Gene Expression Literature Summary

• Symbol: Cryaa
• Name: crystallin, alpha A
• ID: MGI:88515

78 matching records from 78 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18.5	E19	E	P
Immunohistochemistry (section)		1	2	5	3	6	2	9	7	1	12	1	3	1	2		1	1		1	12
In situ RNA (section)		1		2		2		6	3		10		5		2		2			1	3
In situ RNA (whole mount)		1	1	3		1		1
Western blot															1			1			7
RT-PCR	1	1	1			2		4	1		2		5		2	1	2	1	1		6

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cryaa  crystallin, alpha A   (Synonyms: Acry-1, alpha-A-crystallin, Crya-1, Crya1, DAcry-1)
Results	Reference
1	J:237492 Antosova B, Smolikova J, Klimova L, Lachova J, Bendova M, Kozmikova I, Machon O, Kozmik Z, The Gene Regulatory Network of Lens Induction Is Wired through Meis-Dependent Shadow Enhancers of Pax6. PLoS Genet. 2016 Dec;12(12):e1006441
1	J:228518 Arya P, Rainey MA, Bhattacharyya S, Mohapatra BC, George M, Kuracha MR, Storck MD, Band V, Govindarajan V, Band H, The endocytic recycling regulatory protein EHD1 Is required for ocular lens development. Dev Biol. 2015 Dec 1;408(1):41-55
1	J:65765 Ashery-Padan R, Marquardt T, Zhou X, Gruss P, Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev. 2000 Nov 1;14(21):2701-11
1*	J:292622 Barnum CE, Al Saai S, Patel SD, Cheng C, Anand D, Xu X, Dash S, Siddam AD, Glazewski L, Paglione E, Polson SW, Chuma S, Mason RW, Wei S, Batish M, Fowler VM, Lachke SA, The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology. Hum Mol Genet. 2020 Jul 29;29(12):2076-2097
2*	J:119940 Blixt A, Landgren H, Johansson BR, Carlsson P, Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage. Dev Biol. 2007 Feb 1;302(1):218-29
1	J:59880 Blixt A, Mahlapuu M, Aitola M, Pelto-Huikko M, Enerback S, Carlsson P, A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle. Genes Dev. 2000 Jan 15;14(2):245-54
3*	J:63706 Brownell I, Dirksen M, Jamrich M, Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation. Genesis. 2000 Jun;27(2):81-93
1	J:158529 Burgess D, Zhang Y, Siefker E, Vaca R, Kuracha MR, Reneker L, Overbeek PA, Govindarajan V, Activated Ras alters lens and corneal development through induction of distinct downstream targets. BMC Dev Biol. 2010;10:13
1	J:139969 Cain S, Martinez G, Kokkinos MI, Turner K, Richardson RJ, Abud HE, Huelsken J, Robinson ML, de Iongh RU, Differential requirement for beta-catenin in epithelial and fiber cells during lens development. Dev Biol. 2008 Sep 15;321(2):420-33
1	J:182769 Carbe C, Hertzler-Schaefer K, Zhang X, The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Dev Biol. 2012 Mar 1;363(1):320-9
1	J:30314 Chow RL, Roux GD, Roghani M, Palmer MA, Rifkin DB, Moscatelli DA, Lang RA, FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens. Development. 1995 Dec;121(12):4383-93
1	J:273460 Collins TN, Mao Y, Li H, Bouaziz M, Hong A, Feng GS, Wang F, Quilliam LA, Chen L, Park T, Curran T, Zhang X, Crk proteins transduce FGF signaling to promote lens fiber cell elongation. Elife. 2018 Jan 23;7:e32586
1	J:126208 DePianto DJ, Blankenship TN, Hess JF, FitzGerald PG, Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice. Mol Vis. 2003 Jun 30;9:288-94
2	J:73524 Dimanlig PV, Faber SC, Auerbach W, Makarenkova HP, Lang RA, The upstream ectoderm enhancer in Pax6 has an important role in lens induction. Development. 2001 Nov;128(22):4415-24
1*	J:73525 Faber SC, Dimanlig P, Makarenkova HP, Shirke S, Ko K, Lang RA, Fgf receptor signaling plays a role in lens induction. Development. 2001 Nov;128(22):4425-38
1	J:31366 Fromm L, Overbeek PA, Regulation of cyclin and cyclin-dependent kinase gene expression during lens differentiation requires the retinoblastoma protein. Oncogene. 1996 Jan 4;12(1):69-75
2	J:93301 Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S, Kato K, Yonemura S, Inouye S, Nakai A, HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 2004 Nov 27;23(21):4297-306
3	J:170649 Garcia CM, Huang J, Madakashira BP, Liu Y, Rajagopal R, Dattilo L, Robinson ML, Beebe DC, The function of FGF signaling in the lens placode. Dev Biol. 2011 Mar 1;351(1):176-85
2	J:290269 Garg A, Hannan A, Wang Q, Makrides N, Zhong J, Li H, Yoon S, Mao Y, Zhang X, Etv transcription factors functionally diverge from their upstream FGF signaling in lens development. Elife. 2020 Feb 11;9:e51915
3*	J:80501 Gitton Y, Dahmane N, Baik S, Ruiz I Altaba A, Neidhardt L, Scholze M, Herrmann BG, Kahlem P, Benkahla A, Schrinner S, Yildirimman R, Herwig R, Lehrach H, Yaspo ML, A gene expression map of human chromosome 21 orthologues in the mouse. Nature. 2002 Dec 5;420(6915):586-90
1	J:77351 Goudreau G, Petrou P, Reneker LW, Graw J, Loster J, Gruss P, Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8719-24
3	J:103785 Graw J, Loster J, Puk O, Munster D, Haubst N, Soewarto D, Fuchs H, Meyer B, Nurnberg P, Pretsch W, Selby P, Favor J, Wolf E, Hrabe de Angelis M, Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters. Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4671-83
2*	J:51693 Grimm C, Chatterjee B, Favor J, Immervoll T, Loster J, Klopp N, Sandulache R, Graw J, Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern. Dev Genet. 1998;23(4):299-316
1	J:168483 He S, Pirity MK, Wang WL, Wolf L, Chauhan BK, Cveklova K, Tamm ER, Ashery-Padan R, Metzger D, Nakai A, Chambon P, Zavadil J, Cvekl A, Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics Chromatin. 2010;3(1):21
1*	J:62578 Hettmann T, Barton K, Leiden JM, Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. Dev Biol. 2000 Jun 1;222(1):110-23
1*	J:86801 Hirano M, Yamamoto A, Yoshimura N, Tokunaga T, Motohashi T, Ishizaki K, Yoshida H, Okazaki K, Yamazaki H, Hayashi S, Kunisada T, Generation of structures formed by lens and retinal cells differentiating from embryonic stem cells. Dev Dyn. 2003 Dec;228(4):664-71
4	J:184297 Hu WF, Gong L, Cao Z, Ma H, Ji W, Deng M, Liu M, Hu XH, Chen P, Yan Q, Chen HG, Liu J, Sun S, Zhang L, Liu JP, Wawrousek E, Li DW, alphaA- and alphaB-crystallins interact with caspase-3 and Bax to guard mouse lens development. Curr Mol Med. 2012 Feb;12(2):177-87
2*	J:56095 Kawauchi S, Takahashi S, Nakajima O, Ogino H, Morita M, Nishizawa M, Yasuda K, Yamamoto M, Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem. 1999 Jul 2;274(27):19254-60
2*	J:175263 Kenchegowda D, Swamynathan S, Gupta D, Wan H, Whitsett J, Swamynathan SK, Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells. Dev Biol. 2011 Aug 1;356(1):5-18
1*	J:80609 Kim SW, Cheong C, Sohn YC, Goo YH, Oh WJ, Park JH, Joe SY, Kang HS, Kim DK, Kee C, Lee JW, Lee HW, Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol. 2002 Dec;22(24):8409-14
1	J:181400 Kuracha MR, Burgess D, Siefker E, Cooper JT, Licht JD, Robinson ML, Govindarajan V, Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation. Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6887-97
1	J:310318 Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X, Frs2alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci. 2014 Feb 1;127(Pt 3):571-82
1*	J:54071 Li W, Nagineni CN, Ge H, Efiok B, Chepelinsky AB, Egwuagu CE, Interferon consensus sequence-binding protein is constitutively expressed and differentially regulated in the ocular lens. J Biol Chem. 1999 Apr 2;274(14):9686-91
4*	J:270646 Limi S, Senecal A, Coleman R, Lopez-Jones M, Guo P, Polumbo C, Singer RH, Skoultchi AI, Cvekl A, Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process. J Biol Chem. 2018 Aug 24;293(34):13176-13190
2	J:165593 Liu Y, Kawai K, Khashabi S, Deng C, Liu YH, Yiu S, Inactivation of Smad4 leads to impaired ocular development and cataract formation. Biochem Biophys Res Commun. 2010 Oct 1;400(4):476-82
1	J:158407 Machon O, Kreslova J, Ruzickova J, Vacik T, Klimova L, Fujimura N, Lachova J, Kozmik Z, Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm. Genesis. 2010 Feb;48(2):86-95
2	J:151537 Maeda A, Moriguchi T, Hamada M, Kusakabe M, Fujioka Y, Nakano T, Yoh K, Lim KC, Engel JD, Takahashi S, Transcription factor GATA-3 is essential for lens development. Dev Dyn. 2009 Jul 21;238(9):2280-2291
2*	J:133715 Maerker D, Stenzinger A, Schreiner D, Tag C, Wimmer M, Expression of PTPIP51 during mouse eye development. Histochem Cell Biol. 2008 Mar;129(3):345-56
2*	J:69855 Martinez-Morales JR, Signore M, Acampora D, Simeone A, Bovolenta P, Otx genes are required for tissue specification in the developing eye. Development. 2001 Jun;128(11):2019-30
2	J:101355 Medina-Martinez O, Brownell I, Amaya-Manzanares F, Hu Q, Behringer RR, Jamrich M, Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice. Mol Cell Biol. 2005 Oct;25(20):8854-63
2	J:151273 Medina-Martinez O, Shah R, Jamrich M, Pitx3 controls multiple aspects of lens development. Dev Dyn. 2009 Mar 30;238(9):2193-2201
6	J:95535 Min JN, Zhang Y, Moskophidis D, Mivechi NF, Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Genesis. 2004 Dec;40(4):205-17
2*	J:23615 Morgenbesser SD, Schreiber-Agus N, Bidder M, Mahon KA, Overbeek PA, Horner J, DePinho RA, Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo. EMBO J. 1995 Feb 15;14(4):743-56
1*	J:19995 Morgenbesser SD, Williams BO, Jacks T, DePinho RA, p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens [see comments]. Nature. 1994 Sep 1;371(6492):72-4
2	J:46636 Nishiguchi S, Wood H, Kondoh H, Lovell-Badge R, Episkopou V, Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev. 1998 Mar 15;12(6):776-81
1	J:150768 Okado H, Ohtaka-Maruyama C, Sugitani Y, Fukuda Y, Ishida R, Hirai S, Miwa A, Takahashi A, Aoki K, Mochida K, Suzuki O, Honda T, Nakajima K, Ogawa M, Terashima T, Matsuda J, Kawano H, Kasai M, The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex. Dev Biol. 2009 Jul 15;331(2):140-51
1	J:119651 Pan Y, Woodbury A, Esko JD, Grobe K, Zhang X, Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development. Development. 2006 Dec;133(24):4933-44
1	J:154465 Rajagopal R, Huang J, Dattilo LK, Kaartinen V, Mishina Y, Deng CX, Umans L, Zwijsen A, Roberts AB, Beebe DC, The type I BMP receptors, Bmpr1a and Acvr1, activate multiple signaling pathways to regulate lens formation. Dev Biol. 2009 Nov 15;335(2):305-16
3	J:168996 Ren S, Liu T, Jia C, Qi X, Wang Y, Physiological expression of lens alpha-, beta-, and gamma-crystallins in murine and human corneas. Mol Vis. 2010;16:2745-52
7*	J:80502 Reymond A, Marigo V, Yaylaoglu MB, Leoni A, Ucla C, Scamuffa N, Caccioppoli C, Dermitzakis ET, Lyle R, Banfi S, Eichele G, Antonarakis SE, Ballabio A, Human chromosome 21 gene expression atlas in the mouse. Nature. 2002 Dec 5;420(6915):582-6
5*	J:56583 Ring BZ, Cordes SP, Overbeek PA, Barsh GS, Regulation of mouse lens fiber cell development and differentiation by the Maf gene. Development. 2000 Jan;127(2):307-17
8	J:36380 Robinson ML, Overbeek PA, Differential expression of alpha A- and alpha B-crystallin during murine ocular development. Invest Ophthalmol Vis Sci. 1996 Oct;37(11):2276-84
1	J:115522 Sandilands A, Hutcheson AM, Long HA, Prescott AR, Vrensen G, Loster J, Klopp N, Lutz RB, Graw J, Masaki S, Dobson CM, MacPhee CE, Quinlan RA, Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J. 2002 Nov 15;21(22):6005-14
5	J:33890 Santhiya ST, Abd-alla SM, Loster J, Graw J, Reduced levels of gamma-crystallin transcripts during embryonic development of murine Cat2nop mutant lenses. Graefes Arch Clin Exp Ophthalmol. 1995 Dec;233(12):795-800
1	J:195281 Shaham O, Gueta K, Mor E, Oren-Giladi P, Grinberg D, Xie Q, Cvekl A, Shomron N, Davis N, Keydar-Prizant M, Raviv S, Pasmanik-Chor M, Bell RE, Levy C, Avellino R, Banfi S, Conte I, Ashery-Padan R, Pax6 regulates gene expression in the vertebrate lens through miR-204. PLoS Genet. 2013 Mar;9(3):e1003357
2	J:152850 Shaham O, Smith AN, Robinson ML, Taketo MM, Lang RA, Ashery-Padan R, Pax6 is essential for lens fiber cell differentiation. Development. 2009 Aug;136(15):2567-78
2*	J:141960 Swindell EC, Liu C, Shah R, Smith AN, Lang RA, Jamrich M, Eye formation in the absence of retina. Dev Biol. 2008 Oct 1;322(1):56-64
1*	J:158257 Takeuchi T, Kudo T, Ogata K, Hamada M, Nakamura M, Kito K, Abe Y, Ueda N, Yamamoto M, Engel JD, Takahashi S, Neither MafA/L-Maf nor MafB is essential for lens development in mice. Genes Cells. 2009 Aug;14(8):941-7
2	J:194895 Upadhya D, Ogata M, Reneker LW, MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development. Development. 2013 Apr;140(7):1573-82
4*	J:277247 Vetrivel S, Tiso N, Kugler A, Irmler M, Horsch M, Beckers J, Hladik D, Giesert F, Gailus-Durner V, Fuchs H, Sabrautzki S, Adler T, Treise I, Busch DH, Aguilar-Pimentel A, Ollert M, Gotz A, Amarie OV, Stoeger T, Schulz H, Becker L, Klopstock T, Schrewe A, Spielmann N, Bekeredjian R, Garrett L, Holter SM, Zimprich A, Wurst W, Mayer-Kuckuk P, Hans W, Rozman J, Klingenspor M, Neff F, da Silva-Buttkus P, Calzada-Wack J, Racz I, Zimmer A, Rathkolb B, Wolf E, Prehn C, Adamski J, Ostereicher M, Miller G, Steinkamp R, Lengger C, Maier H, Stoeger C, Leuchtenberger S, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Hrabe de Angelis M, Graw J, Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia. Exp Eye Res. 2019 Apr 13;
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
6	J:269956 Wada K, Matsushima Y, Tada T, Hasegawa S, Obara Y, Yoshizawa Y, Takahashi G, Hiai H, Shimanuki M, Suzuki S, Saitou J, Yamamoto N, Ichikawa M, Watanabe K, Kikkawa Y, Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice. PLoS One. 2014;9(10):e111432
1	J:165054 Wang WL, Li Q, Xu J, Cvekl A, Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis. Mol Biol Cell. 2010 Jul 15;21(14):2453-68
1	J:134299 Weng J, Luo J, Cheng X, Jin C, Zhou X, Qu J, Tu L, Ai D, Li D, Wang J, Martin JF, Amendt BA, Liu M, Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6081-6
1	J:170580 Wenzel PL, Chong JL, Saenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, Robinson ML, Leone G, Cell proliferation in the absence of E2F1-3. Dev Biol. 2011 Mar 1;351(1):35-45
1	J:189250 Widau RC, Zheng Y, Sung CY, Zelivianskaia A, Roach LE, Bachmeyer KM, Abramova T, Desgardin A, Rosner A, Cunningham JM, Skapek SX, p19Arf Represses Platelet-Derived Growth Factor Receptor beta by Transcriptional and Posttranscriptional Mechanisms. Mol Cell Biol. 2012 Nov;32(21):4270-82
2	J:53431 Wigle JT, Chowdhury K, Gruss P, Oliver G, Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet. 1999 Mar;21(3):318-22
2	J:211220 Wolf L, Harrison W, Huang J, Xie Q, Xiao N, Sun J, Kong L, Lachke SA, Kuracha MR, Govindarajan V, Brindle PK, Ashery-Padan R, Beebe DC, Overbeek PA, Cvekl A, Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Res. 2013 Dec;41(22):10199-214
5	J:142719 Wolf L, Yang Y, Wawrousek E, Cvekl A, Transcriptional regulation of mouse alpha A-crystallin gene in a 148kb Cryaa BAC and its derivates. BMC Dev Biol. 2008;8:88
1	J:178731 Xie Q, Cvekl A, The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71
1*	J:314897 Xie Q, McGreal R, Harris R, Gao CY, Liu W, Reneker LW, Musil LS, Cvekl A, Regulation of c-Maf and alphaA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling. J Biol Chem. 2016 Feb 19;291(8):3947-58
2	J:82312 Yamada R, Mizutani-Koseki Y, Hasegawa T, Osumi N, Koseki H, Takahashi N, Cell-autonomous involvement of Mab21l1 is essential for lens placode development. Development. 2003 May;130(9):1759-70
1	J:93910 Yamada R, Mizutani-Koseki Y, Koseki H, Takahashi N, Requirement for Mab21l2 during development of murine retina and ventral body wall. Dev Biol. 2004 Oct 15;274(2):295-307
1	J:101730 Yoshimoto A, Saigou Y, Higashi Y, Kondoh H, Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation. Development. 2005 Oct;132(20):4437-48
1	J:148890 Zhang B, Chang J, Fu M, Huang J, Kashyap R, Salavaggione E, Jain S, Shashikant K, Deardorff MA, Uzielli ML, Dorsett D, Beebe DC, Jay PY, Heuckeroth RO, Krantz I, Milbrandt J, Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. PLoS One. 2009;4(5):e5232
1	J:197830 Zhang R, Huang H, Cao P, Wang Z, Chen Y, Pan Y, Sma- and Mad-related protein 7 (Smad7) is required for embryonic eye development in the mouse. J Biol Chem. 2013 Apr 12;288(15):10275-85
1	J:141138 Zhang Y, Burgess D, Overbeek PA, Govindarajan V, Dominant inhibition of lens placode formation in mice. Dev Biol. 2008 Nov 1;323(1):53-63
1	J:106041 Zhao H, Yang Y, Partanen J, Ciruna BG, Rossant J, Robinson ML, Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice. Mol Vis. 2006;12:15-25