Gene Expression Literature Summary
|
Symbol Name ID |
Neurog3
neurogenin 3 MGI:893591 |
| Age | E1.5 | E2 | E2.5 | E3 | E3.5 | E4.5 | E8 | E8.5 | E9 | E9.5 | E10 | E10.5 | E11 | E11.5 | E12 | E12.5 | E13 | E13.5 | E14 | E14.5 | E15 | E15.5 | E16 | E16.5 | E17 | E17.5 | E18 | E18.5 | E19 | E19.5 | E | P |
| Immunohistochemistry (section) | 1 | 1 | 9 | 1 | 22 | 3 | 18 | 2 | 41 | 3 | 52 | 65 | 6 | 103 | 1 | 18 | 2 | 12 | 4 | 14 | 2 | 3 | 34 | |||||||||
| In situ RNA (section) | 2 | 3 | 6 | 1 | 14 | 1 | 7 | 2 | 16 | 3 | 11 | 2 | 22 | 1 | 11 | 1 | 6 | 1 | 6 | 1 | 3 | 5 | 12 | |||||||||
| Immunohistochemistry (whole mount) | 1 | 2 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 2 | 4 | |||||||||||||||||||||
| In situ RNA (whole mount) | 1 | 1 | 1 | 3 | 2 | 2 | 1 | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 1 | ||||||||||||||||
| In situ reporter (knock in) | 1 | 2 | 8 | 6 | 8 | 1 | 2 | 1 | 3 | 1 | 5 | |||||||||||||||||||||
| Northern blot | 1 | 1 | 2 | 1 | 1 | |||||||||||||||||||||||||||
| Western blot | 1 | 1 | 1 | 3 | 1 | 1 | 1 | 1 | 5 | |||||||||||||||||||||||
| RT-PCR | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 3 | 6 | 4 | 12 | 1 | 21 | 1 | 22 | 1 | 43 | 1 | 14 | 1 | 12 | 2 | 17 | 1 | 2 | 1 | 43 | |||||
| cDNA clones | 2 |
| Neurog3 neurogenin 3 (Synonyms: Atoh5, bHLHa7, Math4B, ngn3) | |
| Results | Reference |
| 2 | J:338878 Abarinov V, Levine JA, Churchill AJ, Hopwood B, Deiter CS, Guney MA, Wells KL, Schrunk JM, Guo Y, Hammelman J, Gifford DK, Magnuson MA, Wichterle H, Sussel L, Major beta cell-specific functions of NKX2.2 are mediated via the NK2-specific domain. Genes Dev. 2023 Jun 1;37(11-12):490-504 |
| 1 | J:248945 Abdellatif AM, Oishi H, Itagaki T, Jung Y, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F, Takahashi S, beta-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development. PLoS One. 2016;11(2):e0150010 |
| 1 | J:246645 Adikusuma F, Pederick D, McAninch D, Hughes J, Thomas P, Functional Equivalence of the SOX2 and SOX3 Transcription Factors in the Developing Mouse Brain and Testes. Genetics. 2017 Jul;206(3):1495-1503 |
| 1 | J:219809 Afelik S, Pool B, Schmerr M, Penton C, Jensen J, Wnt7b is required for epithelial progenitor growth and operates during epithelial-to-mesenchymal signaling in pancreatic development. Dev Biol. 2015 Mar 15;399(2):204-17 |
| 2 | J:126886 Ahnfelt-Ronne J, Jorgensen MC, Hald J, Madsen OD, Serup P, Hecksher-Sorensen J, An improved method for three-dimensional reconstruction of protein expression patterns in intact mouse and chicken embryos and organs. J Histochem Cytochem. 2007 Sep;55(9):925-30 |
| 8 | J:178999 Ahnfelt-Ronne J, Jorgensen MC, Klinck R, Jensen JN, Fuchtbauer EM, Deering T, Macdonald RJ, Wright CV, Madsen OD, Serup P, Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism. Development. 2012 Jan;139(1):33-45 |
| 6 | J:169647 Ait-Lounis A, Bonal C, Seguin-Estevez Q, Schmid CD, Bucher P, Herrera PL, Durand B, Meda P, Reith W, The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression. Diabetes. 2010 Jul;59(7):1674-85 |
| 1* | J:102260 Alam S, Zinyk D, Ma L, Schuurmans C, Members of the Plag gene family are expressed in complementary and overlapping regions in the developing murine nervous system. Dev Dyn. 2005 Nov;234(3):772-82 |
| 3 | J:232360 Anastasiou V, Ninou E, Alexopoulou D, Stertmann J, Muller A, Dahl A, Solimena M, Speier S, Serafimidis I, Gavalas A, Aldehyde dehydrogenase activity is necessary for beta cell development and functionality in mice. Diabetologia. 2016 Jan;59(1):139-50 |
| 1* | J:175542 Anderson KR, Singer RA, Balderes DA, Hernandez-Lagunas L, Johnson CW, Artinger KB, Sussel L, The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development. 2011 Aug;138(15):3213-24 |
| 1 | J:156329 Anderson KR, Torres CA, Solomon K, Becker TC, Newgard CB, Wright CV, Hagman J, Sussel L, Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem. 2009 Nov 6;284(45):31236-48 |
| 5 | J:156022 Anderson KR, White P, Kaestner KH, Sussel L, Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. BMC Dev Biol. 2009;9:65 |
| 5 | J:201201 Anthwal N, Pelling M, Claxton S, Mellitzer G, Collin C, Kessaris N, Richardson WD, Gradwohl G, Ang SL, Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity. Dis Model Mech. 2013 Sep-Oct;6(5):1133-45 |
| 8 | J:57072 Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H, Notch signalling controls pancreatic cell differentiation. Nature. 1999 Aug 26;400(6747):877-81 |
| 1* | J:231585 Arnes L, Akerman I, Balderes DA, Ferrer J, Sussel L, betalinc1 encodes a long noncoding RNA that regulates islet beta-cell formation and function. Genes Dev. 2016 Mar 1;30(5):502-7 |
| 3 | J:187468 Arnes L, Leclerc K, Friel JM, Hipkens SB, Magnuson MA, Sussel L, Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis. 2012 Aug;50(8):612-24 |
| 3 | J:240765 Arregi I, Climent M, Iliev D, Strasser J, Gouignard N, Johansson JK, Singh T, Mazur M, Semb H, Artner I, Minichiello L, Pera EM, Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling. Endocrinology. 2016 Dec;157(12):4615-4631 |
| 3 | J:106430 Artner I, Le Lay J, Hang Y, Elghazi L, Schisler JC, Henderson E, Sosa-Pineda B, Stein R, MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Diabetes. 2006 Feb;55(2):297-304 |
| 2 | J:111685 Asayesh A, Sharpe J, Watson RP, Hecksher-Sorensen J, Hastie ND, Hill RE, Ahlgren U, Spleen versus pancreas: strict control of organ interrelationship revealed by analyses of Bapx1-/- mice. Genes Dev. 2006 Aug 15;20(16):2208-13 |
| 5 | J:287136 Aslanpour S, Han S, Schuurmans C, Kurrasch DM, Neurog2 Acts as a Classical Proneural Gene in the Ventromedial Hypothalamus and Is Required for the Early Phase of Neurogenesis. J Neurosci. 2020 Apr 29;40(18):3549-3563 |
| 1 | J:288305 Aslanpour S, Rosin JM, Balakrishnan A, Klenin N, Blot F, Gradwohl G, Schuurmans C, Kurrasch DM, Ascl1 is required to specify a subset of ventromedial hypothalamic neurons. Development. 2020 May 28;147(10):dev180067 |
| 2 | J:260459 Azizoglu DB, Braitsch C, Marciano DK, Cleaver O, Afadin and RhoA control pancreatic endocrine mass via lumen morphogenesis. Genes Dev. 2017 Dec 1;31(23-24):2376-2390 |
| 7 | J:241637 Azzarelli R, Hurley C, Sznurkowska MK, Rulands S, Hardwick L, Gamper I, Ali F, McCracken L, Hindley C, McDuff F, Nestorowa S, Kemp R, Jones K, Gottgens B, Huch M, Evan G, Simons BD, Winton D, Philpott A, Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation. Dev Cell. 2017 May 08;41(3):274-286.e5 |
| 1 | J:327292 Bakhti M, Bastidas-Ponce A, Tritschler S, Czarnecki O, Tarquis-Medina M, Nedvedova E, Jaki J, Willmann SJ, Scheibner K, Cota P, Salinno C, Boldt K, Horn N, Ueffing M, Burtscher I, Theis FJ, Coskun U, Lickert H, Synaptotagmin-13 orchestrates pancreatic endocrine cell egression and islet morphogenesis. Nat Commun. 2022 Aug 4;13(1):4540 |
| 1 | J:204532 Balderes DA, Magnuson MA, Sussel L, Nkx2.2:Cre knock-in mouse line: A novel tool for pancreas- and CNS-specific gene deletion. Genesis. 2013 Dec;51(12):844-51 |
| 1* | J:109310 Ballow D, Meistrich ML, Matzuk M, Rajkovic A, Sohlh1 is essential for spermatogonial differentiation. Dev Biol. 2006 Jun 1;294(1):161-7 |
| 5 | J:270954 Bankaitis ED, Bechard ME, Gu G, Magnuson MA, Wright CVE, ROCK-nmMyoII, Notch and Neurog3 gene-dosage link epithelial morphogenesis with cell fate in the pancreatic endocrine-progenitor niche. Development. 2018 Sep 21;145(18):dev162115 |
| 6 | J:226612 Bankaitis ED, Bechard ME, Wright CV, Feedback control of growth, differentiation, and morphogenesis of pancreatic endocrine progenitors in an epithelial plexus niche. Genes Dev. 2015 Oct 15;29(20):2203-16 |
| 1 | J:336187 Barlow HR, Ahuja N, Bierschenk T, Htike Y, Fassetta L, Azizoglu DB, Flores J, Gao N, De la O S, Sneddon JB, Marciano DK, Cleaver O, Rab11 is essential to pancreas morphogenesis, lumen formation and endocrine mass. Dev Biol. 2023 Jul;499:59-74 |
| 12 | J:278226 Bastidas-Ponce A, Tritschler S, Dony L, Scheibner K, Tarquis-Medina M, Salinno C, Schirge S, Burtscher I, Bottcher A, Theis FJ, Lickert H, Bakhti M, Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis. Development. 2019 Jun 17;146(12):dev173849 |
| 2 | J:213751 Baumgartner BK, Cash G, Hansen H, Ostler S, Murtaugh LC, Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning. Dev Biol. 2014 Jul 1;391(1):89-98 |
| 5 | J:235658 Bechard ME, Bankaitis ED, Hipkens SB, Ustione A, Piston DW, Yang YP, Magnuson MA, Wright CV, Precommitment low-level Neurog3 expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells. Genes Dev. 2016 Aug 15;30(16):1852-65 |
| 1* | J:180770 Bjerknes M, Khandanpour C, Moroy T, Fujiyama T, Hoshino M, Klisch TJ, Ding Q, Gan L, Wang J, Martin MG, Cheng H, Origin of the brush cell lineage in the mouse intestinal epithelium. Dev Biol. 2012 Feb 15;362(2):194-218 |
| 2 | J:333987 Bohuslavova R, Fabriciova V, Lebron-Mora L, Malfatti J, Smolik O, Valihrach L, Benesova S, Zucha D, Berkova Z, Saudek F, Evans SM, Pavlinkova G, ISL1 controls pancreatic alpha cell fate and beta cell maturation. Cell Biosci. 2023 Mar 10;13(1):53 |
| 3 | J:309174 Bohuslavova R, Smolik O, Malfatti J, Berkova Z, Novakova Z, Saudek F, Pavlinkova G, NEUROD1 Is Required for the Early alpha and beta Endocrine Differentiation in the Pancreas. Int J Mol Sci. 2021 Jun 23;22(13) |
| 2 | J:146087 Bonal C, Thorel F, Ait-Lounis A, Reith W, Trumpp A, Herrera PL, Pancreatic inactivation of c-Myc decreases acinar mass and transdifferentiates acinar cells into adipocytes in mice. Gastroenterology. 2009 Jan;136(1):309-319.e9 |
| 1 | J:190582 Bondow BJ, Faber ML, Wojta KJ, Walker EM, Battle MA, E-cadherin is required for intestinal morphogenesis in the mouse. Dev Biol. 2012 Nov 1;371(1):1-12 |
| 1 | J:228228 Bonnavion R, Teinturier R, Jaafar R, Ripoche D, Leteurtre E, Chen YJ, Rehfeld JF, Lepinasse F, Hervieu V, Pattou F, Vantyghem MC, Scoazec JY, Bertolino P, Zhang CX, Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors. Mol Cell Biol. 2015 Oct;35(19):3274-83 |
| 1 | J:87725 Bort R, Martinez-Barbera JP, Beddington RS, Zaret KS, Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas. Development. 2004 Feb;131(4):797-806 |
| 2 | J:279716 Braitsch CM, Azizoglu DB, Htike Y, Barlow HR, Schnell U, Chaney CP, Carroll TJ, Stanger BZ, Cleaver O, LATS1/2 suppress NFkappaB and aberrant EMT initiation to permit pancreatic progenitor differentiation. PLoS Biol. 2019 Jul;17(7):e3000382 |
| 1 | J:54240 Briscoe J, Sussel L, Serup P, Hartigan-O'Connor D, Jessell TM , Rubenstein JL , Ericson J, Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature. 1999 Apr 15;398(6728):622-7 |
| 1 | J:255164 Broche B, Ben Fradj S, Aguilar E, Sancerni T, Benard M, Makaci F, Berthault C, Scharfmann R, Alves-Guerra MC, Duvillie B, Mitochondrial Protein UCP2 Controls Pancreas Development. Diabetes. 2018 Jan;67(1):78-84 |
| 6* | J:135698 Burlison JS, Long Q, Fujitani Y, Wright CV, Magnuson MA, Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. Dev Biol. 2008 Apr 1;316(1):74-86 |
| 1 | J:268361 Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB, Lineage dynamics of murine pancreatic development at single-cell resolution. Nat Commun. 2018 Sep 25;9(1):3922 |
| 4 | J:200985 Cai EP, Wu X, Schroer SA, Elia AJ, Nostro MC, Zacksenhaus E, Woo M, Retinoblastoma tumor suppressor protein in pancreatic progenitors controls alpha- and beta-cell fate. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14723-8 |
| 4* | J:173856 Cai T, Chen X, Wang R, Xu H, You Y, Zhang T, Lan MS, Notkins AL, Expression of insulinoma-associated 2 (INSM2) in pancreatic islet cells is regulated by the transcription factors Ngn3 and NeuroD1. Endocrinology. 2011 May;152(5):1961-9 |
| 2 | J:284608 Campbell SA, McDonald CL, Krentz NAJ, Lynn FC, Hoffman BG, TrxG Complex Catalytic and Non-catalytic Activity Play Distinct Roles in Pancreas Progenitor Specification and Differentiation. Cell Rep. 2019 Aug 13;28(7):1830-1844.e6 |
| 4 | J:217405 Carcagno AL, Di Bella DJ, Goulding M, Guillemot F, Lanuza GM, Neurogenin3 restricts serotonergic neuron differentiation to the hindbrain. J Neurosci. 2014 Nov 12;34(46):15223-33 |
| 1 | J:192746 Carrasco M, Delgado I, Soria B, Martin F, Rojas A, GATA4 and GATA6 control mouse pancreas organogenesis. J Clin Invest. 2012 Oct 1;122(10):3504-15 |
| 1 | J:40190 Cau E, Gradwohl G, Fode C, Guillemot F, Mash1 activates a cascade of bHLH regulators in olfactory neuron progenitors. Development. 1997 APR;124(8):1611-1621 |
| 1 | J:215828 Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS, Menin determines K-RAS proliferative outputs in endocrine cells. J Clin Invest. 2014 Sep 2;124(9):4093-101 |
| 2 | J:164907 Chen H, Houshmand G, Mishra S, Fong GH, Gittes GK, Esni F, Impaired pancreatic development in Hif2-alpha deficient mice. Biochem Biophys Res Commun. 2010 Aug 27;399(3):440-5 |
| 1 | J:87723 Chiang MK, Melton DA, Single-cell transcript analysis of pancreas development. Dev Cell. 2003 Mar;4(3):383-93 |
| 1 | J:193165 Choi E, Kraus MR, Lemaire LA, Yoshimoto M, Vemula S, Potter LA, Manduchi E, Stoeckert CJ Jr, Grapin-Botton A, Magnuson MA, Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells. 2012 Oct;30(10):2297-308 |
| 1 | J:105207 Chu K, Tsai MJ, Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes. 2005 Apr;54(4):1064-73 |
| 3 | J:240413 Churchill AJ, Gutierrez GD, Singer RA, Lorberbaum DS, Fischer KA, Sussel L, Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development. Elife. 2017 Jan 10;6:e20010 |
| 1 | J:98803 Collombat P, Hecksher-Sorensen J, Broccoli V, Krull J, Ponte I, Mundiger T, Smith J, Gruss P, Serup P, Mansouri A, The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the {alpha}- and {beta}-cell lineages in the mouse endocrine pancreas. Development. 2005 Jul;132(13):2969-80 |
| 1 | J:86206 Collombat P, Mansouri A, Hecksher-Sorensen J, Serup P, Krull J, Gradwohl G, Gruss P, Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev. 2003 Oct 15;17(20):2591-603 |
| 4 | J:269131 Cortijo C, Gouzi M, Tissir F, Grapin-Botton A, Planar cell polarity controls pancreatic beta cell differentiation and glucose homeostasis. Cell Rep. 2012 Dec 27;2(6):1593-606 |
| 2 | J:297054 Cozzitorto C, Mueller L, Ruzittu S, Mah N, Willnow D, Darrigrand JF, Wilson H, Khosravinia D, Mahmoud AA, Risolino M, Selleri L, Spagnoli FM, A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation. Dev Cell. 2020 Oct 26;55(2):150-162.e6 |
| 1 | J:152074 Cras-Meneur C, Li L, Kopan R, Permutt MA, Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. Genes Dev. 2009 Sep 1;23(17):2088-101 |
| 1 | J:346123 Darrigrand JF, Salowka A, Torres-Cano A, Tapia-Rojo R, Zhu T, Garcia-Manyes S, Spagnoli FM, Acinar-ductal cell rearrangement drives branching morphogenesis of the murine pancreas in an IGF/PI3K-dependent manner. Dev Cell. 2024 Feb 5;59(3):326-338.e5 |
| 3* | J:170654 Das P, May CL, Expression analysis of the Islet-1 gene in the developing and adult gastrointestinal tract. Gene Expr Patterns. 2011 Mar-Apr;11(3-4):244-54 |
| 1 | J:355694 Davidson RK, Wu W, Kanojia S, George RM, Huter K, Sandoval K, Osmulski M, Casey N, Spaeth JM, The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo. Diabetologia. 2024 Oct;67(10):2275-2288 |
| 6 | J:220324 De Vas MG, Kopp JL, Heliot C, Sander M, Cereghini S, Haumaitre C, Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors. Development. 2015 Mar 1;142(5):871-82 |
| 2 | J:119284 Decker K, Goldman DC, Grasch CL, Sussel L, Gata6 is an important regulator of mouse pancreas development. Dev Biol. 2006 Oct 15;298(2):415-29 |
| 1 | J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41 |
| 1 | J:153962 Desgraz R, Herrera PL, Pancreatic neurogenin 3-expressing cells are unipotent islet precursors. Development. 2009 Nov;136(21):3567-74 |
| 1* | J:82773 Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P, Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. Dev Dyn. 2003 Apr;226(4):663-74 |
| 3* | J:113424 Dichmann DS, Yassin H, Serup P, Analysis of pancreatic endocrine development in GDF11-deficient mice. Dev Dyn. 2006 Nov;235(11):3016-25 |
| 1* | J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582 |
| 3 | J:332289 Dobosz AM, Janikiewicz J, Krogulec E, Dziewulska A, Ajduk A, Szpila M, Nieznanska H, Szczepankiewicz AA, Wypych D, Dobrzyn A, Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of beta-cell identity and alpha-cell expansion in the mature pancreas. Mol Metab. 2022 Dec 15;67:101659 |
| 2 | J:154416 Du A, Hunter CS, Murray J, Noble D, Cai CL, Evans SM, Stein R, May CL, Islet-1 is required for the maturation, proliferation, and survival of the endocrine pancreas. Diabetes. 2009 Sep;58(9):2059-69 |
| 2 | J:184887 Du A, McCracken KW, Walp ER, Terry NA, Klein TJ, Han A, Wells JM, May CL, Arx is required for normal enteroendocrine cell development in mice and humans. Dev Biol. 2012 May 1;365(1):175-88 |
| 1 | J:176523 Dubois CL, Shih HP, Seymour PA, Patel NA, Behrmann JM, Ngo V, Sander M, Sox9-haploinsufficiency causes glucose intolerance in mice. PLoS One. 2011;6(8):e23131 |
| 3* | J:198394 Ejarque M, Cervantes S, Pujadas G, Tutusaus A, Sanchez L, Gasa R, Neurogenin3 cooperates with Foxa2 to autoactivate its own expression. J Biol Chem. 2013 Apr 26;288(17):11705-17 |
| 1 | J:248949 Ejarque M, Mir-Coll J, Gomis R, German MS, Lynn FC, Gasa R, Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8). PLoS One. 2016;11(1):e0146273 |
| 1 | J:198451 El-Gohary Y, Tulachan S, Guo P, Welsh C, Wiersch J, Prasadan K, Paredes J, Shiota C, Xiao X, Wada Y, Diaz M, Gittes G, Smad signaling pathways regulate pancreatic endocrine development. Dev Biol. 2013 Jun 15;378(2):83-93 |
| 1 | J:92056 Esni F, Ghosh B, Biankin AV, Lin JW, Albert MA, Yu X, MacDonald RJ, Civin CI, Real FX, Pack MA, Ball DW, Leach SD, Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas. Development. 2004 Sep;131(17):4213-24 |
| 3* | J:87375 Esni F, Stoffers DA, Takeuchi T, Leach SD, Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mech Dev. 2004 Jan;121(1):15-25 |
| 1 | J:141158 Fontaniere S, Duvillie B, Scharfmann R, Carreira C, Wang ZQ, Zhang CX, Tumour suppressor menin is essential for development of the pancreatic endocrine cells. J Endocrinol. 2008 Nov;199(2):287-98 |
| 1 | J:201964 Fu X, Jin L, Wang X, Luo A, Hu J, Zheng X, Tsark WM, Riggs AD, Ku HT, Huang W, MicroRNA-26a targets ten eleven translocation enzymes and is regulated during pancreatic cell differentiation. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17892-7 |
| 3 | J:129665 Fujikura J, Hosoda K, Iwakura H, Tomita T, Noguchi M, Masuzaki H, Tanigaki K, Yabe D, Honjo T, Nakao K, Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. Cell Metab. 2006 Jan;3(1):59-65 |
| 1 | J:134976 Galichet C, Guillemot F, Parras CM, Neurogenin 2 has an essential role in development of the dentate gyrus. Development. 2008 Jun;135(11):2031-41 |
| 1 | J:234058 Galloway JR, Bethea M, Liu Y, Underwood R, Mobley JA, Hunter CS, SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic beta-Cell Target Genes. Mol Endocrinol. 2015 Dec;29(12):1774-86 |
| 1 | J:143476 Gao N, Lelay J, Vatamaniuk MZ, Rieck S, Friedman JR, Kaestner KH, Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev. 2008 Dec 15;22(24):3435-48 |
| 1 | J:307319 George NM, Boerner BP, Mir SU, Guinn Z, Sarvetnick NE, Exploiting Expression of Hippo Effector, Yap, for Expansion of Functional Islet Mass. Mol Endocrinol. 2015 Nov;29(11):1594-607 |
| 1 | J:192856 George NM, Day CE, Boerner BP, Johnson RL, Sarvetnick NE, Hippo signaling regulates pancreas development through inactivation of Yap. Mol Cell Biol. 2012 Dec;32(24):5116-28 |
| 1 | J:116542 Georgia S, Bhushan A, p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes. 2006 Nov;55(11):2950-6 |
| 1 | J:193959 Georgia S, Kanji M, Bhushan A, DNMT1 represses p53 to maintain progenitor cell survival during pancreatic organogenesis. Genes Dev. 2013 Feb 15;27(4):372-7 |
| 1* | J:119274 Georgia S, Soliz R, Li M, Zhang P, Bhushan A, p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors. Dev Biol. 2006 Oct 1;298(1):22-31 |
| 1 | J:147261 Gesina E, Blondeau B, Milet A, Le Nin I, Duchene B, Czernichow P, Scharfmann R, Tronche F, Breant B, Glucocorticoid signalling affects pancreatic development through both direct and indirect effects. Diabetologia. 2006 Dec;49(12):2939-47 |
| 3 | J:112173 Gierl MS, Karoulias N, Wende H, Strehle M, Birchmeier C, The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev. 2006 Sep 1;20(17):2465-78 |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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