Gene Expression Literature Summary

• Symbol: Cryab
• Name: crystallin, alpha B
• ID: MGI:88516

61 matching records from 61 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16.5	E17.5	E18	E18.5	E19.5	P
Immunohistochemistry (section)			1	1			1	2	3	2	6	5	1	4	1	4	1	2		1	1	11
In situ RNA (section)	1	1	1		2		2		5		3	2		5		4	1					4
In situ RNA (whole mount)				1		1	1
Northern blot																						1
Western blot															1					1		6
RT-PCR			1						1		3	2		3		5	2	1	1	1		9
cDNA clones									1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cryab  crystallin, alpha B   (Synonyms: alpha B-crystallin, Crya-2, Crya2, HspB5)
Results	Reference
1	J:237492 Antosova B, Smolikova J, Klimova L, Lachova J, Bendova M, Kozmikova I, Machon O, Kozmik Z, The Gene Regulatory Network of Lens Induction Is Wired through Meis-Dependent Shadow Enhancers of Pax6. PLoS Genet. 2016 Dec;12(12):e1006441
15*	J:37520 Benjamin IJ, Shelton J, Garry DJ, Richardson JA, Temporospatial expression of the small HSP/alpha B-crystallin in cardiac and skeletal muscle during mouse development. Dev Dyn. 1997 Jan;208(1):75-84
3*	J:63706 Brownell I, Dirksen M, Jamrich M, Forkhead Foxe3 maps to the dysgenetic lens locus and is critical in lens development and differentiation. Genesis. 2000 Jun;27(2):81-93
2	J:306180 Cai W, Zhang J, de Lange WJ, Gregorich ZR, Karp H, Farrell ET, Mitchell SD, Tucholski T, Lin Z, Biermann M, McIlwain SJ, Ralphe JC, Kamp TJ, Ge Y, An Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes. Circ Res. 2019 Nov 8;125(11):936-953
1	J:139969 Cain S, Martinez G, Kokkinos MI, Turner K, Richardson RJ, Abud HE, Huelsken J, Robinson ML, de Iongh RU, Differential requirement for beta-catenin in epithelial and fiber cells during lens development. Dev Biol. 2008 Sep 15;321(2):420-33
1	J:182769 Carbe C, Hertzler-Schaefer K, Zhang X, The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Dev Biol. 2012 Mar 1;363(1):320-9
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
2	J:73524 Dimanlig PV, Faber SC, Auerbach W, Makarenkova HP, Lang RA, The upstream ectoderm enhancer in Pax6 has an important role in lens induction. Development. 2001 Nov;128(22):4415-24
1	J:31366 Fromm L, Overbeek PA, Regulation of cyclin and cyclin-dependent kinase gene expression during lens differentiation requires the retinoblastoma protein. Oncogene. 1996 Jan 4;12(1):69-75
2	J:93301 Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S, Kato K, Yonemura S, Inouye S, Nakai A, HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 2004 Nov 27;23(21):4297-306
2*	J:35178 Haynes JI 2nd, Duncan MK, Piatigorsky J, Spatial and temporal activity of the alpha B-crystallin/small heat shock protein gene promoter in transgenic mice. Dev Dyn. 1996 Sep;207(1):75-88
1	J:259186 Heng X, Guo Q, Leung AW, Li JY, Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Elife. 2017 May 10;6:e23253
1	J:264903 Hoang TV, Horowitz ER, Chaffee BR, Qi P, Flake RE, Bruney DG, Rasor BJ, Rosalez SE, Wagner BD, Robinson ML, Lens development requires DNMT1 but takes place normally in the absence of both DNMT3A and DNMT3B activity. Epigenetics. 2017 Jan 2;12(1):27-40
5	J:184297 Hu WF, Gong L, Cao Z, Ma H, Ji W, Deng M, Liu M, Hu XH, Chen P, Yan Q, Chen HG, Liu J, Sun S, Zhang L, Liu JP, Wawrousek E, Li DW, alphaA- and alphaB-crystallins interact with caspase-3 and Bax to guard mouse lens development. Curr Mol Med. 2012 Feb;12(2):177-87
1	J:125325 Huang L, Min JN, Masters S, Mivechi NF, Moskophidis D, Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption. Genesis. 2007 Aug;45(8):487-501
2*	J:56095 Kawauchi S, Takahashi S, Nakajima O, Ogino H, Morita M, Nishizawa M, Yasuda K, Yamamoto M, Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem. 1999 Jul 2;274(27):19254-60
2*	J:175263 Kenchegowda D, Swamynathan S, Gupta D, Wan H, Whitsett J, Swamynathan SK, Conditional disruption of mouse Klf5 results in defective eyelids with malformed meibomian glands, abnormal cornea and loss of conjunctival goblet cells. Dev Biol. 2011 Aug 1;356(1):5-18
1*	J:80609 Kim SW, Cheong C, Sohn YC, Goo YH, Oh WJ, Park JH, Joe SY, Kang HS, Kim DK, Kee C, Lee JW, Lee HW, Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol. 2002 Dec;22(24):8409-14
1	J:310318 Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X, Frs2alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci. 2014 Feb 1;127(Pt 3):571-82
3	J:157314 Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS, Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biol. 2009;10(10):R104
2	J:296151 Liu J, Chanumolu SK, White KM, Albahrani M, Otu HH, Nawshad A, Transcriptional analysis of cleft palate in TGFbeta3 mutant mice. Sci Rep. 2020 Sep 10;10(1):14940
2	J:165593 Liu Y, Kawai K, Khashabi S, Deng C, Liu YH, Yiu S, Inactivation of Smad4 leads to impaired ocular development and cataract formation. Biochem Biophys Res Commun. 2010 Oct 1;400(4):476-82
1*	J:52895 Loones MT, Morange M, Hsp and chaperone distribution during endochondral bone development in mouse embryo. Cell Stress Chaperones. 1998 Dec;3(4):237-44
1	J:158407 Machon O, Kreslova J, Ruzickova J, Vacik T, Klimova L, Fujimura N, Lachova J, Kozmik Z, Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm. Genesis. 2010 Feb;48(2):86-95
1	J:151537 Maeda A, Moriguchi T, Hamada M, Kusakabe M, Fujioka Y, Nakano T, Yoh K, Lim KC, Engel JD, Takahashi S, Transcription factor GATA-3 is essential for lens development. Dev Dyn. 2009 Jul 21;238(9):2280-2291
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:242077 Mao M, Kiss M, Ou Y, Gould DB, Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse. Dis Model Mech. 2017 Apr 01;10(4):475-485
1	J:326946 Martin JB, Herman K, Houssin NS, Rich W, Reilly MA, Plageman TF Jr, Arvcf Dependent Adherens Junction Stability is Required to Prevent Age-Related Cortical Cataracts. Front Cell Dev Biol. 2022;10:840129
2	J:154998 Mascarenhas MI, Parker A, Dzierzak E, Ottersbach K, Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling. Blood. 2009 Nov 19;114(21):4645-53
1	J:101355 Medina-Martinez O, Brownell I, Amaya-Manzanares F, Hu Q, Behringer RR, Jamrich M, Severe defects in proliferation and differentiation of lens cells in Foxe3 null mice. Mol Cell Biol. 2005 Oct;25(20):8854-63
1	J:151273 Medina-Martinez O, Shah R, Jamrich M, Pitx3 controls multiple aspects of lens development. Dev Dyn. 2009 Mar 30;238(9):2193-2201
1*	J:74121 Meeson AP, Radford N, Shelton JM, Mammen PP, DiMaio JM, Hutcheson K, Kong Y, Elterman J, Williams RS, Garry DJ, Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circ Res. 2001 Apr 13;88(7):713-20
1*	J:205051 Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Sestan N, Gage FH, Lein ES, Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
6	J:95535 Min JN, Zhang Y, Moskophidis D, Mivechi NF, Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Genesis. 2004 Dec;40(4):205-17
2	J:320375 Mirigian LS, Makareeva E, Mertz EL, Omari S, Roberts-Pilgrim AM, Oestreich AK, Phillips CL, Leikin S, Osteoblast Malfunction Caused by Cell Stress Response to Procollagen Misfolding in alpha2(I)-G610C Mouse Model of Osteogenesis Imperfecta. J Bone Miner Res. 2016 Aug;31(8):1608-1616
1*	J:19995 Morgenbesser SD, Williams BO, Jacks T, DePinho RA, p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens [see comments]. Nature. 1994 Sep 1;371(6492):72-4
2	J:46636 Nishiguchi S, Wood H, Kondoh H, Lovell-Badge R, Episkopou V, Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev. 1998 Mar 15;12(6):776-81
1	J:150768 Okado H, Ohtaka-Maruyama C, Sugitani Y, Fukuda Y, Ishida R, Hirai S, Miwa A, Takahashi A, Aoki K, Mochida K, Suzuki O, Honda T, Nakajima K, Ogawa M, Terashima T, Matsuda J, Kawano H, Kasai M, The transcriptional repressor RP58 is crucial for cell-division patterning and neuronal survival in the developing cortex. Dev Biol. 2009 Jul 15;331(2):140-51
1	J:305082 Pathak P, Blech-Hermoni Y, Subedi K, Mpamugo J, Obeng-Nyarko C, Ohman R, Molloy I, Kates M, Hale J, Stauffer S, Sharan SK, Mankodi A, Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCalpha and TSC2-mTOR downregulation. Commun Biol. 2021 Mar 19;4(1):355
1*	J:170493 Pfister S, Jones VJ, Power M, Truisi GL, Khoo PL, Steiner KA, Kanai-Azuma M, Kanai Y, Tam PP, Loebel DA, Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos. Int J Dev Biol. 2011;55(1):45-58
3*	J:56583 Ring BZ, Cordes SP, Overbeek PA, Barsh GS, Regulation of mouse lens fiber cell development and differentiation by the Maf gene. Development. 2000 Jan;127(2):307-17
8	J:36380 Robinson ML, Overbeek PA, Differential expression of alpha A- and alpha B-crystallin during murine ocular development. Invest Ophthalmol Vis Sci. 1996 Oct;37(11):2276-84
1	J:146692 Saint-Geniez M, Kurihara T, D'Amore PA, Role of cell and matrix-bound VEGF isoforms in lens development. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):311-21
2	J:115522 Sandilands A, Hutcheson AM, Long HA, Prescott AR, Vrensen G, Loster J, Klopp N, Lutz RB, Graw J, Masaki S, Dobson CM, MacPhee CE, Quinlan RA, Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J. 2002 Nov 15;21(22):6005-14
1	J:152850 Shaham O, Smith AN, Robinson ML, Taketo MM, Lang RA, Ashery-Padan R, Pax6 is essential for lens fiber cell differentiation. Development. 2009 Aug;136(15):2567-78
2*	J:141960 Swindell EC, Liu C, Shah R, Smith AN, Lang RA, Jamrich M, Eye formation in the absence of retina. Dev Biol. 2008 Oct 1;322(1):56-64
1*	J:158257 Takeuchi T, Kudo T, Ogata K, Hamada M, Nakamura M, Kito K, Abe Y, Ueda N, Yamamoto M, Engel JD, Takahashi S, Neither MafA/L-Maf nor MafB is essential for lens development in mice. Genes Cells. 2009 Aug;14(8):941-7
1	J:306633 Tsyporin J, Tastad D, Ma X, Nehme A, Finn T, Huebner L, Liu G, Gallardo D, Makhamreh A, Roberts JM, Katzman S, Sestan N, McConnell SK, Yang Z, Qiu S, Chen B, Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons. Cell Rep. 2021 Jun;35
2	J:194895 Upadhya D, Ogata M, Reneker LW, MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development. Development. 2013 Apr;140(7):1573-82
1*	J:302089 Vezzali R, Weise SC, Hellbach N, Machado V, Heidrich S, Vogel T, The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons. Oncotarget. 2016 Jun 21;7(25):37436-37455
6	J:269956 Wada K, Matsushima Y, Tada T, Hasegawa S, Obara Y, Yoshizawa Y, Takahashi G, Hiai H, Shimanuki M, Suzuki S, Saitou J, Yamamoto N, Ichikawa M, Watanabe K, Kikkawa Y, Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice. PLoS One. 2014;9(10):e111432
1	J:165054 Wang WL, Li Q, Xu J, Cvekl A, Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis. Mol Biol Cell. 2010 Jul 15;21(14):2453-68
1	J:170580 Wenzel PL, Chong JL, Saenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, Robinson ML, Leone G, Cell proliferation in the absence of E2F1-3. Dev Biol. 2011 Mar 1;351(1):35-45
1	J:53431 Wigle JT, Chowdhury K, Gruss P, Oliver G, Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet. 1999 Mar;21(3):318-22
2	J:211220 Wolf L, Harrison W, Huang J, Xie Q, Xiao N, Sun J, Kong L, Lachke SA, Kuracha MR, Govindarajan V, Brindle PK, Ashery-Padan R, Beebe DC, Overbeek PA, Cvekl A, Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Res. 2013 Dec;41(22):10199-214
1	J:178731 Xie Q, Cvekl A, The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71
1*	J:314897 Xie Q, McGreal R, Harris R, Gao CY, Liu W, Reneker LW, Musil LS, Cvekl A, Regulation of c-Maf and alphaA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling. J Biol Chem. 2016 Feb 19;291(8):3947-58
1	J:101730 Yoshimoto A, Saigou Y, Higashi Y, Kondoh H, Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation. Development. 2005 Oct;132(20):4437-48
2	J:293760 Yu W, Yu Z, Wu D, Zhang J, Zhu Y, Zhang Y, Ning H, Wang M, Zhang J, Zhao J, Lens-specific conditional knockout of Msx2 in mice leads to ocular anterior segment dysgenesis via activation of a calcium signaling pathway. Lab Invest. 2019 Nov;99(11):1714-1727
1	J:106041 Zhao H, Yang Y, Partanen J, Ciruna BG, Rossant J, Robinson ML, Fibroblast growth factor receptor 1 (Fgfr1) is not essential for lens fiber differentiation in mice. Mol Vis. 2006;12:15-25
1	J:263025 Zoupa M, Xavier GM, Bryan S, Theologidis I, Arno M, Cobourne MT, Gene expression profiling in the developing secondary palate in the absence of Tbx1 function. BMC Genomics. 2018 Jun 4;19(1):429