Gene Expression Literature Summary

• Symbol: Crygb
• Name: crystallin, gamma B
• ID: MGI:88522

17 matching records from 17 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E10	E10.5	E11.5	E12	E12.5	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	P
Immunohistochemistry (section)					1	2	2		1				1	1
In situ RNA (section)			1						1					1
Northern blot	1							1		1				2
Western blot									1					2
RT-PCR		1		1	3	2	3		5	1	2	1	1	5

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Crygb  crystallin, gamma B   (Synonyms: Cryg-3, DGcry-3)
Results	Reference
4	J:251150 Aoki H, Ogino H, Tomita H, Hara A, Kunisada T, Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells. PLoS One. 2016;11(9):e0163042
2	J:321232 Dash S, Brastrom LK, Patel SD, Scott CA, Slusarski DC, Lachke SA, The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development. Hum Mol Genet. 2020 Mar 13;29(4):591-604
1	J:126208 DePianto DJ, Blankenship TN, Hess JF, FitzGerald PG, Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice. Mol Vis. 2003 Jun 30;9:288-94
3	J:93301 Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S, Kato K, Yonemura S, Inouye S, Nakai A, HSF4 is required for normal cell growth and differentiation during mouse lens development. EMBO J. 2004 Nov 27;23(21):4297-306
5*	J:17072 Goring DR, Breitman ML, Tsui LC, Temporal regulation of six crystallin transcripts during mouse lens development. Exp Eye Res. 1992 May;54(5):785-95
1*	J:56095 Kawauchi S, Takahashi S, Nakajima O, Ogino H, Morita M, Nishizawa M, Yasuda K, Yamamoto M, Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem. 1999 Jul 2;274(27):19254-60
1*	J:80609 Kim SW, Cheong C, Sohn YC, Goo YH, Oh WJ, Park JH, Joe SY, Kang HS, Kim DK, Kee C, Lee JW, Lee HW, Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: implication for posterior lenticonus with cataract. Mol Cell Biol. 2002 Dec;22(24):8409-14
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1*	J:331971 Martynova E, Zhao Y, Xie Q, Zheng D, Cvekl A, Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3. Open Biol. 2019 Dec;9(12):190220
3	J:95535 Min JN, Zhang Y, Moskophidis D, Mivechi NF, Unique contribution of heat shock transcription factor 4 in ocular lens development and fiber cell differentiation. Genesis. 2004 Dec;40(4):205-17
3*	J:84601 Murer-Orlando M, Paterson RC, Lok S, Tsui LC, Breitman ML, Differential regulation of gamma-crystallin genes during mouse lens development. Dev Biol. 1987 Jan;119(1):260-7
2	J:46636 Nishiguchi S, Wood H, Kondoh H, Lovell-Badge R, Episkopou V, Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice. Genes Dev. 1998 Mar 15;12(6):776-81
8	J:115522 Sandilands A, Hutcheson AM, Long HA, Prescott AR, Vrensen G, Loster J, Klopp N, Lutz RB, Graw J, Masaki S, Dobson CM, MacPhee CE, Quinlan RA, Altered aggregation properties of mutant gamma-crystallins cause inherited cataract. EMBO J. 2002 Nov 15;21(22):6005-14
1	J:53431 Wigle JT, Chowdhury K, Gruss P, Oliver G, Prox1 function is crucial for mouse lens-fibre elongation. Nat Genet. 1999 Mar;21(3):318-22
1	J:178731 Xie Q, Cvekl A, The Orchestration of Mammalian Tissue Morphogenesis through a Series of Coherent Feed-forward Loops. J Biol Chem. 2011 Dec 16;286(50):43259-71
1*	J:314897 Xie Q, McGreal R, Harris R, Gao CY, Liu W, Reneker LW, Musil LS, Cvekl A, Regulation of c-Maf and alphaA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling. J Biol Chem. 2016 Feb 19;291(8):3947-58
4	J:350084 Zhang L, Liu X, Li W, Liu K, Zhang J, Liu X, Wang J, Integrative transcriptomic profiling of ncRNAs and mRNAs in developing mouse lens. Front Genet. 2024;15:1405715