Gene Expression Literature Summary

• Symbol: Col4a2
• Name: collagen, type IV, alpha 2
• ID: MGI:88455

49 matching records from 49 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E3.5	E4.5	E5.5	E6.5	E7.5	E8.5	E9.5	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18	E18.5	P
Immunohistochemistry (section)			1	3	1	1	2	2	1		1	3	2	2	1	3	2	1	4				4	12
In situ RNA (section)								1		1		3	1	2		1		1	3				2	2
Immunohistochemistry (whole mount)	1	1
In situ RNA (whole mount)		1	1					1				2
Northern blot																								2
Western blot							1							1		1
RT-PCR						1	2	2			1			2		3		2	2	1	1	1	2	7
RNase protection								1				1				1			1				1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Col4a2  collagen, type IV, alpha 2   (Synonyms: Col4a-2, MGC:7371)
Results	Reference
3	J:102740 Alpy F, Jivkov I, Sorokin L, Klein A, Arnold C, Huss Y, Kedinger M, Simon-Assmann P, Lefebvre O, Generation of a conditionally null allele of the laminin alpha1 gene. Genesis. 2005 Oct;43(2):59-70
1	J:63137 Andrews KL, Betsuyaku T, Rogers S, Shipley JM, Senior RM, Miner JH, Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of alport syndrome. Am J Pathol. 2000 Jul;157(1):303-11
6	J:128363 Arai KY, Nishiyama T, Developmental Changes in Extracellular Matrix Messenger RNAs in the Mouse Placenta During the Second Half of Pregnancy: Possible Factors Involved in the Regulation of Placental Extracellular Matrix Expression. Biol Reprod. 2007 Dec;77(6):923-33
5	J:150527 Bai X, Dilworth DJ, Weng YC, Gould DB, Developmental distribution of collagen IV isoforms and relevance to ocular diseases. Matrix Biol. 2009 May;28(4):194-201
1	J:64375 Bhatt RS, Tomoda T, Fang Y, Hatten ME, Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons. Genes Dev. 2000 Sep 1;14(17):2216-28
1	J:119559 Bouwman J, Spijker S, Schut D, Wachtler B, Ylstra B, Smit AB, Verhage M, Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse. J Neurochem. 2006 Oct;99(1):84-96
2	J:194489 Chen SR, Chen M, Wang XN, Zhang J, Wen Q, Ji SY, Zheng QS, Gao F, Liu YX, The wilms tumor gene, wt1, maintains testicular cord integrity by regulating the expression of col4a1 and col4a2. Biol Reprod. 2013;88(3):56
1*	J:148410 Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P, Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Dev Dyn. 2009 May;238(5):1033-41
1	J:262653 D'Ignazio L, Michel M, Beyer M, Thompson K, Forabosco A, Schlessinger D, Pelosi E, Lhx8 ablation leads to massive autophagy of mouse oocytes associated with DNA damage. Biol Reprod. 2018 Apr 1;98(4):532-542
6*	J:30369 Enders GC, Kahsai TZ, Lian G, Funabiki K, Killen PD, Hudson BG, Developmental changes in seminiferous tubule extracellular matrix components of the mouse testis: alpha 3(IV) collagen chain expressed at the initiation of spermatogenesis. Biol Reprod. 1995 Dec;53(6):1489-99
2	J:237202 Fantauzzo KA, Soriano P, PDGFRbeta regulates craniofacial development through homodimers and functional heterodimers with PDGFRalpha. Genes Dev. 2016 Nov 01;30(21):2443-2458
2	J:158314 Firtina Z, Danysh BP, Bai X, Gould DB, Kobayashi T, Duncan MK, Abnormal expression of collagen IV in lens activates unfolded protein response resulting in cataract. J Biol Chem. 2009 Dec 18;284(51):35872-84
2*	J:130836 Gerbe F, Cox B, Rossant J, Chazaud C, Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst. Dev Biol. 2008 Jan 15;313(2):594-602
1	J:47014 Gilmour DT, Lyon GJ, Carlton MB, Sanes JR, Cunningham JM, Anderson JR, Hogan BL, Evans MJ, Colledge WH, Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J. 1998 Apr 1;17(7):1860-70
1	J:98572 Gould DB, Phalan FC, Breedveld GJ, van Mil SE, Smith RS, Schimenti JC, Aguglia U, van der Knaap MS, Heutink P, John SW, Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly. Science. 2005 May 20;308(5725):1167-71
2	J:71122 Graus-Porta D, Blaess S, Senften M, Littlewood-Evans A, Damsky C, Huang Z, Orban P, Klein R, Schittny JC, Muller U, Beta1-class integrins regulate the development of laminae and folia in the cerebral and cerebellar cortex. Neuron. 2001 Aug 16;31(3):367-79
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:185218 Hall-Glenn F, De Young RA, Huang BL, van Handel B, Hofmann JJ, Chen TT, Choi A, Ong JR, Benya PD, Mikkola H, Iruela-Arispe ML, Lyons KM, CCN2/connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One. 2012;7(2):e30562
2	J:205039 Hiramatsu R, Matsuoka T, Kimura-Yoshida C, Han SW, Mochida K, Adachi T, Takayama S, Matsuo I, External mechanical cues trigger the establishment of the anterior-posterior axis in early mouse embryos. Dev Cell. 2013 Oct 28;27(2):131-44
1	J:130931 Ichikawa-Shindo Y, Sakurai T, Kamiyoshi A, Kawate H, Iinuma N, Yoshizawa T, Koyama T, Fukuchi J, Iimuro S, Moriyama N, Kawakami H, Murata T, Kangawa K, Nagai R, Shindo T, The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. J Clin Invest. 2008 Jan;118(1):29-39
1	J:263002 Komori T, Ono M, Hara ES, Ueda J, Nguyen HTT, Nguyen HT, Yonezawa T, Maeba T, Kimura-Ono A, Takarada T, Momota R, Maekawa K, Kuboki T, Oohashi T, Type IV collagen alpha6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium. Sci Rep. 2018 Feb 8;8(1):2612
1	J:101687 Maki JM, Sormunen R, Lippo S, Kaarteenaho-Wiik R, Soininen R, Myllyharju J, Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues. Am J Pathol. 2005 Oct;167(4):927-36
1*	J:139122 Manabe R, Tsutsui K, Yamada T, Kimura M, Nakano I, Shimono C, Sanzen N, Furutani Y, Fukuda T, Oguri Y, Shimamoto K, Kiyozumi D, Sato Y, Sado Y, Senoo H, Yamashina S, Fukuda S, Kawai J, Sugiura N, Kimata K, Hayashizaki Y, Sekiguchi K, Transcriptome-based systematic identification of extracellular matrix proteins. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12849-54
1	J:40354 Marin M, Karis A, Visser P, Grosveld F, Philipsen S, Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell. 1997 May 16;89(4):619-28
1	J:91048 Miner JH, Li C, Mudd JL, Go G, Sutherland AE, Compositional and structural requirements for laminin and basement membranes during mouse embryo implantation and gastrulation. Development. 2004 May;131(10):2247-56
4	J:74207 Nagai N, Nakano K, Sado Y, Naito I, Gunduz M, Tsujigiwa H, Nagatsuka H, Ninomiya Y, Siar CH, Localization of type IV collagen a 1 to a 6 chains in basement membrane during mouse molar germ development. Int J Dev Biol. 2001 Oct;45(7):827-31
3	J:353621 Patel VN, Aure MH, Choi SH, Ball JR, Lane ED, Wang Z, Xu Y, Zheng C, Liu X, Martin D, Pailin JY, Prochazkova M, Kulkarni AB, van Kuppevelt TH, Ambudkar IS, Liu J, Hoffman MP, Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
1	J:251718 Pietila I, Prunskaite-Hyyrylainen R, Kaisto S, Tika E, van Eerde AM, Salo AM, Garma L, Miinalainen I, Feitz WF, Bongers EM, Juffer A, Knoers NV, Renkema KY, Myllyharju J, Vainio SJ, Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning. PLoS One. 2016;11(1):e0147171
3*	J:89190 Poschl E, Schlotzer-Schrehardt U, Brachvogel B, Saito K, Ninomiya Y, Mayer U, Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. Development. 2004 Apr;131(7):1619-28
5	J:42107 Qin P, Piechocki M, Lu S, Kurpakus MA, Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye. Dev Dyn. 1997 Aug;209(4):367-76
2	J:331686 Ramadan R, Wouters VM, van Neerven SM, de Groot NE, Garcia TM, Muncan V, Franklin OD, Battle M, Carlson KS, Leach J, Sansom OJ, Boulard O, Chamaillard M, Vermeulen L, Medema JP, Huels DJ, The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut. Biol Open. 2022 Dec 15;11(12)
3	J:93434 Rautavuoma K, Takaluoma K, Sormunen R, Myllyharju J, Kivirikko KI, Soininen R, Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice. Proc Natl Acad Sci U S A. 2004 Oct 28;101(39):14120-5
1	J:277677 Reissig LF, Herdina AN, Rose J, Maurer-Gesek B, Lane JL, Prin F, Wilson R, Hardman E, Galli A, Tudor C, Tuck E, Icoresi-Mazzeo C, White JK, Ryder E, Gleeson D, Adams DJ, Geyer SH, Mohun TJ, Weninger WJ, The Col4a2(em1(IMPC)Wtsi) mouse line: lessons from the Deciphering the Mechanisms of Developmental Disorders program. Biol Open. 2019 Aug 1;8(8):bio042895
1	J:156199 Robel S, Mori T, Zoubaa S, Schlegel J, Sirko S, Faissner A, Goebbels S, Dimou L, Gotz M, Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis. Glia. 2009 Nov 15;57(15):1630-47
4	J:35512 Rothman TP, Chen J, Howard MJ, Costantini F, Schuchardt A, Pachnis V, Gershon MD, Increased expression of laminin-1 and collagen (IV) subunits in the aganglionic bowel of ls/ls, but not c-ret -/- mice. Dev Biol. 1996 Sep 15;178(2):498-513
2	J:113221 Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P, Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis. Cancer Immun. 2006;6:10
1	J:187697 Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW, D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev. 2012 Sep 15;26(18):2038-49
2	J:167396 Szabova L, Son MY, Shi J, Sramko M, Yamada SS, Swaim WD, Zerfas P, Kahan S, Holmbeck K, Membrane-type MMPs are indispensable for placental labyrinth formation and development. Blood. 2010 Dec 16;116(25):5752-61
1*	J:106710 Takemoto M, He L, Norlin J, Patrakka J, Xiao Z, Petrova T, Bondjers C, Asp J, Wallgard E, Sun Y, Samuelsson T, Mostad P, Lundin S, Miura N, Sado Y, Alitalo K, Quaggin SE, Tryggvason K, Betsholtz C, Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J. 2006 Mar 8;25(5):1160-74
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
6*	J:67747 Thut CJ, Rountree RB, Hwa M, Kingsley DM, A large-scale in situ screen provides molecular evidence for the induction of eye anterior segment structures by the developing lens. Dev Biol. 2001 Mar 1;231(1):63-76
1	J:243333 Tian E, Hoffman MP, Ten Hagen KG, O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components. Nat Commun. 2012 May 29;3:869
2*	J:109514 Vats KR, Ishwad C, Singla I, Vats A, Ferrell R, Ellis D, Moritz M, Surti U, Jayakar P, Frederick DR, Vats AN, A locus for renal malformations including vesico-ureteric reflux on chromosome 13q33-34. J Am Soc Nephrol. 2006 Apr;17(4):1158-67
4	J:235682 Villacorte M, Delmarcelle AS, Lernoux M, Bouquet M, Lemoine P, Bolsee J, Umans L, de Sousa Lopes SC, Van Der Smissen P, Sasaki T, Bommer G, Henriet P, Refetoff S, Lemaigre FP, Zwijsen A, Courtoy PJ, Pierreux CE, Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly. Development. 2016 Jun 1;143(11):1958-70
1*	J:344117 Wang S, Matsumoto K, Mehlferber MM, Zhang G, Aronova MA, Yamada KM, Microtubule-dependent apical polarization of basement membrane matrix mRNAs in mouse epithelial cells. Cells Dev. 2023 Dec 14;177:203898
1	J:316132 Wen Y, Ma X, Wang X, Wang F, Dong J, Wu Y, Lv C, Liu K, Zhang Y, Zhang Z, Yuan S, hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9. Theranostics. 2021;11(20):10030-10046
1*	J:40601 Williamson RA, Henry MD, Daniels KJ, Hrstka RF, Lee JC, Sunada Y , Ibraghimov-Beskrovnaya O , Campbell KP, Dystroglycan is essential for early embryonic development: disruption of Reichert's membrane in Dag1-null mice. Hum Mol Genet. 1997 Jun;6(6):831-41
4*	J:33225 Wu JE, Santoro SA, Differential expression of integrin alpha subunits supports distinct roles during lung branching morphogenesis. Dev Dyn. 1996 Jun;206(2):169-81
2	J:315014 Zhou C, Chen D, Ren J, Huang D, Li R, Luo H, Guan C, Cao Y, Wang W, FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex. J Cell Mol Med. 2021 Mar;25(6):3051-3062