Gene Expression Literature Summary

• Symbol: Cryg
• Name: crystallin gamma complex
• ID: MGI:88520

35 matching records from 35 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10.5	E11.5	E12.5	E13	E13.5	E14.5	E15.5	E16.5	E17.5	P
Immunohistochemistry (section)	1	1	9	1	3	8	5	9	2	11
In situ RNA (section)					1	1	1		1	1
Western blot										2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cryg  crystallin gamma complex
Results	Reference
1	J:274581 Agrawal SA, Anand D, Siddam AD, Kakrana A, Dash S, Scheiblin DA, Dang CA, Terrell AM, Waters SM, Singh A, Motohashi H, Yamamoto M, Lachke SA, Compound mouse mutants of bZIP transcription factors Mafg and Mafk reveal a regulatory network of non-crystallin genes associated with cataract. Hum Genet. 2015 Jul;134(7):717-35
4*	J:205268 Ahmad N, Aslam M, Muenster D, Horsch M, Khan MA, Carlsson P, Beckers J, Graw J, Pitx3 directly regulates Foxe3 during early lens development. Int J Dev Biol. 2013;57(9-10):741-51
2	J:251150 Aoki H, Ogino H, Tomita H, Hara A, Kunisada T, Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells. PLoS One. 2016;11(9):e0163042
1	J:228518 Arya P, Rainey MA, Bhattacharyya S, Mohapatra BC, George M, Kuracha MR, Storck MD, Band V, Govindarajan V, Band H, The endocytic recycling regulatory protein EHD1 Is required for ocular lens development. Dev Biol. 2015 Dec 1;408(1):41-55
1	J:212971 Cavalheiro GR, Matos-Rodrigues GE, Gomes AL, Rodrigues PM, Martins RA, c-myc regulates cell proliferation during lens development. PLoS One. 2014;9(2):e87182
1	J:74730 Chen Q, Ash JD, Branton P, Fromm L, Overbeek PA, Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice. Oncogene. 2002 Feb 7;21(7):1028-37
4*	J:225905 Dash S, Dang CA, Beebe DC, Lachke SA, Deficiency of the RNA binding protein caprin2 causes lens defects and features of peters anomaly. Dev Dyn. 2015 Oct;244(10):1313-27
3*	J:253196 Dubail J, Vasudevan D, Wang LW, Earp SE, Jenkins MW, Haltiwanger RS, Apte SS, Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome. Sci Rep. 2016 Sep 30;6:33974
1*	J:77444 Faber SC, Robinson ML, Makarenkova HP, Lang RA, Bmp signaling is required for development of primary lens fiber cells. Development. 2002 Aug;129(15):3727-37
1	J:31366 Fromm L, Overbeek PA, Regulation of cyclin and cyclin-dependent kinase gene expression during lens differentiation requires the retinoblastoma protein. Oncogene. 1996 Jan 4;12(1):69-75
1	J:168483 He S, Pirity MK, Wang WL, Wolf L, Chauhan BK, Cveklova K, Tamm ER, Ashery-Padan R, Metzger D, Nakai A, Chambon P, Zavadil J, Cvekl A, Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics Chromatin. 2010;3(1):21
1	J:312372 Karnam S, Maddala R, Stiber JA, Rao PV, Drebrin, an actin-binding protein, is required for lens morphogenesis and growth. Dev Dyn. 2021 Nov;250(11):1600-1617
1*	J:56095 Kawauchi S, Takahashi S, Nakajima O, Ogino H, Morita M, Nishizawa M, Yasuda K, Yamamoto M, Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem. 1999 Jul 2;274(27):19254-60
1	J:214344 Kerr CL, Zaveri MA, Robinson ML, Williams T, West-Mays JA, AP-2alpha is required after lens vesicle formation to maintain lens integrity. Dev Dyn. 2014 Oct;243(10):1298-309
2	J:181272 Le TT, Conley KW, Mead TJ, Rowan S, Yutzey KE, Brown NL, Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Dev Dyn. 2012 Mar;241(3):493-504
1	J:310318 Li H, Tao C, Cai Z, Hertzler-Schaefer K, Collins TN, Wang F, Feng GS, Gotoh N, Zhang X, Frs2alpha and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci. 2014 Feb 1;127(Pt 3):571-82
1*	J:226036 Maddala R, Nagendran T, Lang RA, Morozov A, Rao PV, Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. Dev Biol. 2015 Oct 1;406(1):74-91
1	J:151537 Maeda A, Moriguchi T, Hamada M, Kusakabe M, Fujioka Y, Nakano T, Yoh K, Lim KC, Engel JD, Takahashi S, Transcription factor GATA-3 is essential for lens development. Dev Dyn. 2009 Jul 21;238(9):2280-2291
1*	J:23615 Morgenbesser SD, Schreiber-Agus N, Bidder M, Mahon KA, Overbeek PA, Horner J, DePinho RA, Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo. EMBO J. 1995 Feb 15;14(4):743-56
2*	J:328989 Patel SD, Anand D, Motohashi H, Katsuoka F, Yamamoto M, Lachke SA, Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects. Front Cell Dev Biol. 2022;10:981893
2	J:236785 Pathania M, Wang Y, Simirskii VN, Duncan MK, beta1-integrin controls cell fate specification in early lens development. Differentiation. 2016 Oct - Nov;92(4):133-147
1	J:173640 Qu X, Hertzler K, Pan Y, Grobe K, Robinson ML, Zhang X, Genetic epistasis between heparan sulfate and FGF-Ras signaling controls lens development. Dev Biol. 2011 Jul 1;355(1):12-20
1	J:270142 Rasiah PK, Maddala R, Bennett V, Rao PV, Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth. Dev Biol. 2019 Feb 1;446(1):119-131
1*	J:95070 Reneker LW, Xie L, Xu L, Govindarajan V, Overbeek PA, Activated Ras induces lens epithelial cell hyperplasia but not premature differentiation. Int J Dev Biol. 2004;48(8-9):879-88
1*	J:56583 Ring BZ, Cordes SP, Overbeek PA, Barsh GS, Regulation of mouse lens fiber cell development and differentiation by the Maf gene. Development. 2000 Jan;127(2):307-17
1*	J:160146 Rowan S, Siggers T, Lachke SA, Yue Y, Bulyk ML, Maas RL, Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity. Genes Dev. 2010 May 15;24(10):980-5
5	J:33890 Santhiya ST, Abd-alla SM, Loster J, Graw J, Reduced levels of gamma-crystallin transcripts during embryonic development of murine Cat2nop mutant lenses. Graefes Arch Clin Exp Ophthalmol. 1995 Dec;233(12):795-800
1*	J:335071 Siddam AD, Duot M, Coomson SY, Anand D, Aryal S, Weatherbee BAT, Audic Y, Paillard L, Lachke SA, High-Throughput Transcriptomics of Celf1 Conditional Knockout Lens Identifies Downstream Networks Linked to Cataract Pathology. Cells. 2023 Apr 1;12(7)
1	J:122566 Simirskii VN, Wang Y, Duncan MK, Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype. Dev Biol. 2007 Jun 15;306(2):658-68
3	J:343554 Sun Q, Li J, Ma J, Zheng Y, Ju R, Li X, Ren X, Huang L, Chen R, Tan X, Luo L, JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development. Invest Ophthalmol Vis Sci. 2023 Dec 1;64(15):15
2	J:194895 Upadhya D, Ogata M, Reneker LW, MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development. Development. 2013 Apr;140(7):1573-82
1*	J:286739 Wazin F, Lovicu FJ, The negative regulatory Spred1 and Spred2 proteins are required for lens and eye morphogenesis. Exp Eye Res. 2020 Feb;191:107917
4	J:345586 Wazin F, Lovicu FJ, Conditional Ablation of Spred1 and Spred2 in the Eye Lens Negatively Impacts Its Development and Growth. Cells. 2024 Feb 6;13(4)
1	J:170580 Wenzel PL, Chong JL, Saenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, Robinson ML, Leone G, Cell proliferation in the absence of E2F1-3. Dev Biol. 2011 Mar 1;351(1):35-45
1	J:83385 Weston CR, Wong A, Hall JP, Goad ME, Flavell RA, Davis RJ, JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure. Genes Dev. 2003 May 15;17(10):1271-80