Gene Expression Literature Summary

• Symbol: Numbl
• Name: numb-like
• ID: MGI:894702

13 matching records from 13 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E9.5	E10.5	E11.5	E12	E12.5	E13	E13.5	E14.5	E15.5	E16.5	E17	E	P
Immunohistochemistry (section)		1	1	2		2	1			1		1		1
In situ RNA (section)	1	1		1		1	1	1		1	1	1		4
In situ RNA (whole mount)	1
In situ reporter (knock in)	1
Northern blot														1
Western blot					1									1
RT-PCR		1	1	1		1		1	1	1
cDNA clones													1
RNase protection										1				2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Numbl  numb-like   (Synonyms: nbl)
Results	Reference
2*	J:58382 Dho SE, French MB, Woods SA, McGlade CJ, Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain. J Biol Chem. 1999 Nov 12;274(46):33097-104
2*	J:73778 Estivill-Torrus G, Pearson H, van Heyningen V, Price DJ, Rashbass P, Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors. Development. 2002 Jan;129(2):455-66
1	J:278143 Ferent J, Giguere F, Jolicoeur C, Morin S, Michaud JF, Makihara S, Yam PT, Cayouette M, Charron F, Boc Acts via Numb as a Shh-Dependent Endocytic Platform for Ptch1 Internalization and Shh-Mediated Axon Guidance. Neuron. 2019 Jun 19;102(6):1157-1171.e5
6	J:193056 Kechad A, Jolicoeur C, Tufford A, Mattar P, Chow RW, Harris WA, Cayouette M, Numb is required for the production of terminal asymmetric cell divisions in the developing mouse retina. J Neurosci. 2012 Nov 28;32(48):17197-210
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
1	J:226670 Moayedi Y, Basch ML, Pacheco NL, Gao SS, Wang R, Harrison W, Xiao N, Oghalai JS, Overbeek PA, Mardon G, Groves AK, The candidate splicing factor Sfswap regulates growth and patterning of inner ear sensory organs. PLoS Genet. 2014 Jan;10(1):e1004055
3	J:182904 Moran TB, Goldberg LB, Serviss SL, Raetzman LT, Numb deletion in POMC-expressing cells impairs pituitary intermediate lobe cell adhesion, progenitor cell localization, and neuro-intermediate lobe boundary formation. Mol Endocrinol. 2011 Jan;25(1):117-27
3	J:92098 Petersen PH, Zou K, Krauss S, Zhong W, Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Nat Neurosci. 2004 Aug;7(8):803-11
2	J:124218 Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P, Sestan N, Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci. 2007 Jul;10(7):819-27
1*	J:73266 Rice D S, Northcutt G M, Kurschner C, The Lnx family proteins function as molecular scaffolds for Numb family proteins. Mol Cell Neurosci. 2001 Nov;18(5):525-40
2	J:202652 Yang J, Bucker S, Jungblut B, Bottger T, Cinnamon Y, Tchorz J, Muller M, Bettler B, Harvey R, Sun QY, Schneider A, Braun T, Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart. Cardiovasc Res. 2012 Nov 1;96(2):276-85
5	J:206589 Zhao C, Guo H, Li J, Myint T, Pittman W, Yang L, Zhong W, Schwartz RJ, Schwarz JJ, Singer HA, Tallquist MD, Wu M, Numb family proteins are essential for cardiac morphogenesis and progenitor differentiation. Development. 2014 Jan;141(2):281-95
8*	J:41027 Zhong W, Jiang MM, Weinmaster G, Jan LY, Jan YN, Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development. 1997 May;124(10):1887-97