Symbol Name ID |
Crh
corticotropin releasing hormone MGI:88496 |
Age | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E | P |
Immunohistochemistry (section) | 1 | 1 | 1 | 1 | 1 | 1 | 4 | 1 | 1 | 1 | 1 | 8 | ||||||||
In situ RNA (section) | 2 | 1 | 1 | 5 | 2 | 7 | 1 | 5 | 2 | 7 | 1 | 18 | ||||||||
In situ reporter (knock in) | 1 | |||||||||||||||||||
Western blot | 1 | 1 | 1 | 1 | ||||||||||||||||
RT-PCR | 1 | 1 | 1 | 1 | 1 | 2 | 6 | |||||||||||||
cDNA clones | 1 |
Crh corticotropin releasing hormone (Synonyms: corticotropin releasing factor, corticotropin-releasing factor, CRF, LOC383938) | |
Results | Reference |
3 | J:58466 Acampora D, Postiglione MP, Avantaggiato V, Di Bonito M, Vaccarino FM, Michaud J, Simeone A, Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene. Genes Dev. 1999 Nov 1;13(21):2787-800 |
6* | J:58937 Bishop GA, King JS, Corticotropin releasing factor in the embryonic mouse cerebellum. Exp Neurol. 1999 Dec;160(2):489-99 |
1 | J:110638 Catalano SM, Messersmith EK, Goodman CS, Shatz CJ, Chedotal A, Many major CNS axon projections develop normally in the absence of semaphorin III. Mol Cell Neurosci. 1998 Jul;11(4):173-82 |
1* | J:264526 Dedic N, Kuhne C, Jakovcevski M, Hartmann J, Genewsky AJ, Gomes KS, Anderzhanova E, Pohlmann ML, Chang S, Kolarz A, Vogl AM, Dine J, Metzger MW, Schmid B, Almada RC, Ressler KJ, Wotjak CT, Grinevich V, Chen A, Schmidt MV, Wurst W, Refojo D, Deussing JM, Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nat Neurosci. 2018 Jun;21(6):803-807 |
1 | J:58438 Deiner MS, Sretavan DW, Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice. J Neurosci. 1999 Nov 15;19(22):9900-12 |
1 | J:196342 Denaxa M, Kalaitzidou M, Garefalaki A, Achimastou A, Lasrado R, Maes T, Pachnis V, Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons. Cell Rep. 2012 Nov 29;2(5):1351-62 |
1 | J:157229 Duplan SM, Boucher F, Alexandrov L, Michaud JL, Impact of Sim1 gene dosage on the development of the paraventricular and supraoptic nuclei of the hypothalamus. Eur J Neurosci. 2009 Dec;30(12):2239-49 |
1 | J:253696 Feng S, Xing C, Shen T, Qiao Y, Wang R, Chen J, Liao J, Lu Z, Yang X, Abd-Allah SM, Li J, Jing N, Tang K, Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII. Sci Rep. 2017 Jul 13;7(1):5282 |
1 | J:161632 Garcia-Moreno F, Pedraza M, Di Giovannantonio LG, Di Salvio M, Lopez-Mascaraque L, Simeone A, De Carlos JA, A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei. Nat Neurosci. 2010 Jun;13(6):680-9 |
1 | J:152865 Georgas K, Rumballe B, Valerius MT, Chiu HS, Thiagarajan RD, Lesieur E, Aronow BJ, Brunskill EW, Combes AN, Tang D, Taylor D, Grimmond SM, Potter SS, McMahon AP, Little MH, Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol. 2009 Aug 15;332(2):273-86 |
1 | J:176609 Goldberg LB, Aujla PK, Raetzman LT, Persistent expression of activated Notch inhibits corticotrope and melanotrope differentiation and results in dysfunction of the HPA axis. Dev Biol. 2011 Oct 1;358(1):23-32 |
1 | J:89548 Goshu E, Jin H, Lovejoy J, Marion JF, Michaud JL, Fan CM, Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus. Mol Endocrinol. 2004 May;18(5):1251-62 |
1 | J:74118 Hosoya T, Oda Y, Takahashi S, Morita M, Kawauchi S, Ema M, Yamamoto M, Fujii-Kuriyama Y, Defective development of secretory neurones in the hypothalamus of Arnt2-knockout mice. Genes Cells. 2001 Apr;6(4):361-74 |
1 | J:191801 Huang CC, Shih MC, Hsu NC, Chien Y, Chung BC, Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression. Endocrinology. 2012 Oct;153(10):4749-56 |
2* | J:226410 Jurek B, Slattery DA, Hiraoka Y, Liu Y, Nishimori K, Aguilera G, Neumann ID, van den Burg EH, Oxytocin Regulates Stress-Induced Crf Gene Transcription through CREB-Regulated Transcription Coactivator 3. J Neurosci. 2015 Sep 2;35(35):12248-60 |
3 | J:258182 Kakizawa K, Watanabe M, Mutoh H, Okawa Y, Yamashita M, Yanagawa Y, Itoi K, Suda T, Oki Y, Fukuda A, A novel GABA-mediated corticotropin-releasing hormone secretory mechanism in the median eminence. Sci Adv. 2016 Aug;2(8):e1501723 |
8 | J:18319 Keegan CE, Herman JP, Karolyi IJ, O'Shea KS, Camper SA, Seasholtz AF, Differential expression of corticotropin-releasing hormone in developing mouse embryos and adult brain. Endocrinology. 1994 Jun;134(6):2547-55 |
1* | J:333645 Lau J, Shi YC, Herzog H, Temperature dependence of the control of energy homeostasis requires CART signaling. Neuropeptides. 2016 Oct;59:97-109 |
1 | J:237344 Lee B, Lee S, Lee SK, Lee JW, The LIM-homeobox transcription factor Isl1 plays crucial roles in the development of multiple arcuate nucleus neurons. Development. 2016 Oct 15;143(20):3763-3773 |
1 | J:343327 Lee H, Weinberg-Wolf H, Lee HL, Lee T, Conte J, Godoy-Parejo C, Demb JB, Rudenko A, Kim IJ, Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat. PLoS Biol. 2023 Nov;21(11):e3002386 |
1 | J:335566 Lu C, Zhang J, Wang B, Gao Q, Ma K, Pei S, Li J, Cui S, Casein kinase 1alpha is required to maintain murine hypothalamic pro-opiomelanocortin expression. iScience. 2023 May 19;26(5):106670 |
3* | J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86 |
2 | J:258670 Mahany EB, Han X, Borges BC, da Silveira Cruz-Machado S, Allen SJ, Garcia-Galiano D, Hoenerhoff MJ, Bellefontaine NH, Elias CF, Obesity and High-Fat Diet Induce Distinct Changes in Placental Gene Expression and Pregnancy Outcome. Endocrinology. 2018 Apr 1;159(4):1718-1733 |
1 | J:60430 Michaud JL, DeRossi C, May NR, Holdener BC, Fan CM, ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus. Mech Dev. 2000 Feb;90(2):253-61 |
3 | J:50772 Michaud JL, Rosenquist T, May NR, Fan CM, Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1. Genes Dev. 1998 Oct 15;12(20):3264-75 |
2 | J:23082 Muglia L, Jacobson L, Dikkes P, Majzoub JA, Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need. Nature. 1995 Feb 2;373(6513):427-32 |
1 | J:342846 Munguba H, Nikouei K, Hochgerner H, Oberst P, Kouznetsova A, Ryge J, Munoz-Manchado AB, Close J, Batista-Brito R, Linnarsson S, Hjerling-Leffler J, Transcriptional maintenance of cortical somatostatin interneuron subtype identity during migration. Neuron. 2023 Nov 15;111(22):3590-3603.e5 |
1 | J:284151 Oleari R, Caramello A, Campinoti S, Lettieri A, Ioannou E, Paganoni A, Fantin A, Cariboni A, Ruhrberg C, PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons. Development. 2019 Nov 5;146(21):dev176461 |
2 | J:134188 Reichardt HM, Schutz G, Feedback control of glucocorticoid production is established during fetal development. Mol Med. 1996 Nov;2(6):735-44 |
1 | J:298882 Roome RB, Bourojeni FB, Mona B, Rastegar-Pouyani S, Blain R, Dumouchel A, Salesse C, Thompson WS, Brookbank M, Gitton Y, Tessarollo L, Goulding M, Johnson JE, Kmita M, Chedotal A, Kania A, Phox2a Defines a Developmental Origin of the Anterolateral System in Mice and Humans. Cell Rep. 2020 Nov 24;33(8):108425 |
1 | J:155932 Rose MF, Ahmad KA, Thaller C, Zoghbi HY, Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22462-7 |
1 | J:305421 Rosin JM, Sinha S, Biernaskie J, Kurrasch DM, A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors. Dev Cell. 2021 May 3;56(9):1326-1345.e6 |
4* | J:30430 Schonemann MD, Ryan AK, McEvilly RJ, O'Connell SM, Arias CA, Kalla KA, Li P, Sawchenko PE, Rosenfeld MG, Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2. Genes Dev. 1995 Dec 15;9(24):3122-35 |
7* | J:168512 Simard M, Cote M, Provost PR, Tremblay Y, Expression of genes related to the hypothalamic-pituitary-adrenal axis in murine fetal lungs in late gestation. Reprod Biol Endocrinol. 2010;8:134 |
1* | J:286599 Song NN, Ma P, Zhang Q, Zhang L, Wang H, Zhang L, Zhu L, He CH, Mao B, Ding YQ, Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development. Development. 2020 Mar 30;147(6):dev185199 |
1* | J:299851 Sutton AK, Gonzalez IE, Sadagurski M, Rajala M, Lu C, Allison MB, Adams JM, Myers MG, White MF, Olson DP, Paraventricular, subparaventricular and periventricular hypothalamic IRS4-expressing neurons are required for normal energy balance. Sci Rep. 2020 Mar 26;10(1):5546 |
5* | J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23 |
8* | J:314223 Wang H, Sakata-Haga H, Masuta H, Tomosugi M, Tsukada T, Shimada H, Sakai D, Shoji H, Hatta T, Leukemia Inhibitory Factor Induces Proopiomelanocortin via CRH/CRHR Pathway in Mouse Trophoblast. Front Cell Dev Biol. 2021;9:618947 |
3 | J:65759 Wang W, Lufkin T, The murine otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus. Dev Biol. 2000 Nov 15;227(2):432-49 |
1* | J:346887 Watanabe M, Sinha AS, Shinmyo Y, Fukuda A, Early establishment of chloride homeostasis in CRH neurons is altered by prenatal stress leading to fetal HPA axis dysregulation. Front Mol Neurosci. 2024;17:1373337 |
1* | J:199203 Wu HH, Levitt P, Prenatal expression of MET receptor tyrosine kinase in the fetal mouse dorsal raphe nuclei and the visceral motor/sensory brainstem. Dev Neurosci. 2013;35(1):1-16 |
2 | J:320691 Yadav VK, Berger JM, Singh P, Nagarajan P, Karsenty G, Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse. J Clin Invest. 2022 Feb 15;132(4):e153752 |
2 | J:344566 Zanini F, Che X, Suresh NE, Knutsen C, Klavina P, Xie Y, Domingo-Gonzalez R, Liu M, Kum A, Jones RC, Quake SR, Alvira CM, Cornfield DN, Hyperoxia prevents the dynamic neonatal increases in lung mesenchymal cell diversity. Sci Rep. 2024 Jan 23;14(1):2033 |
2* | J:341081 Zhao C, Ries C, Du Y, Zhang J, Sakimura K, Itoi K, Deussing JM, Differential CRH expression level determines efficiency of Cre- and Flp-dependent recombination. Front Neurosci. 2023;17:1163462 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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