Gene Expression Literature Summary

• Symbol: Dhfr
• Name: dihydrofolate reductase
• ID: MGI:94890

12 matching records from 12 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E8.5	E11.5	E12.5	E13.5	E14.5	E17.5	P
Immunohistochemistry (section)							1
In situ RNA (section)					3
Western blot		1	1	3	1		1
RT-PCR	1	1	2	1		1	2
RNase protection			1	1			1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Dhfr  dihydrofolate reductase   (Synonyms: 8430436I03Rik)
Results	Reference
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1*	J:224837 Dutchak PA, Laxman S, Estill SJ, Wang C, Wang Y, Wang Y, Bulut GB, Gao J, Huang LJ, Tu BP, Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2. Cell Rep. 2015 Jul 21;12(3):371-9
1	J:272744 Fawal MA, Jungas T, Kischel A, Audouard C, Iacovoni JS, Davy A, Cross Talk between One-Carbon Metabolism, Eph Signaling, and Histone Methylation Promotes Neural Stem Cell Differentiation. Cell Rep. 2018 Jun 5;23(10):2864-2873.e7
1	J:40354 Marin M, Karis A, Visser P, Grosveld F, Philipsen S, Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell. 1997 May 16;89(4):619-28
3*	J:15697 Mitchell PJ, Timmons PM, Hebert JM, Rigby PW, Tjian R, Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes Dev. 1991 Jan;5(1):105-19
1	J:226897 Parker A, Cross SH, Jackson IJ, Hardisty-Hughes R, Morse S, Nicholson G, Coghill E, Bowl MR, Brown SD, The goya mouse mutant reveals distinct newly identified roles for MAP3K1 in the development and survival of cochlear sensory hair cells. Dis Model Mech. 2015 Dec 1;8(12):1555-68
6	J:341708 Saha S, Jungas TT, Ohayon D, Audouard C, Ye T, Fawal MA, Davy A, Dihydrofolate reductase activity controls neurogenic transitions in the developing neocortex. Development. 2023 Oct 15;150(20):dev201696
4*	J:236197 Thoms JA, Knezevic K, Liu JJ, Glaros EN, Thai T, Qiao Q, Campbell H, Packham D, Huang Y, Papathanasiou P, Tunningley R, Whittle B, Yeung AW, Chandrakanthan V, Hesson L, Chen V, Wong JW, Purton LE, Ward RL, Thomas SR, Pimanda JE, Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr. Mol Cell Biol. 2016 Apr;36(8):1222-36
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:310006 Weng Q, Wang J, Wang J, Tan B, Wang J, Wang H, Zheng T, Lu QR, Yang B, He Q, Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKalpha Activity. Sci Rep. 2017 May 11;7(1):1705
1	J:170580 Wenzel PL, Chong JL, Saenz-Robles MT, Ferrey A, Hagan JP, Gomez YM, Rajmohan R, Sharma N, Chen HZ, Pipas JM, Robinson ML, Leone G, Cell proliferation in the absence of E2F1-3. Dev Biol. 2011 Mar 1;351(1):35-45
1	J:264530 Zaffran S, Odelin G, Stefanovic S, Lescroart F, Etchevers HC, Ectopic expression of Hoxb1 induces cardiac and craniofacial malformations. Genesis. 2018 Jun;56(6-7):e23221