Gene Expression Literature Summary

• Symbol: Ext1
• Name: exostosin glycosyltransferase 1
• ID: MGI:894663

17 matching records from 17 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E5.5	E6.5	E7.5	E8	E8.5	E9.5	E10.5	E11.5	E12.5	E13	E13.5	E14.5	E15.5	E16	E16.5	E18	E18.5	E	P
In situ RNA (section)		1	1	1	1		1	1		1	1	2		1	2				1
In situ RNA (whole mount)						1	3	2	3		1
Northern blot																			1
RT-PCR	1	1	1							1	1	1	1	1		1	1	1	2
cDNA clones															1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ext1  exostosin glycosyltransferase 1
Results	Reference
1	J:297362 Bachvarova V, Dierker T, Esko J, Hoffmann D, Kjellen L, Vortkamp A, Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate. Matrix Biol. 2020 Nov;93:43-59
1	J:150524 Chan JA, Balasubramanian S, Witt RM, Nazemi KJ, Choi Y, Pazyra-Murphy MF, Walsh CO, Thompson M, Segal RA, Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses. Nat Neurosci. 2009 Apr;12(4):409-17
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:104933 Hilton MJ, Gutierrez L, Martinez DA, Wells DE, EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development. Bone. 2005 Mar;36(3):379-86
1	J:263185 Huang M, He H, Belenkaya T, Lin X, Multiple roles of epithelial heparan sulfate in stomach morphogenesis. J Cell Sci. 2018 May 29;131(10):jcs210781
2	J:86465 Inatani M, Irie F, Plump AS, Tessier-Lavigne M, Yamaguchi Y, Mammalian brain morphogenesis and midline axon guidance require heparan sulfate. Science. 2003 Nov 7;302(5647):1044-6
7	J:82657 Inatani M, Yamaguchi Y, Gene expression of EXT1 and EXT2 during mouse brain development. Brain Res Dev Brain Res. 2003 Mar 14;141(1-2):129-36
2	J:152572 Iwao K, Inatani M, Matsumoto Y, Ogata-Iwao M, Takihara Y, Irie F, Yamaguchi Y, Okinami S, Tanihara H, Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signaling. J Clin Invest. 2009 Jul;119(7):1997-2008
1	J:158330 Iwao K, Inatani M, Ogata-Iwao M, Yamaguchi Y, Okinami S, Tanihara H, Heparan sulfate deficiency in periocular mesenchyme causes microphthalmia and ciliary body dysgenesis. Exp Eye Res. 2010 Jan;90(1):81-8
7*	J:49122 Lin X, Gan L, Klein WH, Wells D, Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene. Biochem Biophys Res Commun. 1998 Jul 30;248(3):738-43
2*	J:64021 Lin X, Wei G, Shi Z, Dryer L, Esko JD, Wells DE, Matzuk MM, Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice. Dev Biol. 2000 Aug 15;224(2):299-311
1	J:42532 Lin X, Wells D, Isolation of the mouse cDNA homologous to the human EXT1 gene responsible for Hereditary Multiple Exostoses. DNA Seq. 1997;7(3-4):199-202
1	J:306850 Lu T, Lin X, Pan YH, Yang N, Ye S, Zhang Q, Wang C, Zhu R, Zhang T, Wisniewski TM, Cao Z, Ding BS, Dang S, Zhang W, ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation. iScience. 2020 Aug 20;23(9):101472
1	J:170582 Mundy C, Yasuda T, Kinumatsu T, Yamaguchi Y, Iwamoto M, Enomoto-Iwamoto M, Koyama E, Pacifici M, Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine. Dev Biol. 2011 Mar 1;351(1):70-81
7*	J:63309 Stickens D, Brown D, Evans GA, EXT genes are differentially expressed in bone and cartilage during mouse embryogenesis. Dev Dyn. 2000 Jul;218(3):452-64
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
2	J:243036 Zhang R, Cao P, Yang Z, Wang Z, Wu JL, Chen Y, Pan Y, Heparan Sulfate Biosynthesis Enzyme, Ext1, Contributes to Outflow Tract Development of Mouse Heart via Modulation of FGF Signaling. PLoS One. 2015;10(8):e0136518