Gene Expression Literature Summary

• Symbol: Ctsd
• Name: cathepsin D
• ID: MGI:88562

27 matching records from 27 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7	E7.5	E8	E9	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15.5	E16.5	E17.5	E18.5	E19.5	P
Immunohistochemistry (section)		1	1		1	1		1	1											4
In situ RNA (section)			1		1		1	3	2	1	1	1	1	3	1	1				3
In situ RNA (whole mount)									1						1
Northern blot			1	1
Western blot			1	1					1							1		2		8
RT-PCR		1						1		1		1		2	2	1	2	1	1	4
cDNA clones	1															1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ctsd  cathepsin D   (Synonyms: CatD, CD)
Results	Reference
11*	J:58845 Afonso S, Romagnano L, Babiarz B, Expression of cathepsin proteinases by mouse trophoblast in vivo and in vitro. Dev Dyn. 1999 Dec;216(4-5):374-84
2	J:183077 Amarante-Paffaro AM, Hoshida MS, Yokota S, Goncalves CR, Joazeiro PP, Bevilacqua E, Yamada AT, Localization of cathepsins D and B at the maternal-fetal interface and the invasiveness of the trophoblast during the postimplantation period in the mouse. Cells Tissues Organs. 2011;193(6):417-25
9*	J:173463 Bejarano-Escobar R, Holguin-Arevalo MS, Montero JA, Francisco-Morcillo J, Martin-Partido G, Macrophage and microglia ontogeny in the mouse visual system can be traced by the expression of Cathepsins B and D. Dev Dyn. 2011 Jul;240(7):1841-55
2	J:335426 Butera A, Agostini M, Cassandri M, De Nicola F, Fanciulli M, D'Ambrosio L, Falasca L, Nardacci R, Wang L, Piacentini M, Knight RA, Jia W, Sun Q, Shi Y, Wang Y, Candi E, Melino G, ZFP750 affects the cutaneous barrier through regulating lipid metabolism. Sci Adv. 2023 Apr 28;9(17):eadg5423
1	J:305611 Castroflorio E, den Hoed J, Svistunova D, Finelli MJ, Cebrian-Serrano A, Corrochano S, Bassett AR, Davies B, Oliver PL, The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour. Cell Mol Life Sci. 2021 Apr;78(7):3503-3524
1	J:309362 Cochrane CR, Vaghjiani V, Szczepny A, Jayasekara WSN, Gonzalez-Rajal A, Kikuchi K, McCaughan GW, Burgess A, Gough DJ, Watkins DN, Cain JE, Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling. J Clin Invest. 2020 Aug 3;130(8):4006-4018
1	J:161201 Gao N, Kaestner KH, Cdx2 regulates endo-lysosomal function and epithelial cell polarity. Genes Dev. 2010 Jun 15;24(12):1295-305
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1	J:296116 Hirose T, Cabrera-Socorro A, Chitayat D, Lemonnier T, Feraud O, Cifuentes-Diaz C, Gervasi N, Mombereau C, Ghosh T, Stoica L, Bacha JDA, Yamada H, Lauterbach MA, Guillon M, Kaneko K, Norris JW, Siriwardena K, Blaser S, Teillon J, Mendoza-Londono R, Russeau M, Hadoux J, Ito S, Corvol P, Matheus MG, Holden KR, Takei K, Emiliani V, Bennaceur-Griscelli A, Schwartz CE, Nguyen G, Groszer M, ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration. J Clin Invest. 2019 Apr 15;129(5):2145-2162
3*	J:102103 Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T, A neurogenomics approach to gene expression analysis in the developing brain. Brain Res Mol Brain Res. 2004 Dec 20;132(2):116-27
2	J:150394 Jouret F, Auzanneau C, Debaix H, Wada GH, Pretto C, Marbaix E, Karet FE, Courtoy PJ, Devuyst O, Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis. J Am Soc Nephrol. 2005 Nov;16(11):3235-46
2	J:222854 Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen JK, Gomez-Galan M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T, Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease. Nat Neurosci. 2015 Jun;18(6):826-35
9	J:311844 Landin MA, Nygard S, Shabestari MG, Babaie E, Reseland JE, Osmundsen H, Mapping the global mRNA transcriptome during development of the murine first molar. Front Genet. 2015;6:47
3	J:157314 Ling KH, Hewitt CA, Beissbarth T, Hyde L, Banerjee K, Cheah PS, Cannon PZ, Hahn CN, Thomas PQ, Smyth GK, Tan SS, Thomas T, Scott HS, Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Genome Biol. 2009;10(10):R104
1	J:317416 Liu J, Qi Y, Chao J, Sathuvalli P, Y Lee L, Li S, CREG1 promotes lysosomal biogenesis and function. Autophagy. 2021 Dec;17(12):4249-4265
1*	J:124592 Lu J, Qian J, Keppler D, Cardoso WV, Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis. J Biol Chem. 2007 Jul 27;282(30):22176-84
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
2	J:233172 Mehanna S, Suzuki C, Shibata M, Sunabori T, Imanaka T, Araki K, Yamamura K, Uchiyama Y, Ohmuraya M, Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity. Biochem Biophys Res Commun. 2016 Jan 15;469(3):405-11
1*	J:205051 Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Sestan N, Gage FH, Lein ES, Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
1*	J:198109 Oeschger FM, Wang WZ, Lee S, Garcia-Moreno F, Goffinet AM, Arbones ML, Rakic S, Molnar Z, Gene expression analysis of the embryonic subplate. Cereb Cortex. 2012 Jun;22(6):1343-59
1	J:212629 Papanicolaou KN, Kikuchi R, Ngoh GA, Coughlan KA, Dominguez I, Stanley WC, Walsh K, Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Circ Res. 2012 Sep 28;111(8):1012-26
1	J:186307 Peng C, Ye J, Yan S, Kong S, Shen Y, Li C, Li Q, Zheng Y, Deng K, Xu T, Tao W, Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem. 2012 Sep 21;287(39):32861-73
2	J:150220 Rodrigues P, Limback D, McGinnis LK, Plancha CE, Albertini DF, Multiple mechanisms of germ cell loss in the perinatal mouse ovary. Reproduction. 2009 Apr;137(4):709-20
1*	J:85207 Shirahama-Noda K, Yamamoto A, Sugihara K, Hashimoto N, Asano M, Nishimura M, Hara-Nishimura I, Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice. J Biol Chem. 2003 Aug 29;278(35):33194-9
1	J:130173 Wei P, Smeyne RJ, Bao D, Parris J, Morgan JI, Mapping of Cbln1-like immunoreactivity in adult and developing mouse brain and its localization to the endolysosomal compartment of neurons. Eur J Neurosci. 2007 Nov;26(10):2962-78
1*	J:32185 Yasuda Y, Nishi N, Takahashi JA, Konishi H, Ohara I, Fujita H, Ohta M, Itoh N, Hatanaka M, Tanimura T, Induction of avascular yolk sac due to reduction of basic fibroblast growth factor by retinoic acid in mice. Dev Biol. 1992 Apr;150(2):397-413
3*	J:116987 Zuzarte-Luis V, Montero JA, Kawakami Y, Izpisua-Belmonte JC, Hurle JM, Lysosomal cathepsins in embryonic programmed cell death. Dev Biol. 2007 Jan 1;301(1):205-17