Gene Expression Literature Summary

• Symbol: Ctsl
• Name: cathepsin L
• ID: MGI:88564

24 matching records from 24 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8	E8.5	E9	E9.5	E10	E10.5	E11.5	E12	E13.5	E14.5	E15.5	E16.5	E17.5	E18.5	E19.5	P
Immunohistochemistry (section)	1	2				1			1						1
In situ RNA (section)	1	1	1			1		1	1		2	1	1				3
In situ RNA (whole mount)			1		1				1
Northern blot		1	1	1	1		1	1		1		1		1		1	2
Western blot		1	1	1											1		5
RT-PCR					1												4
cDNA clones					1								1
RNase protection	1				1			1		1		1		1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ctsl  cathepsin L   (Synonyms: 1190035F06Rik, Cat L, major excreted protein, MEP)
Results	Reference
2	J:43064 Afonso S, Romagnano L, Babiarz B, The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation. Development. 1997 Sep;124(17):3415-25
11*	J:58845 Afonso S, Romagnano L, Babiarz B, Expression of cathepsin proteinases by mouse trophoblast in vivo and in vitro. Dev Dyn. 1999 Dec;216(4-5):374-84
2	J:142805 Alcalay NI, Sharma M, Vassmer D, Chapman B, Paul B, Zhou J, Brantley JG, Wallace DP, Maser RL, Vanden Heuvel GB, Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1. Am J Physiol Renal Physiol. 2008 Dec;295(6):F1725-34
1	J:342617 Dali O, D'Cruz S, Legoff L, Diba Lahmidi M, Heitz C, Merret PE, Kernanec PY, Pakdel F, Smagulova F, Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Life Sci Alliance. 2024 Feb;7(2)
9*	J:74618 Deussing J, Kouadio M, Rehman S, Werber I, Schwinde A, Peters C, Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13. Genomics. 2002 Feb;79(2):225-40
1	J:197171 Hughes J, Frago S, Buhnemann C, Carter EJ, Hassan AB, Maternal transmission of a humanised igf2r allele results in an igf2 dependent hypomorphic and non-viable growth phenotype. PLoS One. 2013;8(2):e57270
3*	J:102103 Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER, Collins-Racie L, McCoy JM, Curran T, A neurogenomics approach to gene expression analysis in the developing brain. Brain Res Mol Brain Res. 2004 Dec 20;132(2):116-27
1*	J:124592 Lu J, Qian J, Keppler D, Cardoso WV, Cathespin H is an Fgf10 target involved in Bmp4 degradation during lung branching morphogenesis. J Biol Chem. 2007 Jul 27;282(30):22176-84
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1*	J:119141 Mandel S, Rechavi G, Gozes I, Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis. Dev Biol. 2007 Mar 15;303(2):814-24
1	J:233172 Mehanna S, Suzuki C, Shibata M, Sunabori T, Imanaka T, Araki K, Yamamura K, Uchiyama Y, Ohmuraya M, Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity. Biochem Biophys Res Commun. 2016 Jan 15;469(3):405-11
1*	J:205051 Miller JA, Nathanson J, Franjic D, Shim S, Dalley RA, Shapouri S, Smith KA, Sunkin SM, Bernard A, Bennett JL, Lee CK, Hawrylycz MJ, Jones AR, Amaral DG, Sestan N, Gage FH, Lein ES, Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
1	J:100494 Nakagawa O, Arnold M, Nakagawa M, Hamada H, Shelton JM, Kusano H, Harris TM, Childs G, Campbell KP, Richardson JA, Nishino I, Olson EN, Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev. 2005 Sep 1;19(17):2066-77
2	J:65651 Neidhardt L, Gasca S, Wertz K, Obermayr F, Worpenberg S, Lehrach H, Herrmann BG, Large-scale screen for genes controlling mammalian embryogenesis, using high-throughput gene expression analysis in mouse embryos. Mech Dev. 2000 Nov;98(1-2):77-94
1*	J:245627 Oka M, Hashimoto K, Yamaguchi Y, Saitoh SI, Sugiura Y, Motoi Y, Honda K, Kikko Y, Ohata S, Suematsu M, Miura M, Miyake K, Katada T, Kontani K, Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos. J Cell Sci. 2017 Oct 15;130(20):3568-3577
1	J:138768 Screen M, Dean W, Cross JC, Hemberger M, Cathepsin proteases have distinct roles in trophoblast function and vascular remodelling. Development. 2008 Oct;135(19):3311-20
1*	J:85207 Shirahama-Noda K, Yamamoto A, Sugihara K, Hashimoto N, Asano M, Nishimura M, Hara-Nishimura I, Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice. J Biol Chem. 2003 Aug 29;278(35):33194-9
7*	J:59171 Sol-Church K, Shipley J, Beckman DA, Mason RW, Expression of cysteine proteases in extraembryonic tissues during mouse embryogenesis. Arch Biochem Biophys. 1999 Dec 15;372(2):375-81
1*	J:161404 Stevens J, Ermakov A, Braganca J, Hilton H, Underhill P, Bhattacharya S, Brown NA, Norris DP, Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow. BMC Dev Biol. 2010;10:54
3	J:216506 Tholen M, Hillebrand LE, Tholen S, Sedelmeier O, Arnold SJ, Reinheckel T, Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo. Nat Commun. 2014;5:4931
1	J:74242 Timmons PM, Rigby PW, Poirier F, The murine seminiferous epithelial cycle is pre-figured in the Sertoli cells of the embryonic testis. Development. 2002 Feb;129(3):635-47
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:316132 Wen Y, Ma X, Wang X, Wang F, Dong J, Wu Y, Lv C, Liu K, Zhang Y, Zhang Z, Yuan S, hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9. Theranostics. 2021;11(20):10030-10046
1	J:215917 Yu S, Nie Y, Knowles B, Sakamori R, Stypulkowski E, Patel C, Das S, Douard V, Ferraris RP, Bonder EM, Goldenring JR, Ip YT, Gao N, TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis. EMBO J. 2014 Sep 1;33(17):1882-95