Gene Expression Literature Summary

• Symbol: Edn3
• Name: endothelin 3
• ID: MGI:95285

22 matching records from 22 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E9.5	E10	E10.5	E11	E11.5	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	P
Immunohistochemistry (section)																				1
In situ RNA (section)					1	2		1		5
In situ RNA (whole mount)	1	1	4	2	1	1	1							1
Northern blot									1		1		1		1	1	1	1	1	3
RT-PCR	2			1	1	3			1	2	1	1			1			1		4

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Edn3  endothelin 3   (Synonyms: 114-CH19, 114CH19, tmgc48)
Results	Reference
3	J:178973 Adameyko I, Lallemend F, Furlan A, Zinin N, Aranda S, Kitambi SS, Blanchart A, Favaro R, Nicolis S, Lubke M, Muller T, Birchmeier C, Suter U, Zaitoun I, Takahashi Y, Ernfors P, Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest. Development. 2012 Jan;139(2):397-410
3	J:130623 Barlow A, de Graaff E, Pachnis V, Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET. Neuron. 2003 Dec 4;40(5):905-16
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:194534 Chang CY, Pasolli HA, Giannopoulou EG, Guasch G, Gronostajski RM, Elemento O, Fuchs E, NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche. Nature. 2013 Mar 7;495(7439):98-102
1	J:201436 Chang I, Bramall AN, Baynash AG, Rattner A, Rakheja D, Post M, Joza S, McKerlie C, Stewart DJ, McInnes RR, Yanagisawa M, Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3;123(6):2643-53
2*	J:230345 Gordon CT, Weaver KN, Zechi-Ceide RM, Madsen EC, Tavares AL, Oufadem M, Kurihara Y, Adameyko I, Picard A, Breton S, Pierrot S, Biosse-Duplan M, Voisin N, Masson C, Bole-Feysot C, Nitschke P, Delrue MA, Lacombe D, Guion-Almeida ML, Moura PP, Garib DG, Munnich A, Ernfors P, Hufnagel RB, Hopkin RJ, Kurihara H, Saal HM, Weaver DD, Katsanis N, Lyonnet S, Golzio C, Clouthier DE, Amiel J, Mutations in the endothelin receptor type A cause mandibulofacial dysostosis with alopecia. Am J Hum Genet. 2015 Apr 2;96(4):519-31
1	J:353992 Goto A, Sumiyama K, Kamioka Y, Nakasyo E, Ito K, Iwasaki M, Enomoto H, Matsuda M, GDNF and endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1. J Neurosci. 2013 Mar 13;33(11):4901-12
2	J:177673 Kim H, Kang K, Ekram MB, Roh TY, Kim J, Aebp2 as an epigenetic regulator for neural crest cells. PLoS One. 2011;6(9):e25174
1*	J:333327 Kurihara Y, Ekimoto T, Gordon CT, Uchijima Y, Sugiyama R, Kitazawa T, Iwase A, Kotani R, Asai R, Pingault V, Ikeguchi M, Amiel J, Kurihara H, Mandibulofacial dysostosis with alopecia results from ETAR gain-of-function mutations via allosteric effects on ligand binding. J Clin Invest. 2023 Feb 15;133(4)
6*	J:52925 Leibl MA, Ota T, Woodward MN, Kenny SE, Lloyd DA, Vaillant CR, Edgar DH, Expression of endothelin 3 by mesenchymal cells of embryonic mouse caecum [see comments]. Gut. 1999 Feb;44(2):246-52
2*	J:30606 Maemura K, Kurihara H, Kurihara Y, Kuwaki T, Kumada M, Yazaki Y, Gene expression of endothelin isoforms and receptors in endothelin-1 knockout mice. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S17-21
2*	J:31183 Maemura K, Kurihara H, Kurihara Y, Oda H, Ishikawa T, Copeland NG, Gilbert DJ, Jenkins NA, Yazaki Y, Sequence analysis, chromosomal location, and developmental expression of the mouse preproendothelin-1 gene. Genomics. 1996 Jan 15;31(2):177-84
5*	J:133765 Makita T, Sucov HM, Gariepy CE, Yanagisawa M, Ginty DD, Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature. 2008 Apr 10;452(7188):759-63
1	J:250662 Manousiouthakis E, Mendez M, Garner MC, Exertier P, Makita T, Venous endothelin guides sympathetic innervation of the developing mouse heart. Nat Commun. 2014 May 29;5:3918
1*	J:257654 Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstrom E, Pachnis V, Marklund U, Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
2*	J:317548 Nishida S, Yoshizaki H, Yasui Y, Kuwahara T, Kiyokawa E, Kohno M, Collagen VI suppresses fibronectin-induced enteric neural crest cell migration by downregulation of focal adhesion proteins. Biochem Biophys Res Commun. 2018 Jan 1;495(1):1461-1467
7*	J:37680 Reid K, Turnley AM, Maxwell GD, Kurihara Y, Kurihara H, Bartlett PF, Murphy M, Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation. Development. 1996 Dec;122(12):3911-9
1	J:325352 Sahut-Barnola I, Lefrancois-Martinez AM, Dufour D, Botto JM, Kamilaris C, Faucz FR, Stratakis CA, Val P, Martinez A, Steroidogenic Factor-1 Lineage Origin of Skin Lesions in Carney Complex Syndrome. J Invest Dermatol. 2022 May 12;
4*	J:54819 Uchide T, Masuda H, Mitsui Y, Saida K, Gene expression of vasoactive intestinal contractor/endothelin-2 in ovary, uterus and embryo: comprehensive gene expression profiles of the endothelin ligand-receptor system revealed by semi-quantitative reverse transcription-polymerase chain reaction analysis in adult mouse tissues and during late embryonic development. J Mol Endocrinol. 1999 Apr;22(2):161-71
2*	J:116618 Vohra BP, Planer W, Armon J, Fu M, Jain S, Heuckeroth RO, Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis. Dev Dyn. 2007 Jan;236(1):106-17
2	J:25759 Williamson CM, Dutton ER, Abbott CM, Beechey CV, Ball ST, Peters J, Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1, Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal imprinting region of mouse chromosome 2 are not monoallelically expressed. Genet Res. 1995 Apr;65(2):83-93
1	J:316159 Yu Q, Du M, Zhang W, Liu L, Gao Z, Chen W, Gu Y, Zhu K, Niu X, Sun Q, Wang L, Mesenteric Neural Crest Cells Are the Embryological Basis of Skip Segment Hirschsprung's Disease. Cell Mol Gastroenterol Hepatol. 2021;12(1):1-24