Gene Expression Literature Summary

• Symbol: Edn2
• Name: endothelin 2
• ID: MGI:95284

15 matching records from 15 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E7.5	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E14	E14.5	E15	E15.5	E16	E17	E17.5	E18	E18.5	P
Immunohistochemistry (section)																				1
In situ RNA (section)							1		1			1								1
In situ reporter (knock in)									1											2
Northern blot																			1
RT-PCR	1	1	1	1	1	2		1	2	1	2	2	2	1	1	3	1	1		8

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Edn2  endothelin 2   (Synonyms: vasoactive intestinal contractor peptide, VIC)
Results	Reference
1	J:194534 Chang CY, Pasolli HA, Giannopoulou EG, Guasch G, Gronostajski RM, Elemento O, Fuchs E, NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature. 2013 Mar 7;495(7439):98-102
11	J:201436 Chang I, Bramall AN, Baynash AG, Rattner A, Rakheja D, Post M, Joza S, McKerlie C, Stewart DJ, McInnes RR, Yanagisawa M, Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
1	J:223559 Goetz JJ, Martin GM, Chowdhury R, Trimarchi JM, Onecut1 and Onecut2 play critical roles in the development of the mouse retina. PLoS One. 2014;9(10):e110194
1	J:286621 Iwagawa T, Aihara Y, Umutoni D, Baba Y, Murakami A, Miyado K, Watanabe S, Cd9 Protects Photoreceptors from Injury and Potentiates Edn2 Expression. Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):7
2*	J:228563 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H, The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9
1*	J:193822 Lumayag S, Haldin CE, Corbett NJ, Wahlin KJ, Cowan C, Turturro S, Larsen PE, Kovacs B, Witmer PD, Valle D, Zack DJ, Nicholson DA, Xu S, Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
1*	J:30606 Maemura K, Kurihara H, Kurihara Y, Kuwaki T, Kumada M, Yazaki Y, Gene expression of endothelin isoforms and receptors in endothelin-1 knockout mice. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S17-21
3*	J:133765 Makita T, Sucov HM, Gariepy CE, Yanagisawa M, Ginty DD, Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature. 2008 Apr 10;452(7188):759-63
1	J:250662 Manousiouthakis E, Mendez M, Garner MC, Exertier P, Makita T, Venous endothelin guides sympathetic innervation of the developing mouse heart. Nat Commun. 2014 May 29;5:3918
1	J:201133 Rattner A, Yu H, Williams J, Smallwood PM, Nathans J, Endothelin-2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3830-E3839
8*	J:61084 Saida K, Hashimoto M, Mitsui Y, Ishida N, Uchide T, The prepro vasoactive intestinal contractor (VIC)/endothelin-2 gene (EDN2): structure, evolution, production, and embryonic expression. Genomics. 2000 Feb 15;64(1):51-61
2*	J:80865 Saida K, Kometani N, Uchide T, Mitsui Y, Sequence analysis and expression of the mouse full-length vasoactive intestinal contractor/endothelin-2 gene (EDN2): comparison with the endothelin-1 gene (EDN1). Clin Sci (Lond). 2002 Aug;103 Suppl 48:84S-89S
3*	J:80864 Uchide T, Fujimori Y, Sasaki T, Temma K, Adur J, Masuo Y, Kozakai T, Lee YS, Saida K, Expression of endothelin-1 and vasoactive intestinal contractor genes in mouse organs during the perinatal period. Clin Sci (Lond). 2002 Aug;103 Suppl 48:167S-170S
4*	J:54819 Uchide T, Masuda H, Mitsui Y, Saida K, Gene expression of vasoactive intestinal contractor/endothelin-2 in ovary, uterus and embryo: comprehensive gene expression profiles of the endothelin ligand-receptor system revealed by semi-quantitative reverse transcription-polymerase chain reaction analysis in adult mouse tissues and during late embryonic development. J Mol Endocrinol. 1999 Apr;22(2):161-71
1*	J:281175 Yorgan TA, Peters S, Amling M, Schinke T, Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Bone. 2019 Oct;127:155-163