Gene Expression Literature Summary

• Symbol: Crabp2
• Name: cellular retinoic acid binding protein II
• ID: MGI:88491

59 matching records from 59 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6.5	E7	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16.5	E17	E17.5	E18.5	E19.5	E	P
Immunohistochemistry (section)							1	2	1	1	2	1	3	1	1	1		1	1	2	1	1			1	2
In situ RNA (section)	1		1	1	2	1	1		4		2		4		6		10		3	2		1	4	1	2	5
Immunohistochemistry (whole mount)								1
In situ RNA (whole mount)		1		3	2	1	3		4		1		2				1
Northern blot							1						2		2					1						1
Western blot						1		1	1	1		1			1
RT-PCR	1		2		2	2	2	2	3	2	3	2	2	2	4	1	2		3	1	1	2	3		1	5
cDNA clones							1						1		1
RNase protection										1					1	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Crabp2  cellular retinoic acid binding protein II   (Synonyms: Crabp-2, CrabpII)
Results	Reference
1	J:321578 Ang PS, Matrongolo MJ, Tischfield MA, The growth and expansion of meningeal lymphatic networks are affected in craniosynostosis. Development. 2022 Jan 1;149(1):dev200065
1	J:172564 Bami M, Episkopou V, Gavalas A, Gouti M, Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel hox gene effectors. PLoS One. 2011;6(5):e20197
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
4	J:20940 Bloch-Zupan A, Decimo D, Loriot M, Mark MP, Ruch JV, Expression of nuclear retinoic acid receptors during mouse odontogenesis. Differentiation. 1994 Sep;57(3):195-203
1*	J:299356 Chassot AA, Le Rolle M, Jolivet G, Stevant I, Guigonis JM, Da Silva F, Nef S, Pailhoux E, Schedl A, Ghyselinck NB, Chaboissier MC, Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary. Sci Adv. 2020 May;6(21):eaaz1261
1	J:171491 Clugston RD, Zhang W, Alvarez S, de Lera AR, Greer JJ, Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia. Am J Respir Cell Mol Biol. 2010 Mar;42(3):276-85
2*	J:45003 Colbert MC, Rubin WW, Linney E, LaMantia AS, Retinoid signaling and the generation of regional and cellular diversity in the embryonic mouse spinal cord. Dev Dyn. 1995 Sep;204(1):1-12
1	J:197449 Coles GL, Ackerman KG, Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1898-905
4*	J:142873 Collins CA, Watt FM, Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling. Dev Biol. 2008 Dec 1;324(1):55-67
1*	J:291486 Daniel E, Barlow HR, Sutton GI, Gu X, Htike Y, Cowdin MA, Cleaver O, Cyp26b1 is an essential regulator of distal airway epithelial differentiation during lung development. Development. 2020 Feb 20;147(4):dev181560
1	J:335193 Derk J, Como CN, Jones HE, Joyce LR, Kim S, Spencer BL, Bonney S, O'Rourke R, Pawlikowski B, Doran KS, Siegenthaler JA, Formation and function of the meningeal arachnoid barrier around the developing mouse brain. Dev Cell. 2023 Apr 24;58(8):635-644.e4
1	J:297060 DeSisto J, O'Rourke R, Jones HE, Pawlikowski B, Malek AD, Bonney S, Guimiot F, Jones KL, Siegenthaler JA, Single-Cell Transcriptomic Analyses of the Developing Meninges Reveal Meningeal Fibroblast Diversity and Function. Dev Cell. 2020 Jul 6;54(1):43-59.e4
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2	J:308983 Farmer DT, Mlcochova H, Zhou Y, Koelling N, Wang G, Ashley N, Bugacov H, Chen HJ, Parvez R, Tseng KC, Merrill AE, Maxson RE Jr, Wilkie AOM, Crump JG, Twigg SRF, The developing mouse coronal suture at single-cell resolution. Nat Commun. 2021 Aug 10;12(1):4797
2*	J:23773 Fawcett D, Pasceri P, Fraser R, Colbert M, Rossant J, Giguere V, Postaxial polydactyly in forelimbs of CRABP-II mutant mice. Development. 1995 Mar;121(3):671-9
2	J:266955 Gezelius H, Moreno-Juan V, Mezzera C, Thakurela S, Rodriguez-Malmierca LM, Pistolic J, Benes V, Tiwari VK, Lopez-Bendito G, Genetic Labeling of Nuclei-Specific Thalamocortical Neurons Reveals Putative Sensory-Modality Specific Genes. Cereb Cortex. 2017 Nov 1;27(11):5054-5069
1*	J:43344 Ghyselinck NB, Dupe V, Dierich A, Messaddeq N, Garnier JM, Rochette-Egly C , Chambon P , Mark M, Role of the retinoic acid receptor beta (RARbeta) during mouse development. Int J Dev Biol. 1997 Jun;41(3):425-47
7*	J:20074 Giguere V, Lyn S, Yip P, Siu CH, Amin S, Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein. Proc Natl Acad Sci U S A. 1990 Aug;87(16):6233-7
2*	J:20442 Gorry P, Lufkin T, Dierich A, Rochette-Egly C, Decimo D, Dolle P, Mark M, Durand B, Chambon P, The cellular retinoic acid binding protein I is dispensable. Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):9032-6
1	J:229100 Goto M, Hojo M, Ando M, Kita A, Kitagawa M, Ohtsuka T, Kageyama R, Miyamoto S, Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development. Brain Res. 2015 Nov 2;1625:206-17
2*	J:3323 Harnish DC, Jiang H, Soprano KJ, Kochhar DM, Soprano DR, Retinoic acid receptor beta 2 mRNA is elevated by retinoic acid in vivo in susceptible regions of mid-gestation mouse embryos. Dev Dyn. 1992 Jul;194(3):239-46
6*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
1*	J:23950 Horton C, Maden M, Endogenous distribution of retinoids during normal development and teratogenesis in the mouse embryo. Dev Dyn. 1995 Mar;202(3):312-23
13	J:121381 Hu P, Zhang M, Napoli JL, Ontogeny of rdh9 (Crad3) expression: ablation causes changes in retinoid and steroid metabolizing enzymes, but RXR and androgen signaling seem normal. Biochim Biophys Acta. 2007 Apr;1770(4):694-705
1	J:350500 Kibalnyk Y, Afanasiev E, Noble RMN, Watson AES, Poverennaya I, Dittmann NL, Alexiou M, Goodkey K, Greenwell AA, Ussher JR, Adameyko I, Massey J, Graf D, Bourque SL, Stratton JA, Voronova A, The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function. Nat Commun. 2024 Jul 1;15(1):4632
1*	J:237064 Lenti E, Farinello D, Yokoyama KK, Penkov D, Castagnaro L, Lavorgna G, Wuputra K, Sandell LL, Tjaden NE, Bernassola F, Caridi N, De Antoni A, Wagner M, Kozinc K, Niederreither K, Blasi F, Pasini D, Majdic G, Tonon G, Trainor PA, Brendolan A, Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development. J Clin Invest. 2016 Jul 01;126(7):2452-64
1	J:82686 Liu J, Wilson S, Reh T, BMP receptor 1b is required for axon guidance and cell survival in the developing retina. Dev Biol. 2003 Apr 1;256(1):34-48
1*	J:13574 Lufkin T, Lohnes D, Mark M, Dierich A, Gorry P, Gaub MP, LeMeur M, Chambon P, High postnatal lethality and testis degeneration in retinoic acid receptor alpha mutant mice. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7225-9
1*	J:29061 Luo J, Pasceri P, Conlon RA, Rossant J, Giguere V, Mice lacking all isoforms of retinoic acid receptor beta develop normally and are susceptible to the teratogenic effects of retinoic acid. Mech Dev. 1995 Sep;53(1):61-71
4*	J:17838 Lyn S, Giguere V, Localization of CRABP-I and CRABP-II mRNA in the early mouse embryo by whole-mount in situ hybridization: implications for teratogenesis and neural development. Dev Dyn. 1994 Apr;199(4):280-91
4	J:98265 Makita T, Duncan SA, Sucov HM, Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. Dev Biol. 2005 Apr 1;280(1):59-72
4*	J:1937 Mark MP, Bloch-Zupan A, Wolf C, Ruberte E, Ruch JV, Involvement of cellular retinoic acid-binding proteins I and II (CRABPI and CRABPII) and of the cellular retinol-binding protein I (CRBPI) in odontogenesis in the mouse. Differentiation. 1991 Nov;48(2):89-98
1*	J:257918 Massimino L, Flores-Garcia L, Di Stefano B, Colasante G, Icoresi-Mazzeo C, Zaghi M, Hamilton BA, Sessa A, TBR2 antagonizes retinoic acid dependent neuronal differentiation by repressing Zfp423 during corticogenesis. Dev Biol. 2018 Feb 15;434(2):231-248
2	J:256105 Mendelsohn AI, Dasen JS, Jessell TM, Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles. Neuron. 2017 Feb 22;93(4):792-805.e4
1	J:108515 Molotkov A, Molotkova N, Duester G, Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning. Development. 2006 May;133(10):1901-10
1	J:64754 Mulder GB, Manley N, Grant J, Schmidt K, Zeng W, Eckhoff C, Maggio-Price L, Effects of excess vitamin A on development of cranial neural crest-derived structures: A neonatal and embryologic study. Teratology. 2000 Oct;62(4):214-26
1	J:52258 Mulder GB, Manley N, Maggio-Price L, Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1. Teratology. 1998 Dec;58(6):263-75
2	J:65651 Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG, Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Mech Dev. 2000 Nov;98(1-2):77-94
1*	J:96883 Olson LE, Zhang J, Taylor H, Rose DW, Rosenfeld MG, Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3708-13
1	J:85043 Otto DM, Henderson CJ, Carrie D, Davey M, Gundersen TE, Blomhoff R, Adams RH, Tickle C, Wolf CR, Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis. Mol Cell Biol. 2003 Sep;23(17):6103-16
3	J:200551 Paschaki M, Schneider C, Rhinn M, Thibault-Carpentier C, Dembele D, Niederreither K, Dolle P, Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling. PLoS One. 2013;8(4):e62274
3	J:276877 Qu X, Harmelink C, Baldwin HS, Tie2 regulates endocardial sprouting and myocardial trabeculation. JCI Insight. 2019 May 21;5
2	J:343286 Queen R, Crosier M, Eley L, Kerwin J, Turner JE, Yu J, Alqahtani A, Dhanaseelan T, Overman L, Soetjoadi H, Baldock R, Coxhead J, Boczonadi V, Laude A, Cockell SJ, Kane MA, Lisgo S, Henderson DJ, Spatial transcriptomics reveals novel genes during the remodelling of the embryonic human arterial valves. PLoS Genet. 2023 Nov;19(11):e1010777
6	J:89666 Romand R, Sapin V, Ghyselinck NB, Avan P, Le Calvez S, Dolle P, Chambon P, Mark M, Spatio-temporal distribution of cellular retinoid binding protein gene transcripts in the developing and the adult cochlea. Morphological and functional consequences in CRABP- and CRBPI-null mutant mice. Eur J Neurosci. 2000 Aug;12(8):2793-804
2	J:12881 Ruberte E, Friederich V, Chambon P, Morriss-Kay G, Retinoic acid receptors and cellular retinoid binding proteins. III. Their differential transcript distribution during mouse nervous system development. Development. 1993 May;118(1):267-82
8*	J:2390 Ruberte E, Friederich V, Morriss-Kay G, Chambon P, Differential distribution patterns of CRABP I and CRABP II transcripts during mouse embryogenesis. Development. 1992 Aug;115(4):973-87
2*	J:57145 Rubin WW, LaMantia AS, Age-dependent retinoic acid regulation of gene expression distinguishes the cervical, thoracic, lumbar, and sacral spinal cord regions during development. Dev Neurosci. 1999;21(2):113-25
1*	J:182007 Russell MK, Longoni M, Wells J, Maalouf FI, Tracy AA, Loscertales M, Ackerman KG, Pober BR, Lage K, Bult CJ, Donahoe PK, Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2978-83
1	J:44230 Sapin V, Dolle P, Hindelang C, Kastner P, Chambon P, Defects of the chorioallantoic placenta in mouse RXRalpha null fetuses. Dev Biol. 1997 Nov 1;191(1):29-41
12	J:38200 Sapin V, Ward SJ, Bronner S, Chambon P, Dolle P, Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse. Dev Dyn. 1997 Feb;208(2):199-210
2	J:129404 Sirbu IO, Duester G, Retinoic-acid signalling in node ectoderm and posterior neural plate directs left-right patterning of somitic mesoderm. Nat Cell Biol. 2006 Mar;8(3):271-7
3	J:297034 Someda M, Kuroki S, Miyachi H, Tachibana M, Yonehara S, Caspase-8, receptor-interacting protein kinase 1 (RIPK1), and RIPK3 regulate retinoic acid-induced cell differentiation and necroptosis. Cell Death Differ. 2020 May;27(5):1539-1553
18*	J:171116 Stachurska E, Loboda A, Niderla-Bielinska J, Szperl M, Juszynski M, Jozkowicz A, Dulak J, Ratajska A, Expression of cellular retinoic acid-binding protein I and II (CRABP I and II) in embryonic mouse hearts treated with retinoic acid. Acta Biochim Pol. 2011;58(1):19-29
4*	J:61711 Ulven SM, Gundersen TE, Weedon MS, Landaas VO, Sakhi AK, Fromm SH, Geronimo BA, Moskaug JO, Blomhoff R, Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: important role of retinal dehydrogenase type 2 in synthesis of all-trans-retinoic acid. Dev Biol. 2000 Apr 15;220(2):379-91
2	J:95332 Wang Z, Zhai W, Richardson JA, Olson EN, Meneses JJ, Firpo MT, Kang C, Skarnes WC, Tjian R, Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. Genes Dev. 2004 Dec 15;18(24):3106-16
2	J:47808 Whitesides J, Hall M, Anchan R, LaMantia AS, Retinoid signaling distinguishes a subpopulation of olfactory receptor neurons in the developing and adult mouse. J Comp Neurol. 1998 May 18;394(4):445-61
1	J:283063 Wu L, Belyaeva OV, Adams MK, Klyuyeva AV, Lee SA, Goggans KR, Kesterson RA, Popov KM, Kedishvili NY, Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands. J Biol Chem. 2019 Nov 8;294(45):17060-17074
1*	J:149990 Yoshimura K, Kitagawa H, Fujiki R, Tanabe M, Takezawa S, Takada I, Yamaoka I, Yonezawa M, Kondo T, Furutani Y, Yagi H, Yoshinaga S, Masuda T, Fukuda T, Yamamoto Y, Ebihara K, Li DY, Matsuoka R, Takeuchi JK, Matsumoto T, Kato S, Distinct function of 2 chromatin remodeling complexes that share a common subunit, Williams syndrome transcription factor (WSTF). Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9280-5
1	J:157264 Zhao Y, Mailloux CM, Hermesz E, Palkovits M, Westphal H, A role of the LIM-homeobox gene Lhx2 in the regulation of pituitary development. Dev Biol. 2010 Jan 15;337(2):313-23