Gene Expression Literature Summary

• Symbol: Ddc
• Name: dopa decarboxylase
• ID: MGI:94876

61 matching records from 61 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8.5	E10	E10.5	E11.5	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17.5	E18	E18.5	P
Immunohistochemistry (section)				3	2	4			3		4				2	4	17
In situ RNA (section)			1	1	1	7	3		10	1	1	1	2	1		4	10
In situ RNA (whole mount)				1
In situ reporter (knock in)											1		1			1	2
Northern blot							1										2
Western blot											1
RT-PCR	1	1		2		5	4	1	4		1	1	2			2	8
cDNA clones																	1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ddc  dopa decarboxylase   (Synonyms: Aadc, aromatic L-amino acid decarboxylase)
Results	Reference
1	J:104525 Andersson E, Jensen JB, Parmar M, Guillemot F, Bjorklund A, Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2. Development. 2006 Feb;133(3):507-16
2*	J:93300 Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL, Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
8	J:171595 Bonnin A, Goeden N, Chen K, Wilson ML, King J, Shih JC, Blakely RD, Deneris ES, Levitt P, A transient placental source of serotonin for the fetal forebrain. Nature. 2011 Apr 21;472(7343):347-50
2	J:324028 Bonthuis PJ, Steinwand S, Stacher Horndli CN, Emery J, Huang WC, Kravitz S, Ferris E, Gregg C, Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions. Cell Rep. 2022 Mar 8;38(10):110500
2	J:49228 Cases O, Lebrand C, Giros B, Vitalis T, De Maeyer E, Caron MG, Price DJ, Gaspar P, Seif I, Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs. J Neurosci. 1998 Sep 1;18(17):6914-27
1	J:124122 Ferri AL, Lin W, Mavromatakis YE, Wang JC, Sasaki H, Whitsett JA, Ang SL, Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development. 2007 Aug;134(15):2761-9
1	J:209478 Garfield AS, Cowley M, Smith FM, Moorwood K, Stewart-Cox JE, Gilroy K, Baker S, Xia J, Dalley JW, Hurst LD, Wilkinson LS, Isles AR, Ward A, Distinct physiological and behavioural functions for parental alleles of imprinted Grb10. Nature. 2011 Jan 27;469(7331):534-8
1	J:228881 Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, Kurtulmus B, Novikov O, Spatz J, Pereira G, Hubner W, Brodski C, Tucker KL, Blaess S, Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain. Dev Biol. 2016 Jan 1;409(1):55-71
1	J:196329 Havrda MC, Paolella BR, Ward NM, Holroyd KB, Behavioral abnormalities and Parkinson's-like histological changes resulting from Id2 inactivation in mice. Dis Model Mech. 2013 May-Jun;6(3):819-27
2	J:81450 Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, Yamamoto B, Silver J, Weeber EJ, Sweatt JD, Deneris ES, Pet-1 ETS Gene Plays a Critical Role in 5-HT Neuron Development and Is Required for Normal Anxiety-like and Aggressive Behavior. Neuron. 2003 Jan 23;37(2):233-47
2*	J:85047 Hermanson E, Joseph B, Castro D, Lindqvist E, Aarnisalo P, Wallen A, Benoit G, Hengerer B, Olson L, Perlmann T, Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells. Exp Cell Res. 2003 Aug 15;288(2):324-34
2	J:206496 Hoekstra EJ, von Oerthel L, van der Heide LP, Kouwenhoven WM, Veenvliet JV, Wever I, Jin YR, Yoon JK, van der Linden AJ, Holstege FC, Groot Koerkamp MJ, Smidt MP, Lmx1a encodes a rostral set of mesodiencephalic dopaminergic neurons marked by the Wnt/B-catenin signaling activator R-spondin 2. PLoS One. 2013;8(9):e74049
2*	J:174112 Hoerder-Suabedissen A, Wang WZ, Lee S, Davies KE, Goffinet AM, Rakic S, Parnavelas J, Reim K, Nicolic M, Paulsen O, Molnar Z, Novel markers reveal subpopulations of subplate neurons in the murine cerebral cortex. Cereb Cortex. 2009 Aug;19(8):1738-50
1*	J:139177 Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M, Hoodless PA, Jones SJ, Marra MA, Helgason CD, Identification of transcripts with enriched expression in the developing and adult pancreas. Genome Biol. 2008;9(6):R99
2	J:152424 Jacob J, Storm R, Castro DS, Milton C, Pla P, Guillemot F, Birchmeier C, Briscoe J, Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development. 2009 Jul;136(14):2477-85
1*	J:122792 Jacobs FM, Smits SM, Noorlander CW, von Oerthel L, van der Linden AJ, Burbach JP, Smidt MP, Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency. Development. 2007 Jul;134(14):2673-84
1	J:144189 Jacobs FM, van Erp S, van der Linden AJ, von Oerthel L, Burbach JP, Smidt MP, Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression. Development. 2009 Feb;136(4):531-40
1	J:151918 Jiang H, Xiang M, Subtype specification of GABAergic amacrine cells by the orphan nuclear receptor Nr4a2/Nurr1. J Neurosci. 2009 Aug 19;29(33):10449-59
7	J:329940 Juan AM, Foong YH, Thorvaldsen JL, Lan Y, Leu NA, Rurik JG, Li L, Krapp C, Rosier CL, Epstein JA, Bartolomei MS, Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development. Mol Cell. 2022 Oct 6;82(19):3613-3631.e7
2	J:157098 Kadkhodaei B, Ito T, Joodmardi E, Mattsson B, Rouillard C, Carta M, Muramatsu S, Sumi-Ichinose C, Nomura T, Metzger D, Chambon P, Lindqvist E, Larsson NG, Olson L, Bjorklund A, Ichinose H, Perlmann T, Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons. J Neurosci. 2009 Dec 16;29(50):15923-32
1	J:220591 Kim JY, Kim A, Zhao ZQ, Liu XY, Chen ZF, Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem. Mol Brain. 2014;7:48
1	J:310736 Kito-Shingaki A, Seta Y, Toyono T, Kataoka S, Kakinoki Y, Yanagawa Y, Toyoshima K, Expression of GAD67 and Dlx5 in the taste buds of mice genetically lacking Mash1. Chem Senses. 2014 Jun;39(5):403-14
1	J:229533 Kouwenhoven WM, Veenvliet JV, van Hooft JA, van der Heide LP, Smidt MP, Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function. Biol Open. 2016;5(3):279-88
1*	J:263255 Kusumakshi S, Voigt A, Hubner S, Hermans-Borgmeyer I, Ortalli A, Pyrski M, Dorr J, Zufall F, Flockerzi V, Meyerhof W, Montmayeur JP, Boehm U, A Binary Genetic Approach to Characterize TRPM5 Cells in Mice. Chem Senses. 2015 Jul;40(6):413-25
3	J:182759 Lahti L, Peltopuro P, Piepponen TP, Partanen J, Cell-autonomous FGF signaling regulates anteroposterior patterning and neuronal differentiation in the mesodiencephalic dopaminergic progenitor domain. Development. 2012 Mar;139(5):894-905
1	J:165266 Liu C, Maejima T, Wyler SC, Casadesus G, Herlitze S, Deneris ES, Pet-1 is required across different stages of life to regulate serotonergic function. Nat Neurosci. 2010 Oct;13(10):1190-8
2*	J:240101 Lv J, Wang L, Gao Y, Ding YQ, Liu F, 5-hydroxytryptamine synthesized in the aorta-gonad-mesonephros regulates hematopoietic stem and progenitor cell survival. J Exp Med. 2017 Feb;214(2):529-545
7*	J:128957 Menheniott TR, Woodfine K, Schulz R, Wood AJ, Monk D, Giraud AS, Baldwin HS, Moore GE, Oakey RJ, Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10. Mol Cell Biol. 2008 Jan;28(1):386-96
1*	J:112887 Mori AD, Zhu Y, Vahora I, Nieman B, Koshiba-Takeuchi K, Davidson L, Pizard A, Seidman JG, Seidman CE, Chen XJ, Henkelman RM, Bruneau BG, Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Dev Biol. 2006 Sep 15;297(2):566-86
1*	J:234993 Nishiguchi Y, Ohmoto M, Koki J, Enomoto T, Kominami R, Matsumoto I, Hirota J, Bcl11b/Ctip2 is required for development of lingual papillae in mice. Dev Biol. 2016 Aug 1;416(1):98-110
2	J:240032 Nouri N, Awatramani R, A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons. Development. 2017 Mar 01;144(5):916-927
1	J:335201 Ohmoto M, Jyotaki M, Yee KK, Matsumoto I, A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells. eNeuro. 2023 Apr;10(4):ENEURO.0236-22.2023
4	J:191410 Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS, Convergence of the insulin and serotonin programs in the pancreatic beta-cell. Diabetes. 2011 Dec;60(12):3208-16
7*	J:308675 Prickett AR, Montibus B, Barkas N, Amante SM, Franco MM, Cowley M, Puszyk W, Shannon MF, Irving MD, Madon-Simon M, Ward A, Schulz R, Baldwin HS, Oakey RJ, Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart. Front Cell Dev Biol. 2021;9:676543
2	J:186263 Ratzka A, Baron O, Stachowiak MK, Grothe C, Fibroblast growth factor 2 regulates dopaminergic neuron development in vivo. J Neurochem. 2012 Jul;122(1):94-105
2	J:294332 Romanov RA, Tretiakov EO, Kastriti ME, Zupancic M, Haring M, Korchynska S, Popadin K, Benevento M, Rebernik P, Lallemend F, Nishimori K, Clotman F, Andrews WD, Parnavelas JG, Farlik M, Bock C, Adameyko I, Hokfelt T, Keimpema E, Harkany T, Molecular design of hypothalamus development. Nature. 2020 Jun;582(7811):246-252
1	J:155932 Rose MF, Ahmad KA, Thaller C, Zoghbi HY, Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22462-7
2	J:122105 Ryu S, Mahler J, Acampora D, Holzschuh J, Erhardt S, Omodei D, Simeone A, Driever W, Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development. Curr Biol. 2007 May 15;17(10):873-80
1	J:269436 Sabbagh MF, Heng JS, Luo C, Castanon RG, Nery JR, Rattner A, Goff LA, Ecker JR, Nathans J, Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells. Elife. 2018 Sep 6;7:e36187
1	J:317591 Saito Y, Ono T, Takeda N, Nohmi T, Seki M, Enomoto T, Noda T, Uehara Y, Embryonic lethality in mice lacking mismatch-specific thymine DNA glycosylase is partially prevented by DOPS, a precursor of noradrenaline. Tohoku J Exp Med. 2012 Jan;226(1):75-83
1*	J:46856 Saucedo-Cardenas O, Quintana-Hau JD, Le WD, Smidt MP, Cox JJ , De Mayo F , Burbach JP , Conneely OM, Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4013-8
2*	J:169536 Seta Y, Oda M, Kataoka S, Toyono T, Toyoshima K, Mash1 is required for the differentiation of AADC-positive type III cells in mouse taste buds. Dev Dyn. 2011 Apr;240(4):775-84
1	J:185964 Sgado P, Ferretti E, Grbec D, Bozzi Y, Simon HH, The atypical homeoprotein Pbx1a participates in the axonal pathfinding of mesencephalic dopaminergic neurons. Neural Dev. 2012;7:24
4	J:332239 Sheng KY, Nakano T, Yamaguchi S, A region-dependent allele-biased expression of Dopa decarboxylase in mouse brain. Front Cell Dev Biol. 2022;10:1078927
1	J:198880 Shi M, Hu ZL, Zheng MH, Song NN, Huang Y, Zhao G, Han H, Ding YQ, Notch-Rbpj signaling is required for the development of noradrenergic neurons in the mouse locus coeruleus. J Cell Sci. 2012 Sep 15;125(Pt 18):4320-32
2	J:146865 Shiura H, Nakamura K, Hikichi T, Hino T, Oda K, Suzuki-Migishima R, Kohda T, Kaneko-ishino T, Ishino F, Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation. Hum Mol Genet. 2009 Apr 15;18(8):1424-38
2	J:88592 Smidt MP, Smits SM, Bouwmeester H, Hamers FP, van der Linden AJ, Hellemons AJ, Graw J, Burbach JP, Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene Pitx3. Development. 2004 Mar;131(5):1145-55
5	J:89797 Smits SM, Ponnio T, Conneely OM, Burbach JP, Smidt MP, Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons. Eur J Neurosci. 2003 Oct;18(7):1731-8
1*	J:286599 Song NN, Ma P, Zhang Q, Zhang L, Wang H, Zhang L, Zhu L, He CH, Mao B, Ding YQ, Rnf220/Zc4h2-mediated monoubiquitylation of Phox2 is required for noradrenergic neuron development. Development. 2020 Mar 30;147(6):dev185199
2	J:197145 Stott SR, Metzakopian E, Lin W, Kaestner KH, Hen R, Ang SL, Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages. J Neurosci. 2013 May 1;33(18):8022-34
2*	J:171106 Suzuki-Hirano A, Ogawa M, Kataoka A, Yoshida AC, Itoh D, Ueno M, Blackshaw S, Shimogori T, Dynamic spatiotemporal gene expression in embryonic mouse thalamus. J Comp Neurol. 2011 Feb 15;519(3):528-43
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:147559 Thuret S, Alavian KN, Gassmann M, Lloyd CK, Smits SM, Smidt MP, Klein R, Dyck RH, Simon HH, The neuregulin receptor, ErbB4, is not required for normal development and adult maintenance of the substantia nigra pars compacta. J Neurochem. 2004 Dec;91(6):1302-11
2	J:199302 Veenvliet JV, Dos Santos MT, Kouwenhoven WM, von Oerthel L, Lim JL, van der Linden AJ, Koerkamp MJ, Holstege FC, Smidt MP, Specification of dopaminergic subsets involves interplay of En1 and Pitx3. Development. 2013 Aug;140(16):3373-84
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1*	J:309106 Voigt A, Hubner S, Doring L, Perlach N, Hermans-Borgmeyer I, Boehm U, Meyerhof W, Cre-Mediated Recombination in Tas2r131 Cells-A Unique Way to Explore Bitter Taste Receptor Function Inside and Outside of the Taste System. Chem Senses. 2015 Nov;40(9):627-39
1*	J:279388 Weiss AC, Bohnenpoll T, Kurz J, Blank P, Airik R, Ludtke TH, Kleppa MJ, Deuper L, Kaiser M, Mamo TM, Costa R, von Hahn T, Trowe MO, Kispert A, Delayed onset of smooth muscle cell differentiation leads to hydroureter formation in mice with conditional loss of the zinc finger transcription factor gene Gata2 in the ureteric mesenchyme. J Pathol. 2019 Aug;248(4):452-463
2	J:310536 Wever I, Largo-Barrientos P, Hoekstra EJ, Smidt MP, Lmx1b Influences Correct Post-mitotic Coding of Mesodiencephalic Dopaminergic Neurons. Front Mol Neurosci. 2019;12:62
3	J:235000 Wu HH, Choi S, Levitt P, Differential patterning of genes involved in serotonin metabolism and transport in extra-embryonic tissues of the mouse. Placenta. 2016 Jun;42:74-83
1	J:176226 Yan CH, Levesque M, Claxton S, Johnson RL, Ang SL, Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors. J Neurosci. 2011 Aug 31;31(35):12413-25
1	J:312485 Zhang Q, Zhang L, Huang Y, Ma P, Mao B, Ding YQ, Song NN, Satb2 regulates the development of dopaminergic neurons in the arcuate nucleus by Dlx1. Cell Death Dis. 2021 Sep 25;12(10):879