Gene Expression Literature Summary

• Symbol: Cyp11b1
• Name: cytochrome P450, family 11, subfamily b, polypeptide 1
• ID: MGI:88583

31 matching records from 31 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E6	E7	E7.5	E11.5	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	E	P
Immunohistochemistry (section)		1	1	1				1	1	2			1		2	1	7
In situ RNA (section)								4		1		3	1		4		2
In situ RNA (whole mount)					1			1
RT-PCR	1		1			1	1	1		4	1	1		1	1	2	15
cDNA clones										1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cyp11b1  cytochrome P450, family 11, subfamily b, polypeptide 1   (Synonyms: Cyp11b, Cyp11b-1)
Results	Reference
1	J:311885 Bandiera R, Vidal VP, Motamedi FJ, Clarkson M, Sahut-Barnola I, von Gise A, Pu WT, Hohenstein P, Martinez A, Schedl A, WT1 maintains adrenal-gonadal primordium identity and marks a population of AGP-like progenitors within the adrenal gland. Dev Cell. 2013 Oct 14;27(1):5-18
1	J:244906 Berthon A, Faucz FR, Espiard S, Drougat L, Bertherat J, Stratakis CA, Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function. Hum Mol Genet. 2017 Sep 15;26(18):3495-3507
1	J:199581 Bohnenpoll T, Bettenhausen E, Weiss AC, Foik AB, Trowe MO, Blank P, Airik R, Kispert A, Tbx18 expression demarcates multipotent precursor populations in the developing urogenital system but is exclusively required within the ureteric mesenchymal lineage to suppress a renal stromal fate. Dev Biol. 2013 Aug 1;380(1):25-36
3*	J:210262 Boucher E, Provost PR, Tremblay Y, Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20alpha-hydroxysteroid dehydrogenase in the mouse lung. BMC Res Notes. 2014;7:119
1	J:27441 Cole TJ, Blendy JA, Monaghan AP, Krieglstein K, Schmid W, Aguzzi A, Fantuzzi G, Hummler E, Unsicker K, Schutz G, Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev. 1995 Jul 1;9(13):1608-21
1*	J:192943 Cuffe JS, O'Sullivan L, Simmons DG, Anderson ST, Moritz KM, Maternal corticosterone exposure in the mouse has sex-specific effects on placental growth and mRNA expression. Endocrinology. 2012 Nov;153(11):5500-11
1	J:92051 Cui S, Ross A, Stallings N, Parker KL, Capel B, Quaggin SE, Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. Development. 2004 Aug;131(16):4095-105
1	J:198851 Guasti L, Candy Sze WC, McKay T, Grose R, King PJ, FGF signalling through Fgfr2 isoform IIIb regulates adrenal cortex development. Mol Cell Endocrinol. 2013 May 22;371(1-2):182-8
1	J:315113 Hafner R, Bohnenpoll T, Rudat C, Schultheiss TM, Kispert A, Fgfr2 is required for the expansion of the early adrenocortical primordium. Mol Cell Endocrinol. 2015 Sep 15;413:168-77
6*	J:125377 Hu L, Monteiro A, Johnston H, King P, O'shaughnessy PJ, Expression of Cyp21a1 and Cyp11b1 in the fetal mouse testis. Reproduction. 2007 Oct;134(4):585-91
1	J:189572 Huang CC, Liu C, Yao HH, Investigating the role of adrenal cortex in organization and differentiation of the adrenal medulla in mice. Mol Cell Endocrinol. 2012 Sep 25;361(1-2):165-71
3*	J:29760 Keeney DS, Jenkins CM, Waterman MR, Developmentally regulated expression of adrenal 17 alpha-hydroxylase cytochrome P450 in the mouse embryo. Endocrinology. 1995 Nov;136(11):4872-9
2	J:155826 King P, Paul A, Laufer E, Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21185-90
4	J:289490 Menard A, Abou Nader N, Levasseur A, St-Jean G, Le Roy MLG, Boerboom D, Benoit-Biancamano MO, Boyer A, Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate. Endocrinology. 2020 May 1;161(5)
1*	J:53330 Morohashi K, Tsuboi-Asai H, Matsushita S, Suda M, Nakashima M, Sasano H, Hataba Y, Li CL, Fukata J, Irie J, Watanabe T, Nagura H, Li E, Structural and functional abnormalities in the spleen of an mFtz-F1 gene-disrupted mouse. Blood. 1999 Mar 1;93(5):1586-94
7	J:110428 Niakan KK, Davis EC, Clipsham RC, Jiang M, Dehart DB, Sulik KK, McCabe ER, Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis. Mol Genet Metab. 2006 Jul;88(3):261-71
2	J:278935 Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL, Chan LF, MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. FASEB J. 2018 Jun 7;:fj201701274RR
1	J:354194 Oikonomakos I, Tedesco M, Motamedi FJ, Peitzsch M, Nef S, Bornstein SR, Schedl A, Steenblock C, Neirijnck Y, In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells. Stem Cell Reports. 2024 Sep 10;19(9):1289-1303
1	J:222045 Padua MB, Jiang T, Morse DA, Fox SC, Hatch HM, Tevosian SG, Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes. Endocrinology. 2015 May;156(5):1873-86
1	J:179464 Paul A, Laufer E, Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential. Mol Cell Endocrinol. 2011 Apr 10;336(1-2):133-40
1	J:197548 Pihlajoki M, Gretzinger E, Cochran R, Kyronlahti A, Schrade A, Hiller T, Sullivan L, Shoykhet M, Schoeller EL, Brooks MD, Heikinheimo M, Wilson DB, Conditional mutagenesis of Gata6 in SF1-positive cells causes gonadal-like differentiation in the adrenal cortex of mice. Endocrinology. 2013 May;154(5):1754-67
1*	J:30430 Schonemann MD, Ryan AK, McEvilly RJ, O'Connell SM, Arias CA, Kalla KA, Li P, Sawchenko PE, Rosenfeld MG, Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2. Genes Dev. 1995 Dec 15;9(24):3122-35
3	J:287213 Scortegagna M, Berthon A, Settas N, Giannakou A, Garcia G, Li JL, James B, Liddington RC, Vilches-Moure JG, Stratakis CA, Ronai ZA, The E3 ubiquitin ligase Siah1 regulates adrenal gland organization and aldosterone secretion. JCI Insight. 2017 Dec 7;2(23)
1	J:224387 Sisecioglu M, Budak H, Geffers L, Cankaya M, Ciftci M, Thaller C, Eichele G, Kufrevioglu OI, Ozdemir H, A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo. J Lipid Res. 2015 Aug;56(8):1551-9
2	J:224628 Tevosian SG, Jimenez E, Hatch HM, Jiang T, Morse DA, Fox SC, Padua MB, Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors. Endocrinology. 2015 Jul;156(7):2503-17
3	J:114383 Val P, Jeays-Ward K, Swain A, Identification of a novel population of adrenal-like cells in the mammalian testis. Dev Biol. 2006 Nov 1;299(1):250-6
4*	J:62908 Venihaki M, Carrigan A, Dikkes P, Majzoub JA, Circadian rise in maternal glucocorticoid prevents pulmonary dysplasia in fetal mice with adrenal insufficiency. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7336-41
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
3	J:340792 Whiley PAF, Luu MCM, O'Donnell L, Handelsman DJ, Loveland KL, Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure. Front Endocrinol (Lausanne). 2023;14:1234712
2	J:245934 Xing Y, Morohashi KI, Ingraham HA, Hammer GD, Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1. Development. 2017 Oct 15;144(20):3798-3807
5	J:320691 Yadav VK, Berger JM, Singh P, Nagarajan P, Karsenty G, Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse. J Clin Invest. 2022 Feb 15;132(4):e153752