Gene Expression Literature Summary

• Symbol: Cryga
• Name: crystallin, gamma A
• ID: MGI:88521

23 matching records from 23 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E17.5	E	P
Immunohistochemistry (section)		1		3		1		1					1
In situ RNA (section)				3		3				1		1	1
In situ RNA (whole mount)				1
Northern blot	1						1		1				2
Western blot								1					2
RT-PCR		1	1	4	3	5		7	1	2	1		7

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cryga  crystallin, gamma A   (Synonyms: Cryg-4, DGcry-4, Secc)
Results	Reference
4	J:251150 Aoki H, Ogino H, Tomita H, Hara A, Kunisada T, Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells. PLoS One. 2016;11(9):e0163042
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3	J:93301 Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S, Kato K, Yonemura S, Inouye S, Nakai A, HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 2004 Nov 27;23(21):4297-306
2	J:290269 Garg A, Hannan A, Wang Q, Makrides N, Zhong J, Li H, Yoon S, Mao Y, Zhang X, Etv transcription factors functionally diverge from their upstream FGF signaling in lens development. Elife. 2020 Feb 11;9:e51915
5*	J:17072 Goring DR, Breitman ML, Tsui LC, Temporal regulation of six crystallin transcripts during mouse lens development. Exp Eye Res. 1992 May;54(5):785-95
4*	J:58912 Graw J, Jung M, Loster J, Klopp N, Soewarto D, Fella C, Fuchs H, Reis A, Wolf E, Balling R, Hrabe de Angelis M, Mutation in the betaA3/A1-crystallin encoding gene Cryba1 causes a dominant cataract in the mouse. Genomics. 1999 Nov 15;62(1):67-73
2*	J:144758 Ho HY, Chang KH, Nichols J, Li M, Homeodomain protein Pitx3 maintains the mitotic activity of lens epithelial cells. Mech Dev. 2009 Jan-Feb;126(1-2):18-29
1	J:56095 Kawauchi S, Takahashi S, Nakajima O, Ogino H, Morita M, Nishizawa M, Yasuda K, Yamamoto M, Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem. 1999 Jul 2;274(27):19254-60
1*	J:80609 Kim SW, Cheong C, Sohn YC, Goo YH, Oh WJ, Park JH, Joe SY, Kang HS, Kim DK, Kee C, Lee JW, Lee HW, Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol. 2002 Dec;22(24):8409-14
4*	J:270646 Limi S, Senecal A, Coleman R, Lopez-Jones M, Guo P, Polumbo C, Singer RH, Skoultchi AI, Cvekl A, Transcriptional burst fraction and size dynamics during lens fiber cell differentiation and detailed insights into the denucleation process. J Biol Chem. 2018 Aug 24;293(34):13176-13190
1	J:151537 Maeda A, Moriguchi T, Hamada M, Kusakabe M, Fujioka Y, Nakano T, Yoh K, Lim KC, Engel JD, Takahashi S, Transcription factor GATA-3 is essential for lens development. Dev Dyn. 2009 Jul 21;238(9):2280-2291
1*	J:331971 Martynova E, Zhao Y, Xie Q, Zheng D, Cvekl A, Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3. Open Biol. 2019 Dec;9(12):190220
3	J:151273 Medina-Martinez O, Shah R, Jamrich M, Pitx3 controls multiple aspects of lens development. Dev Dyn. 2009 Mar 30;238(9):2193-2201
6	J:95535 Min JN, Zhang Y, Moskophidis D, Mivechi NF, Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Genesis. 2004 Dec;40(4):205-17
3*	J:84601 Murer-Orlando M, Paterson RC, Lok S, Tsui LC, Breitman ML, Differential regulation of gamma-crystallin genes during mouse lens development. Dev Biol. 1987 Jan;119(1):260-7
2	J:46636 Nishiguchi S, Wood H, Kondoh H, Lovell-Badge R, Episkopou V, Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev. 1998 Mar 15;12(6):776-81
5	J:115522 Sandilands A, Hutcheson AM, Long HA, Prescott AR, Vrensen G, Loster J, Klopp N, Lutz RB, Graw J, Masaki S, Dobson CM, MacPhee CE, Quinlan RA, Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J. 2002 Nov 15;21(22):6005-14
1	J:91136 Tasheva ES, Ke A, Deng Y, Jun C, Takemoto LJ, Koester A, Conrad GW, Differentially expressed genes in the lens of mimecan-null mice. Mol Vis. 2004 Jun 17;10:403-16
4	J:269956 Wada K, Matsushima Y, Tada T, Hasegawa S, Obara Y, Yoshizawa Y, Takahashi G, Hiai H, Shimanuki M, Suzuki S, Saitou J, Yamamoto N, Ichikawa M, Watanabe K, Kikkawa Y, Expression of truncated PITX3 in the developing lens leads to microphthalmia and aphakia in mice. PLoS One. 2014;9(10):e111432
1	J:53431 Wigle JT, Chowdhury K, Gruss P, Oliver G, Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet. 1999 Mar;21(3):318-22
1	J:178731 Xie Q, Cvekl A, The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71
1	J:82312 Yamada R, Mizutani-Koseki Y, Hasegawa T, Osumi N, Koseki H, Takahashi N, Cell-autonomous involvement of Mab21l1 is essential for lens placode development. Development. 2003 May;130(9):1759-70
1	J:93910 Yamada R, Mizutani-Koseki Y, Koseki H, Takahashi N, Requirement for Mab21l2 during development of murine retina and ventral body wall. Dev Biol. 2004 Oct 15;274(2):295-307