Cardiovasc Res. 2014 Dec 1;104(3):443-55
10*	J:11916 Oh SP, Griffith CM, Hay ED, Olsen BR, Tissue-specific expression of type XII collagen during mouse embryonic development. Dev Dyn. 1993 Jan;196(1):37-46
2*	J:139634 Peacock JD, Lu Y, Koch M, Kadler KE, Lincoln J, Temporal and spatial expression of collagens during murine atrioventricular heart valve development and maintenance. Dev Dyn. 2008 Sep 24;237(10):3051-3058
1	J:147280 Pryce BA, Watson SS, Murchison ND, Staverosky JA, Dunker N, Schweitzer R, Recruitment and maintenance of tendon progenitors by TGF{beta} signaling are essential for tendon formation. Development. 2009 Apr;136(8):1351-61
1	J:241230 Spitler KM, Ponce JM, Oudit GY, Hall DD, Grueter CE, Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming. Am J Physiol Heart Circ Physiol. 2017 Apr 01;312(4):H768-H780
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:354188 Vallecillo-Garcia P, Kuhnlein MN, Orgeur M, Hansmeier NR, Kotsaris G, Meisen ZG, Timmermann B, Giesecke-Thiel C, Hagerling R, Stricker S, Mesenchymal Osr1+ cells regulate embryonic lymphatic vessel formation. Development. 2024 Sep 1;151(17):dev202747
1	J:336858 Vallecillo-Garcia P, Orgeur M, Comai G, Poehle-Kronnawitter S, Fischer C, Gloger M, Dumas CE, Giesecke-Thiel C, Sauer S, Tajbakhsh S, Hopken UE, Stricker S, A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation. Immunity. 2023 Jun 13;56(6):1204-1219.e8
1	J:254172 Vallecillo-Garcia P, Orgeur M, Vom Hofe-Schneider S, Stumm J, Kappert V, Ibrahim DM, Borno ST, Hayashi S, Relaix F, Hildebrandt K, Sengle G, Koch M, Timmermann B, Marazzi G, Sassoon DA, Duprez D, Stricker S, Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development. Nat Commun. 2017 Oct 31;8(1):1218
2*	J:327901 Ye Q, Bhojwani A, Hu JK, Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539
2	J:315014 Zhou C, Chen D, Ren J, Huang D, Li R, Luo H, Guan C, Cao Y, Wang W, FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex. J Cell Mol Med. 2021 Mar;25(6):3051-3062
4	J:257553 Zvackova I, Matalova E, Lesot H, Regulators of Collagen Fibrillogenesis during Molar Development in the Mouse. Front Physiol. 2017;8:554