Gene Expression Literature Summary

• Symbol: Dmp1
• Name: dentin matrix protein 1
• ID: MGI:94910

57 matching records from 57 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19.5	E20	P
Immunohistochemistry (section)	2		1		3		1		3		1	1	3			14
In situ RNA (section)	3	1	3		5	1	3	2	3	2	2	2	4	2	1	9
In situ RNA (whole mount)			1
In situ reporter (knock in)			1				2		1				1			6
Northern blot																2
Western blot																6
RT-PCR	2	1	2	1	6	1	2		5		3	3	7			18
cDNA clones					1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Dmp1  dentin matrix protein 1
Results	Reference
2	J:87161 Aberg T, Cavender A, Gaikwad JS, Bronckers AL, Wang X, Waltimo-Siren J, Thesleff I, D'Souza RN, Phenotypic changes in dentition of Runx2 homozygote-null mutant mice. J Histochem Cytochem. 2004 Jan;52(1):131-9
1	J:309392 Amano K, Densmore MJ, Lanske B, Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation. J Bone Miner Res. 2015 Dec;30(12):2262-72
3	J:326693 Angelozzi M, Pellegrino da Silva R, Gonzalez MV, Lefebvre V, Single-cell atlas of craniogenesis uncovers SOXC-dependent, highly proliferative, and myofibroblast-like osteodermal progenitors. Cell Rep. 2022 Jul 12;40(2):111045
1	J:291194 Aryal YP, Neupane S, Adhikari N, An CH, Ha JH, Kwon TY, Yamamoto H, Jung JK, Park EK, Kim JY, Cho SW, Sohn WJ, Lee Y, Chae HJ, Kim HR, Kim JY, An endoplasmic reticulum stress regulator, Tmbim6, modulates secretory stage of mice molar. J Cell Physiol. 2019 Nov;234(11):20354-20365
1*	J:60658 Bouwman P, Gollner H, Elsasser HP, Eckhoff G, Karis A, Grosveld F, Philipsen S, Suske G, Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO J. 2000 Feb 15;19(4):655-61
2	J:261043 Chan WL, Steiner M, Witkos T, Egerer J, Busse B, Mizumoto S, Pestka JM, Zhang H, Hausser I, Khayal LA, Ott CE, Kolanczyk M, Willie B, Schinke T, Paganini C, Rossi A, Sugahara K, Amling M, Knaus P, Chan D, Lowe M, Mundlos S, Kornak U, Impaired proteoglycan glycosylation, elevated TGF-beta signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. PLoS Genet. 2018 Mar;14(3):e1007242
10	J:44807 D'Souza RN, Cavender A, Sunavala G, Alvarez J, Ohshima T, Kulkarni AB, MacDougall M, Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo. J Bone Miner Res. 1997 Dec;12(12):2040-9
1	J:65294 Dassule HR, Lewis P, Bei M, Maas R, McMahon AP, Sonic hedgehog regulates growth and morphogenesis of the tooth. Development. 2000 Nov;127(22):4775-85
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:184287 Duverger O, Zah A, Isaac J, Sun HW, Bartels AK, Lian JB, Berdal A, Hwang J, Morasso MI, Neural crest deletion of Dlx3 leads to major dentin defects through down-regulation of Dspp. J Biol Chem. 2012 Apr 6;287(15):12230-40
1	J:308983 Farmer DT, Mlcochova H, Zhou Y, Koelling N, Wang G, Ashley N, Bugacov H, Chen HJ, Parvez R, Tseng KC, Merrill AE, Maxson RE Jr, Wilkie AOM, Crump JG, Twigg SRF, The developing mouse coronal suture at single-cell resolution. Nat Commun. 2021 Aug 10;12(1):4797
6	J:85859 Feng JQ, Huang H, Lu Y, Ye L, Xie Y, Tsutsui TW, Kunieda T, Castranio T, Scott G, Bonewald LB, Mishina Y, The Dentin Matrix Protein 1 (Dmp1) is Specifically Expressed in Mineralized, but not Soft, Tissues during Development. J Dent Res. 2003 Oct;82(10):776-80
7*	J:111429 Feng JQ, Zhang J, Dallas SL, Lu Y, Chen S, Tan X, Owen M, Harris SE, MacDougall M, Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. J Bone Miner Res. 2002 Oct;17(10):1822-31
16*	J:227060 Fujikawa K, Yokohama-Tamaki T, Morita T, Baba O, Qin C, Shibata S, An in situ hybridization study of perlecan, DMP1, and MEPE in developing condylar cartilage of the fetal mouse mandible and limb bud cartilage. Eur J Histochem. 2015;59(3):2553
1	J:73345 Gaikwad JS, Cavender A, D'Souza RN, Identification of tooth-specific downstream targets of Runx2. Gene. 2001 Nov 14;279(1):91-7
1	J:80081 Gritli-Linde A, Bei M, Maas R, Zhang XM, Linde A, McMahon AP, Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development. 2002 Dec;129(23):5323-37
1	J:233764 Gullard A, Gluhak-Heinrich J, Papagerakis S, Sohn P, Unterbrink A, Chen S, MacDougall M, MEPE Localization in the Craniofacial Complex and Function in Tooth Dentin Formation. J Histochem Cytochem. 2016 Apr;64(4):224-36
4*	J:146976 Hao J, Ramachandran A, George A, Temporal and spatial localization of the dentin matrix proteins during dentin biomineralization. J Histochem Cytochem. 2009 Mar;57(3):227-37
2*	J:115165 Hecht J, Seitz V, Urban M, Wagner F, Robinson PN, Stiege A, Dieterich C, Kornak U, Wilkening U, Brieske N, Zwingman C, Kidess A, Stricker S, Mundlos S, Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model. Gene Expr Patterns. 2007 Jan;7(1-2):102-12
1	J:256979 Hoac B, Susan-Resiga D, Essalmani R, Marcinkiweicz E, Seidah NG, McKee MD, Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone. Bone. 2018 Feb;107:45-55
1	J:217455 Holm E, Aubin JE, Hunter GK, Beier F, Goldberg HA, Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization. Bone. 2015 Feb;71:145-54
4	J:279157 Jing B, Zhang C, Liu X, Zhou L, Liu J, Yao Y, Yu J, Weng Y, Pan M, Liu J, Wang Z, Sun Y, Sun YE, Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity. Protein Cell. 2018 Mar;9(3):298-309
1	J:260962 Kamiunten T, Ideno H, Shimada A, Arai Y, Terashima T, Tomooka Y, Nakamura Y, Nakashima K, Kimura H, Shinkai Y, Tachibana M, Nifuji A, Essential roles of G9a in cell proliferation and differentiation during tooth development. Exp Cell Res. 2017 Aug 15;357(2):202-210
1	J:108608 Kilic G, Wang J, Sosa-Pineda B, Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice. Dev Dyn. 2006 Jun;235(6):1659-67
1	J:313928 Kim EJ, Lee JE, Yoon S, Lee DJ, Mai HN, Ida-Yonemochi H, Choi J, Jung HS, Hypoxia-Responsive Oxygen Nanobubbles for Tissues-Targeted Delivery in Developing Tooth Germs. Front Cell Dev Biol. 2021;9:626224
1	J:279226 Kim TH, Bae CH, Lee JC, Kim JE, Yang X, de Crombrugghe B, Cho ES, Osterix regulates tooth root formation in a site-specific manner. J Dent Res. 2015 Mar;94(3):430-8
1	J:294900 Koide M, Yamashita T, Murakami K, Uehara S, Nakamura K, Nakamura M, Matsushita M, Ara T, Yasuda H, Penninger JM, Takahashi N, Udagawa N, Kobayashi Y, Sclerostin expression in trabecular bone is downregulated by osteoclasts. Sci Rep. 2020 Aug 13;10(1):13751
1*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
3	J:197592 Kyono A, Avishai N, Ouyang Z, Landreth GE, Murakami S, FGF and ERK signaling coordinately regulate mineralization-related genes and play essential roles in osteocyte differentiation. J Bone Miner Metab. 2012 Jan;30(1):19-30
2	J:358271 Li Y, Lin Y, Guo J, Huang D, Zuo H, Zhang H, Yuan G, Liu H, Chen Z, CREB3L1 deficiency impairs odontoblastic differentiation and molar dentin deposition partially through the TMEM30B. Int J Oral Sci. 2024 Oct 10;16(1):59
1*	J:203695 Lieben L, Stockmans I, Moermans K, Carmeliet G, Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality. Bone. 2013 Nov;57(1):123-31
4	J:314657 Lin S, Zhang Q, Cao Z, Lu Y, Zhang H, Yan K, Liu Y, McKee MD, Qin C, Chen Z, Feng JQ, Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype. J Biol Chem. 2014 Aug 1;289(31):21533-43
3	J:133879 Lu Y, Zhang S, Xie Y, Pi Y, Feng JQ, Differential regulation of dentin matrix protein 1 expression during odontogenesis. Cells Tissues Organs. 2005;181(3-4):241-7
2	J:320375 Mirigian LS, Makareeva E, Mertz EL, Omari S, Roberts-Pilgrim AM, Oestreich AK, Phillips CL, Leikin S, Osteoblast Malfunction Caused by Cell Stress Response to Procollagen Misfolding in alpha2(I)-G610C Mouse Model of Osteogenesis Imperfecta. J Bone Miner Res. 2016 Aug;31(8):1608-1616
1	J:334075 Mitsiadis TA, Pagella P, Gomes Rodrigues H, Tsouknidas A, Ramenzoni LL, Radtke F, Mehl A, Viriot L, Notch Signaling Pathway in Tooth Shape Variations throughout Evolution. Cells. 2023 Feb 27;12(5)
1	J:213581 Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A, Ono N, Kronenberg HM, Frenette PS, Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development. Dev Cell. 2014 May 12;29(3):340-9
3*	J:96853 Mukhopadhyay P, Greene RM, Zacharias W, Weinrich MC, Singh S, Young WW Jr, Pisano MM, Developmental gene expression profiling of mammalian, fetal orofacial tissue. Birth Defects Res A Clin Mol Teratol. 2004 Dec;70(12):912-26
10*	J:311146 Murata H, Sunohara M, Sato I, Expression of DMP1 in the developing mouse tongue embryo. Ann Anat. 2015 Jul;200:136-48
2*	J:338540 Nakamura T, Honda S, Ito S, Mizoguchi T, Yamamoto T, Kasahara M, Kabe Y, Matsuo K, Suematsu M, Generation of bicistronic Dmp1-Cre knock-in mice using a self-cleaving 2A peptide. J Bone Miner Metab. 2023 Jul;41(4):470-480
1	J:328990 Patel T, Hammelman J, Aziz S, Jang S, Closser M, Michaels TL, Blum JA, Gifford DK, Wichterle H, Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro. Nat Commun. 2022 Sep 15;13(1):5427
1	J:352719 Pina JO, Raju R, Roth DM, Winchester EW, Padilla C, Iben J, Faucz FR, Cotney JL, D'Souza RN, Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in Palatogenesis'. J Dent Res. 2024 Jun 23;:220345241256600
2	J:321080 Prasadam I, Zhou Y, Shi W, Crawford R, Xiao Y, Role of dentin matrix protein 1 in cartilage redifferentiation and osteoarthritis. Rheumatology (Oxford). 2014 Dec;53(12):2280-7
2*	J:147982 Sehic A, Khuu C, Risnes S, Osmundsen H, Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of PPAR-alpha knockout mouse. Eur J Oral Sci. 2009 Apr;117(2):93-104
1*	J:165465 Sehic A, Risnes S, Khan QE, Khuu C, Osmundsen H, Gene expression and dental enamel structure in developing mouse incisor. Eur J Oral Sci. 2010 Apr;118(2):118-30
1	J:159823 Sohaskey ML, Jiang Y, Zhao JJ, Mohr A, Roemer F, Harland RM, Osteopotentia regulates osteoblast maturation, bone formation, and skeletal integrity in mice. J Cell Biol. 2010 May 3;189(3):511-25
1	J:286823 Wang L, Tang Q, Xu J, Li H, Yang T, Li L, Machon O, Hu T, Chen Y, The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice. J Biol Chem. 2020 Apr 17;295(16):5449-5460
3	J:99574 Wilson MJ, Liaw L, Koopman P, Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis development. Dev Dyn. 2005 Aug;233(4):1488-95
6*	J:308930 Xia X, Ruan Y, Li B, Yu Y, Kong X, Zhuang P, Wu H, The Long Non-coding RNA lnc-DMP1 Regulates Dmp1 Expression Through H3K27Ac Modification. Front Genet. 2020;11:233
1*	J:240559 Xiong F, Ji Z, Liu Y, Zhang Y, Hu L, Yang Q, Qiu Q, Zhao L, Chen D, Tian Z, Shang X, Zhang L, Wei X, Liu C, Yu Q, Zhang M, Cheng J, Xiong J, Li D, Wu X, Yuan H, Zhang W, Xu X, Mutation in SSUH2 Causes Autosomal-Dominant Dentin Dysplasia Type I. Hum Mutat. 2017 Jan;38(1):95-104
2	J:164319 Xu Y, Zhang H, Yang H, Zhao X, Lovas S, Lundberg YW, Expression, functional, and structural analysis of proteins critical for otoconia development. Dev Dyn. 2010 Oct;239(10):2659-73
1*	J:307192 Yadav PS, Feng S, Cong Q, Kim H, Liu Y, Yang Y, Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/beta-catenin signaling. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2020100118
2	J:89498 Ye L, MacDougall M, Zhang S, Xie Y, Zhang J, Li Z, Lu Y, Mishina Y, Feng JQ, Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. J Biol Chem. 2004 Apr 30;279(18):19141-8
1*	J:281175 Yorgan TA, Peters S, Amling M, Schinke T, Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Bone. 2019 Oct;127:155-163
4	J:329949 Yuan H, Xie B, Yu X, Lin C, Li M, Zhang Y, Zou X, Lu M, Zhao M, Wen X, A potential role of p75NTR in the regulation of circadian rhythm and incremental growth lines during tooth development. Front Physiol. 2022;13:981311
1	J:168525 Zhang S, Xiao Z, Luo J, He N, Mahlios J, Quarles LD, Dose-dependent effects of Runx2 on bone development. J Bone Miner Res. 2009 Nov;24(11):1889-904
7*	J:336094 Zheng H, Zhang X, Fu J, Xue Y, Chen Z, Yang G, Chen Y, Chen D, Yuan G, CHIP inhibits odontoblast differentiation through promoting DLX3 polyubiquitylation and degradation. Development. 2023 May 15;150(10):dev200848
1	J:292430 Zhou T, Gao B, Fan Y, Liu Y, Feng S, Cong Q, Zhang X, Zhou Y, Yadav PS, Lin J, Wu N, Zhao L, Huang D, Zhou S, Su P, Yang Y, Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ss-catenin. Elife. 2020 Mar 18;9:e52779