Gene Expression Literature Summary

• Symbol: Crhr1
• Name: corticotropin releasing hormone receptor 1
• ID: MGI:88498

11 matching records from 11 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10	E11	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	E18.5	P
Immunohistochemistry (section)			1	1	1	1	1	1		1
In situ RNA (section)			1		1		2	2	1	1	4
In situ reporter (knock in)											1
RT-PCR	1	1			1		1	1	1	1	6

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Crhr1  corticotropin releasing hormone receptor 1   (Synonyms: CRF1R, CRF 1 receptor, CRFR1, CRF-R1alpha)
Results	Reference
1	J:188254 Budry L, Balsalobre A, Gauthier Y, Khetchoumian K, L'honore A, Vallette S, Brue T, Figarella-Branger D, Meij B, Drouin J, The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes Dev. 2012 Oct 15;26(20):2299-310
2*	J:264526 Dedic N, Kuhne C, Jakovcevski M, Hartmann J, Genewsky AJ, Gomes KS, Anderzhanova E, Pohlmann ML, Chang S, Kolarz A, Vogl AM, Dine J, Metzger MW, Schmid B, Almada RC, Ressler KJ, Wotjak CT, Grinevich V, Chen A, Schmidt MV, Wurst W, Refojo D, Deussing JM, Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety. Nat Neurosci. 2018 Jun;21(6):803-807
1	J:176609 Goldberg LB, Aujla PK, Raetzman LT, Persistent expression of activated Notch inhibits corticotrope and melanotrope differentiation and results in dysfunction of the HPA axis. Dev Biol. 2011 Oct 1;358(1):23-32
1	J:191801 Huang CC, Shih MC, Hsu NC, Chien Y, Chung BC, Fetal glucocorticoid synthesis is required for development of fetal adrenal medulla and hypothalamus feedback suppression. Endocrinology. 2012 Oct;153(10):4749-56
3*	J:96061 Juriloff DM, Harris MJ, Dewell SL, Brown CJ, Mager DL, Gagnier L, Mah DG, Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice. Birth Defects Res A Clin Mol Teratol. 2005 Feb;73(2):103-13
2	J:245423 Kadmiel M, Matson BC, Espenschied ST, Lenhart PM, Caron KM, Loss of receptor activity-modifying protein 2 in mice causes placental dysfunction and alters PTH1R regulation. PLoS One. 2017;12(7):e0181597
7	J:88219 King JS, Bishop GA, Localization of the type 1 corticotropin releasing factor receptor (CRF-R1) in the embryonic mouse cerebellum. J Neurocytol. 2003 Mar;32(3):305-16
1	J:214133 Nantie LB, Himes AD, Getz DR, Raetzman LT, Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification. Mol Endocrinol. 2014 May;28(5):731-44
2*	J:308609 Sararols P, Stevant I, Neirijnck Y, Rebourcet D, Darbey A, Curley MK, Kuhne F, Dermitzakis E, Smith LB, Nef S, Specific Transcriptomic Signatures and Dual Regulation of Steroidogenesis Between Fetal and Adult Mouse Leydig Cells. Front Cell Dev Biol. 2021;9:695546
8*	J:168512 Simard M, Cote M, Provost PR, Tremblay Y, Expression of genes related to the hypothalamic-pituitary-adrenal axis in murine fetal lungs in late gestation. Reprod Biol Endocrinol. 2010;8:134
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23